{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:07:45Z","timestamp":1791472065441,"version":"4.3.4"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.ejmech.2017.08.011","type":"journal-article","created":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T12:51:24Z","timestamp":1505220684000},"page":"305-320","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["New chemotype of selective and potent inhibitors of human delta 24-dehydrocholesterol reductase"],"prefix":"10.1016","volume":"140","author":[{"given":"Christoph","family":"M\u00fcller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Hemmers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Bartl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alois","family":"Plodek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"K\u00f6rner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6907-6455","authenticated-orcid":false,"given":"Valbona","family":"Mirakaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1684-1894","authenticated-orcid":false,"given":"Martin","family":"Giera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0009-8629","authenticated-orcid":false,"given":"Franz","family":"Bracher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2017.08.011_bib1","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s10337-014-2796-4","article-title":"Analysis and experimental inhibition of distal cholesterol biosynthesis","volume":"78","author":"Giera","year":"2014","journal-title":"Chromatographia"},{"key":"10.1016\/j.ejmech.2017.08.011_bib2","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1016\/j.bmc.2013.01.041","article-title":"Stereoselective synthesis of a new class of potent and selective inhibitors of human \u03948,7-sterol Isomerase","volume":"21","author":"K\u00f6nig","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2017.08.011_bib3","doi-asserted-by":"crossref","first-page":"6423","DOI":"10.1021\/cr200021m","article-title":"Biosynthesis of cholesterol and other sterols","volume":"111","author":"Nes","year":"2011","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejmech.2017.08.011_bib4","doi-asserted-by":"crossref","first-page":"e07999","DOI":"10.7554\/eLife.07999","article-title":"Flux analysis of cholesterol biosynthesis in\u00a0vivo reveals multiple tissue and cell-type specific pathways","volume":"4","author":"Mitsche","year":"2015","journal-title":"eLife"},{"key":"10.1016\/j.ejmech.2017.08.011_bib5","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1042\/bj3260609","article-title":"Cholesterol biosynthesis from lanosterol: development of a novel assay method and characterization of rat liver microsomal lanosterol delta24-reductase","volume":"326","author":"Bae","year":"1997","journal-title":"Biochem. J."},{"key":"10.1016\/j.ejmech.2017.08.011_bib6","doi-asserted-by":"crossref","first-page":"R75","DOI":"10.1093\/hmg\/ddg072","article-title":"Disorders of cholesterol biosynthesis: prototypic metabolic malformation syndrome","volume":"12","author":"Herman","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ejmech.2017.08.011_bib7","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1038\/ejhg.2011.74","article-title":"The desmosterolosis phenotype: spasticity, microcephaly and micrognathia with agenesis of corpus callosum and loss of white matter","volume":"29","author":"Zolotushko","year":"2011","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.ejmech.2017.08.011_bib8","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.plipres.2013.09.002","article-title":"Desmosterol and DHCR24: unexpected new directions for a terminal step in cholesterol synthesis","volume":"52","author":"Zerenturk","year":"2013","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.ejmech.2017.08.011_bib9","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nchembio.1714","article-title":"Sterol metabolism controls TH17 differentiation by generating endogenous ROR\u03b3 agonists","volume":"11","author":"Hu","year":"2015","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.ejmech.2017.08.011_bib10","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.jhep.2010.12.011","article-title":"Augumentation of DHCR24 expression by hepatitis C virus infection facilitates viral replication in hepatocytes","volume":"55","author":"Takano","year":"2011","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.ejmech.2017.08.011_bib11","doi-asserted-by":"crossref","first-page":"6896","DOI":"10.1021\/ja207391q","article-title":"Lipid metabolite profiling identifies desmosterol metabolism as a new antiviral target for hepatitis C virus","volume":"134","author":"Rodgers","year":"2012","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2017.08.011_bib12","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.cell.2012.06.054","article-title":"Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses","volume":"151","author":"Spann","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.ejmech.2017.08.011_bib13","first-page":"494","article-title":"Cataracts produced by triparanol (MER-29)","volume":"65","author":"Kirby","year":"1967","journal-title":"Trans. Am. Ophthalmol. Soc."},{"key":"10.1016\/j.ejmech.2017.08.011_bib14","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.pharmthera.2010.03.007","article-title":"Perspectives of the non-statin hypolipidemic agents","volume":"127","author":"Rozman","year":"2010","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejmech.2017.08.011_bib15","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/BF00684773","article-title":"Effects of triparanol and 20,25-diazacholesterol in CNS of rat: morphological and biochemical studies","volume":"29","author":"Suzuki","year":"1974","journal-title":"Acta Neuropath."},{"key":"10.1016\/j.ejmech.2017.08.011_bib16","first-page":"1","article-title":"Trifluoperazine for schizophrenia","author":"Marques","year":"2004","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.ejmech.2017.08.011_bib17","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1016\/0006-2952(82)90104-6","article-title":"Interactions of drugs with calmodulin. Biochemical, pharmacological and clinical implications","volume":"31","author":"Weiss","year":"1982","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejmech.2017.08.011_bib18","first-page":"3696","article-title":"Enhancement of sensivity to adriamycin in resistant P388 leukemia by the calmodulin inhibitor trifluoperazine","volume":"43","author":"Ganapathi","year":"1983","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejmech.2017.08.011_bib19","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1016\/j.bbamcr.2013.01.008","article-title":"A\u00a0General framework to characterize inhibitors of calmodulin: use of calmodulin inhibitors to study the interaction between calmodulin and its calmodulin binding domains","volume":"1933","author":"Audran","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejmech.2017.08.011_bib20","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/BF02533989","article-title":"Calmodulin antagonists suppress cholesterol synthesis by inhibiting sterol delta24 reductase","volume":"22","author":"Filipovic","year":"1987","journal-title":"Lipids"},{"key":"10.1016\/j.ejmech.2017.08.011_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.coph.2012.07.001","article-title":"Post-lanosterol biosynthesis of cholesterol and cancer","volume":"12","author":"Lasunci\u00f3n","year":"2012","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.ejmech.2017.08.011_bib22","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s11745-009-3305-7","article-title":"Cholesterol synthesis inhibitor U18666A and the role of sterol metabolism and trafficking in numerous pathophysiological processes","volume":"44","author":"Cenedella","year":"2009","journal-title":"Lipids"},{"key":"10.1016\/j.ejmech.2017.08.011_bib23","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/BF02534300","article-title":"The squalene-2,3-epoxide cyclase as a model for the development of new drugs","volume":"21","author":"Cattel","year":"1986","journal-title":"Lipids"},{"key":"10.1016\/j.ejmech.2017.08.011_bib24","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1002\/iub.522","article-title":"Potential role of nonstatin cholesterol lowering agents","volume":"63","author":"Trapani","year":"2011","journal-title":"IUBMB Life"},{"key":"10.1016\/j.ejmech.2017.08.011_bib25","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1021\/jm01241a014","article-title":"Hypochesterolemic agents. III. N-methyl-N-(dialkylamino)alkyl-17\u03b2-aminoandrost-5-en-3\u03b2-ol","volume":"5","author":"Counsell","year":"1962","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2017.08.011_bib26","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/BF02533023","article-title":"Azasteroids: potent inhibitors of insect molting and metamorphosis","volume":"7","author":"Svoboda","year":"1972","journal-title":"Lipids"},{"key":"10.1016\/j.ejmech.2017.08.011_bib27","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/BF02570897","article-title":"Reduction of blood and liver cholesterol in the rat by straight branched chain alkyl amines","volume":"12","author":"Svoboda","year":"1977","journal-title":"Lipids"},{"key":"10.1016\/j.ejmech.2017.08.011_bib28","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1126\/science.153.3733.312","article-title":"Myotonic response induced by inhibitors of cholesterol biosynthesis","volume":"153","author":"Winer","year":"1966","journal-title":"Science"},{"key":"10.1016\/j.ejmech.2017.08.011_bib29","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1194\/jlr.M800376-JLR200","article-title":"Synthetic LXR agonist attenuates plaque formation in apoE-\/- mice without inducing liver steatosis and hypertriglyceridemia","volume":"50","author":"Kratzer","year":"2009","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.ejmech.2017.08.011_bib30","doi-asserted-by":"crossref","first-page":"285","DOI":"10.2174\/138920111794295774","article-title":"Synthetic LXR agonist suppresses endogenous cholesterol biosynthesis and efficiently lowers plasma cholesterol","volume":"12","author":"Pfeifer","year":"2011","journal-title":"Curr. Pharm. Biotechnol."},{"key":"10.1016\/j.ejmech.2017.08.011_bib31","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.steroids.2007.04.005","article-title":"Fast and easy in\u00a0vitro screening assay for cholesterol biosynthesis inhibitors in the post-squalene pathway","volume":"72","author":"Giera","year":"2007","journal-title":"Steroids"},{"key":"10.1016\/j.ejmech.2017.08.011_bib32","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.steroids.2007.10.015","article-title":"Lathosterol side chain amides \u2013 a new class of human lathosterol oxidase inhibitors","volume":"73","author":"Giera","year":"2008","journal-title":"Steroids"},{"key":"10.1016\/j.ejmech.2017.08.011_bib33","doi-asserted-by":"crossref","first-page":"7614","DOI":"10.1021\/jm3006096","article-title":"A\u00a0new class of selective and potent 7-dehydrocholesterol reductase inhibitors","volume":"55","author":"Horling","year":"2012","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2017.08.011_bib34","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ejmech.2015.12.025","article-title":"Arylpiperidines as a new class of oxidosqualene cyclase inhibitors","volume":"109","author":"Keller","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2017.08.011_bib35","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.steroids.2013.02.006","article-title":"A\u00a0convenient cellular assay for target identification and selective potency determination of quantification of ergosterol biosynthesis","volume":"78","author":"M\u00fcller","year":"2013","journal-title":"Steroids"},{"key":"10.1016\/j.ejmech.2017.08.011_bib36","doi-asserted-by":"crossref","first-page":"8123","DOI":"10.1016\/j.bmc.2009.09.037","article-title":"Side chain azasteroids and thiasteroids as sterol methyltransferase inhibitors in ergosterol biosynthesis","volume":"17","author":"Renard","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2017.08.011_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.steroids.2015.05.004","article-title":"Fungal sterol C22-desaturase is not an antimycotic target as shown by selective inhibitors and testing on clinical isolates","volume":"101","author":"M\u00fcller","year":"2015","journal-title":"Steroids"},{"key":"10.1016\/j.ejmech.2017.08.011_bib38","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1021\/jo00211a028","article-title":"Zinc-modified cyanoborohydride as a selective reducing agent","volume":"50","author":"Kim","year":"1985","journal-title":"J.\u00a0Org. Chem."},{"key":"10.1016\/j.ejmech.2017.08.011_bib39","doi-asserted-by":"crossref","first-page":"5561","DOI":"10.1021\/jo0505829","article-title":"Intramolecular diels-alder reactions of ester-linked 1,3,8-nonatrienes","volume":"70","author":"Cayzer","year":"2005","journal-title":"J.\u00a0Org. Chem."},{"key":"10.1016\/j.ejmech.2017.08.011_bib40","unstructured":"W. Guex, M. Montavon, Unsaturated cyclic ketones and esters and processes for preparing same, U.S. Patent 3,057,913, October 9, 1962."},{"key":"10.1016\/j.ejmech.2017.08.011_bib41","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1002\/hlca.19740570330","article-title":"Vitamin D3 metabolites I. Synthesis of 25-hydroxycholestero1","volume":"57","author":"Partridge","year":"1974","journal-title":"Helv. Chim. Acta"},{"key":"10.1016\/j.ejmech.2017.08.011_bib42","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1002\/hlca.19810640621","article-title":"An efficient procedure for preparing 1\u03b1,3\u03b2-dihydroxy-\u03945-steroids by reduction of 1\u03b1,2\u03b1-epoxy-4,6-dien-3-ones with lithium in ammonia","volume":"64","author":"F\u00fcrst","year":"1981","journal-title":"Helv. Chim. Acta"},{"key":"10.1016\/j.ejmech.2017.08.011_bib43","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J.\u00a0Immunol. Methods"},{"key":"10.1016\/j.ejmech.2017.08.011_bib44","series-title":"Hydrolysis in Drug and Prodrug Metabolism. Chemistry, Biochemistry, and Enzymology","first-page":"455","article-title":"Prodrugs of active alcohols and phenols","author":"Testa","year":"2003"},{"key":"10.1016\/j.ejmech.2017.08.011_bib45","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S1388-1981(00)00138-4","article-title":"Sterol methyl transferase: enzymology and inhibition","volume":"1529","author":"Nes","year":"2000","journal-title":"Biochim. Biophys. Acta"}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523417306141?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523417306141?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,27]],"date-time":"2018-08-27T14:57:18Z","timestamp":1535381838000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523417306141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":45,"alternative-id":["S0223523417306141"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2017.08.011","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"New chemotype of selective and potent inhibitors of human delta 24-dehydrocholesterol reductase","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2017.08.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}