{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T09:58:18Z","timestamp":1760522298752},"reference-count":37,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2005,2,1]],"date-time":"2005-02-01T00:00:00Z","timestamp":1107216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2005,2]]},"DOI":"10.1016\/j.ejmech.2004.09.008","type":"journal-article","created":{"date-parts":[[2004,12,15]],"date-time":"2004-12-15T13:47:39Z","timestamp":1103118459000},"page":"215-223","source":"Crossref","is-referenced-by-count":7,"title":["Estimation of the effect of the acidosis and alkalosis on the anesthetic potency of local anesthetics by biopartitioning micellar chromatography and micellar electrokinetic chromatography"],"prefix":"10.1016","volume":"40","author":[{"given":"N.","family":"Can\u00f3s-Rius","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Mart\u00edn-Biosca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Sagrado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.M.","family":"Villanueva-Cama\u00f1as","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.J.","family":"Medina-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2004.09.008_bib1","series-title":"Comprehensive Medicinal Chemistry","year":"1990"},{"key":"10.1016\/j.ejmech.2004.09.008_bib2","first-page":"400","volume":"18","author":"Kaliszan","year":"1999","journal-title":"TRAC"},{"key":"10.1016\/j.ejmech.2004.09.008_bib3","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/0021-9673(93)80815-P","volume":"656","author":"Dorsey","year":"1993","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.ejmech.2004.09.008_bib4","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/0021-9673(93)80814-O","volume":"656","author":"Lambert","year":"1993","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.ejmech.2004.09.008_bib5","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1021\/ac00008a019","volume":"63","author":"Breyer","year":"1991","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ejmech.2004.09.008_bib6","doi-asserted-by":"crossref","first-page":"619A","DOI":"10.1021\/ac00035a001","volume":"64","author":"Kaliszan","year":"1992","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ejmech.2004.09.008_bib7","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0021-9673(95)00837-3","volume":"728","author":"Ong","year":"1996","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.ejmech.2004.09.008_bib8","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0378-4347(98)00370-3","volume":"720","author":"Lundahl","year":"1999","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.ejmech.2004.09.008_bib9","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/BF02490520","volume":"46","author":"Sanchis-Mallols","year":"1997","journal-title":"Chromatographia"},{"key":"10.1016\/j.ejmech.2004.09.008_bib10","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0021-9673(98)00375-6","volume":"814","author":"Cuenca-Benito","year":"1998","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.ejmech.2004.09.008_bib11","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1021\/ac970464o","volume":"70","author":"Escuder-Gilabert","year":"1998","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ejmech.2004.09.008_bib12","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/bmc.24","volume":"15","author":"Qui\u00f1ones-Torrelo","year":"2001","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.ejmech.2004.09.008_bib13","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0378-4347(00)00546-6","volume":"753","author":"Molero-Monfort","year":"2001","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.ejmech.2004.09.008_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0021-9673(99)01067-5","volume":"870","author":"Molero-Monfort","year":"2000","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.ejmech.2004.09.008_bib15","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1021\/ac00008a019","volume":"63","author":"Breyer","year":"1991","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ejmech.2004.09.008_bib16","series-title":"Bioqu\u00edmica, Omega s.a., Barcelona","author":"Voet","year":"1992"},{"key":"10.1016\/j.ejmech.2004.09.008_bib17","doi-asserted-by":"crossref","first-page":"3154","DOI":"10.1021\/jm9910369","volume":"42","author":"Qui\u00f1ones-Torrelo","year":"1999","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2004.09.008_bib18","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1002\/(SICI)1099-0801(199910)13:6<394::AID-BMC898>3.0.CO;2-0","volume":"13","author":"Molero-Monfort","year":"1999","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.ejmech.2004.09.008_bib19","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1002\/(SICI)1099-0801(199911)13:7<478::AID-BMC916>3.0.CO;2-V","volume":"13","author":"Mart\u00edn-Biosca","year":"1999","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.ejmech.2004.09.008_bib20","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/1521-3838(200006)19:3<247::AID-QSAR247>3.0.CO;2-6","volume":"19","author":"Mart\u00edn-Biosca","year":"2000","journal-title":"Quant. Struct.-, Act. Relatsh."},{"key":"10.1016\/j.ejmech.2004.09.008_bib21","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0003-2670(01)01208-9","volume":"443","author":"Mart\u00edn-Biosca","year":"2001","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.ejmech.2004.09.008_bib22","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0378-4347(01)00124-4","volume":"757","author":"Mart\u00ednez-Pla","year":"2001","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.ejmech.2004.09.008_bib23","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0378-4347(00)00021-9","volume":"740","author":"Escuder-Gilabert","year":"2000","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.ejmech.2004.09.008_bib24","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1002\/bmc.281","volume":"17","author":"Mart\u00ednez-Pla","year":"2003","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.ejmech.2004.09.008_bib25","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0928-0987(03)00195-7","volume":"20","author":"Mart\u00edn-Biosca","year":"2003","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejmech.2004.09.008_bib26","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1021\/ac00105a018","volume":"67","author":"Ishihama","year":"1995","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ejmech.2004.09.008_bib27","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1021\/ac9510402","volume":"68","author":"Ishihama","year":"1996","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ejmech.2004.09.008_bib28","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0021-9673(95)00773-3","volume":"721","author":"Yang","year":"1996","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.ejmech.2004.09.008_bib29","doi-asserted-by":"crossref","first-page":"4281","DOI":"10.1021\/ac960447j","volume":"68","author":"Ishihama","year":"1996","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ejmech.2004.09.008_bib30","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0021-9673(99)00147-8","volume":"845","author":"Ros\u00e9s","year":"1999","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.ejmech.2004.09.008_bib31","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0021-9673(01)01346-2","volume":"939","author":"Monton","year":"2001","journal-title":"J. Chromatogr. A"},{"issue":"2","key":"10.1016\/j.ejmech.2004.09.008_bib32","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1023\/A:1012119527214","volume":"14","author":"Barbato","year":"1997","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejmech.2004.09.008_bib33","series-title":"Perspectivas Terap\u00e9uticas con su Fundamento Farmacol\u00f3gico","author":"Espulgues","year":"1981"},{"key":"10.1016\/j.ejmech.2004.09.008_bib34","series-title":"Pharmacologie des concepts fondamentaux aux pplications th\u00e9rapeutiques","author":"Schorderet","year":"1988"},{"key":"10.1016\/j.ejmech.2004.09.008_bib35","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/00000542-198808000-00019","volume":"69","author":"McIlvaine","year":"1988","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ejmech.2004.09.008_bib37","series-title":"Drug Treatment Principles and Practice of Clinical Pharmacology and Therapeutics","author":"Avery","year":"1976"},{"key":"10.1016\/j.ejmech.2004.09.008_bib38","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1213\/00000539-199102000-00020","volume":"72","author":"Durrani","year":"1991","journal-title":"Anesth. Analg."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523404001928?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523404001928?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T05:26:21Z","timestamp":1548912381000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523404001928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,2]]}},"alternative-id":["S0223523404001928"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2004.09.008","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2005,2]]}}}