{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:56:55Z","timestamp":1791190615180,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"UGC"},{"name":"CSIR-HRDG"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1016\/j.ejmech.2013.12.046","type":"journal-article","created":{"date-parts":[[2014,1,15]],"date-time":"2014-01-15T20:30:48Z","timestamp":1389817848000},"page":"509-523","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"special_numbering":"C","title":["Synthesis and characterization of Cu(II)-based anticancer chemotherapeutic agent targeting topoisomerase I\u03b1: In\u00a0vitro DNA binding, pBR322 cleavage, molecular docking studies and cytotoxicity against human cancer cell lines"],"prefix":"10.1016","volume":"74","author":[{"given":"Sartaj","family":"Tabassum","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehvash","family":"Zaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd.","family":"Afzal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farukh","family":"Arjmand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2013.12.046_bib1","first-page":"S1","volume":"471","author":"Brody","year":"2011","journal-title":"Cancer Prev., Nat. Outlook"},{"key":"10.1016\/j.ejmech.2013.12.046_bib2","doi-asserted-by":"crossref","first-page":"13239","DOI":"10.1039\/c2dt31601c","volume":"41","author":"Gaynora","year":"2012","journal-title":"Dalton Trans."},{"key":"10.1016\/j.ejmech.2013.12.046_bib3","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1016\/j.jinorgbio.2008.06.009","volume":"102","author":"Tamasi","year":"2008","journal-title":"J.\u00a0Inorg. Biochem."},{"key":"10.1016\/j.ejmech.2013.12.046_bib4","doi-asserted-by":"crossref","first-page":"3927","DOI":"10.1039\/c1an15507e","volume":"136","author":"Chen","year":"2011","journal-title":"Analyst"},{"key":"10.1016\/j.ejmech.2013.12.046_bib5","doi-asserted-by":"crossref","first-page":"5992","DOI":"10.1021\/ja058509n","volume":"128","author":"Reed","year":"2006","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2013.12.046_bib6","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1039\/b804627a","volume":"133","author":"Kong","year":"2008","journal-title":"Analyst"},{"key":"10.1016\/j.ejmech.2013.12.046_bib7","doi-asserted-by":"crossref","first-page":"39","DOI":"10.2174\/0929867003375489","volume":"7","author":"Bailly","year":"2000","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.ejmech.2013.12.046_bib8","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1038\/sj.onc.1204264","volume":"20","author":"Shao","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.ejmech.2013.12.046_bib9","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jinorgbio.2012.02.022","volume":"111","author":"David","year":"2012","journal-title":"J.\u00a0Inorg. Biochem."},{"key":"10.1016\/j.ejmech.2013.12.046_bib10a","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.inoche.2012.06.008","volume":"22","author":"Mahmudov","year":"2012","journal-title":"Inorg. Chem. Commun."},{"key":"10.1016\/j.ejmech.2013.12.046_bib10b","doi-asserted-by":"crossref","first-page":"12269","DOI":"10.1016\/S0021-9258(19)86305-6","volume":"254","author":"Sigman","year":"1979","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.ejmech.2013.12.046_bib11","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.saa.2008.03.001","volume":"71","author":"Refat","year":"2008","journal-title":"Spectrochim. Acta Part A"},{"key":"10.1016\/j.ejmech.2013.12.046_bib12","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1081\/SIM-200067057","volume":"35","author":"Nath","year":"2005","journal-title":"Synth. React. Inorg. Met. Org. Nano-Met. Chem."},{"key":"10.1016\/j.ejmech.2013.12.046_bib13","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jphotobiol.2012.06.012","volume":"115","author":"Tabassum","year":"2012","journal-title":"J.\u00a0Photochem. Photobiol. B"},{"key":"10.1016\/j.ejmech.2013.12.046_bib14","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1039\/dt9900001389","author":"Steel","year":"1990","journal-title":"J.\u00a0Chem. Soc. Dalton Trans."},{"key":"10.1016\/j.ejmech.2013.12.046_bib15","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0022-328X(00)00662-8","volume":"619","author":"Esquius","year":"2001","journal-title":"J.\u00a0Organomet. Chem."},{"key":"10.1016\/j.ejmech.2013.12.046_bib16","doi-asserted-by":"crossref","first-page":"2882","DOI":"10.1021\/ic991209k","volume":"39","author":"Colacio","year":"2000","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.ejmech.2013.12.046_bib17","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1021\/ic202198k","volume":"51","author":"Reger","year":"2012","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.ejmech.2013.12.046_bib18a","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.jinorgbio.2010.11.006","volume":"105","author":"Dixit","year":"2011","journal-title":"J.\u00a0Inorg. Biochem."},{"key":"10.1016\/j.ejmech.2013.12.046_bib18b","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molstruc.2011.01.002","volume":"995","author":"Soleimani","year":"2011","journal-title":"J.\u00a0Mol. Struct."},{"key":"10.1016\/j.ejmech.2013.12.046_bib19","doi-asserted-by":"crossref","first-page":"4277","DOI":"10.1016\/j.tsf.2008.11.139","volume":"517","author":"Chen","year":"2009","journal-title":"Thin Solid Films"},{"key":"10.1016\/j.ejmech.2013.12.046_bib20","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.molstruc.2009.11.025","volume":"965","author":"Arjmand","year":"2010","journal-title":"J.\u00a0Mol. Struct."},{"key":"10.1016\/j.ejmech.2013.12.046_bib21","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jphotobiol.2012.05.017","volume":"114","author":"Tabassum","year":"2012","journal-title":"J.\u00a0Photochem. Photobiol. B"},{"key":"10.1016\/j.ejmech.2013.12.046_bib22","doi-asserted-by":"crossref","first-page":"13308","DOI":"10.1039\/c2dt31079a","volume":"41","author":"Ramachandran","year":"2012","journal-title":"Dalton Trans."},{"key":"10.1016\/j.ejmech.2013.12.046_bib23","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.ejmech.2012.09.051","volume":"58","author":"Tabassum","year":"2012","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2013.12.046_bib24","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1271\/bbb.66.1706","volume":"66","author":"Suzuki","year":"2002","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.ejmech.2013.12.046_bib25","doi-asserted-by":"crossref","first-page":"15580","DOI":"10.1021\/bi991792g","volume":"38","author":"Fortune","year":"1999","journal-title":"Biochemistry"},{"key":"10.1016\/j.ejmech.2013.12.046_bib26","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1271\/bbb.62.2073","volume":"62","author":"Suzuki","year":"1998","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.ejmech.2013.12.046_bib27","doi-asserted-by":"crossref","first-page":"12846","DOI":"10.1039\/c1dt10695c","volume":"40","author":"Meng","year":"2011","journal-title":"Dalton Trans."},{"key":"10.1016\/j.ejmech.2013.12.046_bib28","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1039\/B921404F","volume":"46","author":"Haley","year":"2010","journal-title":"Chem. Commun."},{"key":"10.1016\/j.ejmech.2013.12.046_bib29","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1039\/b801433g","volume":"37","author":"Liu","year":"2008","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.ejmech.2013.12.046_bib30","doi-asserted-by":"crossref","first-page":"4388","DOI":"10.1021\/ja0441561","volume":"127","author":"Singh","year":"2005","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2013.12.046_bib31","doi-asserted-by":"crossref","first-page":"7048","DOI":"10.1093\/nar\/gki1008","volume":"33","author":"Rohs","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ejmech.2013.12.046_bib32","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.bmc.2008.11.024","volume":"17","author":"Filosa","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2013.12.046_bib33","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/chir.20372","volume":"19","author":"Corradini","year":"2007","journal-title":"Chirality"},{"key":"10.1016\/j.ejmech.2013.12.046_bib34","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jinorgbio.2012.12.011","volume":"121","author":"Shi","year":"2013","journal-title":"J.\u00a0Inorg. Biochem."},{"key":"10.1016\/j.ejmech.2013.12.046_bib35","doi-asserted-by":"crossref","first-page":"4020","DOI":"10.1002\/anie.200906363","volume":"49","author":"Georgiades","year":"2010","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.ejmech.2013.12.046_bib36","doi-asserted-by":"crossref","first-page":"5293","DOI":"10.1039\/c1cs15117g","volume":"40","author":"Murat","year":"2011","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.ejmech.2013.12.046_bib37","doi-asserted-by":"crossref","first-page":"5661","DOI":"10.1039\/c3dt32640c","volume":"42","author":"Yao","year":"2013","journal-title":"Dalton Trans."},{"key":"10.1016\/j.ejmech.2013.12.046_bib38","doi-asserted-by":"crossref","first-page":"3231","DOI":"10.1021\/jm050017y","volume":"48","author":"Xiao","year":"2005","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2013.12.046_bib39","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.ejmech.2012.01.005","volume":"49","author":"Arjmand","year":"2012","journal-title":"Eur. J. Med. Chem."},{"issue":"65","key":"10.1016\/j.ejmech.2013.12.046_bib40a","first-page":"1","volume":"6","author":"Lammers","year":"2007","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.ejmech.2013.12.046_bib40b","unstructured":"http:\/\/www.google.co.in\/patents\/US4952607."},{"key":"10.1016\/j.ejmech.2013.12.046_bib41","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1039\/DT9960003065","author":"Gelling","year":"1996","journal-title":"J.\u00a0Chem. Soc. Dalton Trans."},{"key":"10.1016\/j.ejmech.2013.12.046_bib42","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1021\/ja01640a067","volume":"76","author":"Reicmann","year":"1954","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2013.12.046_bib43","doi-asserted-by":"crossref","first-page":"6392","DOI":"10.1021\/bi00394a013","volume":"26","author":"Wolfe","year":"1987","journal-title":"Biochemistry"},{"key":"10.1016\/j.ejmech.2013.12.046_bib44","doi-asserted-by":"crossref","first-page":"4161","DOI":"10.1021\/bi00745a020","volume":"12","author":"Lakowiez","year":"1973","journal-title":"Biochemistry"},{"key":"10.1016\/j.ejmech.2013.12.046_bib45","doi-asserted-by":"crossref","first-page":"3549","DOI":"10.1016\/j.ejmech.2010.04.031","volume":"45","author":"Arjmand","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2013.12.046_bib46","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/prot.20569","volume":"60","author":"Mustard","year":"2005","journal-title":"Proteins: Struct., Funct., Bioinf."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523414000087?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523414000087?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T18:52:18Z","timestamp":1648061538000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523414000087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":49,"alternative-id":["S0223523414000087"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2013.12.046","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and characterization of Cu(II)-based anticancer chemotherapeutic agent targeting topoisomerase I\u03b1: In\u00a0vitro DNA binding, pBR322 cleavage, molecular docking studies and cytotoxicity against human cancer cell lines","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2013.12.046","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}