{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T21:17:53Z","timestamp":1791148673779,"version":"4.1.0"},"reference-count":21,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2009,9]]},"DOI":"10.1016\/j.ejmech.2009.01.035","type":"journal-article","created":{"date-parts":[[2009,2,8]],"date-time":"2009-02-08T09:10:54Z","timestamp":1234084254000},"page":"3471-3479","source":"Crossref","is-referenced-by-count":41,"title":["5-Benzylidene-hydantoins: Synthesis and antiproliferative activity on A549 lung cancer cell line"],"prefix":"10.1016","volume":"44","author":[{"given":"Valentina","family":"Zuliani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Carmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirko","family":"Rivara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Fantini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Lodola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Vacondio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Bordi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier Vincenzo","family":"Plazzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Cavazzoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maricla","family":"Galetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta R.","family":"Alfieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier Giorgio","family":"Petronini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Mor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2009.01.035_bib1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3322\/canjclin.49.1.8","volume":"49","author":"Landis","year":"1999","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.ejmech.2009.01.035_bib2","doi-asserted-by":"crossref","first-page":"4021","DOI":"10.1016\/j.bmcl.2006.05.010","volume":"16","author":"Carmi","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2009.01.035_bib3","doi-asserted-by":"crossref","first-page":"3601","DOI":"10.1021\/jm970124v","volume":"40","author":"Traxler","year":"1997","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2009.01.035_bib4","doi-asserted-by":"crossref","first-page":"3244","DOI":"10.1021\/jm000206a","volume":"43","author":"Wissner","year":"2000","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2009.01.035_bib5","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1021\/jm9503613","volume":"39","author":"Bridges","year":"1996","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2009.01.035_bib6","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1158\/1535-7163.MCT-07-0477","volume":"7","author":"Cavazzoni","year":"2008","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.ejmech.2009.01.035_bib7","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/j.bcp.2004.06.006","volume":"68","author":"Chang","year":"2004","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejmech.2009.01.035_bib8","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1158\/0008-5472.CAN-06-2037","volume":"67","author":"Rho","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejmech.2009.01.035_bib9","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1126\/science.191909","volume":"196","author":"Lee","year":"1977","journal-title":"Science"},{"key":"10.1016\/j.ejmech.2009.01.035_bib10","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/jps.2600680616","volume":"68","author":"Waddell","year":"1979","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejmech.2009.01.035_bib11","doi-asserted-by":"crossref","first-page":"9911","DOI":"10.1021\/bi020226+","volume":"41","author":"David-Cordonnier","year":"2002","journal-title":"Biochemistry"},{"key":"10.1016\/j.ejmech.2009.01.035_bib12","first-page":"6304","volume":"51","author":"Kastan","year":"1991","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejmech.2009.01.035_bib13","doi-asserted-by":"crossref","first-page":"3786","DOI":"10.1038\/sj.onc.1208451","volume":"24","author":"Levesque","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.ejmech.2009.01.035_bib14","first-page":"3412","volume":"19","author":"L\u00f3pez-Cobe\u00f1as","year":"2005","journal-title":"Synthesis"},{"key":"10.1016\/j.ejmech.2009.01.035_bib15","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0223-5234(00)01206-X","volume":"36","author":"Ho","year":"2001","journal-title":"Eur. J. Med. Chem."},{"issue":"41","key":"10.1016\/j.ejmech.2009.01.035_bib16","doi-asserted-by":"crossref","first-page":"9901","DOI":"10.1021\/ja954039t","volume":"118","author":"Zhu","year":"1996","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2009.01.035_bib17","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1021\/jm00121a023","volume":"32","author":"Anderson","year":"1989","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2009.01.035_bib18","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1021\/jm00019a005","volume":"38","author":"Edmunds","year":"1995","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2009.01.035_bib19","unstructured":"Casagrande et\u00a0al. U.S. Patent 4579861; 1986."},{"key":"10.1016\/j.ejmech.2009.01.035_bib20","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1021\/ja01636a022","volume":"76","author":"Erlanger","year":"1954","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2009.01.035_bib21","doi-asserted-by":"crossref","first-page":"8439","DOI":"10.1038\/sj.onc.1207847","volume":"23","author":"Cavazzoni","year":"2004","journal-title":"Oncogene"}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523409000518?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523409000518?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,22]],"date-time":"2018-12-22T01:22:32Z","timestamp":1545441752000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523409000518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9]]},"references-count":21,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["S0223523409000518"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2009.01.035","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2009,9]]}}}