{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:15:38Z","timestamp":1792516538859,"version":"4.5.0"},"reference-count":187,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100009085","name":"Jain University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009085","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.ejmech.2017.07.038","type":"journal-article","created":{"date-parts":[[2017,7,22]],"date-time":"2017-07-22T20:45:40Z","timestamp":1500756340000},"page":"1002-1033","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":342,"special_numbering":"C","title":["An overview of benzo [b] thiophene-based medicinal chemistry"],"prefix":"10.1016","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6262-8379","authenticated-orcid":false,"given":"Rangappa S.","family":"Keri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karam","family":"Chand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivasa","family":"Budagumpi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1546-2083","authenticated-orcid":false,"given":"Sasidhar","family":"Balappa Somappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddappa A.","family":"Patil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhari Mallanna","family":"Nagaraja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2017.07.038_bib1","series-title":"Heterocyclic Chemistry","author":"Joule","year":"2010"},{"key":"10.1016\/j.ejmech.2017.07.038_bib2","series-title":"Fundamentals of Heterocyclic Chemistry: Importance in Nature and in the Synthesis of Pharmaceuticals","author":"Quin","year":"2010"},{"key":"10.1016\/j.ejmech.2017.07.038_bib3","series-title":"Advances in Heterocyclic Chemistry","author":"Katritzky","year":"2002"},{"key":"10.1016\/j.ejmech.2017.07.038_bib4","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0223-5234(02)01378-8","article-title":"Hydrazones of 1,2-benzisothiazole hydrazides: synthesis, antimicrobial activity and QSAR investigations","volume":"37","author":"Vicini","year":"2002","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib5","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ejmech.2003.11.004","article-title":"Synthesis and antimicrobial properties of 2-(benzylidene-amino)-benzo[d]isothiazol-3-ones","volume":"39","author":"Zani","year":"2004","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib6","series-title":"Benzothiophene\/indole-substituted Maleimide Derivatives, Photochromic Material Comprising Said Derivatives and Optical Recording Material Using the Same Material","author":"Sugai","year":"1995"},{"key":"10.1016\/j.ejmech.2017.07.038_bib7","unstructured":"A. R. Katritzky, C. W. Rees, Russell and Press, in Comprehensive Heterocyclic Chemistry II, Scriven Eds, E. F. V., Pergamon Press: Oxford, 2, 1996, 679."},{"key":"10.1016\/j.ejmech.2017.07.038_bib8","first-page":"863","volume":"vol. 4","author":"Campaigne","year":"1984"},{"key":"10.1016\/j.ejmech.2017.07.038_bib9","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1002\/jhet.5570290435","article-title":"Synthesis of some novel azido\/tetrazolothienopyrimidines and their reduction to 2,4-diaminothieno[2,3-d]pyrimidines","volume":"29","author":"Shishoo","year":"1992","journal-title":"J.\u00a0Heterocycl. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib10","first-page":"1","article-title":"Biologically active benzo[b]thiophene derivatives Part I","volume":"5","author":"Campaigne","year":"1970","journal-title":"Adv. Drug. Res."},{"key":"10.1016\/j.ejmech.2017.07.038_bib11","first-page":"191","article-title":"Biologically active benzo[b]thiophene derivatives","volume":"11","author":"Bosin","year":"1977","journal-title":"Adv. Drug Res."},{"key":"10.1016\/j.ejmech.2017.07.038_bib12","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1080\/10426509208031537","article-title":"Schwefelverbindungen des erd\u00f6ls xvii.1 dibenzothiophene mit einem verzweigten C3-C5-alkylrest","volume":"72","author":"Boberg","year":"1992","journal-title":"Phosphorus, Sulfur Silicon Relat. Elem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib13","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1021\/np010577+","article-title":"Bryoanthrathiophene, a new antiangiogenic constituent from the Bryozoan Watersipora subtorquata","volume":"65","author":"Jeong","year":"2002","journal-title":"J.\u00a0Nat. Prod."},{"key":"10.1016\/j.ejmech.2017.07.038_bib14","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1021\/ol006127a","article-title":"Synthesis of an orange anthrathiophene pigment isolated from a Japanese Bryozoan","volume":"2","author":"Kelly","year":"2000","journal-title":"Org. Lett."},{"key":"10.1016\/j.ejmech.2017.07.038_bib15","series-title":"In Caffeine","author":"Spiller","year":"1998"},{"key":"10.1016\/j.ejmech.2017.07.038_bib16","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1016\/j.ejmech.2008.02.034","article-title":"Synthesis and pharmacological evaluation of 2-substituted benzo[b]thiophenes as anti-inflammatory and analgesic agents","volume":"44","author":"Fakhr","year":"2009","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib17","first-page":"10","article-title":"Synthesis and preliminary evaluation of some 2-amino-n'-[substituted]-4,5,6,7-tetrahydro-1-benzothiophene-3-carbohydrazide as antimicrobial agents","volume":"9","author":"Jagtap","year":"2015","journal-title":"J.\u00a0Pharm. Res."},{"key":"10.1016\/j.ejmech.2017.07.038_bib18","doi-asserted-by":"crossref","first-page":"3086","DOI":"10.1021\/jm2000773","article-title":"Novel benzo[b]thiophene derivatives as new potential antidepressants with rapid onset of action","volume":"54","author":"Berrade","year":"2011","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib19","series-title":"Benzothiophene Alkanol Piperazine Derivatives and Their Use as Antidepressant","author":"Jianqi","year":"2010"},{"key":"10.1016\/j.ejmech.2017.07.038_bib20","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3181\/00379727-217-44204","article-title":"Selective estrogen receptor modulators: an alternative to hormone replacement therapy","volume":"217","author":"Bryant","year":"1998","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.ejmech.2017.07.038_bib21","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.1021\/jm070079j","article-title":"Benzothiophene selective estrogen receptor modulators with modulated oxidative activity and receptor affinity","volume":"50","author":"Qin","year":"2007","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib22","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1021\/jm070050f","article-title":"Synthesis and biological evaluation of 2- and 3-aminobenzo[b]thiophene derivatives as antimitotic agents and inhibitors of tubulin polymerization","volume":"50","author":"Romagnoli","year":"2007","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib23","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1124\/jpet.110.166173","article-title":"A\u00a0benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor alpha production and has oral anti-inflammatory efficacy in acute and chronic models of inflammation","volume":"333","author":"Mourey","year":"2010","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejmech.2017.07.038_bib24","doi-asserted-by":"crossref","first-page":"417","DOI":"10.2174\/1570180812666141201222527","article-title":"Synthesis and preliminary biological evaluation of new heterocyclic carboxamide models","volume":"12","author":"Sweidan","year":"2015","journal-title":"Lett. Drug Des. Dis."},{"key":"10.1016\/j.ejmech.2017.07.038_bib25","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.ejmech.2014.12.002","article-title":"Synthesis, antiproliferative activity, and in silico insights of new 3-benzoylamino-benzo[b]thiophene derivatives","volume":"90","author":"Martorana","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib26","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ejmech.2014.12.038","article-title":"Synthesis and molecular modeling studies of 8-arylpyrido[3\u2032,2\u2032:4,5]thieno[3,2-d]pyrimidin-4-amines as multitarget Ser\/Thr kinases inhibitors","volume":"92","author":"Loidreau","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib27","doi-asserted-by":"crossref","first-page":"92","DOI":"10.4172\/2150-3494.100092","article-title":"Synthesis, antitubercular and antibacterial activities of some quinazolinone analogs substituted with benzothiophene","volume":"6","author":"Rao","year":"2015","journal-title":"Chem. Sci. J."},{"key":"10.1016\/j.ejmech.2017.07.038_bib28","first-page":"1241","article-title":"Synthesis and anticonvulsant activity of new 3'-aryl-7-bromo-spiro[[1]benzothiophene-3,2'-[1,3] thiazolidine]-2,4'-dione derivatives","volume":"26","author":"Zaher","year":"2010","journal-title":"Ori. J. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib29a","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1002\/iub.543","article-title":"Benzothiophene carboxamide derivatives as novel anti-malarials","volume":"63","author":"Banerjee","year":"2011","journal-title":"IUBMB Life"},{"key":"10.1016\/j.ejmech.2017.07.038_bib29b","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1021\/jm301474t","article-title":"Discovery of novel and ligand-efficient inhibitors of plasmodium falciparum and plasmodium vivax N-myristoyltransferase","volume":"56","author":"Rackham","year":"2013","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib30","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1080\/10426500903241713","article-title":"Synthesis, antimicrobial, and anthelmintic activities of some new 3-chlorobenzothiophene-2-carbonylchloride derivatives","volume":"8","author":"Naganagowda","year":"2010","journal-title":"Phosphorus, Sulfur Silicon Relat. Elem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib31","unstructured":"G. Moinet, C. Leriche, M Kergoat, Antidiabetic compounds comprising benzofuran and benzothiophene derivatives. EP1685121 A1. PCT\/EP2004\/012075."},{"key":"10.1016\/j.ejmech.2017.07.038_bib32","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1021\/jm990560c","article-title":"Novel benzofuran and benzothiophene biphenyls as inhibitors of protein tyrosine phosphatase 1B with antihyperglycemic properties","volume":"43","author":"Malamas","year":"2000","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib33","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/jhet.5570180236","article-title":"Chemical constitution and activity of Herbicides","volume":"39","author":"Kennedy","year":"1981","journal-title":"J.\u00a0Heterocycl. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib34","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.nucmedbio.2006.06.006","article-title":"Synthesis and evaluation of benzothiophene derivatives as ligands for imaging beta-amyloid plaques in Alzheimer's disease","volume":"33","author":"Chang","year":"2006","journal-title":"Nucl. Med. Biol."},{"key":"10.1016\/j.ejmech.2017.07.038_bib35","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.ejmech.2014.10.012","article-title":"Radiolabeled bioactive benzoheterocycles for imaging \u03b2-amyloid plaques in Alzheimer's disease","volume":"87","author":"Yang","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib36","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ejmech.2015.04.016","article-title":"Synthesis of a novel class of substituted benzothiophene or benzofuran derivatives as BMP-2 up-regulators and evaluation of the BMP-2-up-regulating effects in\u00a0vitro and the effects on glucocorticoid-induced osteoporosis in rats","volume":"96","author":"Xue","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib37","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.bmcl.2015.12.101","article-title":"Identification of benzothiophene amides as potent inhibitors of human nicotinamide phosphoribosyltransferase","volume":"26","author":"Chen","year":"2016","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2017.07.038_bib38","doi-asserted-by":"crossref","first-page":"6226","DOI":"10.1016\/j.bmcl.2010.08.103","article-title":"Indole- and benzothiophene-based histamine H3 antagonists","volume":"20","author":"Santillan","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2017.07.038_bib39","doi-asserted-by":"crossref","first-page":"3361","DOI":"10.1016\/j.bmcl.2010.04.020","article-title":"Benzothiophene containing Rho kinase inhibitors: efficacy in an animal model of glaucoma","volume":"20","author":"Davis","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2017.07.038_bib40","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1016\/j.bmc.2012.12.035","article-title":"Potent BRAF kinase inhibitors based on 2,4,5-trisubstituted imidazole with naphthyl and benzothiophene 4-substituents","volume":"21","author":"Niculescu-Duvaz","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib41","doi-asserted-by":"crossref","first-page":"4793","DOI":"10.1021\/jm070289w","article-title":"Discovery of a new series of potent and selective linear Tachykinin NK2 receptor antagonists","volume":"50","author":"Fedi","year":"2007","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib42","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1016\/j.bmcl.2009.03.080","article-title":"Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH)","volume":"19","author":"Johnson","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2017.07.038_bib43","doi-asserted-by":"crossref","first-page":"5984","DOI":"10.1021\/jm0497242","article-title":"Building predictive models for protein tyrosine phosphatase 1B inhibitors based on discriminating structural features by reassembling medicinal chemistry building blocks","volume":"47","author":"Yang","year":"2004","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib44","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1021\/jm00083a023","article-title":"Novel benzothiophene-, benzofuran-, and naphthalene carboxamido tetrazoles as potential antiallergy agents","volume":"35","author":"Connor","year":"1992","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib45","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1021\/jm00374a021","volume":"27","author":"Jones","year":"1984","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib46","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1021\/jm020449y","article-title":"Antiestrogens and selective estrogen receptor modulators as multifunctional medicines. 1. receptor interactions","volume":"46","author":"Jordan","year":"2003","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib47","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1021\/jm020450x","article-title":"Antiestrogens and selective estrogen receptor modulators as multifunctional medicines. 2. clinical considerations and new agents","volume":"46","author":"Jordan","year":"2003","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib48","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1124\/dmd.31.11.1352","article-title":"Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by zileuton, a 5-lipoxygenase inhibitor","volume":"31","author":"Lu","year":"2003","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejmech.2017.07.038_bib49","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1021\/jf60161a608","article-title":"Benzo(b)thienyl carbamate insecticides","volume":"17","author":"Kilsheimer","year":"1969","journal-title":"J.\u00a0Agr. Food Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib50a","doi-asserted-by":"crossref","first-page":"4100","DOI":"10.1021\/ol2016093","article-title":"Palladium-catalyzed C-S coupling: access to thioethers, benzo[b]thiophenes, and thieno[3,2-b]thiophenes","volume":"13","author":"Kuhn","year":"2011","journal-title":"Org. Lett."},{"key":"10.1016\/j.ejmech.2017.07.038_bib50b","doi-asserted-by":"crossref","first-page":"6997","DOI":"10.1016\/j.tetlet.2011.10.098","article-title":"Synthesis of benzothiophene derivatives from dilithio reagents, sulfur, and electrophiles via electrophilic cyclization","volume":"52","author":"Wang","year":"2011","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.ejmech.2017.07.038_bib50c","doi-asserted-by":"crossref","first-page":"7481","DOI":"10.1021\/jo9016698","article-title":"Fused ring construction around pyrrole, indole, and related compounds via palladium-catalyzed oxidative coupling with alkynes","volume":"74","author":"Yamashita","year":"2009","journal-title":"J.\u00a0Org. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib50d","doi-asserted-by":"crossref","first-page":"12680","DOI":"10.1021\/ja0280269","article-title":"Iridium-catalyzed reaction of aroyl chlorides with internal alkynes to produce substituted naphthalenes and anthracenes","volume":"124","author":"Yasukawa","year":"2002","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2017.07.038_bib50e","doi-asserted-by":"crossref","first-page":"12386","DOI":"10.1021\/ja075045f","article-title":"Single microwire transistors of oligoarenes by direct solution process","volume":"129","author":"Zhou","year":"2007","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2017.07.038_bib50f","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1021\/ol200336c","article-title":"Nickel-catalyzed cycloadditions of thiophthalic anhydrides with alkynes","volume":"13","author":"Inami","year":"2011","journal-title":"Org. Lett."},{"key":"10.1016\/j.ejmech.2017.07.038_bib50g","doi-asserted-by":"crossref","first-page":"7064","DOI":"10.1002\/anie.200902843","article-title":"Efficient synthesis of benzothiophenes by an unusual palladium-catalyzed vinylic C-S coupling","volume":"48","author":"Bryan","year":"2009","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.ejmech.2017.07.038_bib50h","doi-asserted-by":"crossref","first-page":"6665","DOI":"10.1016\/S0040-4039(03)01632-0","article-title":"An efficient one-pot synthesis of substituted 2-arylbenzo[b]thiophene derivatives","volume":"44","author":"Patel","year":"2003","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.ejmech.2017.07.038_bib51a","doi-asserted-by":"crossref","first-page":"4755","DOI":"10.1021\/ol047993g","article-title":"Palladium-catalyzed intramolecular O-arylation of enolates:\u2009 application to benzo[b]furan synthesis","volume":"6","author":"Willis","year":"2004","journal-title":"Org. Lett."},{"key":"10.1016\/j.ejmech.2017.07.038_bib51b","doi-asserted-by":"crossref","first-page":"11513","DOI":"10.1016\/j.tet.2006.05.004","article-title":"Palladium catalysed intramolecular enolate O-arylation and thio-enolate S-arylation: synthesis of benzo[b]furans and benzo[b]thiophenes","volume":"62","author":"Willis","year":"2006","journal-title":"Tetrahedron"},{"key":"10.1016\/j.ejmech.2017.07.038_bib52a","doi-asserted-by":"crossref","first-page":"4473","DOI":"10.1002\/anie.200601178","article-title":"Gold-catalyzed intramolecular carbothiolation of alkynes: synthesis of 2,3-disubstituted benzothiophenes from (\u03b1-alkoxy alkyl) (ortho-alkynyl phenyl) sulfides","volume":"45","author":"Nakamura","year":"2006","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.ejmech.2017.07.038_bib52b","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1021\/ol8007556","article-title":"Chirality transfer in gold-catalyzed carbothiolation of o-alkynylphenyl 1-arylethyl sulfides","volume":"10","author":"Nakamura","year":"2008","journal-title":"Org. Lett."},{"key":"10.1016\/j.ejmech.2017.07.038_bib53","doi-asserted-by":"crossref","first-page":"7969","DOI":"10.1016\/j.tet.2014.08.049","article-title":"A\u00a0facile one-pot synthesis of benzothiophenes via copper-catalyzed thiolation annulations of o-halostyrenes with NaSH","volume":"70","author":"Wang","year":"2014","journal-title":"Tetrahedron"},{"key":"10.1016\/j.ejmech.2017.07.038_bib54","doi-asserted-by":"crossref","first-page":"3588","DOI":"10.1016\/j.tetlet.2009.03.087","article-title":"p-Toluenesulfonic acid-mediated cyclization of o-(1-alkynyl)anisoles or thioanisoles: synthesis of 2-arylsubstituted benzofurans and benzothiophenes","volume":"50","author":"Jacubert","year":"2009","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.ejmech.2017.07.038_bib55","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.tetlet.2015.12.091","article-title":"Copper-catalyzed synthesis of benzo[b]thiophene-fused imidazopyridines via the cleavage of C-H bond and C-X bond","volume":"57","author":"Huang","year":"2016","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.ejmech.2017.07.038_bib56","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.1021\/acs.joc.5b00032","article-title":"One-pot synthesis of functionalized benzo[b]thiophenes and their hetero-fused analogues via intramolecular copper-catalyzed S-arylation of in situ generated enethiolates","volume":"80","author":"Acharya","year":"2015","journal-title":"J.\u00a0Org. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib57","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1021\/ol400719d","article-title":"Direct benzothiophene formation via oxygen-triggered intermolecular cyclization of thiophenols and alkynes assisted by manganese\/PhCOOH","volume":"15","author":"Liu","year":"2013","journal-title":"Org. Lett."},{"key":"10.1016\/j.ejmech.2017.07.038_bib58","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1021\/jm9509556","article-title":"Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multidrug-resistant gram-positive bacterial infections","volume":"39","author":"Brickner","year":"1996","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib59","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1021\/jm990373e","article-title":"Substituent effects on the antibacterial activity of nitrogen-carbon-linked (azolylphenyl)oxazolidinones with expanded activity against the fastidious gram-negative organisms haemophilus influenzae and moraxella catarrhalis","volume":"43","author":"Genin","year":"2000","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib60","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1080\/17415993.2011.575943","article-title":"Synthesis and antimicrobial activity of some new 2-(3-chloro-1-benzothiophen-2-yl)-3-(substitutedphenyl)- 4-(3H)-quinazolinones derivatives","volume":"32","author":"Naganagowda","year":"2011","journal-title":"J.\u00a0Sulfur Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib61","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.4067\/S0717-97072012000100019","article-title":"Synthesis and antimicrobial activities of benzothiophene derivatives","volume":"57","author":"Naganagowda","year":"2012","journal-title":"J.\u00a0Chil. Chem. Soc."},{"key":"10.1016\/j.ejmech.2017.07.038_bib62","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1080\/17415993.2011.583394","article-title":"Synthesis and biological activity of some more heterocyclic compounds containing benzothiophene moiety","volume":"32","author":"Naganagowda","year":"2011","journal-title":"J.\u00a0Sulfur Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/921857","article-title":"Synthesis and antimicrobial activity of new schiff base compounds containing 2-hydroxy-4-pentadecylbenzaldehyde moiety","author":"Naganagowda","year":"2014","journal-title":"Adv. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib64","doi-asserted-by":"crossref","first-page":"3914","DOI":"10.5012\/bkcs.2011.32.11.3914","article-title":"Synthesis and antimicrobial activity of oxazolone, imidazolone and triazine derivatives containing benzothiophene","volume":"32","author":"Naganagowda","year":"2011","journal-title":"Bull. Korean Chem. Soc."},{"key":"10.1016\/j.ejmech.2017.07.038_bib65","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1080\/10426500802388433","article-title":"Synthesis of benzo[b]thiophene substituted carbamates, ureas, semicarbazides, and pyrazoles and their antimicrobial and analgesic activity","volume":"184","author":"Suresha Kumar","year":"2009","journal-title":"Phosphorus, Sulfur Silicon Relat. Elem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib66","first-page":"6","article-title":"Synthesis and antimicrobial activity of benzothiophene substituted coumarins, pyrimidines and pyrazole as new scaffold","volume":"28","author":"Nagesh","year":"2014","journal-title":"Int. J. Pharm. Sci. Rev. Res."},{"key":"10.1016\/j.ejmech.2017.07.038_bib67","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1080\/10426500903241713","article-title":"Synthesis, antimicrobial, and anthelmintic activities of some new 3-chlorobenzothiophene-2-carbonylchloride derivatives","volume":"185","author":"Naganagowda","year":"2010","journal-title":"Phosphorus, Sulfur Silicon Relat. Elem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib68","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.ejmech.2009.11.015","article-title":"Synthesis, characterization and biological activities of some new benzo[b]thiophene derivatives","volume":"45","author":"Isloor","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib69","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/ardp.19923250213","article-title":"Benzo[b]thiophenes, part I: Synthesis and antimicrobial activity of benzo[b]thienyl-l,3,4-oxadiazole,- 1,2,4-triazolinea, and thiazoline derivatives","volume":"325","author":"AboulWafaa","year":"1992","journal-title":"Arch. Pharm. (Weinheim)"},{"key":"10.1016\/j.ejmech.2017.07.038_bib70","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1155\/2009\/934706","article-title":"Microwave assisted liquid phase synthesis of benzimidazolo benzothiophenes for antimicrobial activity","volume":"6","author":"Kini","year":"2009","journal-title":"E-J. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib71","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1016\/j.ejmech.2009.12.020","article-title":"Synthesis and antimicrobial activities of some new thiazole and pyrazole derivatives based on 4,5,6,7-tetrahydrobenzothiophene moiety","volume":"45","author":"Gouda","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib72","first-page":"247","article-title":"Synthesis of novel 1,3,4-oxadiazole derivatives as potential antimicrobial agents","volume":"67","author":"Chawla","year":"2010","journal-title":"Acta Pol. Pharma. Drug Res."},{"key":"10.1016\/j.ejmech.2017.07.038_bib73","doi-asserted-by":"crossref","first-page":"6827","DOI":"10.1016\/j.bmc.2006.06.035","article-title":"Synthesis and antimicrobial activity studies of orthochlorodiarylamines and heteroaromatic tetracyclic systems in the benzo[b]thiophene series","volume":"14","author":"Queiroz","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib74","doi-asserted-by":"crossref","first-page":"5831","DOI":"10.1016\/j.bmcl.2004.09.038","article-title":"Screening of antimicrobial activity of diarylamines in the 2,3,5-trimethylbenzo[b]thiophene series: a structure-activity evaluation study","volume":"14","author":"Ferreira","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2017.07.038_bib75","doi-asserted-by":"crossref","first-page":"417","DOI":"10.25004\/IJPSDR.2015.070507","article-title":"Synthesis, characterization and antimicrobial evaluation of some tetrahydroquinazoline derivatives of benzo[b]thiophene","volume":"7","author":"Bhatt","year":"2015","journal-title":"Int. J. Pharm. Sci. Drug Res."},{"key":"10.1016\/j.ejmech.2017.07.038_bib76","first-page":"103","article-title":"Synthesis and evaluation of some novel thiophenes as potential antibacterial and mycolytic agents","volume":"3","author":"Srivastava","year":"2011","journal-title":"Der Pharma Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib77","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1007\/s00044-013-0707-0","article-title":"POM analyses of antimicrobial activity of some 2,3-armed 4,5,6,7-tetrahydro-1-benzothiophenes: favourable and unfavourable physico-chemical parameters in design of antibacterial and mycolytic agents","volume":"23","author":"Hadda","year":"2014","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.ejmech.2017.07.038_bib78","doi-asserted-by":"crossref","first-page":"8172","DOI":"10.1016\/j.bmc.2008.07.042","article-title":"Antifungal activity of synthetic di(hetero)arylamines based on the benzo[b]thiophene moiety","volume":"16","author":"Pinto","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib79","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1016\/j.bmcl.2005.03.042","article-title":"Synthesis and antifungal activity of 5-arylamino-4,7-dioxobenzo[b]thiophenes","volume":"15","author":"Ryu","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2017.07.038_bib80","doi-asserted-by":"crossref","first-page":"4482","DOI":"10.1016\/j.bmc.2007.04.023","article-title":"Synthesis and evaluation of new arylbenzo[b]thiophene and diarylthiophene derivatives as inhibitors of the NorA multidrug transport ter of Staphylococcus aureus","volume":"15","author":"Chabert","year":"2007","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib81","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.3390\/ijms13021951","article-title":"Tumor heterogeneity: mechanisms and bases for a reliable application of molecular marker design","volume":"13","author":"Diaz-Cano","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejmech.2017.07.038_bib82","article-title":"Info NIAC","volume":"11","author":"Rain","year":"2009","journal-title":"Int. Health Org."},{"key":"10.1016\/j.ejmech.2017.07.038_bib83","series-title":"Health Day News","author":"Reinberg","year":"2008"},{"key":"10.1016\/j.ejmech.2017.07.038_bib84","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1002\/cmdc.200700104","article-title":"Structure-activity relationships for a family of benzothiophene selective estrogen receptor modulators including raloxifene and arzoxifene","volume":"2","author":"Overk","year":"2007","journal-title":"Chem. Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib85","series-title":"FDA Approves New Uses for Evista","year":"2007"},{"key":"10.1016\/j.ejmech.2017.07.038_bib86","first-page":"397","article-title":"Antineoplastic agents 463. Synthesis of combretastatin A-3 diphosphate prodrugs","volume":"15","author":"Pettit","year":"2000","journal-title":"Anticancer Drugs Des."},{"key":"10.1016\/j.ejmech.2017.07.038_bib87","first-page":"203","article-title":"Antineoplastic agents 429. Syntheses of the combretastatin A-1 and combretastatin B-1 prodrugs","volume":"15","author":"Pettit","year":"2000","journal-title":"Anticancer Drug Des."},{"key":"10.1016\/j.ejmech.2017.07.038_bib88","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1016\/S0003-4975(01)02408-0","article-title":"Combretastatin A-4 prodrug inhibits growth of human non-small cell lung cancer in a murine xenotransplant model","volume":"71","author":"Boehle","year":"2001","journal-title":"Ann. Thorac. Surg."},{"key":"10.1016\/j.ejmech.2017.07.038_bib89","first-page":"185","article-title":"Antineoplastic agents 460. Synthesis of combretastatin A-2 prodrugs","volume":"16","author":"Pettit","year":"2001","journal-title":"Anticancer Drug Des."},{"key":"10.1016\/j.ejmech.2017.07.038_bib90","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/(SICI)1098-1128(199807)18:4<259::AID-MED3>3.0.CO;2-U","article-title":"Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle","volume":"18","author":"Jordan","year":"1998","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.ejmech.2017.07.038_bib91","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nrc1317","article-title":"Microtubules as a target for anticancer drugs","volume":"4","author":"Jordan","year":"2004","journal-title":"Nat. Rev."},{"key":"10.1016\/j.ejmech.2017.07.038_bib92","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1021\/jm070050f","article-title":"Synthesis and biological evaluation of 2- and 3-aminobenzo[b]thiophene derivatives as antimitotic agents and inhibitors of tubulin polymerization","volume":"50","author":"Romagnoli","year":"2007","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib93","doi-asserted-by":"crossref","first-page":"5114","DOI":"10.1016\/j.bmc.2010.05.068","article-title":"Substituted 2-(3\u2019,4\u2019,5\u2019-trimethoxybenzoyl)-benzo[b]thiophene derivatives as potent tubulin polymerization inhibitors","volume":"18","author":"Romagnoli","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib94","doi-asserted-by":"crossref","first-page":"5781","DOI":"10.1016\/j.ejmech.2010.09.038","article-title":"Synthesis and biological evaluation of 2-(3\u2019, 4\u2019, 5\u2019-trimethoxybenzoyl)-3-aryl\/arylaminobenzo[b]thiophene derivatives as a novel class of antiproliferative agents","volume":"45","author":"Romagnoli","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib95","doi-asserted-by":"crossref","first-page":"7906","DOI":"10.1021\/jm058012o","article-title":"Design, synthesis, and biological evaluation of hybrid molecules containing r-methylene-\u00e7-butyrolactones and r-bromoacryloyl moieties","volume":"48","author":"Romagnoli","year":"2005","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib96","doi-asserted-by":"crossref","first-page":"8811","DOI":"10.1021\/jo0004761","article-title":"Preparation of new anti-tubulin ligands through a dual-mode, addition-elimination reaction to a bromo-substituted \u03b1,\u03b2-unsaturated sulfoxide","volume":"65","author":"Chen","year":"2000","journal-title":"J.\u00a0Org. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib97a","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1039\/c3md00130j","article-title":"Synthesis and evaluation of a series of benzothiophene acrylonitrile analogs as anticancer agents","volume":"4","author":"Penthala","year":"2013","journal-title":"Med. Chem. Comm."},{"key":"10.1016\/j.ejmech.2017.07.038_bib97b","first-page":"2763","volume":"vol. 25","author":"Penthala","year":"2015"},{"key":"10.1016\/j.ejmech.2017.07.038_bib98","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1021\/ol0067179","article-title":"A\u00a0novel palladium-mediated coupling approach to 2,3-disubstituted benzo[b]thiophenes and its application to the synthesis of tubulin binding agents","volume":"3","author":"Flynn","year":"2001","journal-title":"Org. Lett."},{"key":"10.1016\/j.ejmech.2017.07.038_bib99","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.2174\/1568026033451727","article-title":"Estrogen receptor modulators: relationships of ligand structure, receptor affinity and functional activity","volume":"3","author":"Wallace","year":"2003","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib100","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/j.bmcl.2004.12.074","article-title":"Benzothiophenes containing a piperazine side chain as selective ligands for the estrogen receptor \u03b1 and their bioactivities in\u00a0vivo","volume":"15","author":"Yang","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2017.07.038_bib101","doi-asserted-by":"crossref","first-page":"5124","DOI":"10.1016\/j.bmcl.2005.08.084","article-title":"Estrogen receptor ligands. Part 14: application of novel antagonist side chains to existing platforms","volume":"15","author":"Blizzard","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2017.07.038_bib102","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1021\/bc800435m","article-title":"Comparative methods for analysis of protein covalent modification by electrophilic quinoids formed from xenobiotics","volume":"20","author":"Yu","year":"2009","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib103","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1021\/jm9606352","article-title":"Structure-activity relationships of selective estrogen receptor modulators: modifications to the 2-arylbenzothiophene core of raloxifene","volume":"40","author":"Grese","year":"1997","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib104","doi-asserted-by":"crossref","first-page":"5103","DOI":"10.1016\/j.bmcl.2004.07.072","article-title":"Benzothiophene and naphthalene derived constrained SERMs","volume":"14","author":"Wallace","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2017.07.038_bib105","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1002\/cmdc.200700104","article-title":"Structure-activity relationships for a family of benzothiophene selective estrogen receptor modulators including raloxifene and arzoxifene","volume":"2","author":"Overk","year":"2007","journal-title":"Chem. Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib106","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.ctrv.2005.12.006","article-title":"Histone deacetylase inhibitors: multifunctional anticancer agents","volume":"32","author":"Liu","year":"2006","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.ejmech.2017.07.038_bib107","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.2174\/092986706776360905","article-title":"Chemistry and biology of chromatin remodeling agents: state of art and future perspectives of HDAC inhibitors","volume":"13","author":"Rodriquez","year":"2006","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib108","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/nbt1272","article-title":"Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug","volume":"25","author":"Marks","year":"2007","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ejmech.2017.07.038_bib109","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s13148-010-0012-4","article-title":"Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy","volume":"1","author":"Wagner","year":"2010","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.ejmech.2017.07.038_bib110","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/nrd2133","article-title":"Anticancer activities of histone deacetylase inhibitors","volume":"5","author":"Bolden","year":"2006","journal-title":"Nat. Rev. Drug Disc."},{"key":"10.1016\/j.ejmech.2017.07.038_bib111","doi-asserted-by":"crossref","first-page":"4091","DOI":"10.1016\/j.bmcl.2013.05.053","article-title":"Benzofused hydroxamic acids: useful fragments for the preparation of histone deacetylase inhibitors. Part 1: hit identification","volume":"23","author":"Marastoni","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2017.07.038_bib112","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/j.bmcl.2015.02.007","article-title":"Benzofused hydroxamic acids: useful fragments for the preparation of histone deacetylase inhibitors. Part 2: 7-Fluorobenzothiophenes and benzofurans","volume":"25","author":"Marastoni","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2017.07.038_bib113","doi-asserted-by":"crossref","first-page":"9868","DOI":"10.1039\/C5CC03295D","article-title":"Synthesis of benzothiophene-based hydroxamic acids as potent and selective HDAC6 inhibitors","volume":"51","author":"Vreese","year":"2015","journal-title":"Chem. Commun."},{"key":"10.1016\/j.ejmech.2017.07.038_bib114","doi-asserted-by":"crossref","first-page":"4562","DOI":"10.1016\/j.bmcl.2007.05.091","article-title":"Benzo[b]thiophene-based histone deacetylase inhibitors","volume":"17","author":"Witter","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2017.07.038_bib115","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.bmcl.2015.12.101","article-title":"Identification of benzothiophene amides as potent inhibitors of human nicotinamide phosphoribosyltransferase","volume":"26","author":"Chen","year":"2016","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2017.07.038_bib116","doi-asserted-by":"crossref","first-page":"3361","DOI":"10.1016\/j.bmcl.2010.04.020","article-title":"Benzothiophene containing Rho kinase inhibitors: efficacy in an animal model of glaucoma","volume":"20","author":"Davis","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2017.07.038_bib117","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1021\/jm801573v","article-title":"Novel derivatives of pyridylbenzo[b]thiophene-2-carboxamides and benzo[b]thieno[2,3-c]naphthyridin-2-ones: minor structural variations provoke major differences of antitumor action mechanisms","volume":"52","author":"Ester","year":"2009","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib118","doi-asserted-by":"crossref","first-page":"5412","DOI":"10.1021\/om9003835","article-title":"Synthesis and characterization of new organometallic benzo[b]thiophene derivatives with potential antitumor properties","volume":"28","author":"Ferreira","year":"2009","journal-title":"Organomet"},{"key":"10.1016\/j.ejmech.2017.07.038_bib119","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1007\/s10593-013-1259-4","article-title":"Design, synthesis, and cytotoxicity of pyridine, pyrazole, and thiazole derivatives derived from n-alkyl-4,5,6,7-tetrahydro-1-benzothiophene","volume":"49","author":"Kamel","year":"2013","journal-title":"Chem. Heterocyc. Comp."},{"key":"10.1016\/j.ejmech.2017.07.038_bib120","first-page":"545","article-title":"Cytotoxicity of novel 4,5,6,7-tetrahydrobenzo[b]thiophene derivatives and their uses as anti-leishmanial agents","volume":"2","author":"Mohareb","year":"2013","journal-title":"Eur. Chem. Bull."},{"key":"10.1016\/j.ejmech.2017.07.038_bib121","doi-asserted-by":"crossref","first-page":"126","DOI":"10.4236\/ijoc.2012.22020","article-title":"The reaction of 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophenes with benzoyl-Isothiocyanate: synthesis of annulated thiophene derivatives and their antitumor evaluations","volume":"2","author":"El-Sharkawy","year":"2012","journal-title":"Inter. J. Org. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib122","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1021\/acsmedchemlett.5b00278","article-title":"Potent, specific CDK8 kinase inhibitors Lack CDK8- dependent antiproliferative activity in HCT-116 colon cancer cell line","volume":"7","author":"Koehler","year":"2016","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2017.07.038_bib123","doi-asserted-by":"crossref","first-page":"5044","DOI":"10.1021\/jm300505h","article-title":"Novel substituted benzothiophene and thienothiophene carboxanilides and quinolones: synthesis, photochemical synthesis, DNA-binding properties, antitumor evaluation and 3D-derived QSAR analysis","volume":"55","author":"Aleksi\u0107","year":"2012","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib124","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.ejmech.2013.11.010","article-title":"Anilides and quinolones with nitrogen-bearing substituents from benzothiophene and thienothiophene series: synthesis, photochemical synthesis, cytostatic evaluation, 3D-derived QSAR analysis and DNA-binding properties","volume":"71","author":"Aleksic","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib125","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1002\/cmdc.201200307","article-title":"Discovery of a new class of liver receptor homolog-1 (LRH-1) antagonists: virtual screening, synthesis and biological evaluation","volume":"7","author":"Rey","year":"2012","journal-title":"Chem. Med. Chem"},{"key":"10.1016\/j.ejmech.2017.07.038_bib126","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1016\/j.bmc.2011.01.014","article-title":"Structure-activity relationships in glycosylated 2-phenyl-indoles, 2-phenyl-benzo[b]thiophenes and 2-phenyl-benzo[b]furans as DNA binding and potential antitumor agents","volume":"19","author":"Shi","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib127","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.3390\/ph4111450","article-title":"Anti-inflammatory drug design using a molecular hybridization approach","volume":"4","author":"Bosquesi","year":"2011","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.ejmech.2017.07.038_bib128","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1097\/BOR.0b013e328349c2b1","article-title":"Inflammation in osteoarthritis","volume":"23","author":"Goldring","year":"2011","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.ejmech.2017.07.038_bib129","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.2165\/11595870-000000000-00000","article-title":"Current and emerging drug treatment options for Alzheimer's disease: a systematic review","volume":"71","author":"Herrmann","year":"2011","journal-title":"Drugs"},{"key":"10.1016\/j.ejmech.2017.07.038_bib130","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1080\/14756360500480418","article-title":"Synthesis and anti-inflammatory activity of some selected aminothiophene analogs","volume":"21","author":"Mohammed Khan","year":"2006","journal-title":"J.\u00a0Enzy. Inhib. Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib131","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1007\/s00044-013-0900-1","article-title":"Synthesis and pharmacological evaluation of novel thienopyrimidine and triazolothienopyrimidine derivatives","volume":"23","author":"Mulla","year":"2014","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.ejmech.2017.07.038_bib132","article-title":"Synthesis of 3-amino-2-methyl\/ethyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one and its Schiff bases as possible antimicrobial and non-sterodial antiinflammtory agents","volume":"45B","author":"Narayana","year":"2006","journal-title":"Ind. J. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib133","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/iub.1252","article-title":"Evaluation of benzothiophene carboxamides as analgesics and anti-inflammatory agents","volume":"66","author":"Pathak","year":"2014","journal-title":"IUBMB Life"},{"key":"10.1016\/j.ejmech.2017.07.038_bib134","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1002\/iub.553","article-title":"Benzothiophene carboxamide derivatives as inhibitors of plasmodium falciparum enoyl-ACP reductase","volume":"63","author":"Banerjee","year":"2011","journal-title":"IUBMB Life"},{"key":"10.1016\/j.ejmech.2017.07.038_bib135","series-title":"Sherris Medical Microbiology","year":"2004"},{"key":"10.1016\/j.ejmech.2017.07.038_bib136","unstructured":"World Health Organization WHO, http:\/\/whqlibdoc.who.int\/publication\/2010\/9789241564069_eng.pdf."},{"key":"10.1016\/j.ejmech.2017.07.038_bib137","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/S0140-6736(03)14333-4","article-title":"Tuberculosis","volume":"362","author":"Frieden","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.ejmech.2017.07.038_bib138","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7717\/peerj.612","article-title":"Synthesis and anti-tubercular activity of 3-substituted benzo[b]thiophene-1,1-dioxides","volume":"2","author":"Chandrasekera","year":"2014","journal-title":"Peer J."},{"key":"10.1016\/j.ejmech.2017.07.038_bib139","first-page":"586","article-title":"QSAR studies on 4-thiazolifdinones and 2-azetidinones bearing benzothiohene nucleus as potential anti-tubercular agents","volume":"47B","author":"Narute","year":"2008","journal-title":"Ind. J. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib140","first-page":"139","article-title":"Synthesis of some new imidazolones and 1,2,4-triazoles bearing benzo[b]thiophene nucleus as antimicrobial agents","volume":"16","author":"Thaker","year":"2005","journal-title":"J.\u00a0Sci. Islam. Repub. Iran."},{"key":"10.1016\/j.ejmech.2017.07.038_bib141","first-page":"33","article-title":"Synthesis of some new thiosemicarbazide and 1,3,4-thiadiazole heterocycles bearing benzo[b]thiophene nucleus as a potent antitubercular and antimicrobial agents","volume":"16","author":"Vasoya","year":"2005","journal-title":"J.\u00a0Sci. Islam. Repub. Iran."},{"key":"10.1016\/j.ejmech.2017.07.038_bib142","first-page":"709","article-title":"Synthesis of some new thiosemicarbazide and 1,2,4-triazoles heterocycles bearing thiophene nucleus as a potent antitubercular and antimicrobial agents","volume":"84","author":"Vasoya","year":"2007","journal-title":"J.\u00a0Ind. Chem. Soc."},{"key":"10.1016\/j.ejmech.2017.07.038_bib143","first-page":"410","article-title":"Synthesis and pharmacological evaluation of 2-(3',5'-dichlorobenzo[b]thiophen-2'-yl)-5-arylamino-1,3,4-thiadiazoles","volume":"Sec B 44B","author":"Thaker","year":"2005","journal-title":"Ind. J. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib144","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.etap.2014.11.003","article-title":"Anticedants and natural prevention of environmental toxicants induced accelerated aging of skin","volume":"39","author":"Tanuja","year":"2014","journal-title":"Environ. Toxicil. Pharmacol."},{"key":"10.1016\/j.ejmech.2017.07.038_bib145","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/j.radphyschem.2007.01.002","article-title":"Anti-aging and aging factors in life. The role of free radicals","volume":"76","author":"Getoff","year":"2007","journal-title":"Radiat. Phys. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib146","doi-asserted-by":"crossref","first-page":"228","DOI":"10.4172\/2161-0444.1000143","article-title":"Synthesis and antioxidant activity of novel series of naphthoquinone derivatives attached to benzothiophene moiety","volume":"3","author":"Gouda","year":"2013","journal-title":"Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib147","doi-asserted-by":"crossref","first-page":"644","DOI":"10.5155\/eurjchem.5.4.644-651.1125","article-title":"Synthesis and antioxidant evaluation of novel sophisticated carboxamides based on 3-(ethoxycarbonyl)-4, 5, 6, 7-tetrahydro-1-benzothiophen-2-amine","volume":"5","author":"Gouda","year":"2014","journal-title":"Eur. J. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib148","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/j.bmcl.2005.11.035","article-title":"Evaluation of the antioxidant properties of diarylamines in the benzo[b]thiophene series by free radical scavenging activity and reducing power","volume":"16","author":"Ferreira","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2017.07.038_bib149","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1016\/j.bmc.2006.11.035","article-title":"Synthesis and antioxidant activity evaluation of new 7-aryl or 7-heteroarylamino-2,3-dimethylbenzo[b]thiophenes obtained by Buchwald-Hartwig C-N cross-coupling","volume":"15","author":"Queiroz","year":"2007","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib150","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.molstruc.2014.06.039","article-title":"Synthesis, spectroscopic characterization, electrochemistry and biological evaluation of some metal (II) complexes with ONO donor ligand containing benzo[b]thiophene and coumarin moieties","volume":"1074","author":"Mahendra Raj","year":"2014","journal-title":"J.\u00a0Mol. Struct."},{"key":"10.1016\/j.ejmech.2017.07.038_bib151","first-page":"83","article-title":"Synthesis and evaluation of antioxidant activities of novel quinazolinone derivatives","volume":"2","author":"Saravanan","year":"2010","journal-title":"Int. J. Pharm. Sci."},{"key":"10.1016\/j.ejmech.2017.07.038_bib152","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1056\/NEJM200106073442306","article-title":"AIDS-the first 20 years","volume":"344","author":"Sepkowitz","year":"2001","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.ejmech.2017.07.038_bib153","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1016\/j.bmc.2011.01.047","article-title":"Synthesis, biological evaluation and 3D-QSAR studies of 3-keto salicylic acid chalcones and related amides as novel HIV-1 integrase inhibitors","volume":"19","author":"Sharma","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib154","doi-asserted-by":"crossref","first-page":"6642","DOI":"10.1016\/j.bmcl.2012.08.108","article-title":"Anti-HIV-1 activity of resveratrol derivatives and synergistic inhibition of HIV-1 by the combination of resveratrol and decitabine","volume":"22","author":"Clouser","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2017.07.038_bib155","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.1016\/j.bmcl.2012.02.046","article-title":"Synthesis and biological evaluation of novel small non-peptidic HIV-1 PIs: the benzothiophene ring as an effective moiety","volume":"22","author":"Chiummiento","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2017.07.038_bib156","doi-asserted-by":"crossref","first-page":"3034","DOI":"10.1016\/j.bmcl.2006.02.049","article-title":"New HIV-1 reverse transcriptase inhibitors based on a tricyclic benzothiophene scaffold: synthesis, resolution, and inhibitory activity","volume":"16","author":"Krajewski","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2017.07.038_bib157","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1111\/j.1471-4159.2006.03989.x","article-title":"Molecular mechanisms for Alzheimer's disease: implications for neuroimaging and therapeutics","volume":"97","author":"Masters","year":"2006","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib158","series-title":"World Alzheimer Report 2013: Journey of Caring - an Analysis of Long-term Care for Dementia","author":"Prince","year":"2013"},{"key":"10.1016\/j.ejmech.2017.07.038_bib159","doi-asserted-by":"crossref","first-page":"243","DOI":"10.5012\/bkcs.2003.24.2.243","article-title":"Design and synthesis of phenyl boronic acids and benzothiophenones as anticholinesterases","volume":"24","author":"Lee","year":"2003","journal-title":"Bull. Korean Chem. Soc."},{"key":"10.1016\/j.ejmech.2017.07.038_bib160","doi-asserted-by":"crossref","first-page":"377","DOI":"10.4172\/2161-0444.1000373","article-title":"Heterocycles for alzheimer disease: 4- and 5-substituted benzothiophenes as starting scaffold in the construction of potential new inhibitors of BACE 1","volume":"6","author":"Funicello","year":"2016","journal-title":"Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib161","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1016\/j.bmcl.2013.01.122","article-title":"A\u00a0one-pot domino synthesis and discovery of highly functionalized dihydrobenzo[b]thiophenes as AChE inhibitors","volume":"23","author":"Jeyachandran","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2017.07.038_bib162","doi-asserted-by":"crossref","first-page":"7217","DOI":"10.3390\/molecules17067217","article-title":"Synthesis and biological evaluation of thiophene derivatives as acetylcholinesterase inhibitors","volume":"17","author":"Ismail","year":"2012","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2017.07.038_bib163","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.nucmedbio.2006.06.006","article-title":"Synthesis and evaluation of benzothiophene derivatives as ligands for imaging \u03b2-amyloid plaques in Alzheimer's disease","volume":"33","author":"Chang","year":"2006","journal-title":"Nuc. Med. Bio"},{"key":"10.1016\/j.ejmech.2017.07.038_bib164","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.2337\/diacare.27.5.1047","article-title":"Global prevalence of diabetes: estimates for the year 2000 and projections for 2030","volume":"27","author":"Wild","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.ejmech.2017.07.038_bib165","doi-asserted-by":"crossref","first-page":"44","DOI":"10.2337\/diaclin.30.2.44","article-title":"The ideal diabetes therapy: what will it look like? how close are we?","volume":"30","author":"Rotenstein","year":"2012","journal-title":"Clin. Diabetes"},{"key":"10.1016\/j.ejmech.2017.07.038_bib166","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/s40265-014-0204-x","article-title":"Ipragliflozin: first global approval","volume":"74","author":"Poole","year":"2014","journal-title":"Drugs"},{"key":"10.1016\/j.ejmech.2017.07.038_bib167","doi-asserted-by":"crossref","first-page":"3263","DOI":"10.1016\/j.bmc.2012.03.051","article-title":"Discovery of ipragliflozin (ASP1941): a novel C-glucoside with benzothiophene structure as a potent and selective sodium glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes mellitus","volume":"20","author":"Imamura","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib168","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3109\/14756360903179369","article-title":"The effect of substituted thiophene and benzothiophene derivates on PPAR\u03b3 expression and glucose metabolism","volume":"25","author":"Shao","year":"2010","journal-title":"J.\u00a0Enzy. Inhib. Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib169","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1021\/jm00081a006","article-title":"Potent, orally active aldose reductase inhibitors related to Zopolrestat: surrogates for benzothiazole side chain","volume":"35","author":"Mylari","year":"1992","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib170","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1021\/jm501484b","article-title":"Design and synthesis of potent and multifunctional aldose reductase inhibitors based on quinoxalinones","volume":"58","author":"Qin","year":"2015","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib171","series-title":"Preparation of Benzothiophene Derivatives as GPR40 Agonists for the Treatment of Type II Diabetes","author":"Kuo","year":"2016"},{"key":"10.1016\/j.ejmech.2017.07.038_bib172","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1016\/S0960-894X(00)00430-3","article-title":"Synthesis and biological evaluation of novel piperidine carboxamide derived calpain inhibitors","volume":"10","author":"Lubisch","year":"2000","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2017.07.038_bib173","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.ejphar.2015.07.005","article-title":"A\u00a0novel GABAA alpha 5 receptor inhibitor with therapeutic potential","author":"Ling","year":"2015","journal-title":"Eur. J. Pharm."},{"key":"10.1016\/j.ejmech.2017.07.038_bib174","first-page":"1241","article-title":"Synthesis and anticonvulsant activity of new 3'-aryl-7-bromo-spiro[[1]benzothiophene-3,2'-[1,3]thiazolidine]-2,4'-dione derivatives","volume":"26","author":"Zaher","year":"2010","journal-title":"Orient. J. Chem."},{"key":"10.1016\/j.ejmech.2017.07.038_bib175","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1016\/j.bmcl.2010.02.057","article-title":"Design, synthesis and in\u00a0vitro\/in\u00a0vivo evaluation of orally bioavailable prodrugs of a catechol-O-methyltransferase inhibitor","volume":"20","author":"Rautio","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2017.07.038_bib176","doi-asserted-by":"crossref","first-page":"3923","DOI":"10.1016\/j.bmc.2009.04.031","article-title":"Investigation of various N-heterocyclic substituted piperazine versions of 5\/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol: effect on affinity and selectivity for dopamine D3 receptor","volume":"17","author":"Brown","year":"2009","journal-title":"Bioorg. Med. Chem."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523417305603?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523417305603?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T13:26:37Z","timestamp":1750771597000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523417305603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":187,"alternative-id":["S0223523417305603"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2017.07.038","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An overview of benzo[b]thiophene-based medicinal chemistry","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2017.07.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}