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Sci."},{"key":"10.1016\/j.ejmech.2015.04.040_bib233","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1006\/abbi.2000.2149","article-title":"Antioxidant and prooxidant properties of carotenoids","volume":"385","author":"Young","year":"2001","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.ejmech.2015.04.040_bib234","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0014-5793(97)01355-0","article-title":"Relative stability of carotenoid radical cations and homologue tocopheroxyl radicals. 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Food Chem."},{"issue":"2006","key":"10.1016\/j.ejmech.2015.04.040_bib245","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1080\/10715760500540442","article-title":"Antioxidant profile of dihydroxy- and trihydroxyphenolic acids\u2013A structure-activity relationship study","volume":"40","author":"Siquet","year":"2006","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.ejmech.2015.04.040_bib246","doi-asserted-by":"crossref","first-page":"138","DOI":"10.2503\/jjshs.68.138","article-title":"Effect of dark treatment of the eggplant on fruit skin color and its anthocyanin components","volume":"68","author":"Matsuzoe","year":"1999","journal-title":"J.\u00a0Jpn. Soc. Hortic. 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