{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:56:52Z","timestamp":1791194212558,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1016\/j.ejmech.2012.09.044","type":"journal-article","created":{"date-parts":[[2012,10,5]],"date-time":"2012-10-05T15:56:05Z","timestamp":1349452565000},"page":"44-49","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Microwave-assisted synthesis of hydroxyphenyl nitrones with protective action against oxidative stress"],"prefix":"10.1016","volume":"58","author":[{"given":"Cecilia","family":"Chavarr\u00eda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel I.","family":"Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concepci\u00f3n","family":"P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose A.","family":"Morales Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Alonso-Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"P\u00e9rez-Castillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M.","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Williams","family":"Porcal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.ejmech.2012.09.044_bib1","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1016\/j.bbagen.2008.02.005","volume":"1780","author":"Chinta","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"issue":"12","key":"10.1016\/j.ejmech.2012.09.044_bib2","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/S0891-5849(02)00804-3","volume":"32","author":"Giasson","year":"2002","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.ejmech.2012.09.044_bib3","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.neuron.2006.09.026","volume":"52","author":"Lee","year":"2006","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.ejmech.2012.09.044_bib4","doi-asserted-by":"crossref","first-page":"111","DOI":"10.2174\/1567205043332162","volume":"1","author":"Aslan","year":"2004","journal-title":"Curr. Alzheimer Res."},{"issue":"5","key":"10.1016\/j.ejmech.2012.09.044_bib5","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S0197-4580(02)00019-2","article-title":"Oxidative stress in brain aging","volume":"23","author":"Floyd","year":"2002","journal-title":"Neurobiol. Aging"},{"issue":"11","key":"10.1016\/j.ejmech.2012.09.044_bib6","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/S0891-5849(02)00801-8","volume":"32","author":"Tabner","year":"2002","journal-title":"Free Radic. Biol. Med."},{"issue":"2 Suppl. 1","key":"10.1016\/j.ejmech.2012.09.044_bib7","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0026-0495(00)80077-3","volume":"49","author":"Betteridge","year":"2000","journal-title":"Metabolism"},{"issue":"10","key":"10.1016\/j.ejmech.2012.09.044_bib8","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1016\/S0891-5849(00)00252-5","volume":"28","author":"Hensley","year":"2000","journal-title":"Free Radic. Biol. Med."},{"issue":"12","key":"10.1016\/j.ejmech.2012.09.044_bib9","doi-asserted-by":"crossref","first-page":"4003","DOI":"10.1073\/pnas.0307446101","volume":"101","author":"Radi","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.ejmech.2012.09.044_bib10","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1152\/physrev.00029.2006","volume":"87","author":"Pacher","year":"2007","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejmech.2012.09.044_bib11","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/j.1749-6632.2000.tb06192.x","volume":"899","author":"Grunblatt","year":"2000","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/j.ejmech.2012.09.044_bib12","doi-asserted-by":"crossref","unstructured":"X.R. Shi, Z.Y. Hong, H.R. Liu, Y.C. Zhang, Y.Z. Zhu, Neurochem. Int. 58 (8) 851\u2013860.","DOI":"10.1016\/j.neuint.2010.11.007"},{"issue":"8","key":"10.1016\/j.ejmech.2012.09.044_bib13","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/S0047-6374(01)00385-2","volume":"123","author":"Floyd","year":"2002","journal-title":"Mech. Ageing Dev."},{"issue":"18\u201319","key":"10.1016\/j.ejmech.2012.09.044_bib14","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1016\/S0024-3205(99)00443-9","volume":"65","author":"Floyd","year":"1999","journal-title":"Life Sci."},{"issue":"19","key":"10.1016\/j.ejmech.2012.09.044_bib15","doi-asserted-by":"crossref","first-page":"6150","DOI":"10.1021\/jm8006432","volume":"51","author":"Porcal","year":"2008","journal-title":"J.\u00a0Med. Chem."},{"issue":"12","key":"10.1016\/j.ejmech.2012.09.044_bib16","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.2174\/0929867003374183","volume":"7","author":"Goldstein","year":"2000","journal-title":"Curr. Med. Chem."},{"issue":"19","key":"10.1016\/j.ejmech.2012.09.044_bib17","doi-asserted-by":"crossref","first-page":"8868","DOI":"10.1016\/j.bmc.2008.08.075","volume":"16","author":"Sun","year":"2008","journal-title":"Bioorg. Med. Chem."},{"issue":"12","key":"10.1016\/j.ejmech.2012.09.044_bib18","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1016\/j.bmcl.2005.04.043","volume":"15","author":"Balogh","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"12","key":"10.1016\/j.ejmech.2012.09.044_bib19","doi-asserted-by":"crossref","first-page":"3939","DOI":"10.1016\/j.bmc.2012.04.016","volume":"20","author":"Sun","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2012.09.044_bib20","series-title":"Nitrones, Nitronates and Nitroxides","author":"Patai AR","year":"1989"},{"issue":"11","key":"10.1016\/j.ejmech.2012.09.044_bib21","doi-asserted-by":"crossref","first-page":"3995","DOI":"10.1016\/j.bmc.2009.04.004","volume":"17","author":"Dias","year":"2009","journal-title":"Bioorg. Med. Chem."},{"issue":"10","key":"10.1016\/j.ejmech.2012.09.044_bib22","doi-asserted-by":"crossref","first-page":"3572","DOI":"10.1016\/j.bmc.2007.02.033","volume":"15","author":"Kim","year":"2007","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2012.09.044_bib23","doi-asserted-by":"crossref","first-page":"10521","DOI":"10.1016\/j.tet.2008.08.101","volume":"64","author":"Andrade","year":"2008","journal-title":"R.\u00a0C. Tetrahedron"},{"issue":"46","key":"10.1016\/j.ejmech.2012.09.044_bib24","doi-asserted-by":"crossref","first-page":"6250","DOI":"10.1002\/anie.200400655","volume":"43","author":"Kappe","year":"2004","journal-title":"Angew. Chem. Int. Ed. Engl."},{"issue":"5493","key":"10.1016\/j.ejmech.2012.09.044_bib25","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1126\/science.290.5493.985","volume":"290","author":"Giasson","year":"2000","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.ejmech.2012.09.044_bib26","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.freeradbiomed.2008.04.010","volume":"45","author":"Souza","year":"2008","journal-title":"Free Radic. Biol. Med."},{"issue":"24","key":"10.1016\/j.ejmech.2012.09.044_bib27","doi-asserted-by":"crossref","first-page":"18344","DOI":"10.1074\/jbc.M000206200","volume":"275","author":"Souza","year":"2000","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.ejmech.2012.09.044_bib28","series-title":"Nitric Oxide. Biology and Pathobiology","author":"Ignarro","year":"2009"},{"issue":"4","key":"10.1016\/j.ejmech.2012.09.044_bib29","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.freeradbiomed.2003.10.011","volume":"36","author":"Bartesaghi","year":"2004","journal-title":"Free Radic. Biol. Med."},{"issue":"6","key":"10.1016\/j.ejmech.2012.09.044_bib30","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1016\/j.bmcl.2008.01.115","volume":"18","author":"Piao","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2012.09.044_bib31","doi-asserted-by":"crossref","unstructured":"Z.H. Wen, C.H. Chao, M.H. Wu, J.H. Sheu, Eur J Med. Chem. 45 (12) 5998\u20136004.","DOI":"10.1016\/j.ejmech.2010.09.067"},{"issue":"Suppl. 11","key":"10.1016\/j.ejmech.2012.09.044_bib32","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1097\/00005344-198914110-00004","volume":"14","author":"Feelisch","year":"1989","journal-title":"J.\u00a0Cardiovasc. Pharmacol."},{"key":"10.1016\/j.ejmech.2012.09.044_bib33","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0076-6879(99)01100-3","volume":"301","author":"Ischiropoulos","year":"1999","journal-title":"Methods Enzymol."},{"issue":"3\u20134","key":"10.1016\/j.ejmech.2012.09.044_bib34","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1159\/000089619","volume":"2","author":"Pehar","year":"2005","journal-title":"Neurodegener. Dis."},{"issue":"11","key":"10.1016\/j.ejmech.2012.09.044_bib35","doi-asserted-by":"crossref","first-page":"589","DOI":"10.3109\/00207454.2011.598981","volume":"121","author":"Singh","year":"2011","journal-title":"Int. J. Neurosci."},{"issue":"1","key":"10.1016\/j.ejmech.2012.09.044_bib36","first-page":"175","volume":"47","author":"Redondo","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2012.09.044_bib37","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0223-5234(03)00012-6","volume":"38","author":"Di","year":"2003","journal-title":"Eur. J. Med. Chem."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S022352341200596X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S022352341200596X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T13:40:27Z","timestamp":1759326027000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S022352341200596X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":37,"alternative-id":["S022352341200596X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2012.09.044","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microwave-assisted synthesis of hydroxyphenyl nitrones with protective action against oxidative stress","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2012.09.044","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}