{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T04:36:36Z","timestamp":1784608596897,"version":"3.55.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2009,11]]},"DOI":"10.1016\/j.ejmech.2009.07.005","type":"journal-article","created":{"date-parts":[[2009,7,17]],"date-time":"2009-07-17T16:43:19Z","timestamp":1247848999000},"page":"4695-4701","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":70,"title":["Synthesis and antiviral activity of \u03b2-carboline derivatives bearing a substituted carbohydrazide at C-3 against poliovirus and herpes simplex virus (HSV-1)"],"prefix":"10.1016","volume":"44","author":[{"given":"Anelise S.","family":"Nazari Formagio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia R.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Zanoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Ueda-Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilian T.","family":"D\u00fcsman Tonin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celso V.","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Helena","family":"Sarragiotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2009.07.005_bib1","first-page":"2381","volume":"vol. 2","year":"2001"},{"key":"10.1016\/j.ejmech.2009.07.005_bib2","doi-asserted-by":"crossref","first-page":"847","DOI":"10.7326\/0003-4819-121-11-199412010-00004","volume":"121","author":"Benedetti","year":"1994","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.ejmech.2009.07.005_bib3","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1128\/AAC.20.4.518","volume":"20","author":"Furman","year":"1981","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2009.07.005_bib4","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S1386-6532(02)00263-9","author":"Morfin","year":"2003","journal-title":"J. Clin. Vir."},{"key":"10.1016\/j.ejmech.2009.07.005_bib5","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.virusres.2005.04.008","volume":"111","author":"Mueller","year":"2005","journal-title":"J. Cello. Virus Res."},{"key":"10.1016\/j.ejmech.2009.07.005_bib6","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1021\/np0101189","volume":"64","author":"Ishida","year":"2001","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.ejmech.2009.07.005_bib7","first-page":"17","volume":"38","author":"Dong","year":"2007","journal-title":"Chin. Tradit. Herb. Drugs"},{"key":"10.1016\/j.ejmech.2009.07.005_bib8","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1002\/cbdv.200890044","volume":"5","author":"Tang","year":"2008","journal-title":"Chem Biodivers."},{"key":"10.1016\/j.ejmech.2009.07.005_bib9","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.ejmech.2005.01.012","volume":"40","author":"Yu","year":"2005","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2009.07.005_bib10","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/j.ejmech.2006.05.004","volume":"41","author":"Guan","year":"2006","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2009.07.005_bib11","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/j.ejmech.2008.03.044","volume":"44","author":"Tonin","year":"2009","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2009.07.005_bib12","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1248\/cpb.53.32","volume":"53","author":"Shen","year":"2005","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.ejmech.2009.07.005_bib13","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.ejmech.2004.11.005","volume":"40","author":"Cao","year":"2005","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2009.07.005_bib14","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.1016\/S0960-894X(99)00598-3","volume":"9","author":"Ishida","year":"1999","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2009.07.005_bib15","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.ejmech.2005.04.008","volume":"40","author":"Cao","year":"2005","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2009.07.005_bib16","doi-asserted-by":"crossref","first-page":"4613","DOI":"10.1016\/j.bmc.2004.06.038","volume":"12","author":"Cao","year":"2004","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2009.07.005_bib17","doi-asserted-by":"crossref","first-page":"6998","DOI":"10.1016\/j.bmc.2006.06.021","volume":"14","author":"Zhao","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2009.07.005_bib18","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1016\/j.bbrc.2005.10.121","volume":"338","author":"Cao","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejmech.2009.07.005_bib19","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.ejmech.2008.03.030","volume":"44","author":"Wu","year":"2009","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2009.07.005_bib20","doi-asserted-by":"crossref","first-page":"6472","DOI":"10.1016\/j.bmcl.2007.09.102","volume":"17","author":"Al-Mawsawi","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2009.07.005_bib21","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.ejmech.2004.11.016","volume":"40","author":"Marastoni","year":"2005","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2009.07.005_bib22","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1021\/jm040854k","volume":"48","author":"Ragno","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2009.07.005_bib23","doi-asserted-by":"crossref","first-page":"3172","DOI":"10.1021\/jm0512490","volume":"49","author":"Ragno","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejmech.2009.07.005_bib24","doi-asserted-by":"crossref","first-page":"5177","DOI":"10.1016\/S0040-4039(00)95622-3","volume":"28","author":"Bailey","year":"1987","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.ejmech.2009.07.005_bib25","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/S0968-0896(99)00050-4","volume":"7","author":"Srivastava","year":"1999","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2009.07.005_bib26","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1146\/annurev.ge.27.120193.002033","volume":"27","author":"Wimmer","year":"1993","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.ejmech.2009.07.005_bib27","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1023\/A:1020444330011","volume":"19","author":"Zhao","year":"2002","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejmech.2009.07.005_bib28","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(00)00129-0","volume":"46","author":"Lipinski","year":"2001","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ejmech.2009.07.005_bib29","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1016\/S1359-6446(05)03584-1","volume":"10","author":"Tetko","year":"2005","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.ejmech.2009.07.005_bib30","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1023\/A:1009217709851","volume":"11","author":"Marchetti","year":"1998","journal-title":"Biometals"},{"key":"10.1016\/j.ejmech.2009.07.005_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0049-3848(94)90136-8","volume":"75","author":"Lindahl","year":"1994","journal-title":"Thromb. Res."},{"key":"10.1016\/j.ejmech.2009.07.005_bib32","series-title":"Cell Growth and Apoptosis: A Practical Approach","first-page":"169","article-title":"Assays of cell growth and cytotoxicity","author":"Skehan","year":"1995"}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523409003857?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523409003857?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T13:39:27Z","timestamp":1759325967000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523409003857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":32,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["S0223523409003857"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2009.07.005","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2009,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and antiviral activity of \u03b2-carboline derivatives bearing a substituted carbohydrazide at C-3 against poliovirus and herpes simplex virus (HSV-1)","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2009.07.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}