{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:56:56Z","timestamp":1792173416130,"version":"4.4.0"},"reference-count":113,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Major Scientific and Technological Special Project","award":["2012ZX093016-002"],"award-info":[{"award-number":["2012ZX093016-002"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81302681"],"award-info":[{"award-number":["81302681"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Development Plan of the Outstanding Young Scholars of Liaoning Province","award":["LJQ2015064"],"award-info":[{"award-number":["LJQ2015064"]}]},{"name":"Natural Science Foundation Master Plan of Liaoning Province","award":["201602282"],"award-info":[{"award-number":["201602282"]}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2017PH072"],"award-info":[{"award-number":["ZR2017PH072"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.ejmech.2017.08.048","type":"journal-article","created":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T08:31:18Z","timestamp":1503563478000},"page":"926-935","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":79,"special_numbering":"C","title":["Recent advances in polysaccharides for osteoarthritis therapy"],"prefix":"10.1016","volume":"139","author":[{"given":"Qixin","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xintian","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2783-7463","authenticated-orcid":false,"given":"Peixue","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanying","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengshan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2017.08.048_bib1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.5582\/ddt.2015.01028","article-title":"Carbohydrate drugs: current status and development prospect","volume":"9","author":"Zhang","year":"2015","journal-title":"Drug Discov. Ther."},{"key":"10.1016\/j.ejmech.2017.08.048_bib2","doi-asserted-by":"crossref","first-page":"88","DOI":"10.5582\/ddt.2015.01025","article-title":"Polysaccharides: candidates of promising vaccine adjuvants","volume":"9","author":"Li","year":"2015","journal-title":"Drug Discov. Ther."},{"key":"10.1016\/j.ejmech.2017.08.048_bib3","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.ejmech.2014.12.003","article-title":"Leishmanicidal activity of polysaccharides and their oxovanadium(IV\/V) complexes","volume":"90","author":"Amaral","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2017.08.048_bib4","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/j.carbpol.2012.07.026","article-title":"Anticancer polysaccharides from natural resources: a review of recent research","volume":"90","author":"Zong","year":"2012","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ejmech.2017.08.048_bib5","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.ijbiomac.2016.12.003","article-title":"Antioxidant, antibacterial and anti-aging activities of intracellular zinc polysaccharides from Grifola frondosa SH-05","volume":"95","author":"Zhang","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ejmech.2017.08.048_bib6","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0378-5173(01)00720-7","article-title":"Polysaccharides in colon-specific drug delivery","volume":"224","author":"Sinha","year":"2001","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejmech.2017.08.048_bib7","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ijpharm.2017.03.021","article-title":"Direct comparison between millifluidic and bulk-mixing platform in the synthesis of amorphous drug-polysaccharide nanoparticle complex","volume":"523","author":"Dong","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejmech.2017.08.048_bib8","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ijpharm.2017.01.055","article-title":"Hydrophobically modified polysaccharide-based on polysialic acid nanoparticles as carriers for anticancer drugs","volume":"520","author":"Jung","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejmech.2017.08.048_bib9","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.ejmech.2012.12.058","article-title":"Arylsulfonamide inhibitors of aggrecanases as potential therapeutic agents for osteoarthritis: synthesis and biological evaluation","volume":"62","author":"Nuti","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2017.08.048_bib10","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.carbpol.2015.06.004","article-title":"Xanthan gum protects rabbit articular chondrocytes against sodium nitroprusside-induced apoptosis in\u00a0vitro","volume":"131","author":"Chen","year":"2015","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ejmech.2017.08.048_bib11","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/nrrheum.2016.224","article-title":"Osteoarthritis in 2016: anti-NGF treatments for pain [mdash] two steps forward, one step back?","volume":"13","author":"Lane","year":"2017","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.ejmech.2017.08.048_bib12","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/nrrheum.2017.9","article-title":"Osteoarthritis: UCMA links cartilage and bone in OA","volume":"13","author":"Onuora","year":"2017","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.ejmech.2017.08.048_bib13","doi-asserted-by":"crossref","first-page":"16044","DOI":"10.1038\/boneres.2016.44","article-title":"Osteoarthritis: toward a comprehensive understanding of pathological mechanism","volume":"5","author":"Chen","year":"2017","journal-title":"Bone Res."},{"key":"10.1016\/j.ejmech.2017.08.048_bib14","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/nrrheum.2016.65","article-title":"Ageing and the pathogenesis of osteoarthritis","volume":"12","author":"Loeser","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.ejmech.2017.08.048_bib15","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/nrrheum.2011.199","article-title":"Etiology of osteoarthritis: genetics and synovial joint development","volume":"8","author":"Sandell","year":"2012","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.ejmech.2017.08.048_bib16","first-page":"137","article-title":"Novel chitosan hydrogels for the treatment of osteoarthritis: mechanical support, lubrication and prevention of cartilage degradation in a rabbit model of osteoarthritis","volume":"67","author":"Henrotin","year":"2015","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.ejmech.2017.08.048_bib17","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1097\/BOR.0000000000000351","article-title":"Recent developments in emerging therapeutic targets of osteoarthritis","volume":"29","author":"Sun","year":"2017","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.ejmech.2017.08.048_bib18","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.ijpharm.2015.01.052","article-title":"A\u00a0novel biocompatible hyaluronic acid\u2013chitosan hybrid hydrogel for osteoarthrosis therapy","volume":"483","author":"Kaderli","year":"2015","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejmech.2017.08.048_bib19","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.carbpol.2017.01.101","article-title":"Low molecular weight xanthan gum for treating osteoarthritis","volume":"164","author":"Han","year":"2017","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ejmech.2017.08.048_bib20","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.ijpharm.2011.08.046","article-title":"Novel hyaluronic acid\u2013chitosan nanoparticles as non-viral gene delivery vectors targeting osteoarthritis","volume":"420","author":"Lu","year":"2011","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejmech.2017.08.048_bib21","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.carbpol.2017.04.018","article-title":"Low molecular weight xanthan gum suppresses oxidative stress-induced apoptosis in rabbit chondrocytes","volume":"169","author":"Chen","year":"2017","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ejmech.2017.08.048_bib22","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.carbpol.2017.01.101","article-title":"Low molecular weight xanthan gum for treating osteoarthritis","volume":"164","author":"Han","year":"2017","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ejmech.2017.08.048_bib23","doi-asserted-by":"crossref","DOI":"10.1021\/acs.biomac.6b00180","article-title":"Hyaluronan hydrogels for a biomimetic spongiosa layer of tissue engineered heart valve scaffolds","volume":"17","author":"Puperi","year":"2016","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.ejmech.2017.08.048_bib24","first-page":"1","article-title":"Chitosan-based scaffold modified with D-(+) raffinose for cartilage repair: an in\u00a0vivo study","volume":"14","author":"Ravanetti","year":"2015","journal-title":"J.\u00a0Negat. Results Biomed."},{"key":"10.1016\/j.ejmech.2017.08.048_bib25","first-page":"497","article-title":"Injectable chitin-poly(caprolactone)\/nanohydroxyapatite composite microgels prepared by simple regeneration technique for bone tissue engineering","volume":"7","author":"Kumar","year":"2015","journal-title":"Acs Appl. Mater. Interfaces"},{"key":"10.1016\/j.ejmech.2017.08.048_bib26","series-title":"Seminars in Arthritis and Rheumatism","first-page":"140","article-title":"Consensus statement on viscosupplementation with hyaluronic acid for the management of osteoarthritis","author":"Henrotin","year":"2015"},{"key":"10.1016\/j.ejmech.2017.08.048_bib27","doi-asserted-by":"crossref","first-page":"305","DOI":"10.3233\/BIR-14013","article-title":"Viscosupplementation of synovial fluid with xanthan gum for treatment of osteoarthritis and its clearance kinetics in the rabbit knee joint","volume":"51","author":"Shao","year":"2014","journal-title":"Biorheology"},{"key":"10.1016\/j.ejmech.2017.08.048_bib28","doi-asserted-by":"crossref","first-page":"32790","DOI":"10.1038\/srep32790","article-title":"Intra-articular hyaluronic acid in treating knee osteoarthritis: a PRISMA-compliant systematic review of overlapping meta-analysis","volume":"6","author":"Xing","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2017.08.048_bib29","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/nchem.2395","article-title":"A\u00a0threading receptor for polysaccharides","volume":"8","author":"Mooibroek","year":"2016","journal-title":"Nat. Chem."},{"key":"10.1016\/j.ejmech.2017.08.048_bib30","doi-asserted-by":"crossref","first-page":"S152","DOI":"10.1097\/01.blo.0000143804.26638.82","article-title":"Hyaluronan and CD44: modulators of chondrocyte metabolism","volume":"427","author":"Knudson","year":"2004","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.ejmech.2017.08.048_bib31","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s10195-015-0390-7","article-title":"Erratum to: effectiveness of intra-articular injections of sodium hyaluronate-chondroitin sulfate in knee osteoarthritis: a multicenter prospective study","volume":"17","author":"Rivera","year":"2016","journal-title":"J.\u00a0Orthop. Traumatol. Off. J. Italian Soc. Orthop. Traumatol."},{"key":"10.1016\/j.ejmech.2017.08.048_bib32","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.joca.2010.09.014","article-title":"Therapeutic trajectory following intra-articular hyaluronic acid injection in knee osteoarthritis\u2013meta-analysis","volume":"19","author":"Bannuru","year":"2011","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.ejmech.2017.08.048_bib33","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.ejmech.2014.08.067","article-title":"Current research on hyaluronic acid-drug bioconjugates","volume":"86","author":"Zhang","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2017.08.048_bib34","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.joca.2010.09.014","article-title":"Therapeutic trajectory following intra-articular hyaluronic acid injection in knee osteoarthritis\u2013meta-analysis","volume":"19","author":"Bannuru","year":"2011","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.ejmech.2017.08.048_bib35","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1016\/j.carbpol.2012.11.051","article-title":"Intra-articular injection of xanthan gum reduces pain and cartilage damage in a rat osteoarthritis model","volume":"92","author":"Shao","year":"2013","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ejmech.2017.08.048_bib36","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.ijpharm.2012.11.031","article-title":"Intra-articular delivery of liposomal celecoxib-hyaluronate combination;for the treatment of osteoarthritis in rabbit model","volume":"441","author":"Dong","year":"2013","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejmech.2017.08.048_bib37","doi-asserted-by":"crossref","first-page":"40840","DOI":"10.1038\/srep40840","article-title":"High-molecular-weight hyaluronic acid attenuated matrix metalloproteinase-1 and -3 expression via CD44 in tendinopathy","volume":"7","author":"Wu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2017.08.048_bib38","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.joca.2011.07.001","article-title":"Safety and efficacy of retreatment with a bioengineered hyaluronate for painful osteoarthritis of the knee: results of the open-label Extension Study of the FLEXX Trial 1","volume":"19","author":"Altman","year":"2011","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.ejmech.2017.08.048_bib39","first-page":"295","article-title":"Sodium hyaluronate in the treatment of osteoarthritis of the ankle: a controlled, randomized, double-blind pilot study","volume":"88","author":"Salk","year":"2006","journal-title":"J.\u00a0Bone & Jt. Surg. Am. Vol."},{"key":"10.1016\/j.ejmech.2017.08.048_bib40","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.joca.2006.03.003","article-title":"Efficacy of intra-articular hyaluronic acid in patients with osteoarthritis of the ankle: a prospective study","volume":"14","author":"Sun","year":"2006","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.ejmech.2017.08.048_bib41","doi-asserted-by":"crossref","first-page":"657","DOI":"10.3113\/FAI.2008.0657","article-title":"Safety and efficacy of intra-articular sodium hyaluronate (Hyalgan) in a randomized, double-blind study for osteoarthritis of the ankle","volume":"29","author":"Cohen","year":"2008","journal-title":"Foot Ankle Int."},{"key":"10.1016\/j.ejmech.2017.08.048_bib42","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1177\/2325967115S00123","article-title":"Hyaluronic acid versus platelet-rich plasma: double-blind randomized controlled trial comparing clinical outcomes and intra-articular biology for treatment of knee arthritis","volume":"3","author":"Cole","year":"2015","journal-title":"Orthop. J. Sports Med."},{"key":"10.1016\/j.ejmech.2017.08.048_bib43","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1186\/1471-2474-12-221","article-title":"Intra-articular injections of sodium hyaluronate (Hyalgan\u00ae) in osteoarthritis of the knee. a randomized, controlled, double-blind, multicenter trial in the asian population","volume":"12","author":"Huang","year":"2011","journal-title":"BMC Musculoskelet. Disord."},{"key":"10.1016\/j.ejmech.2017.08.048_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13075-015-0557-x","article-title":"Comparison of two hyaluronic acid formulations for safety and efficacy (CHASE) study in knee osteoarthritis: a multicenter, randomized, double-blind, 26 week non-inferiority trial comparing Durolane to Artz","volume":"17","author":"Zhang","year":"2015","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.ejmech.2017.08.048_bib45","doi-asserted-by":"crossref","first-page":"815184","DOI":"10.1155\/2014\/815184","article-title":"Effect of intra-articular hyaluronic injection on postural stability and risk of fall in patients with bilateral knee osteoarthritis","volume":"2014","author":"Khalaj","year":"2014","journal-title":"Sci. World J."},{"key":"10.1016\/j.ejmech.2017.08.048_bib46","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1136\/ard.2011.152017","article-title":"A\u00a040-month multicentre, randomised placebo-controlled study to assess the efficacy and carry-over effect of repeated intra-articular injections of hyaluronic acid in knee osteoarthritis: the AMELIA project","volume":"70","author":"Navarrosarabia","year":"2011","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.ejmech.2017.08.048_bib47","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1185\/030079905X65547","article-title":"Overall tolerability and analgesic activity of intra-articular sodium hyaluronate in the treatment of knee osteoarthritis","volume":"21","author":"Theiler","year":"2005","journal-title":"Curr. Med. Res. Opin."},{"key":"10.1016\/j.ejmech.2017.08.048_bib48","series-title":"Efficacy Evaluation of Highly Purified Intra-articular Hyaluronic Acid (Sinovial(\u00ae)) vs Hylan G-f20 (Synvisc(\u00ae)) in the Treatment of Symptomatic Knee Osteoarthritis. A Double-blind, Controlled, Randomized, Parallel-group Non-inferiority Study","author":"Pavelka","year":"2011"},{"key":"10.1016\/j.ejmech.2017.08.048_bib49","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1038\/nmat4048","article-title":"Enhanced lubrication on tissue and biomaterial surfaces through peptide-mediated binding of hyaluronic acid","volume":"13","author":"Singh","year":"2014","journal-title":"Nat. Mater."},{"key":"10.1016\/j.ejmech.2017.08.048_bib50","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/art.39819","article-title":"Combined treatment with chondroitin sulfate and glucosamine sulfate shows No superiority over placebo for reduction of joint pain and functional impairment in patients with knee osteoarthritis: a six-month multicenter, randomized, double-blind, placebo-con","volume":"69","author":"Roman-Blas","year":"2017","journal-title":"Arthritis & Rheumatol."},{"key":"10.1016\/j.ejmech.2017.08.048_bib51","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.copbio.2016.02.008","article-title":"Recent advances in hyaluronic acid hydrogels for biomedical applications","volume":"40","author":"Highley","year":"2016","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.ejmech.2017.08.048_bib52","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.ijpharm.2015.05.001","article-title":"Hyaluronic acid based micelle for articular delivery of triamcinolone, preparation, in\u00a0vitro and in\u00a0vivo evaluation","volume":"489","author":"Saadat","year":"2015","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejmech.2017.08.048_bib53","article-title":"Hyaluronic acid gel-based scaffolds as potential carrier for growth factors: an in\u00a0vitro bioassay on its osteogenic potential","volume":"5","author":"Fujioka-Kobayashi","year":"2016","journal-title":"J.\u00a0Clin. Med."},{"key":"10.1016\/j.ejmech.2017.08.048_bib54","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3390\/ma9050381","article-title":"Higher ratios of hyaluronic acid enhance chondrogenic differentiation of human MSCs in a hyaluronic acid\u2013gelatin composite scaffold","volume":"9","author":"Pfeifer","year":"2016","journal-title":"Materials"},{"key":"10.1016\/j.ejmech.2017.08.048_bib55","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.triboint.2016.09.025","article-title":"Tribological behaviour of HVOF sprayed WC-12Co, WC-10Co-4Cr and Cr3C2\u221225NiCr coatings","volume":"105","author":"Vashishtha","year":"2017","journal-title":"Tribol. Int."},{"key":"10.1016\/j.ejmech.2017.08.048_bib56","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s10719-016-9665-3","article-title":"Chondroitin sulphate: a focus on osteoarthritis","volume":"33","author":"Bishnoi","year":"2016","journal-title":"Glycoconj. J."},{"key":"10.1016\/j.ejmech.2017.08.048_bib57","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.joca.2016.09.025","article-title":"Osteoarthritis year in review 2016: clinical","volume":"25","author":"Lane","year":"2017","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.ejmech.2017.08.048_bib58","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.ijpharm.2016.05.045","article-title":"Platelet lysate and chondroitin sulfate loaded contact lenses to heal corneal lesions","volume":"509","author":"Sandri","year":"2016","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejmech.2017.08.048_bib59","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.carbpol.2016.09.035","article-title":"Design of chondroitin sulfate-based polyelectrolyte nanoplexes: formation of nanocarriers with chitosan and a case study of salmon calcitonin","volume":"156","author":"Umerska","year":"2017","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ejmech.2017.08.048_bib60","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.ejmech.2014.12.054","article-title":"Anticoagulant and antithrombotic evaluation of native fucosylated chondroitin sulfates and their derivatives as selective inhibitors of intrinsic factor Xase","volume":"92","author":"Wu","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2017.08.048_bib61","doi-asserted-by":"crossref","DOI":"10.1136\/ard.2003.011742","article-title":"EULAR recommendations 2003: an evidence based approach to the management of knee osteoarthritis: report of a task force of the standing committee for international clinical studies including therapeutic trials (ESCISIT)","volume":"62","author":"Jordan","year":"2003","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.ejmech.2017.08.048_bib62","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1002\/acr.22866","article-title":"Long-term effects of glucosamine and chondroitin sulfate on the progression of structural changes in knee osteoarthritis: six-year followup data from the osteoarthritis initiative","volume":"68","author":"Raynauld","year":"2016","journal-title":"Arthritis Care & Res."},{"key":"10.1016\/j.ejmech.2017.08.048_bib63","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s10195-015-0388-1","article-title":"Effectiveness of intra-articular injections of sodium hyaluronate-chondroitin sulfate in knee osteoarthritis: a multicenter prospective study","volume":"17","author":"Rivera","year":"2016","journal-title":"J.\u00a0Orthop. Traumatol."},{"key":"10.1016\/j.ejmech.2017.08.048_bib64","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.apsusc.2016.12.135","article-title":"Chondroitin sulfate immobilization at the surface of electrospun nanofiber meshes for cartilage tissue regeneration approaches","volume":"403","author":"Piai","year":"2017","journal-title":"Appl. Surf. Sci."},{"key":"10.1016\/j.ejmech.2017.08.048_bib65","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1186\/s13075-016-1149-0","article-title":"Chondroitin sulfate efficacy versus celecoxib on knee osteoarthritis structural changes using magnetic resonance imaging: a 2-year multicentre exploratory study","volume":"18","author":"Pelletier","year":"2016","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.ejmech.2017.08.048_bib66","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.3390\/ijms17101685","article-title":"Preparation of low molecular weight chondroitin sulfates, screening of a high anti-complement capacity of low molecular weight chondroitin sulfate and its biological activity studies in attenuating osteoarthritis","volume":"17","author":"Li","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejmech.2017.08.048_bib67","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.carbpol.2016.04.096","article-title":"Injectable long acting chitosan\/tripolyphosphate microspheres for the intra-articular delivery of lornoxicam: optimization and in\u00a0vivo evaluation","volume":"149","author":"Abd-Allah","year":"2016","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ejmech.2017.08.048_bib68","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ijpharm.2016.06.016","article-title":"Hybrid electrospun chitosan-phospholipids nanofibers for transdermal drug delivery","volume":"510","author":"Mendes","year":"2016","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejmech.2017.08.048_bib69","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.ijpharm.2017.01.048","article-title":"Cyclodextrin-mediated self-associating chitosan micro-platelets act as a drug booster against Candida glabrata mucosal infection in immunocompetent mice","volume":"519","author":"Grisin","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejmech.2017.08.048_bib70","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.carbpol.2016.05.028","article-title":"A\u00a0review on chitosan-cellulose blends and nanocellulose reinforced chitosan biocomposites: properties and their applications","volume":"150","author":"Abdul","year":"2016","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ejmech.2017.08.048_bib71","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ijpharm.2016.11.030","article-title":"Fabrication of self-assembled chitosan-dispersed LDL nanoparticles for drug delivery with a one-step green method","volume":"517","author":"Tian","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejmech.2017.08.048_bib72","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.ijpharm.2016.01.010","article-title":"Microfluidic assisted synthesis of silver nanoparticle\u2013chitosan composite microparticles for antibacterial applications","volume":"510","author":"Yang","year":"2016","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejmech.2017.08.048_bib73","doi-asserted-by":"crossref","first-page":"4779","DOI":"10.1016\/j.actbio.2012.08.033","article-title":"Injectable chitosan hyaluronic acid hydrogels for cartilage tissue engineering","volume":"9","author":"Park","year":"2013","journal-title":"Acta Biomater."},{"key":"10.1016\/j.ejmech.2017.08.048_bib74","first-page":"9984","article-title":"Intra-articular delivery of kartogenin-conjugated chitosan nano\/microparticles for cartilage regeneration","volume":"23","author":"Mi","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejmech.2017.08.048_bib75","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/cbin.10181","article-title":"Chitosan-based injectable hydrogel as a promising in situ forming scaffold for cartilage tissue engineering","volume":"38","author":"Naderi-Meshkin","year":"2014","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.ejmech.2017.08.048_bib76","doi-asserted-by":"crossref","first-page":"17802","DOI":"10.1038\/srep17802","article-title":"A\u00a0composite scaffold of MSC affinity peptide-modified demineralized bone matrix particles and chitosan hydrogel for cartilage regeneration","volume":"5","author":"Meng","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2017.08.048_bib77","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.intimp.2015.05.014","article-title":"In\u00a0vivo anti-apoptosis activity of novel berberine-loaded chitosan nanoparticles effectively ameliorates osteoarthritis","volume":"28","author":"Zhou","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ejmech.2017.08.048_bib78","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.biomaterials.2016.09.002","article-title":"Transplantation of allogenic chondrocytes with chitosan hydrogel-demineralized bone matrix hybrid scaffold to repair rabbit cartilage injury","volume":"108","author":"Man","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejmech.2017.08.048_bib79","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.18632\/oncotarget.13748","article-title":"Photo-crosslinked HAMA hydrogel with cordycepin encapsulated chitosan microspheres for osteoarthritis treatment","volume":"8","author":"Xia","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.ejmech.2017.08.048_bib80","series-title":"Chitin and Chitosan for Regenerative Medicine","first-page":"61","article-title":"Chitosan-based scaffolds for cartilage regeneration","author":"Li","year":"2016"},{"key":"10.1016\/j.ejmech.2017.08.048_bib81","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.carbpol.2014.10.025","article-title":"Electrospun aligned poly(propylene carbonate) microfibers with chitosan nanofibers as tissue engineering scaffolds","volume":"117","author":"Jing","year":"2015","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ejmech.2017.08.048_bib82","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biomaterials.2015.12.006","article-title":"Intra-articular delivery of sinomenium encapsulated by chitosan microspheres and photo-crosslinked GelMA hydrogel ameliorates osteoarthritis by effectively regulating autophagy","volume":"81","author":"Chen","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejmech.2017.08.048_bib83","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1039\/C5NR06876B","article-title":"Chitosan microspheres with an extracellular matrix-mimicking nanofibrous structure as cell-carrier building blocks for bottom-up cartilage tissue engineering","volume":"8","author":"Zhou","year":"2016","journal-title":"Nanoscale"},{"key":"10.1016\/j.ejmech.2017.08.048_bib84","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.actbio.2013.09.002","article-title":"Poly(l-glutamic acid)\/chitosan polyelectrolyte complex porous microspheres as cell microcarriers for cartilage regeneration","volume":"10","author":"Fang","year":"2014","journal-title":"Acta Biomater."},{"key":"10.1016\/j.ejmech.2017.08.048_bib85","doi-asserted-by":"crossref","first-page":"121","DOI":"10.33549\/physiolres.932998","article-title":"Polycaprolactone foam functionalized with chitosan microparticles-a suitable scaffold for cartilage regeneration","volume":"65","author":"Filov\u00e1","year":"2016","journal-title":"Physiol. Res."},{"key":"10.1016\/j.ejmech.2017.08.048_bib86","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jconrel.2015.05.005","article-title":"Development of a gene-activated scaffold platform for tissue engineering applications using chitosan-pDNA nanoparticles on collagen-based scaffolds","volume":"210","author":"Raftery","year":"2015","journal-title":"J.\u00a0Control. Release"},{"key":"10.1016\/j.ejmech.2017.08.048_bib87","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1080\/00914037.2015.1099103","article-title":"Incorporation of chitosan nanoparticles into silk fibroin-based porous scaffolds: chondrogenic differentiation of stem cells","volume":"65","author":"Naeimi","year":"2016","journal-title":"Int. J. Polym. Mater. Polym. Biomater."},{"key":"10.1016\/j.ejmech.2017.08.048_bib88","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.compscitech.2014.11.003","article-title":"Electrospun chitosan\/poly (vinyl alcohol) reinforced with CaCO 3 nanoparticles with enhanced mechanical properties and biocompatibility for cartilage tissue engineering","volume":"106","author":"Sambudi","year":"2015","journal-title":"Compos. Sci. Technol."},{"key":"10.1016\/j.ejmech.2017.08.048_bib89","doi-asserted-by":"crossref","DOI":"10.1007\/s00296-009-0969-5","article-title":"Effect of glucosamine or chondroitin sulfate on the osteoarthritis progression: a meta-analysis","volume":"30","author":"Lee","year":"2010","journal-title":"Rheumatol. Int."},{"key":"10.1016\/j.ejmech.2017.08.048_bib90","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ejmech.2015.01.062","article-title":"Design, synthesis and evaluation of a novel class of glucosamine mimetic peptides containing 1,3-dioxane","volume":"93","author":"Zeng","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2017.08.048_bib91","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.carbpol.2014.03.033","article-title":"Oral chondroprotection with nutraceuticals made of chondroitin sulphate plus glucosamine sulphate in osteoarthritis","volume":"109","author":"Bottegoni","year":"2014","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ejmech.2017.08.048_bib92","first-page":"1","article-title":"A\u00a0review of glucosamine for knee osteoarthritis: why patented crystalline glucosamine sulfate should be differentiated from other glucosamines to maximize clinical outcomes","author":"Kucharz","year":"2016","journal-title":"Curr. Med. Res. Opin."},{"key":"10.1016\/j.ejmech.2017.08.048_bib93","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1002\/art.38932","article-title":"Effects of glucosamine and chondroitin supplementation on knee osteoarthritis: an analysis with marginal structural models","volume":"67","author":"Yang","year":"2015","journal-title":"Arthritis & Rheumatol."},{"key":"10.1016\/j.ejmech.2017.08.048_bib94","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1136\/ard.2009.120469","article-title":"Clinical efficacy and safety of glucosamine, chondroitin sulphate, their combination, celecoxib or placebo taken to treat osteoarthritis of the knee: 2-year results from GAIT","volume":"69","author":"Sawitzke","year":"2010","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.ejmech.2017.08.048_bib95","doi-asserted-by":"crossref","first-page":"264","DOI":"10.18433\/J3XG6F","article-title":"The glucosamine controversy; a pharmacokinetic issue","volume":"14","author":"Aghazadeh-Habashi","year":"2011","journal-title":"J.\u00a0Pharm. Pharm. Sci."},{"key":"10.1016\/j.ejmech.2017.08.048_bib96","first-page":"795","article-title":"Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis","volume":"354","author":"Clegg","year":"2006","journal-title":"Dig. World Core Med. J."},{"key":"10.1016\/j.ejmech.2017.08.048_bib97","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1155\/2014\/432463","article-title":"Glucosamine for osteoarthritis: biological effects, clinical efficacy, and safety on glucose metabolism","volume":"2014","author":"Salazar","year":"2014","journal-title":"Arthritis"},{"key":"10.1016\/j.ejmech.2017.08.048_bib98","doi-asserted-by":"crossref","DOI":"10.1002\/app.42035","article-title":"Xanthan gum: a versatile biopolymer for biomedical and technological applications","volume":"132","author":"Petri","year":"2015","journal-title":"J.\u00a0Appl. Polym. Sci."},{"key":"10.1016\/j.ejmech.2017.08.048_bib99","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1016\/j.carbpol.2011.10.016","article-title":"Preparation of xanthan gum injection and its protective effect on articular cartilage in the development of osteoarthritis","volume":"87","author":"Han","year":"2012","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ejmech.2017.08.048_bib100","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.carbpol.2012.04.023","article-title":"The protective effect of xanthan gum on interleukin-1\u03b2 induced rabbit chondrocytes","volume":"89","author":"Han","year":"2012","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ejmech.2017.08.048_bib101","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/nchem.1701","article-title":"Heparin sensing: blue-chip binding","volume":"5","author":"Shriver","year":"2013","journal-title":"Nat. Chem."},{"key":"10.1016\/j.ejmech.2017.08.048_bib102","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1111\/jth.12675","article-title":"Rivaroxaban vs. low molecular weight heparin for the prevention of venous thromboembolism after hip or knee arthroplasty: a cohort study","volume":"12","author":"Lazo-Langner","year":"2014","journal-title":"J.\u00a0Thromb. Haemostasis"},{"key":"10.1016\/j.ejmech.2017.08.048_bib103","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1097\/MBC.0000000000000121","article-title":"Administering aspirin, rivaroxaban and low-molecular-weight heparin to prevent deep venous thrombosis after total knee arthroplasty","volume":"25","author":"Zou","year":"2014","journal-title":"Blood Coagul. Fibrinolysis An Int. J. Haemostasis Thromb."},{"key":"10.1016\/j.ejmech.2017.08.048_bib104","first-page":"1","article-title":"The effect of aspirin and low-molecular-weight heparin on venous thromboembolism after knee replacement: a non-randomised comparison using National Joint Registry data","volume":"95-B","author":"Jameson","year":"2013","journal-title":"Bone & Jt. J. Orthop. Proc. Suppl."},{"key":"10.1016\/j.ejmech.2017.08.048_bib105","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1002\/pds.4089","article-title":"Safety and efficacy of new oral anticoagulants and low-molecular-weight heparins compared with aspirin in patients undergoing total knee and hip replacements","volume":"25","author":"Nielen","year":"2016","journal-title":"Pharmacoepidemiol. Drug Saf."},{"key":"10.1016\/j.ejmech.2017.08.048_bib106","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1016\/j.joca.2015.04.019","article-title":"Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is increased in osteoarthritis and regulates chondrocyte catabolic and anabolic activities","volume":"23","author":"Long","year":"2015","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.ejmech.2017.08.048_bib107","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/7697031","article-title":"Winnicka, Latarzyna, Alginate \u2013 current use and future perspectives in pharmaceutical and biomedical applications","volume":"2016","author":"Szekalska","year":"2016","journal-title":"Int. J. Polym. Sci."},{"key":"10.1016\/j.ejmech.2017.08.048_bib108","series-title":"Marine OMICS","first-page":"243","article-title":"Marine oligosaccharides: the most important aspects in the recent literature","author":"Trincone","year":"2016"},{"key":"10.1016\/j.ejmech.2017.08.048_bib109","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1177\/1947603511418959","article-title":"Therapeutic effects of intra-articular ultrapurified low endotoxin alginate administration on experimental osteoarthritis in rabbits","volume":"3","author":"Igarashi","year":"2012","journal-title":"Cartilage"},{"key":"10.1016\/j.ejmech.2017.08.048_bib110","doi-asserted-by":"crossref","first-page":"76","DOI":"10.22203\/eCM.v033a06","article-title":"Biomimetic sulphated alginate hydrogels suppress IL-1\u03b2-induced inflammatory responses in human chondrocytes","volume":"33","author":"Arlov","year":"2017","journal-title":"Eur. Cells Mater."},{"key":"10.1016\/j.ejmech.2017.08.048_bib111","doi-asserted-by":"crossref","first-page":"18507","DOI":"10.3390\/ijms160818507","article-title":"Differentiation effects of platelet-rich plasma concentrations on synovial fluid mesenchymal stem cells from pigs cultivated in alginate complex hydrogel","volume":"16","author":"Tang","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejmech.2017.08.048_bib112","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3390\/jfb5030197","article-title":"The effect of chondroitin sulphate and hyaluronic acid on chondrocytes cultured within a fibrin-alginate hydrogel","volume":"5","author":"Little","year":"2014","journal-title":"J.\u00a0Funct. Biomater."},{"key":"10.1016\/j.ejmech.2017.08.048_bib113","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jff.2015.03.025","article-title":"Induction of apoptosis in S180 tumour bearing mice by polysaccharide from Lentinus edodes via mitochondria apoptotic pathway","volume":"15","author":"Zhang","year":"2015","journal-title":"J.\u00a0Funct. Foods"}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523417306591?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523417306591?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T04:46:04Z","timestamp":1602823564000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523417306591"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":113,"alternative-id":["S0223523417306591"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2017.08.048","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Recent advances in polysaccharides for osteoarthritis therapy","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2017.08.048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}