{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:25:05Z","timestamp":1791725105115,"version":"4.3.4"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Thailand Toray Science Foundation (TTSF)"},{"DOI":"10.13039\/501100007959","name":"Chulabhorn Research Institute (CRI)","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007959","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Chulabhorn Graduate Institute (CGI)"},{"name":"Center of Excellence on Environmental Health and Toxicology (EHT)"},{"name":"Ministry of Education"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1016\/j.ejmech.2015.02.047","type":"journal-article","created":{"date-parts":[[2015,2,25]],"date-time":"2015-02-25T21:48:17Z","timestamp":1424900897000},"page":"56-62","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":68,"special_numbering":"C","title":["Synthesis of isocryptolepine analogues and their structure\u2013activity relationship studies as antiplasmodial and antiproliferative agents"],"prefix":"10.1016","volume":"94","author":[{"given":"Pasuk","family":"Aroonkit","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charnsak","family":"Thongsornkleeb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jumreang","family":"Tummatorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suppachai","family":"Krajangsri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathirut","family":"Mungthin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somsak","family":"Ruchirawat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2015.02.047_bib1","series-title":"World Health Organization","author":"World Malaria Report","year":"2013"},{"key":"10.1016\/j.ejmech.2015.02.047_bib2","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1056\/NEJMoa1314981","article-title":"Spread of artemisinin resistance in Plasmodium falciparum malaria","volume":"371","author":"Ashley","year":"2014","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.ejmech.2015.02.047_bib3","unstructured":"World Cancer Report 2014; Stewart, B. W., Wild, C. P., Eds.; World Health Organization, International Agency for Research on Cancer: Lyon, France, 2014."},{"key":"10.1016\/j.ejmech.2015.02.047_bib4","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/0031-9422(94)00925-J","article-title":"Isocryptolepine from Cryptolepis sanguinolenta","volume":"39","author":"Pousset","year":"1995","journal-title":"Phytochemistry"},{"key":"10.1016\/j.ejmech.2015.02.047_bib5","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1002\/jps.2600681212","article-title":"Cryptolepine hydrochloride effect on Staphylococcus aureus","volume":"68","author":"Boakye-Yiadom","year":"1979","journal-title":"J.\u00a0Pharm. Sci."},{"key":"10.1016\/j.ejmech.2015.02.047_bib6","doi-asserted-by":"crossref","first-page":"A98","DOI":"10.1055\/s-2006-960380","article-title":"Biologcal activities of Cryptolepine, an alkaloid from Cryptolepis sanguinolenta","volume":"57","author":"Cimanka","year":"1991","journal-title":"Planta Med."},{"key":"10.1016\/j.ejmech.2015.02.047_bib7","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1021\/jm9704816","article-title":"Ethnobotanical-directed discovery of the antihyperglycemic properties of cryptolepine: its isolation from cryptolepis sanguinolenta, synthesis, and in\u00a0vitro and in\u00a0vivo activities","volume":"41","author":"Bierer","year":"1998","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2015.02.047_bib8","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1055\/s-2006-961531","article-title":"Cryptolepis sanguinolenta: Antimuscarinic properties of cryptolepine and the alkaloid fraction at M1, M2 and M3 receptors","volume":"58","author":"Rauwald","year":"1992","journal-title":"Planta Med."},{"key":"10.1016\/j.ejmech.2015.02.047_bib9","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1016\/S0968-0896(01)00401-1","article-title":"Substituted indoloquinolines as new antifungal agents","volume":"10","author":"Ablordeppey","year":"2002","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2015.02.047_bib10","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/ptr.2650090510","article-title":"In\u00a0vitro and in\u00a0vivo antimalarial activity of cryptolepine, a plant-derived indoloquinoline","volume":"9","author":"Kirby","year":"1995","journal-title":"Phytother. Res."},{"key":"10.1016\/j.ejmech.2015.02.047_bib11","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/(SICI)1099-1573(199606)10:4<317::AID-PTR858>3.0.CO;2-0","article-title":"Antimalarial activity of cryptolepine and isocryptolepine, alkaloids isolated from Cryptolepis sanguinolenta","volume":"10","author":"Grellier","year":"1996","journal-title":"Phytother. Res."},{"key":"10.1016\/j.ejmech.2015.02.047_bib12","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nsb729","article-title":"The antimalarial and cytotoxic drug cryptolepine intercalates into DNA at cytosine-cytosine sites","volume":"9","author":"Lisgarten","year":"2002","journal-title":"Nat. Struct. Biol."},{"key":"10.1016\/j.ejmech.2015.02.047_bib13","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.ejmech.2014.03.038","article-title":"Synthesis and in\u00a0vitro cytotoxic effect of 6-amino-substituted 11H- and 11Me-indolo[3,2-c]quinolines","volume":"78","author":"Wang","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2015.02.047_bib14","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/adsc.200700328","article-title":"Auto-tandem catalysis: synthesis of substituted 11H-Indolo [3,2-c]quinolines via Palladium-catalyzed intermolecular C\u2013N and intramolecular C\u2013C Bond formation","volume":"350","author":"Meyers","year":"2008","journal-title":"Adv. Synth. Catal."},{"key":"10.1016\/j.ejmech.2015.02.047_bib15","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/ejoc.200800929","article-title":"New route to the synthesis of the isocryptolepine alkaloid and its related skeletons using a modified Pictet\u2013Spengler reaction","author":"Agarwal","year":"2009","journal-title":"Eur. J. Org. Chem."},{"key":"10.1016\/j.ejmech.2015.02.047_bib16","doi-asserted-by":"crossref","first-page":"4137","DOI":"10.1016\/j.tetlet.2010.05.141","article-title":"A\u00a0direct synthesis of neocryptolepine and isocryptolepine","volume":"51","author":"Kraus","year":"2010","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.ejmech.2015.02.047_bib17","doi-asserted-by":"crossref","first-page":"3686","DOI":"10.1016\/j.tetlet.2011.05.049","article-title":"An efficient new route towards biologically active isocryptolepine and \u03b3-carboline derivatives using an intramolecular thermal electrocyclization strategy","volume":"52","author":"Hingane","year":"2011","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.ejmech.2015.02.047_bib18","doi-asserted-by":"crossref","first-page":"7519","DOI":"10.1016\/j.bmc.2011.10.037","article-title":"Synthesis and antimalarial evaluation of novel isocryptolepine derivatives","volume":"19","author":"Whittell","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2015.02.047_bib19","doi-asserted-by":"crossref","first-page":"7262","DOI":"10.1039\/c2ob25836f","article-title":"From biomass to medicines. A simple synthesis of indolo[3,2-c]quinolines, antimalarial alkaloid isocryptolepine, and its derivatives","volume":"10","author":"Uchuskin","year":"2012","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.ejmech.2015.02.047_bib20","doi-asserted-by":"crossref","first-page":"4732","DOI":"10.1016\/j.tet.2012.04.014","article-title":"Acid-promoted rearrangement of arylmethyl azides: applications toward the synthesis of N-arylmethyl arenes and polycyclic heteroaromatic compounds","volume":"68","author":"Tummatorn","year":"2012","journal-title":"Tetrahedron"},{"key":"10.1016\/j.ejmech.2015.02.047_bib21","series-title":"Fluorine in Medicinal Chemistry and Chemical Biology","year":"2009"},{"key":"10.1016\/j.ejmech.2015.02.047_bib22","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1039\/JR9500000607","article-title":"Attempts to find new antimalarials. Part XXIX. The synthesis of various derivatives of 2:3-Benz-\u03b3-carboline","author":"Kermack","year":"1950","journal-title":"J.\u00a0Chem. Soc."},{"key":"10.1016\/j.ejmech.2015.02.047_bib23","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1055\/s-0034-1378225","article-title":"Practical and metal-free electrophilic aromatic halogenation by interhalogen compounds senerated in situ from n-halosuccinimide and catalytic TMSCl","volume":"25","author":"Maibunkaew","year":"2014","journal-title":"Synlett"}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523415001439?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523415001439?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T13:42:53Z","timestamp":1759326173000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523415001439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":23,"alternative-id":["S0223523415001439"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2015.02.047","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis of isocryptolepine analogues and their structure\u2013activity relationship studies as antiplasmodial and antiproliferative agents","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2015.02.047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}