{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T11:12:53Z","timestamp":1764587573614,"version":"3.40.2"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1016\/j.ejmech.2012.03.020","type":"journal-article","created":{"date-parts":[[2012,3,19]],"date-time":"2012-03-19T20:00:49Z","timestamp":1332187249000},"page":"221-229","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Synthesis, characterization and biological activity of hydroxyl-bisphosphonic analogs of bile acids"],"prefix":"10.1016","volume":"52","author":[{"given":"Olga","family":"Bortolini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giancarlo","family":"Fantin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Fogagnolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Rossetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loredana","family":"Maiuolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gemma","family":"Di Pompo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia","family":"Avnet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donatella","family":"Granchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2012.03.020_bib1a","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1126\/science.165.3899.1262","volume":"165","author":"Fleisch","year":"1969","journal-title":"Science"},{"key":"10.1016\/j.ejmech.2012.03.020_bib1b","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1039\/B512310K","volume":"36","author":"Zhang","year":"2007","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.ejmech.2012.03.020_bib1c","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.bone.2010.11.008","volume":"49","author":"Rogers","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.ejmech.2012.03.020_bib2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.bone.2011.04.022","volume":"49","author":"Russell","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.ejmech.2012.03.020_bib3","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0169-409X(00)00061-2","volume":"42","author":"Ezra","year":"2000","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ejmech.2012.03.020_bib4","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/BF02196199","volume":"6","author":"Russell","year":"1970","journal-title":"Calcif. Tissue Res."},{"key":"10.1016\/j.ejmech.2012.03.020_bib5","doi-asserted-by":"crossref","first-page":"3721","DOI":"10.1021\/jm020819i","volume":"45","author":"Widler","year":"2002","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2012.03.020_bib6","first-page":"233","volume":"9","author":"Ebetino","year":"1998","journal-title":"Rev. Contemp. Pharmacother."},{"key":"10.1016\/j.ejmech.2012.03.020_bib7","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.bone.2005.05.003","volume":"38","author":"Nancollas","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.ejmech.2012.03.020_bib8","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0022-3565(24)38786-5","volume":"296","author":"Dunford","year":"2001","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejmech.2012.03.020_bib9","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1021\/jm7015733","volume":"51","author":"Dunford","year":"2008","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2012.03.020_bib10","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.4065\/83.9.1032","volume":"83","author":"Drake","year":"2008","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.ejmech.2012.03.020_bib11","doi-asserted-by":"crossref","first-page":"3385","DOI":"10.1002\/ejoc.200300699","author":"Virtanen","year":"2004","journal-title":"Eur. J. Org. Chem."},{"key":"10.1016\/j.ejmech.2012.03.020_bib12","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jconrel.2010.04.028","volume":"146","author":"Shmeeda","year":"2010","journal-title":"J.\u00a0Control. Rel."},{"key":"10.1016\/j.ejmech.2012.03.020_bib13","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.ejps.2010.06.020","volume":"41","author":"Dissette","year":"2010","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejmech.2012.03.020_bib14a","first-page":"1666","volume":"87","author":"Mukhopadhyay","year":"2004","journal-title":"Curr. Sci."},{"key":"10.1016\/j.ejmech.2012.03.020_bib14b","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S1359-6446(96)10046-5","volume":"3","author":"Enhsen","year":"1998","journal-title":"Drug Disc. Today"},{"key":"10.1016\/j.ejmech.2012.03.020_bib15a","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/00365529409103618","volume":"29","author":"Hofmann","year":"1994","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.ejmech.2012.03.020_bib15b","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0168-3659(85)90028-8","volume":"2","author":"Hofmann","year":"1985","journal-title":"J.\u00a0Control. Rel."},{"key":"10.1016\/j.ejmech.2012.03.020_bib16_1","unstructured":"For examples of bisphosphonates substituted with steroidal groups see:"},{"key":"10.1016\/j.ejmech.2012.03.020_bib16a","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1248\/bpb.20.1183","volume":"20","author":"Fujisaki","year":"1997","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.ejmech.2012.03.020_bib16b","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10426509408036901","volume":"88","author":"Guervenou","year":"1994","journal-title":"Phosph. Sulf. Silicon"},{"key":"10.1016\/j.ejmech.2012.03.020_bib16c","unstructured":"J.A. Gallagher, J.P. Moore, W.B. Bowler, P.C. Page, PCT Int. Appl. (1998), WO 98\/00438."},{"key":"10.1016\/j.ejmech.2012.03.020_bib17","first-page":"3","volume":"1","author":"Kritchevsky","year":"1971"},{"key":"10.1016\/j.ejmech.2012.03.020_bib18","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.tox.2009.12.016","volume":"268","author":"Westphal","year":"2010","journal-title":"Toxicology"},{"key":"10.1016\/j.ejmech.2012.03.020_bib19","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1359\/jbmr.1998.13.11.1721","volume":"13","author":"Breuil","year":"1998","journal-title":"J.\u00a0Bone Miner. Res."},{"key":"10.1016\/j.ejmech.2012.03.020_bib20","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S8756-3282(98)00133-1","volume":"23","author":"Filipponi","year":"1998","journal-title":"Bone"},{"key":"10.1016\/j.ejmech.2012.03.020_bib21","doi-asserted-by":"crossref","first-page":"8475","DOI":"10.1016\/S0040-4039(01)01844-5","volume":"42","author":"Lecouvey","year":"2001","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.ejmech.2012.03.020_bib22a","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.ab.2010.08.030","volume":"408","author":"Lenevich","year":"2011","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ejmech.2012.03.020_bib22b","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1021\/ja0759949","volume":"130","author":"Mukherjee","year":"2008","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2012.03.020_bib22c","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1016\/j.biomaterials.2004.05.019","volume":"26","author":"Josse","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejmech.2012.03.020_bib23","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1002\/cmdc.201000016","volume":"5","author":"Jahnke","year":"2010","journal-title":"Chem. Med. Chem."},{"key":"10.1016\/j.ejmech.2012.03.020_bib24a","first-page":"149","author":"Lawson","year":"2009","journal-title":"J.\u00a0Biomed. Mater. Res. Part B: Appl. Biomater."},{"key":"10.1016\/j.ejmech.2012.03.020_bib24b","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.1016\/j.bmc.2010.02.058","volume":"18","author":"Lolli","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2012.03.020_bib25","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.molstruc.2006.04.032","volume":"825","author":"Robinson","year":"2006","journal-title":"J.\u00a0Mol. Struct."},{"key":"10.1016\/j.ejmech.2012.03.020_bib26","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.bone.2011.03.774","volume":"49","author":"Ebetino","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.ejmech.2012.03.020_bib27","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1021\/js960177k","volume":"86","author":"Csizmadia","year":"1997","journal-title":"J.\u00a0Pharm. Sci."},{"key":"10.1016\/j.ejmech.2012.03.020_bib28","doi-asserted-by":"crossref","first-page":"3652","DOI":"10.1016\/j.bmc.2008.02.016","volume":"16","author":"Wiemer","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2012.03.020_bib29","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/0142-9612(96)88670-4","volume":"17","author":"Ciapetti","year":"1996","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejmech.2012.03.020_bib30","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.bone.2004.06.001","volume":"35","author":"Frediani","year":"2004","journal-title":"Bone"},{"key":"10.1016\/j.ejmech.2012.03.020_bib31","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s00198-007-0540-8","volume":"19","author":"Russell","year":"2008","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.ejmech.2012.03.020_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5435\/00124635-200301000-00001","volume":"11","author":"Lin","year":"2003","journal-title":"J.\u00a0Am. Acad. Orthop. Surg."},{"key":"10.1016\/j.ejmech.2012.03.020_bib33","doi-asserted-by":"crossref","first-page":"134","DOI":"10.5483\/BMBRep.2002.35.1.134","volume":"35","author":"Kim","year":"2002","journal-title":"J.\u00a0Biochem. Mol. Biol."},{"key":"10.1016\/j.ejmech.2012.03.020_bib34","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.steroids.2005.03.008","volume":"70","author":"Babu","year":"2005","journal-title":"Steroids"},{"key":"10.1016\/j.ejmech.2012.03.020_bib35","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1016\/j.biomaterials.2004.07.045","volume":"26","author":"Granchi","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejmech.2012.03.020_bib36","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1002\/ijc.20308","volume":"111","author":"Granchi","year":"2004","journal-title":"Int. J. Cancer"}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523412001821?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523412001821?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T15:15:14Z","timestamp":1742742914000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523412001821"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":46,"alternative-id":["S0223523412001821"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2012.03.020","relation":{},"ISSN":["0223-5234"],"issn-type":[{"type":"print","value":"0223-5234"}],"subject":[],"published":{"date-parts":[[2012,6]]}}}