{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T23:22:25Z","timestamp":1784762545963,"version":"3.55.0"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31260206"],"award-info":[{"award-number":["31260206"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Jiangxi Natural Science Foundation","award":["20151BAB203011"],"award-info":[{"award-number":["20151BAB203011"]}]},{"name":"Innovation Research Teams Project of Jiangxi Province","award":["20133BCB24011"],"award-info":[{"award-number":["20133BCB24011"]}]},{"name":"Key Technology R&D Program of Jiangxi Province","award":["20141BBG70070"],"award-info":[{"award-number":["20141BBG70070"]}]},{"name":"Key Technology R&D Program of Jiangxi Province","award":["20142BBG70107"],"award-info":[{"award-number":["20142BBG70107"]}]},{"name":"Science Project of Jiangxi Provincial Department of Education","award":["GJJ150989"],"award-info":[{"award-number":["GJJ150989"]}]},{"name":"Natural Science Foundation of Gannan Normal University","award":["2015-34"],"award-info":[{"award-number":["2015-34"]}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"crossref","award":["S2013020013091"],"award-info":[{"award-number":["S2013020013091"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"crossref"}]},{"name":"City of Guangzhou Science and Technology Plan Projects","award":["156300018"],"award-info":[{"award-number":["156300018"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.ejmech.2016.03.037","type":"journal-article","created":{"date-parts":[[2016,3,17]],"date-time":"2016-03-17T03:23:05Z","timestamp":1458184985000},"page":"291-294","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Discovery of molluscicidal and cercaricidal activities of 3-substituted quinazolinone derivatives by a scaffold hopping approach using a pseudo-ring based on the intramolecular hydrogen bond formation"],"prefix":"10.1016","volume":"115","author":[{"given":"Wei","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lv-Yin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Dong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren-Miao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ding-Qiao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Lin","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2016.03.037_bib1","doi-asserted-by":"crossref","first-page":"11138","DOI":"10.1021\/cr500098f","article-title":"Recent approaches to chemical discovery and development against malaria and the neglected tropical diseases human African trypanosomiasis and schistosomiasis","volume":"114","author":"Njoroge","year":"2014","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejmech.2016.03.037_bib2","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s11908-013-0329-1","article-title":"Schistosomiasis: current epidemiology and management in travelers","volume":"15","author":"Meltzer","year":"2013","journal-title":"Curr. Infect. Dis. Rep."},{"key":"10.1016\/j.ejmech.2016.03.037_bib3a","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/jtm.12031","article-title":"Imported African schistotomiasis: is it an emerging public health concern in China? response 1","volume":"20","author":"Lim","year":"2014","journal-title":"J.\u00a0Travel. Med."},{"key":"10.1016\/j.ejmech.2016.03.037_bib3b","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s10795-006-2252-1","article-title":"Design of hydraulic structures to prevent the spread of intermediate snails hosts of schistosomiasis","volume":"20","author":"Li","year":"2006","journal-title":"Irrig. Drain. Sys."},{"key":"10.1016\/j.ejmech.2016.03.037_bib4","first-page":"43","article-title":"Schistosomiasis control in China: the impact of a 10-year Workd Bank Loan Project (1992\u20132001)","volume":"83","author":"Chen","year":"2005","journal-title":"Bull. World Health Organ"},{"key":"10.1016\/j.ejmech.2016.03.037_bib5","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s11908-001-0060-1","article-title":"Recent advances in schistosomiasis","volume":"3","author":"Olds","year":"2001","journal-title":"Curr. Infect. Dis. Rep."},{"key":"10.1016\/j.ejmech.2016.03.037_bib6","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S1471-4922(02)02301-2","article-title":"Schistosomiasis: from risk assessment to control","volume":"18","author":"Bergquist","year":"2002","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.ejmech.2016.03.037_bib7","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s00436-008-0988-2","article-title":"A\u00a0novel molluscicidal formulation of niclosamide","volume":"103","author":"Dai","year":"2008","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.ejmech.2016.03.037_bib8a","doi-asserted-by":"crossref","first-page":"38667","DOI":"10.1074\/jbc.M006997200","article-title":"Schistosome invasion of human skin and degradation of dermal elastin are mediated by a single serine protease","volume":"275","author":"Salter","year":"2000","journal-title":"J.\u00a0Bio. Chem."},{"key":"10.1016\/j.ejmech.2016.03.037_bib8b","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.pt.2004.06.006","article-title":"Invasion by schistosome cercariae: neglected aspects in Schistosoma japonicum","volume":"20","author":"Ruppel","year":"2004","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.ejmech.2016.03.037_bib9","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.parint.2004.12.003","article-title":"Transport of Schistosoma japonicum cercariae and the feasibility of niclosamide for cercariae control","volume":"54","author":"Lowe","year":"2005","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.ejmech.2016.03.037_bib10","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1111\/cbdd.12439","article-title":"Design, synthesis, and cercaricidal activity of novel high-efficient, low-toxic self-spreading PEG-N-salicylanilide derivatives against cercariae larvae of Schistosome Japonicum floating on the water surface","volume":"85","author":"Guo","year":"2015","journal-title":"Chem. Biol. Drug. Des."},{"key":"10.1016\/j.ejmech.2016.03.037_bib11","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/mabi.200300003","article-title":"Polymeric controlled release formulations of niclosamide for control of Biomphalaria Alexandrina, the vector snail of schistosomiasis","volume":"4","author":"Kenawy","year":"2004","journal-title":"Macromol. Biosci."},{"key":"10.1016\/j.ejmech.2016.03.037_bib12","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.cclet.2008.01.014","article-title":"Synthesis and cercaricidal activities of a serial of novel self-diffused cercaricides derived from niphensamide","volume":"19","author":"Guo","year":"2008","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.ejmech.2016.03.037_bib13a","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.dyepig.2010.08.002","article-title":"Novel derivatives of niclosamide synthesis: its bioactivity and interaction with Schistosoma japonicum cercariae","volume":"88","author":"Wu","year":"2011","journal-title":"Dyes Pigments"},{"key":"10.1016\/j.ejmech.2016.03.037_bib13b","doi-asserted-by":"crossref","first-page":"19956","DOI":"10.1039\/c3ra44328k","article-title":"Nano-film pesticide for Schistosoma japonicum cercariae: synthesis, characterization, toxicity and insecticidal effect","volume":"3","author":"Li","year":"2013","journal-title":"RSC Adv."},{"key":"10.1016\/j.ejmech.2016.03.037_bib14a","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.bmcl.2005.06.088","article-title":"Acryloylamino-salicylanilides as EGFR PTK inhibitors","volume":"16","author":"Deng","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2016.03.037_bib14b","doi-asserted-by":"crossref","first-page":"5217","DOI":"10.1016\/j.bmcl.2006.07.010","article-title":"From arylureas to biarylamides to aminoquinazolines: discovery of a novel, potent TRPV1 antagonist","volume":"16","author":"Zheng","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2016.03.037_bib15","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1246\/bcsj.73.2335","article-title":"Studies on the conformations of antimicrobial salicylanilide derivatives by spectroscopy","volume":"73","author":"Suezawa","year":"2000","journal-title":"Bull. Chem. Soc. Jpn."},{"key":"10.1016\/j.ejmech.2016.03.037_bib16","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.ejmech.2015.03.053","article-title":"Distinct novel quinazolinone exhibits selective inhibition in MGC-803 cancer cells by dictating mutant p53 function","volume":"95","author":"Zhang","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2016.03.037_bib17","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ejmech.2015.02.057","article-title":"Luotonin-A based quinazolinones cause apoptosis and senescence via HDAC inhibition and activation of tumor suppressor proteins in HeLa cells","volume":"94","author":"Venkatesh","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2016.03.037_bib18","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.ejmech.2015.03.014","article-title":"Synthesis, crystal structure and biological evaluation of substituted quinazolinone benzoates as novel antituberculosis agents targeting acetohydroxyacid synthase","volume":"94","author":"Lu","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2016.03.037_bib19","series-title":"The Control of Schistosomiasis Geneva","author":"WHO, World Health Organisation","year":"1993"}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523416302112?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523416302112?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T12:14:54Z","timestamp":1589631294000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523416302112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":23,"alternative-id":["S0223523416302112"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2016.03.037","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery of molluscicidal and cercaricidal activities of 3-substituted quinazolinone derivatives by a scaffold hopping approach using a pseudo-ring based on the intramolecular hydrogen bond formation","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2016.03.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}