{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T04:26:00Z","timestamp":1789878360534,"version":"4.0.1"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["NSC-102-2113-M-007-010"],"award-info":[{"award-number":["NSC-102-2113-M-007-010"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["103-2113-M-007-020"],"award-info":[{"award-number":["103-2113-M-007-020"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005057","name":"National Tsing Hua University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004391","name":"China Medical University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004391","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.ejmech.2014.11.050","type":"journal-article","created":{"date-parts":[[2014,11,25]],"date-time":"2014-11-25T20:18:06Z","timestamp":1416946686000},"page":"428-435","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["Design, synthesis, and bioevaluation of paeonol derivatives as potential anti-HBV agents"],"prefix":"10.1016","volume":"90","author":[{"given":"Tsurng-Juhn","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Chuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chuan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Hsien","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Cherng","family":"Horng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Cheng","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Wen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-Yuan","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Chieh","family":"Yen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Ching","family":"Chou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8711-8815","authenticated-orcid":false,"given":"Ming-Hua","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2014.11.050_bib1","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1093\/clinchem\/43.8.1500","article-title":"Hepatitis B: diagnosis, prevention, and treatment","volume":"43","author":"Gitlin","year":"1997","journal-title":"Clin. Chem."},{"issue":"Suppl.\u00a01","key":"10.1016\/j.ejmech.2014.11.050_bib2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1055\/s-2005-915644","article-title":"Epidemiology and natural history of hepatitis B","volume":"25","author":"McMahon","year":"2005","journal-title":"Semin. Liver. Dis."},{"key":"10.1016\/j.ejmech.2014.11.050_bib3","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1002\/hep.1840070425","article-title":"Relation of the hepatitis B virus carrier state to hepatocellular carcinoma","volume":"7","author":"Popper","year":"1987","journal-title":"Hepatology"},{"key":"10.1016\/j.ejmech.2014.11.050_bib4","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1136\/pgmj.2006.047431","article-title":"Chronic hepatitis B in hepatocarcinogenesis","volume":"82","author":"Park","year":"2006","journal-title":"Postgrad. Med. J."},{"key":"10.1016\/j.ejmech.2014.11.050_bib5","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1177\/135965350400900621","article-title":"Management of hepatitis B patients with antiviral resistance","volume":"9","author":"Fung","year":"2004","journal-title":"Antivir. Ther."},{"key":"10.1016\/j.ejmech.2014.11.050_bib6","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1177\/135965350400900522","article-title":"Management of antiviral resistance in patients with chronic hepatitis B","volume":"9","author":"Locarnini","year":"2004","journal-title":"Antivir. Ther."},{"key":"10.1016\/j.ejmech.2014.11.050_bib7","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1055\/s-2005-915647","article-title":"Current treatment of chronic hepatitis B: benefits and limitations","volume":"25","author":"Perrillo","year":"2005","journal-title":"Semin. Liver. Dis."},{"key":"10.1016\/j.ejmech.2014.11.050_bib8","first-page":"283a","article-title":"A\u00a0critical appraisal of current approaches to treatment of chronic hepatitis B (CHB) based on a review by an international panel of investigators and a survey of ASSLD","volume":"42","author":"Perrillo","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.ejmech.2014.11.050_bib9","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/S0002-9440(10)64980-2","article-title":"Viruses, immunity, and cancer: lessons from hepatitis B","volume":"156","author":"Chisari","year":"2000","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ejmech.2014.11.050_bib10","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.antiviral.2013.11.007","article-title":"Antiviral activity of chemical compound isolated from artemisia morrisonensis against hepatitis B virus in\u00a0vitro","volume":"101","author":"Huang","year":"2014","journal-title":"Antivir. Res."},{"key":"10.1016\/j.ejmech.2014.11.050_bib11","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.phytochem.2013.12.014","article-title":"Synthesis and antiviral effects of isosteviol-derived analogues against the hepatitis B virus","volume":"99","author":"Huang","year":"2014","journal-title":"Phytochemistry"},{"key":"10.1016\/j.ejmech.2014.11.050_bib12","series-title":"Hepadnaviridae: the Viruses and their Replication","author":"Ganem","year":"2001"},{"key":"10.1016\/j.ejmech.2014.11.050_bib13","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1053\/jhep.2002.30531","article-title":"New therapeutic strategies for hepatitis C","volume":"35","author":"Di Bisceglie","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.ejmech.2014.11.050_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/095632020101200101","article-title":"Resistance of hepatitis B virus to antiviral drugs: current aspects and directions for future investigation","volume":"12","author":"Delaney","year":"2001","journal-title":"Antivir. Chem. Chemother."},{"key":"10.1016\/j.ejmech.2014.11.050_bib15","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1517\/13543784.11.2.169","article-title":"Evolving therapies for the treatment of chronic hepatitis B virus infection","volume":"11","author":"Delaney","year":"2002","journal-title":"Expert Opin. Investig. Drug"},{"key":"10.1016\/j.ejmech.2014.11.050_bib16","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1086\/656624","article-title":"Review of hepatitis B therapeutics","volume":"51","author":"Bhattacharya","year":"2010","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.ejmech.2014.11.050_bib17","doi-asserted-by":"crossref","first-page":"5878","DOI":"10.3390\/molecules15095878","article-title":"Discovery and development of anti-HBV agents and their resistance","volume":"15","author":"Kim","year":"2010","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2014.11.050_bib18","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.fitote.2012.11.003","article-title":"Anti-HBV agents derived from botanical origin","volume":"84","author":"Qiu","year":"2013","journal-title":"Fitoterapia"},{"key":"10.1016\/j.ejmech.2014.11.050_bib19","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1155\/2012\/837513","article-title":"Anti-Inflammatory and anticoagulative effects of paeonol on LPS-induced acute lung injury in rats","volume":"2012","author":"Fu","year":"2012","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"10.1016\/j.ejmech.2014.11.050_bib20","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1038\/sj.bjp.0705360","article-title":"Anti-inflammatory and analgesic effects of paeonol in carrageenan-evoked thermal hyperalgesia","volume":"139","author":"Chou","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejmech.2014.11.050_bib21","doi-asserted-by":"crossref","first-page":"4672","DOI":"10.3390\/molecules17044672","article-title":"Effect of paeonol on antioxidant and immune regulatory activity in hepatocellular carcinoma rats","volume":"17","author":"Chen","year":"2012","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2014.11.050_bib22","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.phymed.2007.01.007","article-title":"Pharmacological investigations of the anti-diabetic effect of cortex moutan and its active component paeonol","volume":"14","author":"Lau","year":"2007","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ejmech.2014.11.050_bib23","doi-asserted-by":"crossref","first-page":"7857","DOI":"10.1021\/jf048708a","article-title":"Acaricidal activity of paeonia suffruticosa root bark-derived compounds against dermatophagoides farinae and dermatophagoides pteronyssinus (acari: pyroglyphidae)","volume":"52","author":"Kim","year":"2004","journal-title":"J.\u00a0Agric. Food Chem."},{"key":"10.1016\/j.ejmech.2014.11.050_bib24","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.tiv.2012.04.022","article-title":"Paeonol from hippocampus kuda bleeler suppressed the neuro-inflammatory responses in\u00a0vitro via NF-\u03baB and MAPK signaling pathways","volume":"26","author":"Himaya","year":"2012","journal-title":"Toxicol. In\u00a0Vitro"},{"key":"10.1016\/j.ejmech.2014.11.050_bib25","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.3109\/09553002.2013.825058","article-title":"The radiosensitizing effect of paeonol on lung adenocarcinoma by augmentation of radiation-induced apoptosis and inhibition of the PI3K\/Akt pathway","volume":"89","author":"Lei","year":"2012","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.ejmech.2014.11.050_bib26","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1142\/S0192415X13500730","article-title":"Novel effect of paeonol on the formation of foam cells: promotion of LXRa-ABCA1-dependent cholesterol efflux in macrophages","volume":"41","author":"Zhao","year":"2013","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.ejmech.2014.11.050_bib27","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1155\/2012\/932823","article-title":"Paeonol protects memory after ischemic stroke via inhibiting \u03b2-secretase and apoptosis","volume":"2012","author":"Su","year":"2012","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"10.1016\/j.ejmech.2014.11.050_bib28","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.inoche.2010.03.030","article-title":"Evaluation of the antioxidant, DNA interaction and tumor cell cytotoxicity activities of copper(II) complexes with paeonol schiff-base","volume":"13","author":"Qin","year":"2010","journal-title":"Inorg. Chem. Commun."},{"key":"10.1016\/j.ejmech.2014.11.050_bib29","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.ijbiomac.2013.09.056","article-title":"Synthesis, characterization and biological evaluation of paeonol thiosemicarbazone analogues as mushroom tyrosinase inhibitors","volume":"62","author":"Zhu","year":"2013","journal-title":"Int. J. Biol. Macromolec"},{"key":"10.1016\/j.ejmech.2014.11.050_bib30","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1021\/jm960793t","article-title":"Substituted 3-(phenylsulfonyl)-1-phenylimidazolidine-2,4-dione derivatives as novel nonpeptide inhibitors of human heart chymase","volume":"40","author":"Niwata","year":"1997","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2014.11.050_bib31","doi-asserted-by":"crossref","first-page":"3231","DOI":"10.1021\/jm010887p","article-title":"Structure-based design and synthesis of potent matrix metalloproteinase inhibitors derived from a 6H-1,3,4-thiadiazine scaffold","volume":"44","author":"Schr\u00f6der","year":"2001","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2014.11.050_bib32","doi-asserted-by":"crossref","first-page":"5229","DOI":"10.1021\/jm200502u","article-title":"Discovery and optimization of sulfonyl acrylonitriles as selective, covalent inhibitors of protein phosphatase methylesterase-1","volume":"54","author":"Bachovchin","year":"2011","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2014.11.050_bib33","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1021\/jm1013693","article-title":"Synopsis of some recent tactical application of bioisosteres in drug design","volume":"54","author":"Meanwell","year":"2011","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2014.11.050_bib34","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1073\/pnas.84.4.1005","article-title":"Production of hepatitis B virus particles in Hep G2 cells transfected with cloned hepatitis B virus DNA","volume":"84","author":"Sells","year":"1987","journal-title":"P.\u00a0Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.ejmech.2014.11.050_bib35","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.antiviral.2008.12.011","article-title":"Inhibitory effect of HMGN2 protein on human hepatitis B virus expression and replication in the HepG2.2.15 cell line","volume":"81","author":"Feng","year":"2009","journal-title":"Antivir. Res."},{"key":"10.1016\/j.ejmech.2014.11.050_bib36","first-page":"444","article-title":"Study on the detection of duck hepatitis B virus with SYBR based quantitative real-time PCR","volume":"12","author":"Zou","year":"2004","journal-title":"Zhonghua Gan Zang Bing Za Zhi"},{"key":"10.1016\/j.ejmech.2014.11.050_bib37","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1073\/pnas.82.3.891","article-title":"Infectious hepatitis B virus from cloned DNA of known nucleotide sequence","volume":"82","author":"Will","year":"1985","journal-title":"P.\u00a0Natl. Acad. Sci. U S A"}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523414010824?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523414010824?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:56:37Z","timestamp":1777528597000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523414010824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":37,"alternative-id":["S0223523414010824"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2014.11.050","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design, synthesis, and bioevaluation of paeonol derivatives as potential anti-HBV agents","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2014.11.050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}