{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T17:17:41Z","timestamp":1788887861782,"version":"build-2803163510"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Internal Grant Agency of Palack\u00fd University"},{"name":"Faculty of Chemistry and Chemical Technology, University of Pardubice"},{"DOI":"10.13039\/501100001823","name":"Czech Ministry of Education, Youth and Sports","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1016\/j.ejmech.2013.08.009","type":"journal-article","created":{"date-parts":[[2013,8,14]],"date-time":"2013-08-14T01:16:31Z","timestamp":1376442991000},"page":"253-259","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Substituted 2-hydroxy-N-(arylalkyl)benzamides induce apoptosis in\u00a0cancer cell lines"],"prefix":"10.1016","volume":"68","author":[{"given":"Ale\u0161","family":"Imramovsk\u00fd","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radek","family":"Jorda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karel","family":"Pauk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"\u0158ezn\u00ed\u010dkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Du\u0161ek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u0159\u00ed","family":"Hanusek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladim\u00edr","family":"Kry\u0161tof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2013.08.009_bib1","unstructured":"www.who.int."},{"key":"10.1016\/j.ejmech.2013.08.009_bib2","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/nbt.2284","article-title":"Combinatorial drug therapy for cancer in the post-genomic era","volume":"30","author":"Al-Lazikani","year":"2012","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ejmech.2013.08.009_bib3","doi-asserted-by":"crossref","first-page":"5007","DOI":"10.1016\/j.tetlet.2006.05.110","article-title":"Salicylanilide esterification: unexpected formation of novel seven-membered rings","volume":"47","author":"Imramovsk\u00fd","year":"2006","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.ejmech.2013.08.009_bib4","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1021\/cc900168s","article-title":"Synthetic route for the preparation of 2-hydroxy-N-[1-(2-hydroxyphenylamino)-1-oxoalkan-2-yl]benzamides","volume":"12","author":"Imramovsk\u00fd","year":"2010","journal-title":"J.\u00a0Comb. Chem."},{"key":"10.1016\/j.ejmech.2013.08.009_bib5","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1517\/14728220902866851","article-title":"Targeting the proteasome pathway","volume":"13","author":"Tsukamoto","year":"2009","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.ejmech.2013.08.009_bib6","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.bmc.2012.11.024","article-title":"Inhibitory effect of novel somatostatin peptide analogues on human cancer cell growth based on the selective inhibition of DNA polymerase \u03b2","volume":"15","author":"Kuriyama","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2013.08.009_bib7","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.3390\/molecules16032414","article-title":"Investigating spectrum of biological activity of 4- and 5-chloro-2-hydroxy-N-[2-(arylamino)-1-alkyl-2-oxoethyl]benzamides","volume":"16","author":"Imramovsk\u00fd","year":"2011","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2013.08.009_bib8","doi-asserted-by":"crossref","first-page":"11342","DOI":"10.1021\/ja0752585","article-title":"En route to an efficient catalytic asymmetric synthesis of AS-3201","volume":"129","author":"Mahsiko","year":"2007","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2013.08.009_bib9","unstructured":"L.A. Gaudioso, M.A. Weglarz, Novel Process for the Synthesis of Exochelins. WO 2000\/09547."},{"key":"10.1016\/j.ejmech.2013.08.009_bib10","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/S0955-0674(99)00044-7","article-title":"How do small GTPase signal transduction pathways regulate cell cycle entry?","volume":"11","author":"Marshall","year":"1999","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.ejmech.2013.08.009_bib11","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.4161\/cc.7.19.6784","article-title":"Metastasis and AKT activation","volume":"7","author":"Qiao","year":"2008","journal-title":"Cell Cycle"},{"key":"10.1016\/j.ejmech.2013.08.009_bib12","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.2144\/03345dd02","article-title":"One-step cellular caspase-3\/7 assay","volume":"34","author":"Carrasco","year":"2003","journal-title":"Biotechniques"},{"key":"10.1016\/j.ejmech.2013.08.009_bib13","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.ceb.2003.10.004","article-title":"Bcl-2-family proteins and the role of mitochondria in apoptosis","volume":"15","author":"Kuwana","year":"2003","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.ejmech.2013.08.009_bib14","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1101\/gad.13.15.1899","article-title":"BCL-2 family members and the mitochondria in apoptosis","volume":"13","author":"Gross","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.ejmech.2013.08.009_bib15","doi-asserted-by":"crossref","first-page":"4077","DOI":"10.1242\/jcs.00739","article-title":"Apoptosis \u2013 the p53 network","volume":"116","author":"Haupt","year":"2003","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.ejmech.2013.08.009_bib16","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1038\/cdd.2009.33","article-title":"Life and death partners: apoptosis, autophagy and the cross-talk between them","volume":"16","author":"Eisenberg-Lerner","year":"2009","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ejmech.2013.08.009_bib17","first-page":"317645","article-title":"Novel insights into the interplay between apoptosis and autophagy","author":"Rikiishi","year":"2012","journal-title":"Int. J. Cell Biol."},{"key":"10.1016\/j.ejmech.2013.08.009_bib18","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1146\/annurev-genet-102808-114910","article-title":"Regulation mechanisms and signaling pathways of autophagy","volume":"43","author":"He","year":"2009","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.ejmech.2013.08.009_bib19","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1158\/0008-5472.CAN-11-2291","article-title":"p53\/HMGB1 complexes regulate autophagy and apoptosis","volume":"72","author":"Livesey","year":"2012","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejmech.2013.08.009_bib20","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1021\/bm300697h","article-title":"Polymers from amino acids: development of dual ester-urethane melt condensation approach and mechanistic aspects","volume":"13","author":"Anantharaj","year":"2012","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.ejmech.2013.08.009_bib21","doi-asserted-by":"crossref","first-page":"2980","DOI":"10.1021\/jm200064p","article-title":"Pyrazolo[4,3-d]pyrimidine bioisostere of roscovitine: evaluation of a novel selective inhibitor of cyclin-dependent kinases with antiproliferative activity","volume":"54","author":"Jorda","year":"2011","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2013.08.009_bib22","doi-asserted-by":"crossref","first-page":"6500","DOI":"10.1021\/jm0605740","article-title":"4-Arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects","volume":"49","author":"Kry\u0161tof","year":"2006","journal-title":"J.\u00a0Med. Chem."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523413005102?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523413005102?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T13:41:13Z","timestamp":1759326073000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523413005102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":22,"alternative-id":["S0223523413005102"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2013.08.009","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Substituted 2-hydroxy-N-(arylalkyl)benzamides induce apoptosis in\u00a0cancer cell lines","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2013.08.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}