{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T02:20:45Z","timestamp":1781749245713,"version":"3.54.5"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21272129"],"award-info":[{"award-number":["21272129"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21372133"],"award-info":[{"award-number":["21372133"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","award":["B06005"],"award-info":[{"award-number":["B06005"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.ejmech.2016.04.005","type":"journal-article","created":{"date-parts":[[2016,4,6]],"date-time":"2016-04-06T01:32:16Z","timestamp":1459906336000},"page":"167-178","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["Syntheses, biological activities and SAR studies of novel carboxamide compounds containing piperazine and arylsulfonyl moieties"],"prefix":"10.1016","volume":"117","author":[{"given":"Bao-Lei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Xia","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Jun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Xue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Yuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing-Hai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Hong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng-Ming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao-Ju","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2016.04.005_bib1","doi-asserted-by":"crossref","first-page":"6385","DOI":"10.1016\/j.bmcl.2012.08.071","article-title":"Synthesis and biological evaluation of novel piperazine derivatives of flavone as potent anti-inflammatory and antimicrobial agent","volume":"22","author":"Hatnapure","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2016.04.005_bib2","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1021\/ol100407f","article-title":"Piperazine bridged resorcinarene cages","volume":"12","author":"Beyeh","year":"2010","journal-title":"Org. Lett."},{"key":"10.1016\/j.ejmech.2016.04.005_bib3","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1021\/jm9016976","article-title":"Characterization of tunable piperidine and piperazine carbamates as inhibitors of endocannabinoid hydrolases","volume":"53","author":"Long","year":"2010","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2016.04.005_bib4","first-page":"429","article-title":"Synthesis and antibacterial activities of 1-substituted-4-[5-(4-substitutedphenyl)-1,3,4-thiadiazol-2-sulfonyl]piperazine derivatives","volume":"22","author":"Wu","year":"2014","journal-title":"Chin. J. Synth. Chem."},{"key":"10.1016\/j.ejmech.2016.04.005_bib5","first-page":"797","article-title":"Design and synthesis of thieno[3,2-d]pyrimidine derivatives containing a piperazine unit as anticancer agents","volume":"34","author":"Jiang","year":"2012","journal-title":"Chem. Reag."},{"key":"10.1016\/j.ejmech.2016.04.005_bib6","first-page":"71","article-title":"Synthesis and the antifungal activity of 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-[(4-substituted)-piperazine-1-yl]-2-propanols","volume":"14","author":"Liang","year":"2004","journal-title":"Chin. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2016.04.005_bib7","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1080\/104265090517280","article-title":"Synthesis and tuberculostatic activity of some 2-piperazinmethylene derivatives 1,2,4-triazole-3-thiones","volume":"180","author":"Foks","year":"2005","journal-title":"Phosphorus Sulfur Silicon Relat. Elem."},{"key":"10.1016\/j.ejmech.2016.04.005_bib8","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1021\/jf60209a023","article-title":"Residues and disappearance of Triforine from various crops","volume":"25","author":"Bourke","year":"1997","journal-title":"J.\u00a0Agric. Food Chem."},{"key":"10.1016\/j.ejmech.2016.04.005_bib9","first-page":"200l","article-title":"Synthesis of piperazine derivatives containing pyridinemethyl\/thiazolemethyl and their biological activities","volume":"28","author":"Li","year":"2008","journal-title":"Chin. J. Org. Chem."},{"key":"10.1016\/j.ejmech.2016.04.005_bib10","series-title":"An Introduction to Medicinal Chemistry","author":"Patrick","year":"1995"},{"key":"10.1016\/j.ejmech.2016.04.005_bib11","series-title":"N-(2-Chloro-4-nitrophenyl)-benezene-sulfonamide Derivative and Agricultural Fungicide Containing Same","author":"Yoshimoto","year":"1989"},{"key":"10.1016\/j.ejmech.2016.04.005_bib12","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1021\/op700281w","article-title":"Process development for the sulfonamide herbicide pyroxsulam","volume":"12","author":"Gonzalez","year":"2008","journal-title":"Org. Process Res. Dev."},{"key":"10.1016\/j.ejmech.2016.04.005_bib13","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1021\/jf00027a009","article-title":"Analysis of sulfonylurea herbicides by gas-liquid chromatography. 1. Formation of thermostable derivatives of chlorsulfuron and metsulfuron-methyl","volume":"41","author":"Klaffenbach","year":"1993","journal-title":"J.\u00a0Agric. Food Chem."},{"key":"10.1016\/j.ejmech.2016.04.005_bib14","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.diabres.2015.05.046","article-title":"Sulfonylurea monotherapy and emergency room utilization among elderly patients with type 2 diabetes","volume":"109","author":"Rajpathak","year":"2015","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.ejmech.2016.04.005_bib15","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ejmech.2012.01.011","article-title":"Synthesis and evaluation of novel monosubstituted sulfonylurea derivatives as antituberculosis agents","volume":"50","author":"Pan","year":"2012","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2016.04.005_bib16","first-page":"672","article-title":"Design, synthesis and biological activity of novel sulfonylurea derivatives containing phenyl-substituted pyrimidine moiety","volume":"36","author":"Chen","year":"2015","journal-title":"Chem. J. Chin. U."},{"key":"10.1016\/j.ejmech.2016.04.005_bib17","doi-asserted-by":"crossref","first-page":"4773","DOI":"10.1021\/bi9721389","article-title":"Kinetic and mass spectrometric analyses of the interactions between plant acetohydroxy acid isomeroreductase and thiadiazole derivatives","volume":"37","author":"Halgand","year":"1998","journal-title":"Biochem."},{"key":"10.1016\/j.ejmech.2016.04.005_bib18","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1747-0285.2011.01132.x","article-title":"Synthesis, structure and biological activity of novel 1,2,4-triazole Mannich bases containing a substituted benzylpiperazine moiety","volume":"78","author":"Wang","year":"2011","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.ejmech.2016.04.005_bib19","first-page":"809","article-title":"Synthesis and biological activity of new 1-[4-(substituted)-piperazin-1-ylmethyl]-1H-benzotriazole","volume":"12","author":"He","year":"2006","journal-title":"J.\u00a0Chem. Res."},{"key":"10.1016\/j.ejmech.2016.04.005_bib20","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.ejmech.2007.04.021","article-title":"Synthesis antifungal activity and CoMFA analysis of novel l,2,4-triazolo[1,5-a]pyrimidine derivatives","volume":"43","author":"Chen","year":"2008","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2016.04.005_bib21","doi-asserted-by":"crossref","first-page":"12725","DOI":"10.3390\/molecules181012725","article-title":"Microwave assisted synthesis, antifungal activity and DFT theoretical study of some novel 1,2,4-triazole derivatives containing the 1,2,3-thiadiazole moiety","volume":"18","author":"Sun","year":"2013","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2016.04.005_bib22","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.pestbp.2011.08.006","article-title":"Synthesis, crystal structure, bioactivity and DFT calculation of new oxime ester derivatives containing cyclopropane moiety","volume":"101","author":"Liu","year":"2011","journal-title":"Pest. Biochem. Physiol."},{"key":"10.1016\/j.ejmech.2016.04.005_bib23","first-page":"531","article-title":"Theoretical studies on the structure-activity relationship of N\u2019-(substituted pyrimidin-2-yl)-N-substituted formyl thioureas","volume":"22","author":"Wang","year":"2005","journal-title":"Comput. Appl. Chem."},{"key":"10.1016\/j.ejmech.2016.04.005_bib24","first-page":"1459","article-title":"Synthesis and herbicidal activity of new sulfonylurea derivatives","volume":"26","author":"Li","year":"2005","journal-title":"Chem. J. Chin. U."},{"key":"10.1016\/j.ejmech.2016.04.005_bib25","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1021\/jo01100a622","article-title":"Some N-arylculfonyl-N\u2019-alkylureas","volume":"23","author":"Marshall","year":"1958","journal-title":"J.\u00a0Org. Chem."},{"key":"10.1016\/j.ejmech.2016.04.005_bib26","first-page":"32","article-title":"The new synthesis process of o-aminobenzenesulfonic acid","volume":"4","author":"Qiu","year":"1997","journal-title":"Tianjin Chem. Ind."},{"key":"10.1016\/j.ejmech.2016.04.005_bib27","first-page":"61","article-title":"An improved procedure for synthesizing o-aminobenzene sulfonic acid","volume":"2","author":"Song","year":"1995","journal-title":"Fine Chem."},{"key":"10.1016\/j.ejmech.2016.04.005_bib28","series-title":"Herbicidal Sulfonamides","author":"Hillemann","year":"1986"},{"key":"10.1016\/j.ejmech.2016.04.005_bib29","series-title":"Preparation of Chloro-benzene-sulphonamide","author":"Oniscu","year":"1998"},{"issue":"1","key":"10.1016\/j.ejmech.2016.04.005_bib30","first-page":"15","article-title":"Synthesis of chlorosulfuron","volume":"20","author":"Sun","year":"1995","journal-title":"Shanghai Chem. Ind."},{"key":"10.1016\/j.ejmech.2016.04.005_bib31","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/BF00482503","article-title":"Synthesis of N-(2-chlorophenylsulfonyl)-N'-(4-methoxy-6- methyl-1,3,5-triazin-2-yl)-urea with a radioactive label","volume":"25","author":"Sokolova","year":"1989","journal-title":"Chem. Heterocycl. Compd."},{"key":"10.1016\/j.ejmech.2016.04.005_bib32","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/0223-5234(96)85875-2","article-title":"Synthesis of 1-(4-acyloxybenzoyloxyacetyl)-4-alkylpiperazines and 1-(4-acyloxybenzoyl)-4-alkylpiperazines as inhibitors of chymotrypsin","volume":"31","author":"Zlatoidsk\u00fd","year":"1996","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2016.04.005_bib33","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1021\/ja01230a031","article-title":"Preparation of N-monosubstituted and unsymmetrically disubstituted piperazines","volume":"66","author":"Baltzly","year":"1944","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2016.04.005_bib34","series-title":"Piperazine and Homopiperazine Bronchodilators","author":"Shapiro","year":"1962"},{"key":"10.1016\/j.ejmech.2016.04.005_bib35","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1021\/ja01221a012","article-title":"Heterocyclic basic compounds. IV. 2-Aminoalkylamino- pyrimidines","volume":"67","author":"Adams","year":"1945","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2016.04.005_bib36","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/ps.972","article-title":"Synthesis, crystal structure and hebricidal activity of mimics of intermediates of the KARI reaction","volume":"61","author":"Wang","year":"2005","journal-title":"Pest Manage. Sci."},{"key":"10.1016\/j.ejmech.2016.04.005_bib37","first-page":"126","article-title":"Fungicidal activity of novel fungicide chlorphenomizole and efficacy in controlling main diseases on vegetable in field","volume":"9","author":"Shi","year":"2007","journal-title":"Chin. J. Pestic. Sci."},{"key":"10.1016\/j.ejmech.2016.04.005_bib38","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.plantsci.2004.11.020","article-title":"Cyclopropane-1,1-dicarboxylate is a slow-, tight-binding inhibitor of rice ketol-acid reductoisomerase","volume":"168","author":"Lee","year":"2005","journal-title":"Plant Sci."},{"key":"10.1016\/j.ejmech.2016.04.005_bib39","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0003-2697(85)90442-7","article-title":"Measurement of protein using bicinchoninic acid","volume":"150","author":"Smith","year":"1985","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ejmech.2016.04.005_bib40","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2016.04.005_bib41","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/j.1747-0285.2009.00779.x","article-title":"Synthesis of some N, N\u2019-diacylhydrazine derivatives with radical scavenging and antifungal activity","volume":"73","author":"Liu","year":"2009","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.ejmech.2016.04.005_bib42","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/BF00124364","article-title":"Sample-distance partial least squares PLS optimized for many variables, with application to CoMFA","volume":"7","author":"Bush","year":"1993","journal-title":"J.\u00a0Comput. Aided Mol. Des."},{"key":"10.1016\/j.ejmech.2016.04.005_bib43","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1103\/PhysRevB.37.785","article-title":"Development of the Colle-Salvetti correlationenergy formula into a functional of the electron density","volume":"37","author":"Lee","year":"1988","journal-title":"Phys. Rev. B"},{"key":"10.1016\/j.ejmech.2016.04.005_bib44","series-title":"Gaussian 03, Revision C. 01","author":"Frisch","year":"2004"}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S022352341630277X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S022352341630277X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,26]],"date-time":"2022-06-26T19:27:25Z","timestamp":1656271645000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S022352341630277X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":44,"alternative-id":["S022352341630277X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2016.04.005","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Syntheses, biological activities and SAR studies of novel carboxamide compounds containing piperazine and arylsulfonyl moieties","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2016.04.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}