{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:58:45Z","timestamp":1791284325199,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1016\/j.ejmech.2014.07.007","type":"journal-article","created":{"date-parts":[[2014,7,3]],"date-time":"2014-07-03T20:17:43Z","timestamp":1404418663000},"page":"135-145","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"special_numbering":"C","title":["New praziquantel derivatives containing NO-donor furoxans and related furazans as active agents against Schistosoma mansoni"],"prefix":"10.1016","volume":"84","author":[{"given":"Stefano","family":"Guglielmo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Cortese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Vottero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Rolando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie P.","family":"Kommer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Fruttero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Gasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2014.07.007_bib1","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.idc.2012.03.004","article-title":"Schistosomiasis","volume":"26","author":"Gryseels","year":"2012","journal-title":"Infect. Dis. Clin. N. Am."},{"key":"10.1016\/j.ejmech.2014.07.007_bib2","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S1473-3099(06)70521-7","article-title":"Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk","volume":"6","author":"Steinmann","year":"2006","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.ejmech.2014.07.007_bib3","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0001-706X(03)00029-9","article-title":"Quantification of clinical morbidity associated with schistosoma infection in Sub-Saharan Africa","volume":"86","author":"Van der Werf","year":"2003","journal-title":"Acta Trop."},{"key":"10.1016\/j.ejmech.2014.07.007_bib4","first-page":"17936","article-title":"Schistosomiasis chemotherapy","volume":"53","author":"Thetiot-Laurent","year":"2013","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.ejmech.2014.07.007_bib5","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/BF00389899","article-title":"Praziquantel, a new broad-spectrum antischistosomal agent","volume":"52","author":"Gonnert","year":"1977","journal-title":"Z.\u00a0Parasitenk"},{"key":"10.1016\/j.ejmech.2014.07.007_bib6","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/chir.20251","article-title":"Investigation of the phase diagrams of chiral praziquantel","volume":"18","author":"Liu","year":"2006","journal-title":"Chirality"},{"key":"10.1016\/j.ejmech.2014.07.007_bib7","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1002\/cmdc.201000202","article-title":"Praziquantel and schistosomiasis","volume":"5","author":"Doemling","year":"2010","journal-title":"ChemMedChem"},{"key":"10.1016\/j.ejmech.2014.07.007_bib8","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1097\/01.qco.0000247591.13671.6a","article-title":"Schistosomiasis: challenges for control, treatment and drug resistance","volume":"19","author":"Fenwick","year":"2006","journal-title":"Curr. Opin. Infect. Dis."},{"key":"10.1016\/j.ejmech.2014.07.007_bib9","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.molbiopara.2008.11.007","article-title":"Towards an understanding of the mechanism of action of praziquantel","volume":"164","author":"Aragon","year":"2009","journal-title":"Mol. Biochem. Parasitol"},{"key":"10.1016\/j.ejmech.2014.07.007_bib10","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.bmcl.2011.11.108","article-title":"Synthesis of new praziquantel analogues: potential candidates for the treatment of schistosomiasis","volume":"22","author":"Sadhu","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2014.07.007_bib11","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1517\/14656560902722463","article-title":"Pharmacotherapy of helminth infection","volume":"10","author":"van den Enden","year":"2009","journal-title":"Exp. Opin. Pharmacother."},{"key":"10.1016\/j.ejmech.2014.07.007_bib12","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1007\/s00436-012-3151-z","article-title":"Susceptibility or resistance of praziquantel in human schistosomiasis: a review","volume":"111","author":"Wang","year":"2011","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.ejmech.2014.07.007_bib13","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.molbiopara.2010.05.003","article-title":"Schistosoma mansoni express higher levels of multidrug resistance-associated protein 1 (SmMRP1) juvenile worms and in response to praziquantel","volume":"173","author":"Kasinathan","year":"2010","journal-title":"Mol. Biochem. Parasitol"},{"key":"10.1016\/j.ejmech.2014.07.007_bib14","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nm1737","article-title":"Identification of oxadiazoles as new drug leads for the control of schistosomiasis","volume":"14","author":"Sayed","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejmech.2014.07.007_bib15","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1016\/j.tetlet.2009.01.120","article-title":"Synthesis of oxadiazole-2-oxide analogues as potential antischistosomal agents","volume":"50","author":"Rai","year":"2009","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.ejmech.2014.07.007_bib16","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0065-2725(08)60789-8","article-title":"Furoxans and benzofuroxans","volume":"29","author":"Gasco","year":"1981","journal-title":"Adv. Heterocycl. Chem."},{"key":"10.1016\/j.ejmech.2014.07.007_bib17","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/0006-2952(92)90379-W","article-title":"Thiol-mediated generation of nitric-oxide accounts for the vasodilator action of furoxans","volume":"44","author":"Feelisch","year":"1992","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejmech.2014.07.007_bib18","series-title":"Nitric Oxide Donors","first-page":"131","article-title":"The NO-releasing heterocycles","author":"Gasco","year":"2005"},{"key":"10.1016\/j.ejmech.2014.07.007_bib19","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/S0020-7519(02)00108-X","article-title":"Molecular and enzimatic characterization of Schistosoma mansoni thioredoxin","volume":"32","author":"Alger","year":"2002","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.ejmech.2014.07.007_bib20","doi-asserted-by":"crossref","first-page":"6474","DOI":"10.1021\/jm901021k","article-title":"Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis","volume":"52","author":"Rai","year":"2009","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2014.07.007_bib21","unstructured":"To be submitted for publication."},{"key":"10.1016\/j.ejmech.2014.07.007_bib22a","doi-asserted-by":"crossref","first-page":"4944","DOI":"10.1021\/jm00025a012","article-title":"The furoxan system as a useful tool for balancing \"Hybrids\" with mixed alpha-1-Antagonist and NO-like vasodilator activities","volume":"38","author":"Fruttero","year":"1995","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2014.07.007_bib22b","doi-asserted-by":"crossref","first-page":"5003","DOI":"10.1021\/jm0704595","article-title":"Nitric oxide donor beta(2)-agonists: furoxan derivatives containing the fenoterol moiety and related furazans","volume":"50","author":"Buonsanti","year":"2007","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2014.07.007_bib22c","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.niox.2008.04.013","article-title":"Nitrates and NO-NSAIDs in cancer chemoprevention and therapy: in\u00a0vitro evidence querying the NO donor functionality","volume":"19","author":"Dunlap","year":"2008","journal-title":"Nitric Oxide-Biol. Chem."},{"key":"10.1016\/j.ejmech.2014.07.007_bib23","doi-asserted-by":"crossref","first-page":"12296","DOI":"10.1002\/chem.201002046","article-title":"Efficient multicomponent reaction synthesis of the schistosomiasis drug praziquantel","volume":"16","author":"Cao","year":"2010","journal-title":"Chem. Eur. J."},{"key":"10.1016\/j.ejmech.2014.07.007_bib24","first-page":"131","article-title":"Molecular bases for the anti-parasitic effect of NO (Review)","volume":"9","author":"Colasanti","year":"2002","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.ejmech.2014.07.007_bib25","doi-asserted-by":"crossref","first-page":"5467","DOI":"10.1021\/jm100066y","article-title":"Phenylsulfonylfuroxans as modulators of multidrug-resistance associated protein-1 and P-glycoprotein","volume":"53","author":"Fruttero","year":"2010","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2014.07.007_bib26","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1021\/ml100302t","article-title":"Nitric oxide donor doxorubicins accumulate into doxorubicin-resistant human colon cancer cells inducing cytotoxicity","volume":"2","author":"Chegaev","year":"2011","journal-title":"Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2014.07.007_bib27","doi-asserted-by":"crossref","first-page":"7395","DOI":"10.1016\/S0040-4020(98)00401-3","article-title":"Formation of pyrazinoisoquinoline ring system by the tandem amidoalkylation and N-acyliminium ion cyclization: an efficient synthesis of praziquantel","volume":"54","author":"Kim","year":"1998","journal-title":"Tetrahedron"},{"key":"10.1016\/j.ejmech.2014.07.007_bib28","first-page":"1029","article-title":"Das Tetramere der Knallsaure (Isocyanilsaure) und seine Derivate (Nitrile oxides. XVIII. Tetramer of fulminic acid (isocyanilic acid) and its derivatives)","author":"Grundmann","year":"1976","journal-title":"Liebigs Ann. Chem."},{"key":"10.1016\/j.ejmech.2014.07.007_bib29","doi-asserted-by":"crossref","first-page":"5393","DOI":"10.1021\/jm9803267","article-title":"New 1,4-dihydropyridines conjugated to furoxanyl moieties, endowed with both nitric oxide-like and calcium channel antagonist vasodilator activities","volume":"41","author":"Di Stilo","year":"1998","journal-title":"J.\u00a0Med. Chem"},{"key":"10.1016\/j.ejmech.2014.07.007_bib30","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/ddr.10284","article-title":"Synthesis and anti-Helicobacter pylori properties of NO-donor\/metronidazole hybrids and related compounds","volume":"60","author":"Bertinaria","year":"2003","journal-title":"Drug. Dev. Res."},{"key":"10.1016\/j.ejmech.2014.07.007_bib31","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1039\/jr9640000904","article-title":"The 3,4-bisarenesulphonylfuroxans","author":"Farrar","year":"1964","journal-title":"J.\u00a0Chem. Soc."},{"key":"10.1016\/j.ejmech.2014.07.007_bib32","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1023\/A:1012136030849","article-title":"Studies on agents with mixed NO-dependent vasodilating and beta-blocking activities","volume":"14","author":"Boschi","year":"1997","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejmech.2014.07.007_bib33","series-title":"Current Protocols in Immunology","first-page":"19.11.11","article-title":"Schistosomiasis","author":"Lewis","year":"1998"},{"key":"10.1016\/j.ejmech.2014.07.007_bib34","first-page":"1071","article-title":"Thioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug target","volume":"4","author":"Kuntz","year":"2007","journal-title":"PLoS Med."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523414006138?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523414006138?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T18:56:00Z","timestamp":1538420160000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523414006138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":36,"alternative-id":["S0223523414006138"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2014.07.007","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"New praziquantel derivatives containing NO-donor furoxans and related furazans as active agents against Schistosoma mansoni","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2014.07.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Masson SAS. Published by Elsevier Masson SAS All rights reserved.","name":"copyright","label":"Copyright"}]}}