{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T21:17:24Z","timestamp":1791148644357,"version":"4.1.0"},"reference-count":18,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2005,6]]},"DOI":"10.1016\/j.ejmech.2005.01.009","type":"journal-article","created":{"date-parts":[[2005,3,4]],"date-time":"2005-03-04T15:04:06Z","timestamp":1109948646000},"page":"590-596","source":"Crossref","is-referenced-by-count":22,"title":["Synthesis, physicochemical and in vitro pharmacological investigation of new platinum (II) complexes with some cycloalkanespiro-5\u2032-hydantoins"],"prefix":"10.1016","volume":"40","author":[{"given":"Adriana","family":"Bakalova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossen","family":"Buyukliev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgi","family":"Momekov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darvin","family":"Ivanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitar","family":"Todorov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spiro","family":"Konstantinov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Karaivanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2005.01.009_bib1","series-title":"A Clinician's Guide to Chemotherapy Pharmacokinetics and Pharmacodynamics","first-page":"345","author":"Canal","year":"1998"},{"key":"10.1016\/j.ejmech.2005.01.009_bib2","series-title":"Cancer Medicine, fourth ed","first-page":"648","author":"Michael-Colvin","year":"1998"},{"key":"10.1016\/j.ejmech.2005.01.009_bib3","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S1040-8428(01)00219-0","volume":"42","author":"Desoize","year":"2002","journal-title":"Crit. Rev. Oncol."},{"key":"10.1016\/j.ejmech.2005.01.009_bib4","first-page":"47","volume":"1","author":"Hanigan","year":"2003","journal-title":"Cancer Ther."},{"key":"10.1016\/j.ejmech.2005.01.009_bib5","series-title":"Kompendium Internistische Onkologie, Teil 1","first-page":"1131","author":"Bokemeyer","year":"1996"},{"key":"10.1016\/j.ejmech.2005.01.009_bib6","first-page":"1663","volume":"10","author":"Boulikas","year":"2003","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.ejmech.2005.01.009_bib7","first-page":"143","volume":"14","author":"Akiyama","year":"1999","journal-title":"Anticancer Drug Des."},{"key":"10.1016\/j.ejmech.2005.01.009_bib8","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S1367-5931(03)00081-4","volume":"7","author":"Xin Zhang","year":"2003","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.ejmech.2005.01.009_bib9","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/S1367-5931(99)80037-4","volume":"3","author":"Reedijk","year":"1999","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.ejmech.2005.01.009_bib10","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s002800000261","volume":"47","author":"Amtmann","year":"2001","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.ejmech.2005.01.009_bib11","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0887-2333(02)00022-X","volume":"16","author":"Marzano","year":"2002","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.ejmech.2005.01.009_bib12","first-page":"39","volume":"46","author":"Tcholakova","year":"1993","journal-title":"Compt. Rend. Acad. Bulg. Sci."},{"key":"10.1016\/j.ejmech.2005.01.009_bib13","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0223-5234(03)00080-1","volume":"38","author":"Bakalova","year":"2003","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2005.01.009_bib14","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1021\/ic50071a024","volume":"8","author":"Harris","year":"1969","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.ejmech.2005.01.009_bib15","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S1359-6446(97)01156-2","volume":"3","author":"Kearns","year":"1998","journal-title":"DDT"},{"key":"10.1016\/j.ejmech.2005.01.009_bib16","first-page":"140","volume":"4","author":"Cleare","year":"1979","journal-title":"US Patent"},{"key":"10.1016\/j.ejmech.2005.01.009_bib17","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.ejmech.2005.01.009_bib18","series-title":"Freshney's Culture of Animal Cells\u2014A Multimedia Guide CD-ROM","author":"Freshney","year":"1999"}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523405000280?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523405000280?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T09:57:23Z","timestamp":1548669443000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523405000280"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,6]]}},"alternative-id":["S0223523405000280"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2005.01.009","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2005,6]]}}}