{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T16:58:55Z","timestamp":1790096335930,"version":"4.0.1"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["#21576239"],"award-info":[{"award-number":["#21576239"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.ejmech.2016.03.014","type":"journal-article","created":{"date-parts":[[2016,3,6]],"date-time":"2016-03-06T00:07:15Z","timestamp":1457222835000},"page":"132-140","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Systematic comparison of the mono-, dimethyl- and trimethyl 3-hydroxy-4(1H)-pyridones \u2013 Attempted optimization of the orally active iron chelator, deferiprone"],"prefix":"10.1016","volume":"115","author":[{"given":"Yuan-Yuan","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zidong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Le","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukhi","family":"Bansal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Hider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2016.03.014_bib1","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1006\/bcmd.2002.0510","article-title":"Deferiprone versus desferrioxamine in patients with thalassemia major: a randomized clinical trial","volume":"28","author":"Maggio","year":"2002","journal-title":"Blood Cells, Mol. Dis."},{"key":"10.1016\/j.ejmech.2016.03.014_bib2","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1159\/000081268","article-title":"Five-Year trial of deferiprone chelation therapy in thalassaemia major patients","volume":"112","author":"Taher","year":"2004","journal-title":"Acta Haematol."},{"key":"10.1016\/j.ejmech.2016.03.014_bib3","doi-asserted-by":"crossref","first-page":"557","DOI":"10.3324\/haematol.2009.014696","article-title":"Tailoring iron chelation by iron intake and serum ferritin: the prospective EPIC study of deferasirox in 1744 patients with transfusion-dependent anemias","volume":"95","author":"Pennell","year":"2010","journal-title":"Haematologica"},{"key":"10.1016\/j.ejmech.2016.03.014_bib4","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3389\/fphar.2014.00217","article-title":"Randomized controlled trials of iron chelators for the treatment of cardiac siderosis in thalassaemia major","volume":"5","author":"Baksi","year":"2014","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejmech.2016.03.014_bib5","doi-asserted-by":"crossref","first-page":"2816","DOI":"10.2174\/092986712800609724","article-title":"Chelating agents for the treatment of systemic iron overload","volume":"19","author":"Ma","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.ejmech.2016.03.014_bib6","doi-asserted-by":"crossref","first-page":"3220","DOI":"10.1039\/C2DT32149A","article-title":"Iron speciation in the cytosol: an overview","volume":"42","author":"Hider","year":"2013","journal-title":"Dalton Trans."},{"key":"10.1016\/j.ejmech.2016.03.014_bib7","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/S0090-9556(25)08575-7","article-title":"Urinary metabolic profiles in human and rat of 1,2-dimethyl- and 1,2-diethyl-substituted 3-hydroxypyridin-4-ones","volume":"20","author":"Singh","year":"2002","journal-title":"Drug Metabol. Dispos."},{"key":"10.1016\/j.ejmech.2016.03.014_bib8","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1046\/j.1365-2141.2002.03554.x","article-title":"The safety and effectiveness of deferiprone in a large-scale, 3-year study in Italian patients","volume":"118","author":"Ceci","year":"2002","journal-title":"Brit. J. Haematol."},{"key":"10.1016\/j.ejmech.2016.03.014_bib9","doi-asserted-by":"crossref","first-page":"3436","DOI":"10.1182\/blood-2006-02-002394","article-title":"Oral chelators deferasirox and deferiprone for transfusional iron overload in thalassemia major: new data, new questions","volume":"107","author":"Neufeld","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.ejmech.2016.03.014_bib10","doi-asserted-by":"crossref","first-page":"17120","DOI":"10.1039\/C4DT02687J","article-title":"Synthesis and characterization of pyridazine-based iron chelators","volume":"43","author":"Ma","year":"2014","journal-title":"Dalton Trans."},{"key":"10.1016\/j.ejmech.2016.03.014_bib11","doi-asserted-by":"crossref","first-page":"5230","DOI":"10.1016\/j.tetlet.2010.07.134","article-title":"Design and synthesis of fluorine-substituted 3-hydroxypyridin-4-ones","volume":"51","author":"Ma","year":"2010","journal-title":"Tet. Lett."},{"key":"10.1016\/j.ejmech.2016.03.014_bib12","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1039\/C2AN36186H","article-title":"A\u00a0novel fluorescence method for determination of pFe(3+)","volume":"138","author":"Ma","year":"2013","journal-title":"Analyst"},{"key":"10.1016\/j.ejmech.2016.03.014_bib13","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1021\/jm00069a002","article-title":"Synthesis, physicochemical properties, and biological evaluation of N-substituted 2-alkyl-3-hydroxy-4(1H)-pyridinones: orally active iron chelators with clinical potential","volume":"36","author":"Dobbin","year":"1993","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2016.03.014_bib14","doi-asserted-by":"crossref","first-page":"6549","DOI":"10.1039\/c2dt12396g","article-title":"Prediction of 3-hydroxypyridin-4-one (HPO) hydroxyl pK(a) values","volume":"41","author":"Chen","year":"2012","journal-title":"Dalton Trans."},{"key":"10.1016\/j.ejmech.2016.03.014_bib15","doi-asserted-by":"crossref","first-page":"10784","DOI":"10.1039\/c2dt31254a","article-title":"Prediction of 3-hydroxypyridin-4-one (HPO) log K-1 values for Fe(III)","volume":"41","author":"Chen","year":"2012","journal-title":"Dalton Trans."},{"key":"10.1016\/j.ejmech.2016.03.014_bib16","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1021\/jm9707784","article-title":"Synthesis, physicochemical properties and evaluation of N-substituted-2-alkyl-3-hydroxy-4(1H)-pyridinones","volume":"41","author":"Rai","year":"1998","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2016.03.014_bib17","series-title":"Gaussian 09, Revision D.01","author":"Frisch","year":"2009"},{"key":"10.1016\/j.ejmech.2016.03.014_bib18","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1021\/jp809062x","article-title":"Effects of heteroatoms on aromatic \u03c0\u2212\u03c0 interactions: benzene\u2212Pyridine and pyridine dimers","volume":"113","author":"Hohenstein","year":"2009","journal-title":"J.\u00a0Phys. Chem. A"},{"key":"10.1016\/j.ejmech.2016.03.014_bib19","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1365-2141.1993.tb08660.x","article-title":"Contrasting interspecies efficacy and toxicology of 1, 2-diethyl-3 -hydroxypyridin-4-one, CP94, relates to differing metabolism of the iron chelating site","volume":"85","author":"Porter","year":"1993","journal-title":"Brit. J. Haematotl."},{"key":"10.1016\/j.ejmech.2016.03.014_bib20","doi-asserted-by":"crossref","first-page":"3659","DOI":"10.1021\/jm960220g","article-title":"Synthesis, physicochemical properties, and biological evaluation of hydroxypyranones and hydroxypyridinones:\u2009 novel bidentate ligands for cell-labeling","volume":"39","author":"Ellis","year":"1996","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2016.03.014_bib21","first-page":"45","article-title":"Determination of equilibrium constants from spectrophometric data obtained from solutions of known pH: the program pHab","volume":"89","author":"Gans","year":"1999","journal-title":"Ann. Chim."},{"key":"10.1016\/j.ejmech.2016.03.014_bib22","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0010-8545(98)00260-4","article-title":"Hyperquad simulation and speciation (HySS): a utility program for the investigation of equilibria involving soluble and partially soluble species","volume":"184","author":"Alderighi","year":"1999","journal-title":"Coord. Chem. Rev."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S022352341630188X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S022352341630188X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T17:04:20Z","timestamp":1748797460000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S022352341630188X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":22,"alternative-id":["S022352341630188X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2016.03.014","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systematic comparison of the mono-, dimethyl- and trimethyl 3-hydroxy-4(1H)-pyridones \u2013 Attempted optimization of the orally active iron chelator, deferiprone","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2016.03.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}