{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:28:49Z","timestamp":1792700929082,"version":"4.5.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004792","name":"Minist\u00c3\u00a8re de l'Enseignement Sup\u00c3\u00a9rieur et de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004792","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004099","name":"Ligue Contre le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009895","name":"Canc\u00c3\u00a9rop\u00c3\u00b4le Grand Ouest","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009895","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2009,10]]},"DOI":"10.1016\/j.ejmech.2009.04.012","type":"journal-article","created":{"date-parts":[[2009,4,15]],"date-time":"2009-04-15T04:15:24Z","timestamp":1239768924000},"page":"3858-3865","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"title":["Synthesis and antitumoral activity of novel thiazolobenzotriazole, thiazoloindolo[3,2-c]quinoline and quinolinoquinoline derivatives"],"prefix":"10.1016","volume":"44","author":[{"given":"Anne","family":"Beauchard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Jaunet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Murillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Baldeyrou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lie","family":"Lansiaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Ren\u00e9","family":"Ch\u00e9rouvrier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisianne","family":"Domon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Picot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Bailly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Besson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Thi\u00e9ry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2009.04.012_bib1","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/0031-9422(94)00925-J","volume":"39","author":"Pousset","year":"1995","journal-title":"Phytochemistry"},{"key":"10.1016\/j.ejmech.2009.04.012_bib2","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/jhet.5570330204","volume":"33","author":"Sharaf","year":"1996","journal-title":"J. Heterocycl. Chem."},{"key":"10.1016\/j.ejmech.2009.04.012_bib3","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1248\/cpb.37.675","volume":"37","author":"Helissey","year":"1989","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.ejmech.2009.04.012_bib4","doi-asserted-by":"crossref","first-page":"5587","DOI":"10.1021\/jo960266h","volume":"61","author":"Molina","year":"1996","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.ejmech.2009.04.012_bib5","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1039\/b001318h","author":"Schmitt","year":"2000","journal-title":"Chem. Commun."},{"key":"10.1016\/j.ejmech.2009.04.012_bib6","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1016\/S0960-894X(00)00427-3","volume":"10","author":"Lamazzi","year":"2000","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2009.04.012_bib7","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0223-5234(02)01420-4","volume":"38","author":"He","year":"2003","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2009.04.012_bib8","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1021\/jm040893w","volume":"48","author":"Onyeibor","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2009.04.012_bib9","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1016\/j.tet.2004.11.073","volume":"61","author":"Hostyn","year":"2005","journal-title":"Tetrahedron"},{"key":"10.1016\/j.ejmech.2009.04.012_bib10","doi-asserted-by":"crossref","first-page":"6258","DOI":"10.1016\/j.tet.2006.04.050","volume":"62","author":"Dhanabal","year":"2006","journal-title":"Tetrahedron"},{"key":"10.1016\/j.ejmech.2009.04.012_bib11","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/jhet.5570450232","volume":"45","author":"Etukala","year":"2008","journal-title":"J. Heterocycl. Chem."},{"key":"10.1016\/j.ejmech.2009.04.012_bib12","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.cbi.2008.06.008","volume":"176","author":"Chien","year":"2008","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.ejmech.2009.04.012_bib13","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/0022-2836(70)90121-X","volume":"54","author":"Wells","year":"1970","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.ejmech.2009.04.012_bib14","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S0960-894X(00)00027-5","volume":"10","author":"Wells","year":"2000","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2009.04.012_bib15","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/bjc.1998.122","volume":"77","author":"Bradshaw","year":"1998","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.ejmech.2009.04.012_bib16","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1021\/cr00021a009","volume":"93","author":"Molinski","year":"1993","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejmech.2009.04.012_bib17","doi-asserted-by":"crossref","first-page":"4856","DOI":"10.1021\/ja00222a071","volume":"110","author":"Gunawardana","year":"1988","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2009.04.012_bib18","doi-asserted-by":"crossref","first-page":"4359","DOI":"10.1016\/S0040-4039(00)99360-2","volume":"30","author":"Gunawardana","year":"1989","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.ejmech.2009.04.012_bib19","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1080\/1475636021000005703","volume":"17","author":"Lamazzi","year":"2002","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.ejmech.2009.04.012_bib20","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0040-4020(02)01593-4","volume":"59","author":"Fr\u00e8re","year":"2003","journal-title":"Tetrahedron"},{"key":"10.1016\/j.ejmech.2009.04.012_bib21","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1080\/14756360400004607","volume":"19","author":"Chabane","year":"2004","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.ejmech.2009.04.012_bib22","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/j.ejmech.2007.09.020","volume":"43","author":"Log\u00e9","year":"2008","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2009.04.012_bib23","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1016\/j.tet.2005.09.153","volume":"62","author":"Beauchard","year":"2006","journal-title":"Tetrahedron"},{"key":"10.1016\/j.ejmech.2009.04.012_bib24","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1021\/np020016y","volume":"65","author":"Skyler","year":"2002","journal-title":"Nat. Prod."},{"key":"10.1016\/j.ejmech.2009.04.012_bib25","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1021\/ol052552y","volume":"8","author":"Vera-Luque","year":"2006","journal-title":"Org. Lett."},{"key":"10.1016\/j.ejmech.2009.04.012_bib26","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/S0076-6879(01)40445-9","article-title":"DNA","volume":"340","author":"Bailly","year":"2001","journal-title":"Methods Enzymol."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523409002086?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523409002086?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T13:38:31Z","timestamp":1759325911000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523409002086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":26,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["S0223523409002086"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2009.04.012","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2009,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and antitumoral activity of novel thiazolobenzotriazole, thiazoloindolo[3,2-c]quinoline and quinolinoquinoline derivatives","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2009.04.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}