{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T11:30:42Z","timestamp":1780918242915,"version":"3.54.1"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004809","name":"Financiadora de Estudos e Projetos","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["554349\/2008-6 e 559157\/2008-8"],"award-info":[{"award-number":["554349\/2008-6 e 559157\/2008-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1016\/j.ejmech.2015.03.022","type":"journal-article","created":{"date-parts":[[2015,3,14]],"date-time":"2015-03-14T01:21:48Z","timestamp":1426296108000},"page":"267-276","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"special_numbering":"C","title":["Activity and in\u00a0vivo tracking of Amphotericin B loaded PLGA nanoparticles"],"prefix":"10.1016","volume":"95","author":[{"given":"A.C.O.","family":"Souza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.L.","family":"Nascimento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.M.","family":"de Vasconcelos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.S.","family":"Jer\u00f4nimo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.M.","family":"Siqueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"R-Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.O.S.","family":"Cintra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.L.","family":"Fuscaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.R.","family":"Pires J\u00fanior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Titze-de-Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.F.","family":"Borin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.N.","family":"B\u00e1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.P.","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.N.","family":"Cardoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.O.","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.R.","family":"Mortari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.C.","family":"Tedesco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.C.","family":"Amaral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.S.S.","family":"Felipe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.L.","family":"Bocca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2015.03.022_bib1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.riam.2009.06.003","article-title":"Amphotericin B: side effects and toxicity","volume":"26","author":"Laniado-Labor\u00edn","year":"2009","journal-title":"Rev. Iberoam. Micol."},{"issue":"Suppl.\u00a01","key":"10.1016\/j.ejmech.2015.03.022_bib2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/jac\/49.suppl_1.7","article-title":"Amphotericin B: spectrum and resistance","volume":"49","author":"Ellis","year":"2002","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.ejmech.2015.03.022_bib3","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1093\/jac\/dkn539","article-title":"Amphotericin B in poly(lactic-co-glycolic acid) (PLGA) and dimercaptosuccinic acid (DMSA) nanoparticles against paracoccidioidomycosis","volume":"63","author":"Amaral","year":"2009","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.ejmech.2015.03.022_bib4","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.progpolymsci.2005.09.004","article-title":"Polymer\u2013drug conjugates: progress in polymeric prodrugs","volume":"31","author":"Khandare","year":"2006","journal-title":"Prog. Polym. Sci."},{"key":"10.1016\/j.ejmech.2015.03.022_bib5","doi-asserted-by":"crossref","DOI":"10.2217\/nnm.12.74","article-title":"Characterization and evaluation of BNIPDaoct-loaded PLGA nanoparticles for visceral leishmaniasis: in\u00a0vitro and in\u00a0vivo studies","author":"Costa Lima","year":"2012","journal-title":"Nanomedicine (Lond)"},{"key":"10.1016\/j.ejmech.2015.03.022_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0025744","article-title":"Peroral amphotericin B polymer nanoparticles lead to comparable or superior in\u00a0vivo antifungal activity to that of intravenous Ambisome\u00ae or Fungizone\u2122","author":"Italia","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ejmech.2015.03.022_bib7","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1007\/s11095-009-9841-2","article-title":"Biodegradable nanoparticles improve oral bioavailability of amphotericin B and show reduced nephrotoxicity compared to intravenous Fungizone","volume":"26","author":"Italia","year":"2009","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejmech.2015.03.022_bib8","first-page":"2002","article-title":"Applications of nanobiotechnology in clinical diagnostics","volume":"2009","author":"Jain","year":"2009","journal-title":"Clin. Chem."},{"key":"10.1016\/j.ejmech.2015.03.022_bib9","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.jconrel.2012.05.037","article-title":"PLGA nanoparticles and nanosuspensions with amphotericin B: potent in\u00a0vitro and in\u00a0vivo alternatives to Fungizone and AmBisome","volume":"161","author":"Van De","year":"2012","journal-title":"J.\u00a0Control Release"},{"key":"10.1016\/j.ejmech.2015.03.022_bib10","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1166\/jbn.2011.1230","article-title":"Loading and release of amphotericin-B from biodegradable poly(lactic-co-glycolic acid) nanoparticles","volume":"7","author":"Verma","year":"2011","journal-title":"J.\u00a0Biomed. Nanotechnol."},{"key":"10.1016\/j.ejmech.2015.03.022_bib11","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.2217\/fmb.13.68","article-title":"Paracoccidioidomycosis: eco-epidemiology, taxonomy and clinical and therapeutic issues","volume":"8","author":"Bocca","year":"2013","journal-title":"Future Microbiol."},{"key":"10.1016\/j.ejmech.2015.03.022_bib12","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.prrv.2009.08.001","article-title":"Paracoccidioidomycosis","volume":"10","author":"Ferreira","year":"2009","journal-title":"Paediatr. Respir. Rev."},{"key":"10.1016\/j.ejmech.2015.03.022_bib13","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.jmmm.2005.02.053","article-title":"Morphological analysis of mouse lungs after treatment with magnetite-based magnetic fluid stabilized with DMSA","volume":"293","author":"Garcia","year":"2005","journal-title":"J.\u00a0Magn. Magn. Mater."},{"key":"10.1016\/j.ejmech.2015.03.022_bib14","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.nano.2008.03.007","article-title":"Development, characterization, and toxicity evaluation of amphotericin B-loaded gelatin nanoparticles","volume":"4","author":"Nahar","year":"2008","journal-title":"Nanomedicine"},{"key":"10.1016\/j.ejmech.2015.03.022_bib15","doi-asserted-by":"crossref","first-page":"108","DOI":"10.2307\/3576888","article-title":"Measurement of DNA damage in mammalian cells using flow cytometry","volume":"110","author":"Milner","year":"1987","journal-title":"Radiat. Res."},{"key":"10.1016\/j.ejmech.2015.03.022_bib16","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1095\/biolreprod54.3.631","article-title":"Analysis of atresia in bovine follicles using different methods: flow cytometry, enzyme-linked immunosorbent assay, and classic histology","volume":"54","author":"Blondin","year":"1996","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.ejmech.2015.03.022_bib17","article-title":"Sensitive high-pressure liquid chromatographic assay for amphotericin B which incorporates an internal standard. Sensitive high-pressure liquid chromatographic assay for amphotericin b which incorporates an internal standard","author":"Granich","year":"1986","journal-title":"Microbiology"},{"key":"10.1016\/j.ejmech.2015.03.022_bib18","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0378-4347(92)80390-C","article-title":"High-performance liquid chromatographic analysis of amphotericin B in plasma, blood, urine and tissues for pharmacokinetic and tissue distribution studies","volume":"579","author":"Wang","year":"1992","journal-title":"J.\u00a0Chromatogr."},{"key":"10.1016\/j.ejmech.2015.03.022_bib19","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0021-9673(98)00425-7","article-title":"High-performance liquid chromatographic determination of amphotericin B in plasma and tissue. Application to pharmacokinetic and tissue distribution studies in rats","volume":"819","author":"Echevarr\u00eda","year":"1998","journal-title":"J.\u00a0Chromatogr. A"},{"key":"10.1016\/j.ejmech.2015.03.022_bib20","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0731-7085(97)00062-9","article-title":"Rapid and sensitive high performance liquid chromatographic method for the determination of itraconazole and its hydroxy-metabolite in human serum","volume":"16","author":"Gubbins","year":"1998","journal-title":"J.\u00a0Pharm. Biomed. Anal."},{"key":"10.1016\/j.ejmech.2015.03.022_bib21","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1128\/AAC.44.4.898-904.2000","article-title":"Comparative pharmacokinetics, tissue distributions, and effects on renal function of novel polymeric formulations of amphotericin B and amphotericin B-deoxycholate in rats","volume":"44","author":"Echevarr\u00eda","year":"2000","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2015.03.022_bib22","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1128\/AAC.46.3.828-833.2002","article-title":"Pharmacokinetics, excretion, and mass balance of liposomal amphotericin B (AmBisome) and amphotericin B deoxycholate in humans","volume":"46","author":"Bekersky","year":"2002","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2015.03.022_bib23","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.jchromb.2003.09.054","article-title":"High-performance liquid chromatographic mass spectrometric method for the determination of ursodeoxycholic acid and its glycine and taurine conjugates in human plasma","volume":"798","author":"Tessier","year":"2003","journal-title":"J.\u00a0Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.ejmech.2015.03.022_bib24","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1093\/jac\/dkl141","article-title":"Amphotericin B tissue distribution in autopsy material after treatment with liposomal amphotericin B and amphotericin B colloidal dispersion","volume":"57","author":"Vogelsinger","year":"2006","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.ejmech.2015.03.022_bib25","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.micinf.2008.07.027","article-title":"Additive effect of P10 immunization and chemotherapy in anergic mice challenged intratracheally with virulent yeasts of Paracoccidioides brasiliensis","volume":"10","author":"Marques","year":"2008","journal-title":"Microbes Infect."},{"key":"10.1016\/j.ejmech.2015.03.022_bib26","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1080\/00362176785190051","article-title":"Vital staining of Histoplasma capsulatum with Janus Green B","volume":"5","author":"Berliner","year":"1967","journal-title":"Med. Mycol."},{"key":"10.1016\/j.ejmech.2015.03.022_bib27","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/S0142-9612(01)00251-4","article-title":"Synthesis and characterization of novel water soluble amphotericin B-arabinogalactan conjugates","volume":"23","author":"Ehrenfreund-Kleinman","year":"2002","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejmech.2015.03.022_bib28","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/tcm.1770090403","article-title":"Cell cycle alterations and cell death in cyclophosphamide teratogenesis","volume":"9","author":"Chernoff","year":"1989","journal-title":"Teratog. Carcinog. Mutagen"},{"key":"10.1016\/j.ejmech.2015.03.022_bib29","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0027-5107(95)00039-L","article-title":"Cyclophosphamide: review of its mutagenicity for an assessment of potential germ cell risks","volume":"330","author":"Anderson","year":"1995","journal-title":"Mutat. Res."},{"issue":"Suppl.\u00a01","key":"10.1016\/j.ejmech.2015.03.022_bib30","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2165\/11315530-000000000-00000","article-title":"Invasive fungal infections: the challenge continues","volume":"69","author":"Gullo","year":"2009","journal-title":"Drugs"},{"key":"10.1016\/j.ejmech.2015.03.022_bib31","first-page":"2461","article-title":"Antifungal therapy","volume":"43","author":"De","year":"2011","journal-title":"TPS"},{"key":"10.1016\/j.ejmech.2015.03.022_bib32","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1517\/17425240902802861","article-title":"The reformulation of amphotericin B for oral administration to treat systemic fungal infections and visceral leishmaniasis","volume":"6","author":"Thornton","year":"2009","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.ejmech.2015.03.022_bib33","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1016\/j.vaccine.2009.11.062","article-title":"HSP65 DNA as therapeutic strategy to treat experimental paracoccidioidomycosis","volume":"28","author":"Ribeiro","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.ejmech.2015.03.022_bib34","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.vaccine.2008.10.022","article-title":"DNAhsp65 vaccination induces protection in mice against Paracoccidioides brasiliensis infection","volume":"27","author":"Ribeiro","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.ejmech.2015.03.022_bib35","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0378-5173(00)00537-8","article-title":"Effect of solvent on the preparation of surfactant-free poly(DL-lactide-co-glycolide) nanoparticles and norfloxacin release characteristics","volume":"207","author":"Jeon","year":"2000","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejmech.2015.03.022_bib36","doi-asserted-by":"crossref","first-page":"4344","DOI":"10.1166\/jnn.2012.5926","article-title":"Synthesis and characterization of silver nanoparticle composite with poly(p-Br-phenylsilane)","volume":"12","author":"Kim","year":"2012","journal-title":"J.\u00a0Nanosci. Nanotechnol."},{"key":"10.1016\/j.ejmech.2015.03.022_bib37","doi-asserted-by":"crossref","first-page":"185602","DOI":"10.1088\/0957-4484\/23\/18\/185602","article-title":"Synthesis and characterization of PbSe nanoparticles obtained by a colloidal route using Extran as a surfactant at low temperature","volume":"23","author":"Romano-Trujillo","year":"2012","journal-title":"Nanotechnology"},{"key":"10.1016\/j.ejmech.2015.03.022_bib38","doi-asserted-by":"crossref","first-page":"095707","DOI":"10.1088\/0957-4484\/24\/9\/095707","article-title":"Subsurface synthesis and characterization of Ag nanoparticles embedded in MgO","volume":"24","author":"Vilayurganapathy","year":"2013","journal-title":"Nanotechnology"},{"key":"10.1016\/j.ejmech.2015.03.022_bib39","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1023\/A:1018908705446","article-title":"Enhancement of nasal absorption of insulin using chitosan nanoparticles","volume":"16","author":"Fern\u00e1ndez-Urrusuno","year":"1999","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejmech.2015.03.022_bib40","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0168-3659(98)00116-3","article-title":"PLGA nanoparticles prepared by nanoprecipitation: drug loading and release studies of a water soluble drug","volume":"57","author":"Govender","year":"1999","journal-title":"J.\u00a0Control Release"},{"key":"10.1016\/j.ejmech.2015.03.022_bib41","doi-asserted-by":"crossref","first-page":"321","DOI":"10.2174\/1567201043334605","article-title":"Pegylated poly(lactide) and poly(lactide-co-glycolide) nanoparticles: preparation, properties and possible applications in drug delivery","volume":"1","author":"Avgoustakis","year":"2004","journal-title":"Curr. Drug Deliv."},{"key":"10.1016\/j.ejmech.2015.03.022_bib42","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1590\/S0100-40422003000500017","article-title":"Caracteriza\u00e7\u00e3o e estabilidade f\u00edsico-qu\u00edmica de sistemas polim\u00e9ricos nanoparticulados para administra\u00e7\u00e3o de f\u00e1rmacos","volume":"26","author":"Schaffazick","year":"2003","journal-title":"Quim Nova"},{"key":"10.1016\/j.ejmech.2015.03.022_bib43","first-page":"561","article-title":"Nanoparticles \u2013 a review","volume":"5","author":"Mohanraj","year":"2006","journal-title":"Trop. J. Pharm. Res."},{"issue":"Suppl.\u00a01","key":"10.1016\/j.ejmech.2015.03.022_bib44","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ijantimicag.2006.03.013","article-title":"What is the current and future status of conventional amphotericin B?","volume":"27","author":"Kleinberg","year":"2006","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.ejmech.2015.03.022_bib45","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1615\/CritRevTherDrugCarrierSyst.v23.i4.10","article-title":"Functional polymeric nanoparticles: an efficient and promising tool for active delivery of bioactives","volume":"23","author":"Nahar","year":"2006","journal-title":"Crit. Rev. Ther. Drug Carr. Syst."},{"key":"10.1016\/j.ejmech.2015.03.022_bib46","doi-asserted-by":"crossref","first-page":"29","DOI":"10.4161\/cam.5.1.13558","article-title":"Leukocyte transepithelial migration in lung induced by DMSA functionalized magnetic nanoparticles","volume":"5","author":"Azevedo","year":"2011","journal-title":"Cell. Adhes. Migr."},{"key":"10.1016\/j.ejmech.2015.03.022_bib47","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1093\/qjmed\/hcp114","article-title":"Use of oral dimercaptosuccinic acid (succimer) in adult patients with inorganic lead poisoning","volume":"102","author":"Bradberry","year":"2009","journal-title":"Qjm"},{"key":"10.1016\/j.ejmech.2015.03.022_bib48","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1590\/S1516-31802008000300003","article-title":"Estimation of absolute renal uptake with technetium-99m dimercaptosuccinic acid: direct comparison with the radioactivity of nephrectomy specimens","volume":"126","author":"Lopes de Lima","year":"2008","journal-title":"Sao Paulo Med. J."},{"key":"10.1016\/j.ejmech.2015.03.022_bib49","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0378-5173(03)00224-2","article-title":"Effect of copolymer composition on the physicochemical characteristics, in\u00a0vitro stability, and biodistribution of PLGA-mPEG nanoparticles","volume":"259","author":"Avgoustakis","year":"2003","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejmech.2015.03.022_bib50","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.nano.2010.02.002","article-title":"In\u00a0vivo evaluation of the biodistribution and safety of PLGA nanoparticles as drug delivery systems","volume":"6","author":"Semete","year":"2010","journal-title":"Nanomedicine"}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523415001890?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523415001890?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T13:42:36Z","timestamp":1759326156000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523415001890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":50,"alternative-id":["S0223523415001890"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2015.03.022","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activity and in\u00a0vivo tracking of Amphotericin B loaded PLGA nanoparticles","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2015.03.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}