{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:53:14Z","timestamp":1791237194301,"version":"4.1.0"},"reference-count":59,"publisher":"Elsevier BV","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1016\/j.ejmech.2014.04.076","type":"journal-article","created":{"date-parts":[[2014,4,28]],"date-time":"2014-04-28T02:00:19Z","timestamp":1398650419000},"page":"523-534","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":78,"special_numbering":"C","title":["Probing the aurone scaffold against Plasmodium falciparum: Design, synthesis and antimalarial activity"],"prefix":"10.1016","volume":"80","author":[{"given":"Marta P.","family":"Carrasco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana S.","family":"Newton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00eddia","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"G\u00f3is","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiri","family":"Gut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1tima","family":"Nogueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"H\u00e4nscheid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5790-9181","authenticated-orcid":false,"given":"Rita C.","family":"Guedes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.V.A.","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J.","family":"Rosenthal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0727-9852","authenticated-orcid":false,"given":"Rui","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2014.04.076_bib1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.2174\/138955708783744092","article-title":"Malaria combination therapies: advantages and shortcomings","volume":"8","author":"Martinelli","year":"2008","journal-title":"Mini Reviews in Medicinal Chemistry"},{"key":"10.1016\/j.ejmech.2014.04.076_bib2","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1146\/annurev.pharmtox.45.120403.095946","article-title":"Molecular mechanisms of resistance in antimalarial chemotherapy: the unmet challenge","volume":"45","author":"Arav-Boger","year":"2005","journal-title":"Annual Review of Pharmacology"},{"key":"10.1016\/j.ejmech.2014.04.076_bib3","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.pt.2008.09.005","article-title":"Recent highlights in antimalarial drug resistance and chemotherapy research","volume":"24","author":"Fidock","year":"2008","journal-title":"Trends in Parasitology"},{"key":"10.1016\/j.ejmech.2014.04.076_bib4","doi-asserted-by":"crossref","first-page":"3229","DOI":"10.1016\/j.bmc.2009.02.050","article-title":"Antimalarials from nature","volume":"17","author":"Kaur","year":"2009","journal-title":"Bioorganic & Medicinal Chemistry"},{"key":"10.1016\/j.ejmech.2014.04.076_bib5","doi-asserted-by":"crossref","first-page":"S55","DOI":"10.1007\/s00436-002-0768-3","article-title":"Natural products as antiparasitic drugs","volume":"90","author":"Kayser","year":"2003","journal-title":"Parasitology Research"},{"key":"10.1016\/j.ejmech.2014.04.076_bib6","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.2174\/092986712800672085","article-title":"Recent advances in the medicinal chemistry of aurones","volume":"19","author":"Haudecoeur","year":"2012","journal-title":"Current Medicinal Chemistry"},{"key":"10.1016\/j.ejmech.2014.04.076_bib7","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.2174\/0929867033456468","article-title":"Aurones: a subclass of flavones with promising biological potential","volume":"10","author":"Boumendjel","year":"2003","journal-title":"Current Medicinal Chemistry"},{"key":"10.1016\/j.ejmech.2014.04.076_bib8","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1016\/j.ejmech.2010.03.023","article-title":"Functionalized aurones as inducers of NAD(P)H: quinone oxidoreductase 1 that activate AhR\/XRE and Nrf2\/ARE signaling pathways: synthesis, evaluation and SAR","volume":"45","author":"Lee","year":"2010","journal-title":"European Journal of Medicinal Chemistry"},{"key":"10.1016\/j.ejmech.2014.04.076_bib9","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.bmcl.2006.09.057","article-title":"2-Arylidenedihydroindole-3-ones: design, synthesis, and biological activity on bladder carcinoma cell lines","volume":"17","author":"Gerby","year":"2007","journal-title":"Bioorganic & Medicinal Chemistry Letters"},{"key":"10.1016\/j.ejmech.2014.04.076_bib10","doi-asserted-by":"crossref","first-page":"5191","DOI":"10.1016\/j.bmc.2007.05.022","article-title":"Design, synthesis, and antitumor activity of novel chromone and aurone derivatives","volume":"15","author":"Huang","year":"2007","journal-title":"Bioorganic & Medicinal Chemistry"},{"key":"10.1016\/j.ejmech.2014.04.076_bib11","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1002\/cbic.201100716","article-title":"Versatile effects of aurone structure on mushroom tyrosinase activity","volume":"13","author":"Dubois","year":"2012","journal-title":"Chembiochem: a European Journal of Chemical Biology"},{"key":"10.1016\/j.ejmech.2014.04.076_bib12","doi-asserted-by":"crossref","first-page":"6160","DOI":"10.1016\/j.bmcl.2012.08.017","article-title":"Ethylenediamine diacetate (EDDA) mediated synthesis of aurones under ultrasound: their evaluation as inhibitors of SIRT1","volume":"22","author":"Manjulatha","year":"2012","journal-title":"Bioorganic & Medicinal Chemistry Letters"},{"key":"10.1016\/j.ejmech.2014.04.076_bib13","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1021\/jm050715i","article-title":"Discovery of benzylidenebenzofuran-3(2H)-one (aurones) as inhibitors of tyrosinase derived from human melanocytes","volume":"49","author":"Okombi","year":"2006","journal-title":"Journal of Medicinal Chemistry"},{"key":"10.1016\/j.ejmech.2014.04.076_bib14","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1016\/j.ejmech.2010.03.045","article-title":"Synthesis and biological evaluation of a novel series of 2,2-bisaminomethylated aurone analogues as anti-inflammatory and antimicrobial agents","volume":"45","author":"Bandgar","year":"2010","journal-title":"European Journal of Medicinal Chemistry"},{"key":"10.1016\/j.ejmech.2014.04.076_bib15","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1055\/s-1999-13993","article-title":"In\u00a0vitro leishmanicidal activity of aurones","volume":"65","author":"Kayser","year":"1999","journal-title":"Planta Medica"},{"key":"10.1016\/j.ejmech.2014.04.076_bib16","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1055\/s-2001-18356","article-title":"In\u00a0vitro activity of aurones against Plasmodium falciparum strains K1 and NF54","volume":"67","author":"Kayser","year":"2001","journal-title":"Planta Medica"},{"key":"10.1016\/j.ejmech.2014.04.076_bib17","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1515\/znc-2002-7-828","article-title":"Aurones interfere with Leishmania major mitochondrial fumarate reductase","volume":"57c","author":"Kayser","year":"2002","journal-title":"Zeitschrift f\u00fcr Naturforschung"},{"key":"10.1016\/j.ejmech.2014.04.076_bib18","doi-asserted-by":"crossref","first-page":"5724","DOI":"10.1016\/j.bmc.2010.06.008","article-title":"1-Azaaurones derived from the naturally occurring aurones as potential antimalarial drugs","volume":"18","author":"Souard","year":"2010","journal-title":"Bioorganic & Medicinal Chemistry"},{"key":"10.1016\/j.ejmech.2014.04.076_bib19","doi-asserted-by":"crossref","first-page":"5395","DOI":"10.1021\/jm200242p","article-title":"Discovery of naturally occurring aurones that are potent allosteric inhibitors of Hepatitis C virus RNA-dependent RNA polymerase","volume":"54","author":"Haudecoeur","year":"2011","journal-title":"Journal of Medicinal Chemistry"},{"key":"10.1016\/j.ejmech.2014.04.076_bib20","doi-asserted-by":"crossref","first-page":"4520","DOI":"10.1016\/j.bmcl.2011.05.117","article-title":"Synthesis of aurones and their inhibitory effects on nitric oxide and PGE(2) productions in LPS-induced RAW 264.7 cells","volume":"21","author":"Shin","year":"2011","journal-title":"Bioorganic & Medicinal Chemistry Letters"},{"key":"10.1016\/j.ejmech.2014.04.076_bib21","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.ejps.2008.07.008","article-title":"Dimethoxyaurones: potent inhibitors of ABCG2 (breast cancer resistance protein)","volume":"35","author":"Sim","year":"2008","journal-title":"European Journal of Pharmaceutical Sciences: Official Journal of the European Federation for Pharmaceutical Sciences"},{"key":"10.1016\/j.ejmech.2014.04.076_bib22","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1002\/cmdc.201000520","article-title":"Aurones as modulators of ABCG2 and ABCB1: synthesis and structure-activity relationships","volume":"6","author":"Sim","year":"2011","journal-title":"Chemical Medicinal Chemistry"},{"key":"10.1016\/j.ejmech.2014.04.076_bib23","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1016\/j.bcp.2011.08.002","article-title":"In\u00a0vitro and in\u00a0vivo modulation of ABCG2 by functionalized aurones and structurally related analogs","volume":"82","author":"Sim","year":"2011","journal-title":"Biochemical Pharmacology"},{"key":"10.1016\/j.ejmech.2014.04.076_bib24","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1021\/jm021099i","article-title":"Modulation of P-glycoprotein-mediated multidrug resistance by flavonoid derivatives and analogues","volume":"46","author":"Hadjeri","year":"2003","journal-title":"Journal of Medicinal Chemistry"},{"key":"10.1016\/j.ejmech.2014.04.076_bib25","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1248\/cpb.50.854","article-title":"4-hydroxy-6-methoxyaurones with high-affinity binding to cytosolic domain of P-glycoprotein","volume":"50","author":"Boumendjel","year":"2002","journal-title":"Chemical & Pharmaceutical Bulletin"},{"key":"10.1016\/j.ejmech.2014.04.076_bib26","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ejmech.2008.03.003","article-title":"Design, synthesis and AChE inhibitory activity of indanone and aurone derivatives","volume":"44","author":"Sheng","year":"2009","journal-title":"European Journal of Medicinal Chemistry"},{"key":"10.1016\/j.ejmech.2014.04.076_bib27","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1016\/j.bmcl.2011.12.056","article-title":"A\u00a0scaffold hopping approach to identify novel monoamine oxidase B inhibitors","volume":"22","author":"Geldenhuys","year":"2012","journal-title":"Bioorganic & Medicinal Chemistry Letters"},{"key":"10.1016\/j.ejmech.2014.04.076_bib28","doi-asserted-by":"crossref","first-page":"4814","DOI":"10.1039\/b610734f","article-title":"Microwave enhanced palladium catalysed coupling reactions: a diversity-oriented synthesis approach to functionalised flavones","author":"Fitzmaurice","year":"2006","journal-title":"Chemical Communications"},{"key":"10.1016\/j.ejmech.2014.04.076_bib29","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nature09099","article-title":"Chemical genetics of Plasmodium falciparum","volume":"465","author":"Guiguemde","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2014.04.076_bib30","doi-asserted-by":"crossref","first-page":"5937","DOI":"10.1016\/S0040-4039(00)61093-6","article-title":"Alumina-mediated condensation - a simple synthesis of aurones","volume":"33","author":"Varma","year":"1992","journal-title":"Tetrahedron Letters"},{"key":"10.1016\/j.ejmech.2014.04.076_bib31","doi-asserted-by":"crossref","first-page":"7146","DOI":"10.1021\/jm101144f","article-title":"Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer","volume":"53","author":"Liu","year":"2010","journal-title":"Journal of Medicinal Chemistry"},{"key":"10.1016\/j.ejmech.2014.04.076_bib32","doi-asserted-by":"crossref","first-page":"6499","DOI":"10.1021\/jo00125a041","article-title":"A\u00a0novel oxidative cyclization of 2'-hydroxychalcones to 4,5-dialkoxyaurone by thallium(III) nitrate","volume":"60","author":"Thakkar","year":"1995","journal-title":"The Journal of Organic Chemistry"},{"key":"10.1016\/j.ejmech.2014.04.076_bib33","doi-asserted-by":"crossref","first-page":"967","DOI":"10.3987\/COM-01-9182","article-title":"An efficient synthesis of 4,6 dimethoxyaurones","volume":"55","author":"Beney","year":"2001","journal-title":"Heterocycles"},{"key":"10.1016\/j.ejmech.2014.04.076_bib34","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1248\/cpb.49.105","article-title":"Two new aurones from marine brown alga Spatoglossum variabile","volume":"49","author":"Atta-Ur-Rahman","year":"2001","journal-title":"Chemical & Pharmaceutical Bulletin"},{"key":"10.1016\/j.ejmech.2014.04.076_bib35","doi-asserted-by":"crossref","first-page":"479","DOI":"10.2174\/156802606776743147","article-title":"A\u00a0medicinal chemistry perspective on 4-aminoquinoline antimalarial drugs","volume":"6","author":"O'Neill","year":"2006","journal-title":"Current Topics in Medicinal Chemistry"},{"key":"10.1016\/j.ejmech.2014.04.076_bib36","doi-asserted-by":"crossref","first-page":"4443","DOI":"10.1021\/jm0101747","article-title":"Antimalarial alkoxylated and hydroxylated chalones: structure-activity relationship analysis","volume":"44","author":"Liu","year":"2001","journal-title":"Journal of Medicinal Chemistry"},{"key":"10.1016\/j.ejmech.2014.04.076_bib37","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1016\/j.bcp.2007.03.011","article-title":"Activity of piperaquine and other 4-aminoquinoline antiplasmodial drugs against chloroquine-sensitive and resistant blood-stages of Plasmodium falciparum \u2013 role of beta-haematin inhibition and drug concentration in vacuolar water- and lipid-phases","volume":"73","author":"Warhurst","year":"2007","journal-title":"Biochemical Pharmacology"},{"key":"10.1016\/j.ejmech.2014.04.076_bib38","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.1128\/AAC.00121-11","article-title":"Use of the NP-40 detergent-mediated assay in discovery of inhibitors of beta-hematin crystallization","volume":"55","author":"Sandlin","year":"2011","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.ejmech.2014.04.076_bib39","doi-asserted-by":"crossref","first-page":"4339","DOI":"10.1128\/AAC.00536-09","article-title":"Novel antimalarial aminoquinolines: heme binding and effects on normal or Plasmodium falciparum-parasitized human erythrocytes","volume":"53","author":"Omodeo-Sale","year":"2009","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.ejmech.2014.04.076_bib40","doi-asserted-by":"crossref","first-page":"e41006","DOI":"10.1371\/journal.pone.0041006","article-title":"A\u00a0novel way to grow hemozoin-like crystals in\u00a0vitro and its use to screen for hemozoin inhibiting antimalarial compounds","volume":"7","author":"Thomas","year":"2012","journal-title":"Plos One"},{"key":"10.1016\/j.ejmech.2014.04.076_bib41","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/978-1-4419-8414-2_3","article-title":"Falcipains and other cysteine proteases of malaria parasites","volume":"712","author":"Rosenthal","year":"2011","journal-title":"Advances in Experimental Medicine and Biology"},{"key":"10.1016\/j.ejmech.2014.04.076_bib42","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.molbiopara.2004.11.009","article-title":"Biosynthesis, localization, and processing of falcipain cysteine proteases of Plasmodium falciparum","volume":"139","author":"Dahl","year":"2005","journal-title":"Molecular and Biochemical Parasitology"},{"key":"10.1016\/j.ejmech.2014.04.076_bib43","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.2174\/138955707782110105","article-title":"Michael acceptors as cysteine protease inhibitors","volume":"7","author":"Santos","year":"2007","journal-title":"Mini Reviews in Medicinal Chemistry"},{"key":"10.1016\/j.ejmech.2014.04.076_bib44","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S0968-0896(99)00004-8","article-title":"Antimalarial effects in mice of orally administered peptidyl cysteine protease inhibitors","volume":"7","author":"Olson","year":"1999","journal-title":"Bioorganic & Medicinal Chemistry"},{"key":"10.1016\/j.ejmech.2014.04.076_bib45","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.molbiopara.2003.08.015","article-title":"P-glycoprotein inhibitors modulate accumulation and efflux of xenobiotics in extra and intracellular Toxoplasma gondii","volume":"134","author":"Sauvage","year":"2004","journal-title":"Molecular and Biochemical Parasitology"},{"key":"10.1016\/j.ejmech.2014.04.076_bib46","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1054\/drup.2001.0183","article-title":"The ABC transporter genes of Plasmodium falciparum and drug resistance","volume":"4","author":"Peel","year":"2001","journal-title":"Drug Resist Update"},{"key":"10.1016\/j.ejmech.2014.04.076_bib47","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1128\/AAC.42.9.2254","article-title":"Antimalarial synergy of cysteine and aspartic protease inhibitors","volume":"42","author":"Semenov","year":"1998","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.ejmech.2014.04.076_bib48","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1128\/AAC.46.9.2889-2894.2002","article-title":"In\u00a0vitro and in\u00a0vivo synergy of fosmidomycin, a novel antimalarial drug, with clindamycin","volume":"46","author":"Wiesner","year":"2002","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.ejmech.2014.04.076_bib49","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1136\/bmj.326.7390.628","article-title":"Evidence of Plasmodium falciparum malaria resistant to atovaquone and proguanil hydrochloride: case reports","volume":"326","author":"Farnert","year":"2003","journal-title":"British Medical Journal"},{"key":"10.1016\/j.ejmech.2014.04.076_bib50","article-title":"Additive in\u00a0vitro antiplasmodial effect of N-alkyl and N-benzyl-1,10-phenanthroline derivatives and cysteine protease inhibitor e64","volume":"2010","author":"Wijayanti","year":"2010","journal-title":"Malarial Research and Treatment"},{"key":"10.1016\/j.ejmech.2014.04.076_bib51","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.exppara.2013.03.022","article-title":"Chemosensitization potential of P-glycoprotein inhibitors in malaria parasites","volume":"134","author":"Alcantara","year":"2013","journal-title":"Experimental Parasitology"},{"key":"10.1016\/j.ejmech.2014.04.076_bib52","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1126\/science.781840","article-title":"Human malaria parasites in continuous culture","volume":"193","author":"Trager","year":"1976","journal-title":"Science"},{"key":"10.1016\/j.ejmech.2014.04.076_bib53","doi-asserted-by":"crossref","first-page":"418","DOI":"10.2307\/3280287","article-title":"Synchronization of Plasmodium falciparum erythrocytic stages in culture","volume":"65","author":"Lambros","year":"1979","journal-title":"The Journal of Parasitology"},{"key":"10.1016\/j.ejmech.2014.04.076_bib54","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1039\/c2md20011b","article-title":"Squaric acid: a valuable scaffold for developing antimalarials?","volume":"3","author":"Kumar","year":"2012","journal-title":"Medicinal Chemistry Communications"},{"key":"10.1016\/j.ejmech.2014.04.076_bib55","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1039\/c2md20090b","article-title":"Structure based virtual screening for discovery of novel human neutrophil elastase inhibitors","volume":"3","author":"Lucas","year":"2012","journal-title":"Medicinal Chemistry Communications"},{"key":"10.1016\/j.ejmech.2014.04.076_bib56","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s10822-005-8694-y","article-title":"Virtual computational chemistry laboratory \u2013 design and description","volume":"19","author":"Tetko","year":"2005","journal-title":"Journal of Computer Aided Molecular Design"},{"key":"10.1016\/j.ejmech.2014.04.076_bib57","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/qsar.19950140405","article-title":"A\u00a0rigorous test for SPARC's chemical reactivity models: estimation of more than 4300 ionization pK(a)s","volume":"14","author":"Hilal","year":"1995","journal-title":"Quantitative Structure\u2013Activity Relationship"},{"key":"10.1016\/j.ejmech.2014.04.076_bib58","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1021\/ja01064a025","article-title":"Electrical effects of ortho-substituents in pyridines and quinolines","volume":"86","author":"Charton","year":"1964","journal-title":"Journal of the American Chemical Society"},{"key":"10.1016\/j.ejmech.2014.04.076_bib59","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1039\/qr9641800295","article-title":"Prediction of the strengths of organic bases","volume":"18","author":"Clark","year":"1964","journal-title":"Quantitative Reviews of the Chemical Society"}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S022352341400405X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S022352341400405X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T18:58:00Z","timestamp":1565377080000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S022352341400405X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":59,"alternative-id":["S022352341400405X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2014.04.076","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2014,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Probing the aurone scaffold against Plasmodium falciparum: Design, synthesis and antimalarial activity","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2014.04.076","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}