{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T16:37:11Z","timestamp":1779208631555,"version":"3.51.4"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Deanship of Scientific Research at King Saud University","award":["RGP-VPP-302"],"award-info":[{"award-number":["RGP-VPP-302"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.ejmech.2014.09.059","type":"journal-article","created":{"date-parts":[[2014,9,19]],"date-time":"2014-09-19T16:04:30Z","timestamp":1411142670000},"page":"186-196","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"special_numbering":"C","title":["Novel sulfonamides bearing pyrrole and pyrrolopyrimidine moieties as carbonic anhydrase inhibitors: Synthesis, cytotoxic activity and molecular modeling"],"prefix":"10.1016","volume":"87","author":[{"given":"Mostafa M.","family":"Ghorab","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariangela","family":"Ceruso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mansour S.","family":"Alsaid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yassin M.","family":"Nissan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reem K.","family":"Arafa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2014.09.059_bib1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3322\/caac.20107","volume":"61","author":"Jemal","year":"2011","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.ejmech.2014.09.059_bib2","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1093\/carcin\/bgp263","volume":"31","author":"Thun","year":"2010","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.ejmech.2014.09.059_bib3","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.bcp.2005.11.009","volume":"71","author":"Heffeter","year":"2006","journal-title":"Biochem.. Pharmacol."},{"key":"10.1016\/j.ejmech.2014.09.059_bib4","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1677\/erc.0.0080161","volume":"8","author":"Zwick","year":"2001","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.ejmech.2014.09.059_bib5","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1007\/s00044-012-0217-5","volume":"22","author":"Mohammed","year":"2013","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.ejmech.2014.09.059_bib6","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1080\/10426500701557104","volume":"183","author":"Ghorab","year":"2007","journal-title":"Phosphorus, Sulfur, Silicon Relat. Elem."},{"key":"10.1016\/j.ejmech.2014.09.059_bib7","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.bmcl.2006.12.018","volume":"17","author":"Clark","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2014.09.059_bib8","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0163-7258(03)00084-6","volume":"100","author":"Merighi","year":"2003","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejmech.2014.09.059_bib9","doi-asserted-by":"crossref","first-page":"5778","DOI":"10.1016\/j.bmcl.2006.08.080","volume":"16","author":"Moriarty","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2014.09.059_bib10","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1016\/j.bmc.2007.11.072","volume":"16","author":"Abou El Ella","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2014.09.059_bib11","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1080\/10426500802111207","volume":"184","author":"Hassan","year":"2009","journal-title":"Phosphorus, Sulfur, Silicon Relat. Elem."},{"key":"10.1016\/j.ejmech.2014.09.059_bib12","doi-asserted-by":"crossref","first-page":"5243","DOI":"10.1016\/j.ejmech.2010.08.043","volume":"45","author":"Hilmy","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2014.09.059_bib13","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1128\/AAC.31.4.544","volume":"31","author":"Turk","year":"1987","journal-title":"Antimicrobial. Agents. Chemother."},{"key":"10.1016\/j.ejmech.2014.09.059_bib14","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.1128\/AAC.46.8.2470-2476.2002","volume":"46","author":"Evers","year":"2002","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2014.09.059_bib15","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1021\/ja982078+","volume":"12","author":"Boger","year":"1999","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2014.09.059_bib16","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1039\/b605245m","volume":"23","author":"Walsh","year":"2006","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.ejmech.2014.09.059_bib17","doi-asserted-by":"crossref","first-page":"5105","DOI":"10.1016\/j.bmc.2007.05.037","volume":"15","author":"Ozbek","year":"2007","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2014.09.059_bib18","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1039\/b800767e","volume":"6","author":"Temperini","year":"2008","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.ejmech.2014.09.059_bib19","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.ejmech.2013.06.003","volume":"66","author":"Suthar","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2014.09.059_bib20","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1517\/13543776.2013.798648","volume":"23","author":"Monti","year":"2013","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.ejmech.2014.09.059_bib21","doi-asserted-by":"crossref","first-page":"8177","DOI":"10.1039\/c2cc33415a","volume":"48","author":"Winum","year":"2012","journal-title":"Chem. Commun."},{"key":"10.1016\/j.ejmech.2014.09.059_bib22","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1517\/13543776.10.5.575","volume":"10","author":"Supuran","year":"2000","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.ejmech.2014.09.059_bib23","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.1016\/j.bmcl.2010.05.009","volume":"20","author":"Supuran","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2014.09.059_bib24","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrd2467","volume":"7","author":"Supuran","year":"2008","journal-title":"Nat. Rev. Drug. Discov."},{"key":"10.1016\/j.ejmech.2014.09.059_bib25","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1152\/physrev.1967.47.4.595","volume":"47","author":"Maren","year":"1967","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejmech.2014.09.059_bib26","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.resp.2006.03.007","volume":"154","author":"Esbaugh","year":"2006","journal-title":"Respir. Physiolo. Neurobiol."},{"key":"10.1016\/j.ejmech.2014.09.059_bib27","doi-asserted-by":"crossref","first-page":"7229","DOI":"10.1016\/j.bmc.2007.08.037","volume":"15","author":"Nishimori","year":"2007","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2014.09.059_bib28","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/nrd3554","volume":"10","author":"Neri","year":"2011","journal-title":"Nat. Rev. Drug Disc"},{"key":"10.1016\/j.ejmech.2014.09.059_bib29","doi-asserted-by":"crossref","first-page":"4336","DOI":"10.1016\/j.bmc.2007.04.020","volume":"15","author":"Supuran","year":"2007","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2014.09.059_bib30","doi-asserted-by":"crossref","first-page":"619","DOI":"10.3109\/14756366.2013.833197","volume":"29","author":"Bashandy","year":"2014","journal-title":"J.\u00a0Enz. Inhib. Med. Chem."},{"key":"10.1016\/j.ejmech.2014.09.059_bib31","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.ejmech.2013.08.048","volume":"69","author":"Al-Dosari","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2014.09.059_bib32","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1248\/cpb.c12-00812","volume":"61","author":"Al-Dosari","year":"2013","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.ejmech.2014.09.059_bib33","first-page":"2170","volume":"10","author":"Ghorab","year":"2013","journal-title":"Life Sci. J."},{"key":"10.1016\/j.ejmech.2014.09.059_bib34","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/jlac.19274590104","volume":"459","author":"Dimroth","year":"1927","journal-title":"Justus. Liebigs. Ann. Chem."},{"key":"10.1016\/j.ejmech.2014.09.059_bib35","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1021\/jm301625s","volume":"56","author":"Tars","year":"2013","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2014.09.059_bib36","doi-asserted-by":"crossref","first-page":"4268","DOI":"10.1021\/cr200176r","volume":"112","author":"Alterio","year":"2012","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejmech.2014.09.059_bib37","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1021\/ja809683v","volume":"131","author":"Maresca","year":"2009","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2014.09.059_bib38","doi-asserted-by":"crossref","first-page":"8271","DOI":"10.1021\/jm200983e","volume":"54","author":"Touisni","year":"2011","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2014.09.059_bib39","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.bmcl.2011.11.018","volume":"22","author":"Carta","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2014.09.059_bib40","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1021\/jm901287j","volume":"53","author":"Maresca","year":"2010","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2014.09.059_bib41","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1016\/j.bmc.2012.07.021","volume":"21","author":"Davis","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2014.09.059_bib42","doi-asserted-by":"crossref","first-page":"880","DOI":"10.3109\/14756366.2011.637202","volume":"27","author":"Kazancioglu","year":"2012","journal-title":"J.\u00a0Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.ejmech.2014.09.059_bib43","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1093\/jnci\/82.13.1107","volume":"82","author":"Skehan","year":"1990","journal-title":"J.\u00a0Natl. Cancer Inst."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523414008770?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523414008770?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,15]],"date-time":"2019-08-15T05:48:52Z","timestamp":1565848132000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523414008770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":43,"alternative-id":["S0223523414008770"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2014.09.059","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel sulfonamides bearing pyrrole and pyrrolopyrimidine moieties as carbonic anhydrase inhibitors: Synthesis, cytotoxic activity and molecular modeling","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2014.09.059","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}