{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T19:27:46Z","timestamp":1770233266027,"version":"3.49.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Department of Science and Technology, New Delhi","award":["IF140407"],"award-info":[{"award-number":["IF140407"]}]},{"name":"INSPIRE-Fellowship scheme"},{"DOI":"10.13039\/501100014738","name":"VGST","doi-asserted-by":"crossref","award":["VGST\/CISEE\/282"],"award-info":[{"award-number":["VGST\/CISEE\/282"]}],"id":[{"id":"10.13039\/501100014738","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100014738","name":"VGST","doi-asserted-by":"crossref","award":["VGST\/CISEE\/231"],"award-info":[{"award-number":["VGST\/CISEE\/231"]}],"id":[{"id":"10.13039\/501100014738","id-type":"DOI","asserted-by":"crossref"}]},{"name":"CISEE Programme"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.ejmech.2016.03.040","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T02:49:51Z","timestamp":1458355791000},"page":"342-351","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Design and synthesis of diamide-coupled benzophenones as potential anticancer agents"],"prefix":"10.1016","volume":"115","author":[{"family":"Zabiulla","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.G.","family":"Shamanth Neralagundi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Bushra Begum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.T.","family":"Prabhakar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaukath Ara","family":"Khanum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2016.03.040_bib1","first-page":"490","volume":"56","author":"Hahn","year":"1996","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejmech.2016.03.040_bib2","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/nm0603-653","volume":"9","author":"Carmeliet","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejmech.2016.03.040_bib3","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/nrd2115","volume":"6","author":"Folkman","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejmech.2016.03.040_bib4","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/S0968-0004(98)01344-9","article-title":"Oncogenic alteration of metabolism","volume":"24","author":"Dang","year":"1999","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.ejmech.2016.03.040_bib5","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.biopha.2015.08.030","article-title":"Benzophenone derivatives as cysteine protease inhibitors and biological activity against Leishmania(L) amazonensis amastigotes","volume":"75","author":"de Almeida","year":"2015","journal-title":"Biomed. Pharmocother."},{"issue":"17","key":"10.1016\/j.ejmech.2016.03.040_bib6","doi-asserted-by":"crossref","first-page":"3694","DOI":"10.1016\/j.bmcl.2015.06.036","article-title":"Synthesis and biological evaluation of N-cyclopropylbenzamide-benzophenone hybrids as novel and selective p38 mitogen activated protein kinase (MAPK) inhibitors","volume":"25","author":"Heo","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2016.03.040_bib7","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.1016\/j.ejmech.2008.09.010","article-title":"Synthesis and antioxidant potential of novel synthetic benzophenone analogues","volume":"44","author":"Tzanova","year":"2009","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2016.03.040_bib8","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/j.ejmech.2005.04.005","article-title":"Synthesis and antimicrobial study of novel heterocyclic compounds from hydroxyl benzophenones","volume":"40","author":"Khanum","year":"2005","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2016.03.040_bib9","first-page":"1","article-title":"Design, synthesis, and anticancer properties of novel benzophenone-conjugated coumarin analogs","volume":"346","author":"Ranganatha","year":"2013","journal-title":"Arch. Pharm."},{"key":"10.1016\/j.ejmech.2016.03.040_bib10","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1016\/j.bmcl.2014.03.076","article-title":"Synthesis and biological evaluation of cinnamido linked benzophenone hybrids as tubulin polymerization inhibitors and apoptosis including agents","volume":"24","author":"Ahmed kamal","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2016.03.040_bib11","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.bmc.2005.08.039","article-title":"Antitumor and proapoptotic effect of novel synthetic benzophenone analogs in ehrlich ascites tumor cells","volume":"14","author":"Prabhakar","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2016.03.040_bib12","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.ejmech.2013.02.040","article-title":"Synthesis and evaluation of 2,5-di(4-aryloylaryloxymethyl)-1,3,4-oxadiazoles as anti-cancer agents","volume":"63","author":"Gurupadaswamy","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2016.03.040_bib13","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.ejmech.2014.09.069","article-title":"Synthesis and evaluation of novel benzophenone- thiazole derivatives as potent VEGF-A inhibitors","volume":"87","author":"Prashanth","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2016.03.040_bib14","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ejmech.2014.01.050","article-title":"Synthesis and tumor inhibitory activity of novel coumarin analogs targeting angiogenesis and apoptosis","volume":"75","author":"Vijay Avin","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2016.03.040_bib15","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2010.12.017","volume":"144","author":"Douglas","year":"2011","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.ejmech.2016.03.040_bib16","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/nrd2115","article-title":"Angiogenesis: an organizing principle for drug discovery?","volume":"6","author":"Folkman","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"issue":"9","key":"10.1016\/j.ejmech.2016.03.040_bib17","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/nrclinonc.2012.120","article-title":"Cancer prevention by targeting angiogenesis","volume":"9","author":"Albini","year":"2012","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.ejmech.2016.03.040_bib18","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s10637-006-6587-0","article-title":"Antiangiogenic effect of 2- benzoyl-phenoxy acetamide in EAT cell is mediated by HIF-1a and down regulation of VEGF of in\u00a0vivo","volume":"24","author":"Prabhakar","year":"2006","journal-title":"Invest. New Drugs"},{"key":"10.1016\/j.ejmech.2016.03.040_bib19","first-page":"223","article-title":"Inhibition of HIF-1\u03b1 activity by BP-1 ameliorates adjuvant induced arthritis in rats","volume":"387","author":"Shankar","year":"2009","journal-title":"BBRC"},{"key":"10.1016\/j.ejmech.2016.03.040_bib20","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/978-1-59745-416-2_4","volume":"471","author":"Sloane","year":"2009","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ejmech.2016.03.040_bib21","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.critrevonc.2005.01.006","volume":"55","author":"Hotta","year":"2005","journal-title":"Crit. Rev. Oncol. Hematol."},{"issue":"1","key":"10.1016\/j.ejmech.2016.03.040_bib22","doi-asserted-by":"crossref","first-page":"60","DOI":"10.59566\/IJBS.2010.6060","article-title":"Synthesis and evaluation of benzophenone-N-ethyl morpholine ethers as anti-inflammatory agents","volume":"6","author":"Khanum","year":"2010","journal-title":"Int. J. Biomed. Sci."},{"issue":"4","key":"10.1016\/j.ejmech.2016.03.040_bib23","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.bioorg.2004.04.003","article-title":"Synthesis and anti-inflammatory activity of benzophenone analogues","volume":"32","author":"Khanum","year":"2004","journal-title":"Bioorg Chem."},{"key":"10.1016\/j.ejmech.2016.03.040_bib24","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.lfs.2013.10.001","article-title":"Synthesis, angiopreventive activity, and in\u00a0vivo tumor inhibition of novel benzophenone\u2013 benzimidazole analogs","volume":"93","author":"Ranganath","year":"2013","journal-title":"Life Sci."},{"key":"10.1016\/j.ejmech.2016.03.040_bib25","doi-asserted-by":"crossref","first-page":"4100","DOI":"10.1016\/j.bmcl.2005.06.012","article-title":"Synthesis of benzoyl phenyl benzoates as effective inhibitors for phospholipase A2 and hyaluronidase enzymes","volume":"15","author":"Khanum","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2016.03.040_bib26","series-title":"Anticancer Drug Development Unique Aspects of Pharmaceutical Development Pharmaceutical Perspectives of Cancer Therapeutics","first-page":"49","author":"Ajit Narang","year":"2009"},{"key":"10.1016\/j.ejmech.2016.03.040_bib27","series-title":"Preclinical Screening for New Anticancer Agents. Handbook of Anticancer Pharmacokinetics and Pharmacodynamics","first-page":"23","author":"Angelika Burger","year":"2014"},{"key":"10.1016\/j.ejmech.2016.03.040_bib28","doi-asserted-by":"crossref","first-page":"793","DOI":"10.2353\/ajpath.2007.060929","volume":"170","author":"Talmadge","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ejmech.2016.03.040_bib29","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1254\/jphs.94.177","volume":"94","author":"Gupta","year":"2004","journal-title":"J.\u00a0Pharmacol. Sci."},{"key":"10.1016\/j.ejmech.2016.03.040_bib30","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/nrc2868","article-title":"Targeting the tumor vasculature: insights from physiological angiogenesis","volume":"10","author":"Alicia Chung","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ejmech.2016.03.040_bib31","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s00432-008-0497-9","article-title":"Evaluation of serum vascular endothelial growth factor (VEGF) and micro vessel density (MVD) as prognostic indicators in carcinoma breast","volume":"135","author":"Shivakumar","year":"2008","journal-title":"J.\u00a0Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.ejmech.2016.03.040_bib32","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.lfs.2013.10.001","article-title":"Synthesis, angiopreventive activity, and in\u00a0vivo tumor inhibition of novel benzophenone\u2013benzimidazole analogs","volume":"93","author":"Lakshmi Ranganatha","year":"2013","journal-title":"Life Sci."},{"key":"10.1016\/j.ejmech.2016.03.040_bib33","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s002800051102","article-title":"Involvement of VEGF and its receptor in ascites tumor formation","volume":"43","author":"Shibuya","year":"1999","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.ejmech.2016.03.040_bib34","series-title":"The Chickembryochorioallantoicmembrane as a Model for Tumor Biology Experimental Cell Research","first-page":"314","author":"Domenico Ribattin","year":"2014"},{"key":"10.1016\/j.ejmech.2016.03.040_bib35","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nrc2403","article-title":"VEGF-targeted therapy: mechanisms of antitumor activity","volume":"8","author":"Lee Ellis","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ejmech.2016.03.040_bib36","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/jnci\/82.1.4","article-title":"What is the evidence that tumors are angiogenesis dependent?","volume":"82","author":"Folkman","year":"1990","journal-title":"J.\u00a0Natl. Cancer Inst."},{"issue":"3","key":"10.1016\/j.ejmech.2016.03.040_bib37","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0092-8674(00)80108-7","article-title":"Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis","volume":"86","author":"Hanahan","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.ejmech.2016.03.040_bib38","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1254\/jphs.94.177","volume":"94","author":"Gupta","year":"2004","journal-title":"J.\u00a0Pharmacol. Sci."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523416302227?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523416302227?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T04:06:40Z","timestamp":1718424400000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523416302227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":38,"alternative-id":["S0223523416302227"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2016.03.040","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design and synthesis of diamide-coupled benzophenones as potential anticancer agents","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2016.03.040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}