{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:34:15Z","timestamp":1786988055081,"version":"build-2736575974"},"reference-count":72,"publisher":"Elsevier BV","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1016\/j.ejmech.2013.06.033","type":"journal-article","created":{"date-parts":[[2013,6,25]],"date-time":"2013-06-25T16:17:05Z","timestamp":1372177025000},"page":"310-324","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Synthesis and antiprotozoal activities of benzyl phenyl ether diamidine derivatives"],"prefix":"10.1016","volume":"67","author":[{"given":"Donald A.","family":"Patrick","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanislav A.","family":"Bakunov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana M.","family":"Bakunova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan Kilgore","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Wenzler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Barszcz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvind","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Boykin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl A.","family":"Werbovetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reto","family":"Brun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard R.","family":"Tidwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2013.06.033_bib4","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S1473-3099(02)00321-3","article-title":"Treatment of human African trypanosomiasis \u2013 present situation and needs for research and development","volume":"2","author":"Legros","year":"2002","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.ejmech.2013.06.033_bib5","first-page":"71","article-title":"Human African trypanosomiasis (sleeping sickness): epidemiological update","volume":"81","author":"Anonymous","year":"2006","journal-title":"Wkly. Epidemiol. Rec."},{"key":"10.1016\/j.ejmech.2013.06.033_bib6","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/S0140-6736(03)14694-6","article-title":"The trypanosomiases","volume":"362","author":"Barrett","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.ejmech.2013.06.033_bib7","first-page":"174","article-title":"Eliminating human African trypanosomiasis: where do we stand and what comes next?","volume":"5","author":"Simmarro","year":"2008","journal-title":"PLoS Med."},{"key":"10.1016\/j.ejmech.2013.06.033_bib8","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S0140-6736(09)60829-1","article-title":"Human African trypanosomiasis","volume":"375","author":"Brun","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.ejmech.2013.06.033_bib11","doi-asserted-by":"crossref","first-page":"e35671","DOI":"10.1371\/journal.pone.0035671","article-title":"Leishmaniasis worldwide and global estimates of its incidence","volume":"7","author":"Alvar","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ejmech.2013.06.033_bib12","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1128\/CMR.00061-07","article-title":"The relationship between leishmaniasis and AIDS: the second 10 years","volume":"21","author":"Alvar","year":"2008","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.ejmech.2013.06.033_bib13","first-page":"357","article-title":"Leishmania\/HIV co-infections in the second decade","volume":"123","author":"Cruz","year":"2006","journal-title":"Indian J. Med. Res."},{"issue":"Suppl.\u00a01","key":"10.1016\/j.ejmech.2013.06.033_bib14","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1179\/000349803225002499","article-title":"Leishmania\/HIV co-infections: epidemiology in Europe","volume":"97","author":"Desjeux","year":"2003","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"10.1016\/j.ejmech.2013.06.033_bib15","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.1086\/595710","article-title":"Parasite susceptibility to amphotericin B in failures of treatment for visceral leishmaniasis in patients coinfected with HIV type 1 and Leishmania infantum","volume":"48","author":"Lachaud","year":"2009","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.ejmech.2013.06.033_bib16","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1046\/j.1198-743x.2001.00262.x","article-title":"HIV-associated visceral leishmaniasis","volume":"7","author":"Pintado","year":"2003","journal-title":"Clin. Microbiol. Infect."},{"issue":"Suppl.\u00a01","key":"10.1016\/j.ejmech.2013.06.033_bib17","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1179\/000349803225002507","article-title":"Leishmania\/HIV co-infection in Brazil: an appraisal","volume":"97","author":"Rabello","year":"2003","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"10.1016\/j.ejmech.2013.06.033_bib18","doi-asserted-by":"crossref","first-page":"e91","DOI":"10.1093\/cid\/cir521","article-title":"Liposomal amphotericin B for visceral leishmaniasis in human immunodeficiency virus-coinfected patients: 2-year treatment outcomes in Bihar, India","volume":"53","author":"Sinha","year":"2011","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.ejmech.2013.06.033_bib19","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s004300100082","article-title":"Emerging Leishmania\/HIV co-infection in Africa","volume":"190","author":"Wolday","year":"2001","journal-title":"Med. Microbiol. Immunol."},{"key":"10.1016\/j.ejmech.2013.06.033_bib20","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.pt.2005.08.026","article-title":"Chemotherapy of trypanosomiases and leishmaniasis","volume":"21","author":"Croft","year":"2005","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.ejmech.2013.06.033_bib21","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/415670a","article-title":"Malaria in 2002","volume":"415","author":"Greenwood","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2013.06.033_bib22","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.coph.2005.05.004","article-title":"Current drug development portfolio for antimalarial therapies","volume":"5","author":"Biagini","year":"2005","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.ejmech.2013.06.033_bib23","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1007\/s00018-006-6071-1","article-title":"Antimalarial drugs: recent advances in molecular determinants of resistance and their clinical significance","volume":"63","author":"Woodrow","year":"2006","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.ejmech.2013.06.033_bib24","doi-asserted-by":"crossref","first-page":"5807","DOI":"10.1021\/jm0708634","article-title":"Synthesis and in\u00a0vitro antiprotozoal activity of bisbenzofuran cations","volume":"50","author":"Bakunova","year":"2007","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2013.06.033_bib25","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1021\/jm0612867","article-title":"Synthesis and in\u00a0vitro antiprotozoal activities of dicationic 3,5-diphenylisoxazoles","volume":"50","author":"Patrick","year":"2007","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2013.06.033_bib26","doi-asserted-by":"crossref","first-page":"7339","DOI":"10.1021\/jm9004835","article-title":"Neglected tropical diseases: multi-target-directed ligands in the search for novel lead candidates against Trypanosoma and Leishmania","volume":"52","author":"Cavalli","year":"2009","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2013.06.033_bib27","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/S1473-3099(10)70011-6","article-title":"Combination therapy for visceral leishmaniasis","volume":"10","author":"Griensven","year":"2010","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.ejmech.2013.06.033_bib28","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/S0140-6736(05)67629-5","article-title":"Advances in leishmaniasis","volume":"366","author":"Murray","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.ejmech.2013.06.033_bib29","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1086\/591972","article-title":"New treatment approach in Indian visceral leishmaniasis: single-dose liposomal amphotericin B followed by short-course oral miltefosine","volume":"47","author":"Sundar","year":"2008","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.ejmech.2013.06.033_bib30","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1365-4632.2009.03883.x","article-title":"Evaluation of treatment with pentamidine for cutaneous leishmaniasis in Suriname","volume":"48","author":"van der Meide","year":"2009","journal-title":"Int. J. Dermatol."},{"key":"10.1016\/j.ejmech.2013.06.033_bib31","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1021\/jm00219a023","article-title":"Synthesis and antiprotozoal activity of 2,5-bis(4-guanylphenyl)furans","volume":"20","author":"Das","year":"1977","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2013.06.033_bib32","first-page":"147","article-title":"Diamidines as antitrypanosomal, antileishmanial and antimalarial agents","volume":"7","author":"Werbovetz","year":"2006","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"10.1016\/j.ejmech.2013.06.033_bib33","first-page":"1086","article-title":"DB-289 Immtech International","volume":"6","author":"Yeates","year":"2003","journal-title":"IDrugs"},{"key":"10.1016\/j.ejmech.2013.06.033_bib34","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1086\/430928","article-title":"Efficacy of DB289 in Thai patients with Plasmodium vivax or acute, uncomplicated Plasmodium falciparum infections","volume":"192","author":"Yeramian","year":"2005","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.ejmech.2013.06.033_bib35","first-page":"876","article-title":"Diamidines for human African trypanosomiasis","volume":"11","author":"Paine","year":"2010","journal-title":"Curr. Opin. Investig. Drugs (BioMed Cent.)"},{"key":"10.1016\/j.ejmech.2013.06.033_bib36","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/jcla.20380","article-title":"Application of monoclonal antibodies to measure metabolism of an anti-trypanosomal compound in\u00a0vitro and in\u00a0vivo","volume":"24","author":"Goldsmith","year":"2010","journal-title":"J.\u00a0Clin. Lab. Anal."},{"key":"10.1016\/j.ejmech.2013.06.033_bib37","doi-asserted-by":"crossref","first-page":"5763","DOI":"10.1021\/jm9006406","article-title":"Synthesis and antiprotozoal properties of pentamidine congeners bearing the benzofuran motif","volume":"52","author":"Bakunov","year":"2009","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2013.06.033_bib38","doi-asserted-by":"crossref","first-page":"6927","DOI":"10.1021\/jm800918v","article-title":"Synthesis and antiprotozoal activity of cationic 2-phenylbenzofurans","volume":"51","author":"Bakunov","year":"2008","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2013.06.033_bib39","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1021\/jm901178d","article-title":"Synthesis and antiprotozoal activity of cationic 1,4-diphenyl-1H-1,2,3-triazoles","volume":"53","author":"Bakunov","year":"2010","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2013.06.033_bib40","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1021\/jm801547t","article-title":"Structure\u2013activity study of pentamidine analogues as antiprotozoal agents","volume":"52","author":"Bakunova","year":"2009","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2013.06.033_bib41","doi-asserted-by":"crossref","first-page":"4657","DOI":"10.1021\/jm900805v","article-title":"Synthesis and antiprotozoal activity of pyridyl analogues of pentamidine","volume":"52","author":"Bakunova","year":"2009","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2013.06.033_bib42","doi-asserted-by":"crossref","first-page":"3543","DOI":"10.1016\/j.ejmech.2009.03.014","article-title":"Synthesis and antiprotozoal activities of dicationic bis(phenoxymethyl)benzenes, bis(phenoxymethyl)naphthalenes, and bis(benzyloxy)naphthalenes","volume":"44","author":"Patrick","year":"2009","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2013.06.033_bib43","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1039\/jr9420000103","article-title":"Chemotherapeutic comparison of the trypanocidal action of some aromatic diamidines","author":"Ashley","year":"1942","journal-title":"J.\u00a0Chem. Soc."},{"key":"10.1016\/j.ejmech.2013.06.033_bib44","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1021\/jm00239a007","article-title":"New aromatic diamidines with central \u03b1-oxyalkane or \u03b1,\u03c9-dioxyalkane chains. Structure\u2013activity relationships for the inhibition of trypsin, pancreatic kallikrein, and thrombin and for the inhibition of the overall coagulation process","volume":"18","author":"Geratz","year":"1975","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2013.06.033_bib45","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1021\/jm00209a008","article-title":"Structure\u2013activity relationships for the inhibition of acrosin by benzamidine derivatives","volume":"21","author":"Parrish","year":"1978","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2013.06.033_bib46","first-page":"353","article-title":"Synthesis of aromatic amidino compounds with ether structure","volume":"30","author":"Wagner","year":"1975","journal-title":"Pharmazie"},{"key":"10.1016\/j.ejmech.2013.06.033_bib47","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1021\/jm00306a019","article-title":"Irreversible enzyme inhibitors. CLXIV. Proteolytic enzymes. 14. Inhibition of guinea pig complement by meta-substituted benzamidines","volume":"12","author":"Baker","year":"1969","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2013.06.033_bib48","doi-asserted-by":"crossref","first-page":"5169","DOI":"10.1128\/AAC.49.12.5169-5171.2005","article-title":"Interaction of monobenzamidine-linked trypanocides with the Trypanosoma brucei P2 aminopurine transporter","volume":"49","author":"Stewart","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2013.06.033_bib49","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.vetpar.2010.01.019","article-title":"In\u00a0vitro activity and preliminary toxicity of various diamidine compounds against Trypanosoma evansi","volume":"169","author":"Gillingwater","year":"2010","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.ejmech.2013.06.033_bib50","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1021\/jm00267a003","article-title":"Diamidino-\u03b1,\u03c9-diphenoxyalkanes. Structure\u2013activity relationships for the inhibition of thrombin, pancreatic Kallikrein, and trypsin","volume":"16","author":"Geratz","year":"1973","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2013.06.033_bib51","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.3987\/COM-03-9716","article-title":"Synthesis of metabolites of the prodrug 2,5-bis(4-O-methoxyamidinophenyl)furan","volume":"60","author":"Anbazhagan","year":"2003","journal-title":"Heterocycles"},{"key":"10.1016\/j.ejmech.2013.06.033_bib52","first-page":"38","article-title":"Antiparasitic agents. Part VI. Synthesis of 1,2-, 1,3-, and 1,4-bis[4-substituted(aryloxy)]benzenes and their biological activities","volume":"27","author":"Chauhan","year":"1988","journal-title":"Indian J. Chem. Sect. B"},{"key":"10.1016\/j.ejmech.2013.06.033_bib53","first-page":"315","article-title":"An \u201cin\u00a0vitro selectivity index\u201d for evaluation of cytotoxicity of antitrypanosomal compounds","volume":"9","author":"Kaminsky","year":"1996","journal-title":"In\u00a0Vitro Toxicol."},{"key":"10.1016\/j.ejmech.2013.06.033_bib54","doi-asserted-by":"crossref","first-page":"4185","DOI":"10.1128\/AAC.00225-09","article-title":"New treatment option for second-stage African sleeping sickness: in\u00a0vitro and in\u00a0vivo efficacy of aza analogs of DB289","volume":"53","author":"Wenzler","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2013.06.033_bib55","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.pt.2012.12.005","article-title":"Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story","volume":"29","author":"Baker","year":"2013","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.ejmech.2013.06.033_bib56","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1006\/expr.1996.4131","article-title":"Effects of pentamidine on polyamine level and biosynthesis in wild-type, pentamidine-treated, and pentamidine-resistant Leishmania","volume":"85","author":"Basselin","year":"1997","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.ejmech.2013.06.033_bib57","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1021\/jm00081a003","article-title":"Structure and DNA binding activity of analogs of 1,5-bis(4-amidinophenoxy)pentane (pentamidine)","volume":"35","author":"Cory","year":"1992","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2013.06.033_bib58","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/S0020-7519(01)00167-9","article-title":"Transporters in African trypanosomes: role in drug action and resistance","volume":"31","author":"de Koning","year":"2001","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.ejmech.2013.06.033_bib59","first-page":"78S","article-title":"Inhibition of topoisomerases from Pneumocystis carinii by aromatic dicationic molecules","volume":"38","author":"Dykstra","year":"1991","journal-title":"J.\u00a0Protozool."},{"key":"10.1016\/j.ejmech.2013.06.033_bib60","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/0014-4894(85)90047-5","article-title":"Leishmania donovani: amastigote inhibition and mode of action of berberine","volume":"60","author":"Ghosh","year":"1985","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.ejmech.2013.06.033_bib61","doi-asserted-by":"crossref","first-page":"3968","DOI":"10.1128\/AAC.48.10.3968-3974.2004","article-title":"DB75, a novel trypanocidal agent, disrupts mitochondrial function in Saccharomyces cerevisiae","volume":"48","author":"Lanteri","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2013.06.033_bib62","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1128\/AAC.00005-07","article-title":"Diphenyl furans and aza analogs: effects of structural modification on in\u00a0vitro activity, DNA binding, and accumulation and distribution in trypanosomes","volume":"51","author":"Mathis","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2013.06.033_bib63","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1006\/abbi.1996.0041","article-title":"Pentamidine is an uncoupler of oxidative phosphorylation in rat liver mitochondria","volume":"326","author":"Moreno","year":"1996","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.ejmech.2013.06.033_bib64","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1124\/mol.59.5.1298","article-title":"Diamidine compounds: selective uptake and targeting in Plasmodium falciparum","volume":"59","author":"Stead","year":"2001","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejmech.2013.06.033_bib65","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1021\/jm00166a026","article-title":"Analogs of 1,5-bis(4-amidinophenoxy)pentane (pentamidine) in the treatment of experimental Pneumocystis carinii pneumonia","volume":"33","author":"Tidwell","year":"1990","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2013.06.033_bib66","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1517\/14728222.6.4.407","article-title":"Promising therapeutic targets for antileishmanial drugs","volume":"6","author":"Werbovetz","year":"2002","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.ejmech.2013.06.033_bib67","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1073\/pnas.1219899110","article-title":"Antibacterial drug leads targeting isoprenoid biosynthesis","volume":"110","author":"Zhu","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejmech.2013.06.033_bib68","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1378\/chest.94.6.1303","article-title":"Recurrent ventricular tachycardia due to pentamidine-induced cardiotoxicity","volume":"94","author":"Bibler","year":"1988","journal-title":"Chest"},{"key":"10.1016\/j.ejmech.2013.06.033_bib69","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1111\/j.1476-5381.1996.tb16014.x","article-title":"Indirect muscarinic receptor activation by pentamidine on airway smooth muscle","volume":"119","author":"Biyah","year":"1996","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejmech.2013.06.033_bib70","doi-asserted-by":"crossref","first-page":"40","DOI":"10.2337\/diabetes.31.1.40","article-title":"Diabetes mellitus following pentamidine-induced hypoglycemia in humans","volume":"31","author":"Bouchard","year":"1982","journal-title":"Diabetes"},{"key":"10.1016\/j.ejmech.2013.06.033_bib71","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1128\/AAC.12.4.451","article-title":"In\u00a0vitro inhibition of platelet function and coagulation by pentamidine isethionate","volume":"12","author":"Kempin","year":"1977","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2013.06.033_bib72","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1001\/archinte.1981.00340010052013","article-title":"Acute pancreatitis associated with pentamidine therapy","volume":"141","author":"Murphey","year":"1981","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.ejmech.2013.06.033_bib73","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1001\/archinte.1985.00360050081015","article-title":"The treatment of Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome","volume":"145","author":"Small","year":"1985","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.ejmech.2013.06.033_bib74","doi-asserted-by":"crossref","first-page":"234","DOI":"10.7326\/0003-4819-70-1-234_2","article-title":"Pentamidine nontoxicity","volume":"70","author":"Western","year":"1969","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.ejmech.2013.06.033_bib75","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3390\/md8010047","article-title":"Inhibitory activity of marine sponge-derived natural products against parasitic protozoa","volume":"8","author":"Orhan","year":"2010","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.ejmech.2013.06.033_bib76","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0166-6851(98)00146-7","article-title":"Purification, characterization, and drug susceptibility of tubulin from Leishmania","volume":"98","author":"Werbovetz","year":"1999","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.ejmech.2013.06.033_bib77","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1124\/mol.64.6.1325","article-title":"Selective antimicrotubule activity of N1-phenyl-3,5-dinitro-N4,N4-di-n-propylsulfonilamide (GB_II-5) against kinetoplastid parasites","volume":"64","author":"Werbovetz","year":"2003","journal-title":"Mol. Pharmacol."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523413004017?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523413004017?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T04:55:26Z","timestamp":1563252926000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523413004017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":72,"alternative-id":["S0223523413004017"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2013.06.033","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2013,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and antiprotozoal activities of benzyl phenyl ether diamidine derivatives","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2013.06.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}