{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:27:39Z","timestamp":1790958459691,"version":"4.1.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2005,12]]},"DOI":"10.1016\/j.ejmech.2005.06.005","type":"journal-article","created":{"date-parts":[[2005,7,23]],"date-time":"2005-07-23T12:07:56Z","timestamp":1122120476000},"page":"1405-1413","source":"Crossref","is-referenced-by-count":87,"title":["Novel milrinone analogs of pyridine-3-carbonitrile derivatives as promising cardiotonic agents"],"prefix":"10.1016","volume":"40","author":[{"given":"Adnan A.","family":"Bekhit","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azza M.","family":"Baraka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2A","key":"10.1016\/j.ejmech.2005.06.005_bib1","first-page":"1A","article-title":"Consensus recommendations for the management of chronic heart failure. On behalf of the membership of the advisory council to improve outcomes nationwide in heart failure","volume":"83","year":"1999","journal-title":"Am. J. Cardiol."},{"issue":"8 Suppl.","key":"10.1016\/j.ejmech.2005.06.005_bib2","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1016\/S1053-2498(99)00107-2","volume":"19","author":"Young","year":"2000","journal-title":"J. Heart Lung Transplant."},{"key":"10.1016\/j.ejmech.2005.06.005_bib3","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/0002-8703(81)90736-5","volume":"102","author":"Braunwald","year":"1981","journal-title":"Am. Heart J."},{"key":"10.1016\/j.ejmech.2005.06.005_bib4","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1161\/01.CIR.73.1.14","volume":"73","author":"Yusuf","year":"1986","journal-title":"Ciculation"},{"key":"10.1016\/j.ejmech.2005.06.005_bib5","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/0735-1097(88)90437-8","volume":"12","author":"Packer","year":"1988","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ejmech.2005.06.005_bib6","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/0024-3205(78)90083-8","volume":"22","author":"Farah","year":"1978","journal-title":"Life Sci."},{"key":"10.1016\/j.ejmech.2005.06.005_bib7","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1016\/0024-3205(83)90686-0","volume":"33","author":"Pastelin","year":"1983","journal-title":"Life Sci."},{"key":"10.1016\/j.ejmech.2005.06.005_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/138620730101220118143111","volume":"1","author":"Domling","year":"1998","journal-title":"Comb. Chem. High Throughput Screen."},{"key":"10.1016\/j.ejmech.2005.06.005_bib9","series-title":"Statistical principles in experimental design, second ed","author":"Winer","year":"1971"},{"key":"10.1016\/j.ejmech.2005.06.005_bib10","first-page":"19","volume":"49","author":"Dorigo","year":"1994","journal-title":"Farmaco"},{"key":"10.1016\/j.ejmech.2005.06.005_bib11","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1021\/jm00069a005","volume":"36","author":"Dorigo","year":"1993","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2005.06.005_bib12","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1161\/01.CIR.88.5.2267","volume":"88","author":"Schwinger","year":"1993","journal-title":"Circulation"},{"key":"10.1016\/j.ejmech.2005.06.005_bib13","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/j.1476-5381.1986.tb14578.x","volume":"87","author":"Dorigo","year":"1986","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejmech.2005.06.005_bib14","first-page":"420","volume":"49","author":"Yoshimura","year":"1999","journal-title":"Arzneimittelforschung"},{"issue":"6","key":"10.1016\/j.ejmech.2005.06.005_bib15","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1161\/hc3201.092285","volume":"104","author":"Gomej","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.ejmech.2005.06.005_bib16","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3109\/10641968809046798","volume":"10","author":"Bing","year":"1988","journal-title":"Clin. Exp. Hypertens."},{"key":"10.1016\/j.ejmech.2005.06.005_bib17","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/0223-5234(94)90193-7","volume":"29","author":"Verma","year":"1994","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2005.06.005_bib18","first-page":"99","volume":"96","author":"Litchfield","year":"1949","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejmech.2005.06.005_bib19","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/ardp.200390007","volume":"336","author":"Bekhit","year":"2003","journal-title":"Arch. Pharm. Pharm. Med. Chem."},{"key":"10.1016\/j.ejmech.2005.06.005_bib20","first-page":"166","volume":"335","author":"Karth","year":"1987","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.ejmech.2005.06.005_bib21","first-page":"H734","volume":"244","author":"Belardinelli","year":"1983","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ejmech.2005.06.005_bib22","first-page":"115","article-title":"Orient","volume":"6","author":"El-Kerdawy","year":"1990","journal-title":"J. Chem."},{"key":"10.1016\/j.ejmech.2005.06.005_bib23","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/0306-3623(92)90124-3","volume":"23","author":"Dorigo","year":"1992","journal-title":"Gen. Pharmacol."},{"key":"10.1016\/j.ejmech.2005.06.005_bib24","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/BF01857762","volume":"4","author":"Dorigo","year":"1990","journal-title":"Cardiovasc. Drugs Ther."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523405001728?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523405001728?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T20:24:19Z","timestamp":1683145459000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523405001728"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12]]},"references-count":24,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["S0223523405001728"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2005.06.005","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2005,12]]}}}