{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:47:11Z","timestamp":1791863231084,"version":"4.3.4"},"reference-count":71,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1016\/j.ejmech.2011.05.013","type":"journal-article","created":{"date-parts":[[2011,5,20]],"date-time":"2011-05-20T16:24:03Z","timestamp":1305908643000},"page":"3179-3189","source":"Crossref","is-referenced-by-count":275,"title":["Recent progress in biological activities of synthesized phenothiazines"],"prefix":"10.1016","volume":"46","author":[{"given":"Krystian","family":"Pluta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata","family":"Morak-M\u0142odawska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Jele\u0144","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2011.05.013_bib1","series-title":"Phenothiazines and 1,4-Benzothiazines \u2013 Chemical and Biological Aspects","first-page":"1","article-title":"Synthesis, properties and reactions of phenothiazines","author":"Gupta","year":"1988"},{"key":"10.1016\/j.ejmech.2011.05.013_bib2","doi-asserted-by":"crossref","first-page":"237","DOI":"10.2174\/1389450003349191","article-title":"Antitumor potential and possible targets of phenothiazine-related compounds","volume":"1","author":"Motohashi","year":"2000","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.ejmech.2011.05.013_bib3","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.2174\/138945006778226624","article-title":"Cytotoxic potential of phenothiazines","volume":"7","author":"Motohashi","year":"2006","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.ejmech.2011.05.013_bib4","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/7081_2008_125","article-title":"Bioactive Phenothiazines and Benzo[a]phenothiazines: spectroscopic studies and biological and biomedical properties and applications","volume":"16","author":"Aaron","year":"2009","journal-title":"Top. Heterocycl. Chem."},{"key":"10.1016\/j.ejmech.2011.05.013_bib5","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/7081_2007_108","article-title":"Antibacterial activity of artificial phenothiazines and isoflavones from plants","volume":"15","author":"Dasgupta","year":"2008","journal-title":"Top. Heterocycl. Chem."},{"key":"10.1016\/j.ejmech.2011.05.013_bib6","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.2174\/138945006778226606","article-title":"Luminescence and photophisical properties of benzo[a]phenothiazines-therapeutic, physico-chemical and analytical applications","volume":"7","author":"Gaye-Seye","year":"2006","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.ejmech.2011.05.013_bib7","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.2174\/138945006778226552","article-title":"Phenothiazine: the parent molecule","volume":"7","author":"Mitchell","year":"2006","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.ejmech.2011.05.013_bib8","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/01.mjt.0000212897.20458.63","article-title":"Phenothiazine molecule provides the basic chemical structure for various classes of pharmacotherapeutic agents","volume":"13","author":"Mosnaim","year":"2006","journal-title":"Am. J. Therapeut."},{"key":"10.1016\/j.ejmech.2011.05.013_bib9","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0924-8579(01)00432-0","article-title":"Phenothiazines: potential management of Creutzfeldt\u2013Jacob disease and its variants","volume":"18","author":"Amaral","year":"2001","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.ejmech.2011.05.013_bib10","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/jhet.42","article-title":"Synthesis and properties of diaza-,\u00a0triaza- and tetraazaphenothiazines","volume":"46","author":"Pluta","year":"2009","journal-title":"J.\u00a0Heterocycl. Chem."},{"key":"10.1016\/j.ejmech.2011.05.013_bib11","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1016\/j.bmcl.2006.11.091","article-title":"Synthesis and antitubercular activity of quaternized promazine and promathazine derivatives","volume":"17","author":"Bata","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2011.05.013_bib12","doi-asserted-by":"crossref","first-page":"4548","DOI":"10.1073\/pnas.0500469102","article-title":"Inhibitors of type II NADH: menaquinone oxidoreductase represent a clas of antitubercular drugs","volume":"102","author":"Weinstein","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejmech.2011.05.013_bib13","first-page":"590","article-title":"Antimicrobial activity of N-acylphenothiazines and their influence on lipid model membranes and erythrocyte membranes","volume":"53","author":"Motohashi","year":"2003","journal-title":"Arzneim.Forsch.\/Drug Res."},{"key":"10.1016\/j.ejmech.2011.05.013_bib14","doi-asserted-by":"crossref","first-page":"3014","DOI":"10.1016\/j.bmcl.2007.03.064","article-title":"Synthesis and antitubercular activity of phenothiazines with reduced binding to dopamine and serotonine receptors","volume":"17","author":"Madrid","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2011.05.013_bib15","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.bmcl.2006.10.094","article-title":"Design, synthesis and evolution of efflux substrate-metal chelator conjugates as potential antimicrobial agents","volume":"17","author":"Zhang","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2011.05.013_bib16","first-page":"199","article-title":"Synthesis of 5-((10N-phenothiazin-yl)methyl)-4-(benzylideneamino-3-mercaptotriazoles as antibacterial and antifungal agents","volume":"77(A)","author":"Srivastava","year":"2007","journal-title":"Proc. Natl. Acad. Sci. India"},{"key":"10.1016\/j.ejmech.2011.05.013_bib17","doi-asserted-by":"crossref","first-page":"5094","DOI":"10.1016\/j.ejmech.2009.07.006","article-title":"Synthesis and antimicrobial activity of some new N-acyl substituted phenothiazines","volume":"44","author":"Bansode","year":"2009","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2011.05.013_bib18","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s11094-009-0297-9","article-title":"Synthesis, antimicrobial and antifungal activity of 1,3-di(2-substituted 10H-phenothiazin-10-yl)propan-1-one","volume":"43","author":"Bansode","year":"2009","journal-title":"Pharm. Chem. J."},{"key":"10.1016\/j.ejmech.2011.05.013_bib19","first-page":"1583","article-title":"Synthesis of phtalimido or succinimido-[2-aryl-4-oxo-3-[{2-oxo-2-(phenothiazin-10-yl)ethyl} amino]-1,3-thiazolidin-5-yl]ethanoate and their antimicrobial activities","volume":"48B","author":"Salvi","year":"2009","journal-title":"Ind. J. Chem."},{"key":"10.1016\/j.ejmech.2011.05.013_bib20","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/hc.10165","article-title":"Potential antimicrobial agents trifluoromethyl-10H-phenothiazines and ribofuranosides","volume":"14","author":"Singh","year":"2003","journal-title":"Heteroatom. Chem."},{"key":"10.1016\/j.ejmech.2011.05.013_bib21","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1080\/10426500601161023","article-title":"Synthesis of some substituted 10 H-Phenothiazines, ribofuranosides, and their antioxidant activity","volume":"182","author":"Gautam","year":"2007","journal-title":"Phosphorus Sulfur Silicon"},{"key":"10.1016\/j.ejmech.2011.05.013_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10426500701544557","article-title":"Synthesis and biological activities of some new phenothiazines, their sulfones, and ribofuranosides","volume":"183","author":"Dixit","year":"2008","journal-title":"Phosphorus Sulfur Silicon"},{"key":"10.1016\/j.ejmech.2011.05.013_bib23","first-page":"357","article-title":"Synthesis of 10 H-phenothiazines, their sulfones and ribofuranosides as potential chemotherapeutic agents","volume":"3","author":"Dixit","year":"2008","journal-title":"Jordan J. Chem."},{"key":"10.1016\/j.ejmech.2011.05.013_bib24","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1080\/15257770903362206","article-title":"Synthesis and antimicrobial activities of novel biologically active heterocycles: 10 H-Phenothiazines, their ribofuranosides and sulfone derivatives","volume":"28","author":"Dixit","year":"2009","journal-title":"Nucleosides Nucleotides Nucleic Acids"},{"issue":"S1","key":"10.1016\/j.ejmech.2011.05.013_bib25","first-page":"1063","article-title":"Synthesis of bioactive fluorinated 10 H-Phenothiazines and their sulfone derivatives","volume":"5","author":"Dixit","year":"2008","journal-title":"Eur. J. Chem."},{"key":"10.1016\/j.ejmech.2011.05.013_bib26","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3998\/ark.5550190.0006.d03","article-title":"Synthesis and antimicrobial activity of new tetrazolopyridinyl phenothiazines","author":"Raval","year":"2005","journal-title":"ARKIVOC (xiii)"},{"issue":"S1","key":"10.1016\/j.ejmech.2011.05.013_bib27","first-page":"S254","article-title":"Synthesis and antimicrobial activity of 1-[2-(10-p-chlorobenzyl)phenothiazinyl]-3-(substituted aryl)-2-propen-1-ones","volume":"6","author":"Upadhyay","year":"2009","journal-title":"Eur. J. Chem."},{"key":"10.1016\/j.ejmech.2011.05.013_bib28","doi-asserted-by":"crossref","first-page":"210","DOI":"10.3998\/ark.5550190.0009.223","article-title":"Design, synthesis, characterization and antitubercular activity of some 2-heterocycle-substituted phenothiazines","author":"Triverdi","year":"2008","journal-title":"ARKIVOC (ii)"},{"key":"10.1016\/j.ejmech.2011.05.013_bib29","first-page":"2015","article-title":"Synthesis and antimicrobial activities of novel 10 H-pyrido[3,2-b][1,4]benzo-[b]thiazine ribofuranoside","volume":"42","author":"Kumar","year":"2003","journal-title":"Ind. J. Chem."},{"key":"10.1016\/j.ejmech.2011.05.013_bib30","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.1016\/j.ejmech.2009.03.006","article-title":"Design, synthesis and biological evaluation of novel nitrogen and sulfur containing hetero-1,4-naphthoquinones as antifungal and antibacterial agents","volume":"44","author":"Tandon","year":"2009","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2011.05.013_bib31","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.ejmech.2008.06.025","article-title":"2,3-Disubstituted-1,4-naphthoquinones, 12H-benzo[b]phenothiazine-6,11-diones and related compounds: synthesis and biological evaluation as potential antiproliferative and antifungal agents","volume":"44","author":"Tandon","year":"2009","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2011.05.013_bib32","first-page":"14","article-title":"Synthesis and antibacterial activity of some new phenothiazine derivatives","volume":"4","author":"Swarnkar","year":"2007","journal-title":"Eur. J. Chem."},{"key":"10.1016\/j.ejmech.2011.05.013_bib33","series-title":"Phenothiazines and 1,4-Benzothiazines \u2013 Chemical and Biological Aspects","first-page":"705","article-title":"Antitumor activity of phenothiazines (phenothiazine oncology)","author":"Motohashi","year":"1988"},{"key":"10.1016\/j.ejmech.2011.05.013_bib34","first-page":"2533","article-title":"Induction of DNA fragmentation in human Myelogenous Leukaemic cell lines by phenothiazine-related compounds","volume":"15","author":"Sakagami","year":"1995","journal-title":"Anticancer Res."},{"key":"10.1016\/j.ejmech.2011.05.013_bib35","first-page":"1933","article-title":"Cytotoxicity and differentiation-inducing activity of phenothiazie and benzo[a]phenothiazine derivatives","volume":"11","author":"Motohashi","year":"1991","journal-title":"Anticancer Res."},{"key":"10.1016\/j.ejmech.2011.05.013_bib36","first-page":"337","article-title":"The primary in\u00a0vitro anticancer activity of \u201chalf-mustard type\u201d phenothiazines in NCI\u2019s revised anticancer screening paradigm","volume":"18","author":"Wuonola","year":"1998","journal-title":"Anticancer Res."},{"key":"10.1016\/j.ejmech.2011.05.013_bib37","first-page":"1859","article-title":"Chemical structure and tumor type specificity of \u201chalf-mustard type\u201d phenothiazines","volume":"19","author":"Motohashi","year":"1999","journal-title":"Anticancer Res."},{"key":"10.1016\/j.ejmech.2011.05.013_bib38","first-page":"1915","article-title":"Antitumor activity of phenothiazine-related compounds","volume":"16","author":"Nagy","year":"1996","journal-title":"Anticancer Res."},{"key":"10.1016\/j.ejmech.2011.05.013_bib39","first-page":"2525","article-title":"Synthesis and antitumor activity of 1-[2(chloroethyl)-3-(-substituted-10H-phenothiazin-10-yl)]alkyl-1-ureas as potent anticancer agents","volume":"16","author":"Motohashi","year":"1996","journal-title":"Anticancer Res."},{"key":"10.1016\/j.ejmech.2011.05.013_bib40","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0924-8579(99)00156-9","article-title":"Synthesis and biological activity of N-acylphenothiazines","volume":"14","author":"Motohashi","year":"2000","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.ejmech.2011.05.013_bib41","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.toxlet.2006.05.011","article-title":"Phenothiazine and carbazole-related compounds inhibit mitotic kinesin Eg5 and trigger apoptosis in transformed culture cells","volume":"166","author":"Okumara","year":"2006","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.ejmech.2011.05.013_bib42","unstructured":"K.K. Rozman, S. Mission, K. Fried, P.F. Terrranova, G.I. Georg, A. Dutta, Phenothiazine derivatives and their method of use, US 2005\/0288279 A1, 2005."},{"key":"10.1016\/j.ejmech.2011.05.013_bib43","doi-asserted-by":"crossref","first-page":"6474","DOI":"10.1016\/j.bmc.2008.05.040","article-title":"Multidrug resistance reverting activity and antitumor profil of new phenothiazine derivatives","volume":"16","author":"Bisi","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2011.05.013_bib44","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.3987\/COM-07-11035","article-title":"Synthesis of novel dipyrido-1,4-thiazines","volume":"71","author":"Morak-M\u0142odawska","year":"2007","journal-title":"Heterocycles"},{"key":"10.1016\/j.ejmech.2011.05.013_bib45","doi-asserted-by":"crossref","first-page":"622","DOI":"10.2478\/s11658-009-0025-1","article-title":"The immunesuppresive activities of newly synthesized azaphenothiazines in human and mouse models","volume":"14","author":"Zimecki","year":"2009","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.ejmech.2011.05.013_bib46","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S1734-1140(10)70272-3","article-title":"Anticancer activity of newly synthesized azaphenothiazines from NCI\u2019s anticancer screening bank","volume":"62","author":"Pluta","year":"2010","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.ejmech.2011.05.013_bib47","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.bbamem.2005.11.011","article-title":"Phenothiazine maleates stimulate MRP1 transport activity in human erythrocytes","volume":"1720","author":"Weso\u0142owska","year":"2005","journal-title":"Biochem. Biophys. Acta"},{"key":"10.1016\/j.ejmech.2011.05.013_bib48","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S0006-291X(03)00580-1","article-title":"New phenothiazine \u2013 type multidrug resistance modifiers: anti-MDR activity versus membrane perturbing potency","volume":"304","author":"Hendrich","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejmech.2011.05.013_bib49","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0924-8579(03)00214-0","article-title":"Phenothiazines are potent modulators of yeast multidrug resistance","volume":"22","author":"Kolaczkowski","year":"2003","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.ejmech.2011.05.013_bib50","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.ejmech.2005.11.011","article-title":"Correlation of calculated molecular orbital energies of some phenothiazine compounds with MDR reversal properties","volume":"41","author":"Hilgeroth","year":"2006","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2011.05.013_bib51","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1021\/jm010549o","article-title":"Design, synthesis and evaluation of new chemosensitizers in MDR Plasmodium falciparum","volume":"45","author":"Guan","year":"2002","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2011.05.013_bib52","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.bbrc.2006.05.058","article-title":"Inhibition of the MDR transporter by new phenothiazine derivatives","volume":"346","author":"K\u00f3nya","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejmech.2011.05.013_bib53","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3998\/ark.5550190.0005.714","article-title":"Synthesis of new tetrazolyldienylphenothiazines as potential multidrug resistance inhibitory compounds","author":"Nagy","year":"2004","journal-title":"Arkivoc (vii)"},{"key":"10.1016\/j.ejmech.2011.05.013_bib54","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1023\/A:1026295017158","article-title":"Quinolizidinyl derivatives of iminodibezyl and phenothiazine as multidrug resistance modulators in ovarian cancer cells","volume":"21","author":"Barbieri","year":"2003","journal-title":"Invest. New Drug"},{"key":"10.1016\/j.ejmech.2011.05.013_bib55","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/S0006-2952(01)00840-1","article-title":"Novel phenothiazine antimalarials: synthesis, antimalarial activity and inhibition of the formation of \u03b2-haematin","volume":"63","author":"Kalkanidis","year":"2002","journal-title":"Biochim. Pharm."},{"key":"10.1016\/j.ejmech.2011.05.013_bib56","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.chembiol.2006.07.009","article-title":"Synthesis and testing of a focused phenothiazine library of binding to HIV-1 TAR RNA","volume":"13","author":"Mayer","year":"2006","journal-title":"Chem. Biol."},{"key":"10.1016\/j.ejmech.2011.05.013_bib57","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0924-8579(01)00323-5","article-title":"Combination of benzo[a]phenothiazines with acyclovir against herpes simpex virus","volume":"18","author":"Mucsi","year":"2001","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.ejmech.2011.05.013_bib58","first-page":"18","article-title":"Synthesis and anti-inflamatory activity of some heterocyclic derivatives of phenothiazine","volume":"60","author":"Sharma","year":"2005","journal-title":"Pharmazie"},{"key":"10.1016\/j.ejmech.2011.05.013_bib59","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.1016\/j.bmcl.2009.03.124","article-title":"Synthesis and structure-activity relationships of phenothiazine carboxylic acids having pyrimidine-dione as novel histamine H1 antagonists","volume":"19","author":"Kubota","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2011.05.013_bib60","first-page":"235","article-title":"Synthesis and anti-inflammatory activity of some 1\u2014[(1-Acyl-1H-tetrazol-5-yl)ethyl)-10H-phenothiazines","volume":"45","author":"Rajasekaran","year":"2003","journal-title":"Acta Pharm. Turcica"},{"key":"10.1016\/j.ejmech.2011.05.013_bib61","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.ejmech.2003.11.016","article-title":"Synthesis and analgesic evolution of some 5-[\u03b2-(10-phenothiazinyl)ethyl]-1-(acyl)-1,2,3,4-tetrazoles","volume":"39","author":"Rajasekaran","year":"2004","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2011.05.013_bib62","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1016\/j.bmc.2004.04.009","article-title":"New class of potent antinociceptive and antiplatelet 10H-phenothiazine-1-acylhydrazone derivatives","volume":"12","author":"Silva","year":"2004","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2011.05.013_bib63","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.ejmech.2008.02.028","article-title":"10H-Phenothiazines: a new class of enzyme inhibitors for inflammatory diseases","volume":"44","author":"Sadanandam","year":"2009","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2011.05.013_bib64","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1248\/cpb.50.922","article-title":"Inhibitors of adhesion molecules expression; the synthesis and pharmacological properties of 10 H-pyrazino[2,3- b][1,4]benzothiazine derivatives","volume":"50","author":"Kaneko","year":"2002","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.ejmech.2011.05.013_bib65","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1248\/cpb.52.675","article-title":"Piperidine carboxylic acid derivatives of 10H-pyrazino[2,3-b][1,4]benzothiazine as orally-active adhesion molecule inhibitors","volume":"52","author":"Kaneko","year":"2004","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.ejmech.2011.05.013_bib66","first-page":"301","article-title":"Synthesis of novel indolyl phenothiazinyl substituted 2-oxo\/thiobarbituric acid derivatives as potent anticonvulsant agents","volume":"53","author":"Archana","year":"2003","journal-title":"Arzneim.Forsch.\/Drug Res."},{"key":"10.1016\/j.ejmech.2011.05.013_bib67","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.bmc.2004.09.059","article-title":"Structure\u2013activity relationships for inhibition of human cholinoesterases by alkyl amide phenothiazine derivatives","volume":"13","author":"Darvesh","year":"2005","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2011.05.013_bib68","doi-asserted-by":"crossref","first-page":"6367","DOI":"10.1016\/j.bmc.2007.06.060","article-title":"Selective reversible inhibition of human butyrylcholinesterase by aryl amide derivatives of phenothiazine","volume":"15","author":"Darvesh","year":"2007","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2011.05.013_bib69","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.bmcl.2008.11.099","article-title":"Synthesis of spiro[chroman-2,4\u2032-piperidin]-4-one derivatives as acetyl-CoA carboxylase inhibitors","volume":"19","author":"Shinde","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2011.05.013_bib70","doi-asserted-by":"crossref","first-page":"6689","DOI":"10.1016\/j.bmc.2008.05.074","article-title":"The use of natural product scaffolds as leads in the search for trypanothione reductase inhibitors","volume":"16","author":"Galarreta","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2011.05.013_bib71","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1016\/j.bmc.2006.12.022","article-title":"Design and synthesis of pyrimido[4,5-b][1,4]benzothiazine derivatives as potent 15-lipoxygenase inhibitors","volume":"15","author":"Bakavoli","year":"2007","journal-title":"Bioorg. Med. Chem."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523411003758?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523411003758?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,2]],"date-time":"2018-12-02T14:51:39Z","timestamp":1543762299000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523411003758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":71,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["S0223523411003758"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2011.05.013","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2011,8]]}}}