{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T16:22:54Z","timestamp":1777566174530,"version":"3.51.4"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Polish Ministry of Science and Higher Education","award":["IP2012013272"],"award-info":[{"award-number":["IP2012013272"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1016\/j.ejmech.2015.01.045","type":"journal-article","created":{"date-parts":[[2015,1,27]],"date-time":"2015-01-27T07:32:04Z","timestamp":1422343924000},"page":"33-41","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"special_numbering":"C","title":["Synthesis and biological activity of salinomycin conjugates with floxuridine"],"prefix":"10.1016","volume":"93","author":[{"given":"Adam","family":"Huczy\u0144ski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micha\u0142","family":"Antoszczak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Kleczewska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Lewandowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Maj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Stefa\u0144ska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Wietrzyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Janczak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lech","family":"Celewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2015.01.045_bib1","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.addr.2008.02.004","article-title":"Efficient construction of therapeutics, bioconjugates, biomaterial and bioactive surfaces using azide-alkyne \u201cclick\u201d chemistry","volume":"60","author":"Lutz","year":"2008","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ejmech.2015.01.045_bib2","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1021\/bc200173e","article-title":"Novel anticancer polymeric conjugates of activated nucleoside analogues","volume":"22","author":"Senanayake","year":"2011","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.ejmech.2015.01.045_bib3","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1517\/13543784.2014.857401","article-title":"Histone deacetylases inhibitors: conjugation to other anti-tumour pharmacophores provides novel tools for cancer treatment","volume":"23","author":"Papavassiliou","year":"2014","journal-title":"Exp. Opin. Invest. Drugs"},{"key":"10.1016\/j.ejmech.2015.01.045_bib4","doi-asserted-by":"crossref","first-page":"3373","DOI":"10.2174\/138161212801227005","article-title":"Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias","volume":"18","author":"Robak","year":"2012","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.ejmech.2015.01.045_bib5","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.canlet.2012.03.007","article-title":"Overcoming nucleoside analog chemoresistance of pancreatic cancer: a therapeutic challenge","volume":"320","author":"Hung","year":"2012","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ejmech.2015.01.045_bib6","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1080\/15257770.2012.657383","article-title":"Ten paths to the discovery of antivirally active nucleoside and nucleotide analogues","volume":"31","author":"De Clercq","year":"2012","journal-title":"Nucleos. Nucleot. Nucl."},{"key":"10.1016\/j.ejmech.2015.01.045_bib7","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1007\/s00706-010-0360-y","article-title":"Synthesis and antiviral evaluation of new 2,5-disubstituted 1,3,4-oxadiazole derivatives and their acyclic nucleoside analogues","volume":"141","author":"El-Sayed","year":"2010","journal-title":"Mon. Chem."},{"key":"10.1016\/j.ejmech.2015.01.045_bib8","doi-asserted-by":"crossref","first-page":"981","DOI":"10.3851\/IMP2229","article-title":"Antiviral activity of nucleoside analogues against norovirus","volume":"17","author":"Costantini","year":"2012","journal-title":"Antivir. Ther."},{"key":"10.1016\/j.ejmech.2015.01.045_bib9","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nrc1074","article-title":"5-Fluorouracil: mechanisms of action and clinical strategies","volume":"3","author":"Longley","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ejmech.2015.01.045_bib10","doi-asserted-by":"crossref","first-page":"215","DOI":"10.2165\/00003088-198916040-00002","article-title":"Clinical pharmacology of 5-fluorouracil","volume":"16","author":"Diasio","year":"1989","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.ejmech.2015.01.045_bib11","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.clpt.2006.06.007","article-title":"A\u00a0pharmacokinetic-based test to prevent severe 5-fluorouracil toxicity","volume":"80","author":"Bocci","year":"2006","journal-title":"Clin. Pharm. Ther."},{"key":"10.1016\/j.ejmech.2015.01.045_bib12","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.canlet.2006.09.006","article-title":"5-Fluorouracil-related severe toxicity: a comparison of different methods for the pretherapeutic detection of dihydropyrimidine dehydrogenase deficiency","volume":"249","author":"Boisdron-Celle","year":"2007","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ejmech.2015.01.045_bib13","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1245\/s10434-010-1505-2","article-title":"Selective intra-arterial chemotherapy with floxuridine as second- or third-line approach in patients with unresectable colorectal liver metastases","volume":"18","author":"Samaras","year":"2011","journal-title":"Ann. Surg. Oncol."},{"key":"10.1016\/j.ejmech.2015.01.045_bib14","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1158\/1535-7163.MCT-08-0709","article-title":"The role of floxuridine in metastatic liver disease","volume":"8","author":"Power","year":"2009","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.ejmech.2015.01.045_bib15","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1023\/A:1006416410198","article-title":"5-Fluorouracil: forty-plus and still ticking. A review of its preclinical and clinical development","volume":"18","author":"Grem","year":"2000","journal-title":"Invest. New. Drugs"},{"key":"10.1016\/j.ejmech.2015.01.045_bib16","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1158\/1535-7163.MCT-04-0290","article-title":"Targeted delivery to PEPT1-overexpressing cells: acidic, basic, and secondary floxuridine amino acid ester prodrugs","volume":"4","author":"Landowski","year":"2005","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.ejmech.2015.01.045_bib17","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1021\/cr900019j","article-title":"Impact of natural products on developing new anti-cancer agents","volume":"109","author":"Cragg","year":"2009","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejmech.2015.01.045_bib18","first-page":"9","article-title":"Natural sources as potential anti-cancer agents: a review","volume":"3","author":"Bhanot","year":"2011","journal-title":"Int. J. Phytomedicine"},{"key":"10.1016\/j.ejmech.2015.01.045_bib19","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.cell.2009.06.034","volume":"138","author":"Gupta","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.ejmech.2015.01.045_bib20","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.apsb.2013.02.006","article-title":"Cancer stem cells: therapeutic implications and perspectives in cancer therapy","volume":"3","author":"Han","year":"2013","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.ejmech.2015.01.045_bib21","doi-asserted-by":"crossref","first-page":"4095","DOI":"10.2174\/15672050113109990199","article-title":"Salinomycin: a novel anti-cancer agent with known anti-coccidial activities","volume":"20","author":"Zhou","year":"2013","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.ejmech.2015.01.045_bib22","article-title":"Salinomycin inhibits proliferation and induces apoptosis of human hepatocellular carcinoma cells in\u00a0vitro and in\u00a0vivo","volume":"7","author":"Wang","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ejmech.2015.01.045_bib23","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2407-12-466","article-title":"Impact of salinomycin on human cholangiocarcinoma: induction of apoptosis and impairment of tumor cell proliferation in\u00a0vitro","volume":"12","author":"Lieke","year":"2012","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ejmech.2015.01.045_bib24","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.biopha.2011.06.006","article-title":"Salinomycin can effectively kill ALDHhigh stem-like cells on gastric cancer","volume":"65","author":"Zhi","year":"2011","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejmech.2015.01.045_bib25","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.canlet.2011.07.016","article-title":"Salinomycin inhibits osteosarcoma by targeting its tumor stem cells","volume":"311","author":"Tang","year":"2011","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ejmech.2015.01.045_bib26","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.molstruc.2012.05.019","article-title":"X-ray, FT-IR, NMR and PM5 structural studies and antibacterial activity of unexpectedly stable salinomycin\u2013benzotriazole intermediate ester","volume":"1022","author":"Huczy\u0144ski","year":"2012","journal-title":"J.\u00a0Mol. Struct."},{"key":"10.1016\/j.ejmech.2015.01.045_bib27","doi-asserted-by":"crossref","first-page":"4697","DOI":"10.1016\/j.bmcl.2012.05.081","article-title":"Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic\u2014salinomycin","volume":"22","author":"Huczy\u0144ski","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2015.01.045_bib28","doi-asserted-by":"crossref","first-page":"7146","DOI":"10.1016\/j.bmcl.2012.09.068","article-title":"Antiproliferative activity of salinomycin and its derivatives","volume":"22","author":"Huczy\u0144ski","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2015.01.045_bib29","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1016\/j.bmcl.2014.02.042","article-title":"Synthesis, antiproliferative and antibacterial activity of new amides of salinomycin","volume":"24","author":"Antoszczak","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2015.01.045_bib30","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.ejmech.2014.02.031","article-title":"Synthesis, cytotoxicity and antibacterial activity of new esters of polyether antibiotic \u2013 salinomycin","volume":"76","author":"Antoszczak","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2015.01.045_bib31","doi-asserted-by":"crossref","first-page":"9944","DOI":"10.1039\/c3cc45983g","article-title":"Synthetic modification of salinomycin: selective O-acylation and biological evaluation","volume":"49","author":"Borgstr\u00f6m","year":"2013","journal-title":"Chem. Commun."},{"key":"10.1016\/j.ejmech.2015.01.045_bib32","article-title":"Salinomycin as a drug for targeting human cancer stem cells","volume":"2012","author":"Naujokat","year":"2012","journal-title":"J.\u00a0Biomed. Biotechnol."},{"key":"10.1016\/j.ejmech.2015.01.045_bib33","article-title":"The synergistic in\u00a0vitro and in\u00a0vivo antitumor effect of combination therapy with salinomycin and 5-fluorouracil against hepatocellular carcinoma","volume":"9","author":"Wang","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ejmech.2015.01.045_bib34","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.ejmech.2013.06.047","article-title":"Synthesis of 3\u2032-azido-2',3'-dideoxy-5-fluorouridine phosphoramidates and evaluation of their anticancer activity","volume":"67","author":"Lewandowska","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2015.01.045_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00280-005-0141-1","article-title":"Multidrug resistance proteins and folate supplementation: therapeutic implications for antifolates and other classes of drugs in cancer treatment","volume":"58","author":"Hooijberg","year":"2006","journal-title":"Cancer Chem. Pharm."},{"key":"10.1016\/j.ejmech.2015.01.045_bib36","doi-asserted-by":"crossref","first-page":"4423","DOI":"10.1016\/0006-2952(88)90656-9","article-title":"Intracellular doxorubicin concentrations and drug-induced DNA damage in a human colon adenocarcinoma cell line and in a drug-resistant subline","volume":"37","author":"Broggini","year":"1988","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejmech.2015.01.045_bib37","doi-asserted-by":"crossref","first-page":"3611","DOI":"10.1016\/0006-2952(89)90134-2","article-title":"Mechanisms of multidrug resistance in HL60 cells. Analysis of resistance associated membrane proteins and levels of mdr gene expression","volume":"38","author":"McGrath","year":"1989","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejmech.2015.01.045_bib38","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.critrevonc.2013.08.015","article-title":"Methods of overcoming treatment resistance in colorectal cancer","volume":"89","author":"Temraz","year":"2014","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.ejmech.2015.01.045_bib39","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/859871","article-title":"Tumor initiating cells and chemoresistance: which is the best strategy to target colon cancer stem cells?","volume":"2014","author":"Paldino","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.ejmech.2015.01.045_bib40","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1093\/jnci\/61.1.75","article-title":"Further biologic characteristics of a human carcinoembryonic antigen-producing colon carcinoma cell line","volume":"61","author":"Drewinko","year":"1978","journal-title":"J.\u00a0Natl. Cancer Inst."},{"key":"10.1016\/j.ejmech.2015.01.045_bib41","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/BF02796440","article-title":"Human colonic adenocarcinoma cells. I. Establishment and description of a new line","volume":"12","author":"Tom","year":"1976","journal-title":"Vitro"},{"key":"10.1016\/j.ejmech.2015.01.045_bib42","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1016\/0959-8049(95)00435-1","article-title":"Development of immunogenic colorectal cancer cell lines for vaccination: expression of CD80 (B7.1) is not sufficient to restore impaired primary T cell activation in\u00a0vitro","volume":"31A","author":"Habicht","year":"1995","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.ejmech.2015.01.045_bib43","first-page":"4542","article-title":"Multidrug resistance in mitoxantrone HL leukemia cells in the absence of Pglycoprotein overexpression","volume":"49","author":"Harker","year":"1989","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejmech.2015.01.045_bib44","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1023\/A:1025745824632","article-title":"Amino acid ester prodrugs of floxuridine: synthesis and effects of structure, stereochemistry and site of esterification on the rate of hydrolysis","volume":"20","author":"Vig","year":"2003","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejmech.2015.01.045_bib45","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1124\/jpet.105.092726","article-title":"Nucleoside ester prodrug substrate specificity of liver carboxylesterase","volume":"316","author":"Landowski","year":"2006","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejmech.2015.01.045_bib46","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1124\/pr.56.1.3","article-title":"Enzyme catalyzed activation of anticancer prodrugs","volume":"56","author":"Rooseboom","year":"2004","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.ejmech.2015.01.045_bib47","doi-asserted-by":"crossref","first-page":"519","DOI":"10.3390\/molecules13030519","article-title":"Prodrugs for amines","volume":"13","author":"Simpl\u00edcio","year":"2008","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2015.01.045_bib48","series-title":"CrysAlis CCD and CrysAlis RED, V. 1.171.33.42","year":"2009"},{"key":"10.1016\/j.ejmech.2015.01.045_bib49","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1107\/S0108767307043930","volume":"A64","author":"Sheldrick","year":"2008","journal-title":"Acta Cryst."},{"key":"10.1016\/j.ejmech.2015.01.045_bib50","series-title":"Diamond v. 3.1","author":"Brandenburg","year":"2008"},{"key":"10.1016\/j.ejmech.2015.01.045_bib51","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1055\/s-2001-18722","article-title":"Dry column vacuum chromatography","volume":"16","author":"Pedersen","year":"2001","journal-title":"Synthesis"},{"key":"10.1016\/j.ejmech.2015.01.045_bib52","series-title":"Performance Standards for Antimicrobial Disk Susceptibility Tests","author":"Clinical and Laboratory Standards Institute","year":"2006"},{"key":"10.1016\/j.ejmech.2015.01.045_bib53","series-title":"Method for Antifungal Disk Diffusion Susceptibility Testing of Yeasts; Proposed Guideline","author":"Clinical and Laboratory Standards Institute","year":"2003"},{"key":"10.1016\/j.ejmech.2015.01.045_bib54","series-title":"Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically","author":"Clinical and Laboratory Standards Institute","year":"2006"}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523415000653?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523415000653?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T04:45:35Z","timestamp":1566276335000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523415000653"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":54,"alternative-id":["S0223523415000653"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2015.01.045","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and biological activity of salinomycin conjugates with floxuridine","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2015.01.045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}