{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:25:02Z","timestamp":1785403502256,"version":"3.56.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21502224"],"award-info":[{"award-number":["21502224"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["17XD1404700"],"award-info":[{"award-number":["17XD1404700"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai \u201cShuGuang\u201d Project","award":["14SG33"],"award-info":[{"award-number":["14SG33"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.ejmech.2017.10.043","type":"journal-article","created":{"date-parts":[[2017,10,16]],"date-time":"2017-10-16T20:34:01Z","timestamp":1508186041000},"page":"1510-1523","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Discovery of simplified sampangine derivatives as novel fungal biofilm inhibitors"],"prefix":"10.1016","volume":"143","author":[{"given":"Na","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjuan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanying","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wannian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9489-804X","authenticated-orcid":false,"given":"Chunquan","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2017.10.043_bib1","doi-asserted-by":"crossref","first-page":"165rv113","DOI":"10.1126\/scitranslmed.3004404","article-title":"Hidden killers: human fungal infections","volume":"4","author":"Brown","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ejmech.2017.10.043_bib2","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1126\/science.1222236","article-title":"Tackling human fungal infections","volume":"336","author":"Brown","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.ejmech.2017.10.043_bib3","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a019703","article-title":"Antifungal drug development: challenges, unmet clinical needs, and new approaches","volume":"4","author":"Roemer","year":"2014","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.ejmech.2017.10.043_bib4","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/S0966-842X(03)00117-3","article-title":"Antifungal agents: mechanisms of action","volume":"11","author":"Odds","year":"2003","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.ejmech.2017.10.043_bib5","doi-asserted-by":"crossref","first-page":"791","DOI":"10.2217\/fmb.14.32","article-title":"Antifungal drug discovery: the process and outcomes","volume":"9","author":"Calderone","year":"2014","journal-title":"Future Microbiol."},{"key":"10.1016\/j.ejmech.2017.10.043_bib6","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.4155\/fmc-2016-0020","article-title":"Strategies in the discovery of novel antifungal scaffolds","volume":"8","author":"Liu","year":"2016","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.ejmech.2017.10.043_bib7","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.amjmed.2011.11.001","article-title":"Antifungal drug resistance: mechanisms, epidemiology, and consequences for treatment","volume":"125","author":"Pfaller","year":"2012","journal-title":"Am. J. Med."},{"key":"10.1016\/j.ejmech.2017.10.043_bib8","doi-asserted-by":"crossref","first-page":"a019752","DOI":"10.1101\/cshperspect.a019752","article-title":"Mechanisms of antifungal drug resistance","volume":"5","author":"Cowen","year":"2014","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.ejmech.2017.10.043_bib9","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1097\/QCO.0b013e32835ebcb7","article-title":"New antifungal antibiotics","volume":"26","author":"Paiva","year":"2013","journal-title":"Curr. Opin. Infect. Dis."},{"key":"10.1016\/j.ejmech.2017.10.043_bib10","doi-asserted-by":"crossref","first-page":"733","DOI":"10.2174\/092986711794480113","article-title":"New lead structures in antifungal drug discovery","volume":"18","author":"Sheng","year":"2011","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.ejmech.2017.10.043_bib11","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1039\/b914961a","article-title":"Natural products as antifungal agents against clinically relevant pathogens","volume":"27","author":"Di Santo","year":"2010","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.ejmech.2017.10.043_bib12","doi-asserted-by":"crossref","first-page":"4090","DOI":"10.1016\/j.bmcl.2014.07.064","article-title":"Scaffold hopping of sampangine: discovery of potent antifungal lead compound against Aspergillus fumigatus and Cryptococcus neoformans","volume":"24","author":"Jiang","year":"2014","journal-title":"Bioorg Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2017.10.043_bib13","doi-asserted-by":"crossref","first-page":"14648","DOI":"10.1039\/C5CC05699C","article-title":"The discovery of novel antifungal scaffolds by structural simplification of the natural product sampangine","volume":"51","author":"Jiang","year":"2015","journal-title":"Chem. Commun. (Camb)"},{"key":"10.1016\/j.ejmech.2017.10.043_bib14","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1146\/annurev-micro-091014-104330","article-title":"Candida albicans biofilms and human disease","volume":"69","author":"Nobile","year":"2015","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.ejmech.2017.10.043_bib15","article-title":"Activity of sanguinarine against Candida albicans biofilms","volume":"60","author":"Zhong","year":"2017","journal-title":"Antimicrob. agents Chemother."},{"key":"10.1016\/j.ejmech.2017.10.043_bib16","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1021\/acs.jmedchem.6b01203","article-title":"Tackling fungal resistance by biofilm inhibitors","volume":"60","author":"Wu","year":"2017","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2017.10.043_bib17","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1034\/j.1600-0463.2002.1100902.x","article-title":"Candida glabrata, an emerging fungal pathogen, exhibits superior relative cell surface hydrophobicity and adhesion to denture acrylic surfaces compared with Candida albicans","volume":"110","author":"Luo","year":"2002","journal-title":"APMIS acta Pathol., Microbiol. Immunol. Scand."},{"key":"10.1016\/j.ejmech.2017.10.043_bib18","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1574-6968.2008.01292.x","article-title":"Factors associated with adherence to and biofilm formation on polystyrene by Stenotrophomonas maltophilia: the role of cell surface hydrophobicity and motility","volume":"287","author":"Pompilio","year":"2008","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.ejmech.2017.10.043_bib19","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1111\/j.1699-0463.1995.tb01427.x","article-title":"Relationship between the cell surface hydrophobicity and adherence of Candida krusei and Candida albicans to epithelial and denture acrylic surfaces","volume":"103","author":"Samaranayake","year":"1995","journal-title":"APMIS acta Pathol., Microbiol. Immunol. Scand."},{"key":"10.1016\/j.ejmech.2017.10.043_bib20","doi-asserted-by":"crossref","first-page":"e25395","DOI":"10.1371\/journal.pone.0025395","article-title":"Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways","volume":"6","author":"Midkiff","year":"2011","journal-title":"PloS one"},{"key":"10.1016\/j.ejmech.2017.10.043_bib21","first-page":"737","article-title":"Growth of Candida albicans hyphae, Nature reviews","volume":"9","author":"Sudbery","year":"2011","journal-title":"Microbiology"},{"key":"10.1016\/j.ejmech.2017.10.043_bib22","doi-asserted-by":"crossref","first-page":"e79671","DOI":"10.1371\/journal.pone.0079671","article-title":"Effect of tetrandrine against Candida albicans biofilms","volume":"8","author":"Zhao","year":"2013","journal-title":"PloS one"},{"key":"10.1016\/j.ejmech.2017.10.043_bib23","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1128\/AAC.01583-13","article-title":"In\u00a0vitro and in\u00a0vivo activities of pterostilbene against Candida albicans biofilms","volume":"58","author":"Li","year":"2014","journal-title":"Antimicrob. agents Chemother."},{"key":"10.1016\/j.ejmech.2017.10.043_bib24","doi-asserted-by":"crossref","first-page":"3648","DOI":"10.1128\/IAI.61.9.3648-3655.1993","article-title":"Cloning and characterization of ECE1, a gene expressed in association with cell elongation of the dimorphic pathogen Candida albicans","volume":"61","author":"Birse","year":"1993","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ejmech.2017.10.043_bib25","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1038\/sj.emboj.7600195","article-title":"Hgc1, a novel hypha-specific G1 cyclin-related protein regulates Candida albicans hyphal morphogenesis","volume":"23","author":"Zheng","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.ejmech.2017.10.043_bib26","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1128\/MMBR.00032-07","article-title":"Candida albicans cell wall proteins","volume":"72","author":"Chaffin","year":"2008","journal-title":"Microbiol. Mol. Biol. Rev. MMBR"},{"key":"10.1016\/j.ejmech.2017.10.043_bib27","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1091\/mbc.e07-11-1110","article-title":"UME6, a novel filament-specific regulator of Candida albicans hyphal extension and virulence","volume":"19","author":"Banerjee","year":"2008","journal-title":"Mol. Biol. cell"},{"key":"10.1016\/j.ejmech.2017.10.043_bib28","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1080\/13693780802206435","article-title":"Adherence mechanisms in human pathogenic fungi","volume":"46","author":"Tronchin","year":"2008","journal-title":"Med. Mycol."},{"key":"10.1016\/j.ejmech.2017.10.043_bib29","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1099\/mic.0.2007\/013789-0","article-title":"Distinct domains of the Candida albicans adhesin Eap1p mediate cell-cell and cell-substrate interactions","volume":"154","author":"Li","year":"2008","journal-title":"Microbiology"},{"key":"10.1016\/j.ejmech.2017.10.043_bib30","doi-asserted-by":"crossref","first-page":"3631","DOI":"10.1091\/mbc.12.11.3631","article-title":"Signaling through adenylyl cyclase is essential for hyphal growth and virulence in the pathogenic fungus Candida albicans","volume":"12","author":"Rocha","year":"2001","journal-title":"Mol. Biol. cell"},{"key":"10.1016\/j.ejmech.2017.10.043_bib31","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1093\/emboj\/16.8.1982","article-title":"Efg1p, an essential regulator of morphogenesis of the human pathogen Candida albicans, is a member of a conserved class of bHLH proteins regulating morphogenetic processes in fungi","volume":"16","author":"Stoldt","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/j.ejmech.2017.10.043_bib32","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1128\/IAI.66.6.2713-2721.1998","article-title":"Roles of the Candida albicans mitogen-activated protein kinase homolog, Cek1p, in hyphal development and systemic candidiasis","volume":"66","author":"Csank","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ejmech.2017.10.043_bib33","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1126\/science.7992058","article-title":"Suppression of hyphal formation in Candida albicans by mutation of a STE12 homolog","volume":"266","author":"Liu","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.ejmech.2017.10.043_bib34","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0002-9378(98)80001-X","article-title":"Vulvovaginal candidiasis: epidemiologic, diagnostic, and therapeutic considerations","volume":"178","author":"Sobel","year":"1998","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.ejmech.2017.10.043_bib35","doi-asserted-by":"crossref","first-page":"13594","DOI":"10.1073\/pnas.1305982110","article-title":"Chemical screening identifies filastatin, a small molecule inhibitor of Candida albicans adhesion, morphogenesis, and pathogenesis","volume":"110","author":"Fazly","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejmech.2017.10.043_bib36","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1080\/00362177585190271","article-title":"An amino acid liquid synthetic medium for the development of mycelial and yeast forms of Candida Albicans","volume":"13","author":"Lee","year":"1975","journal-title":"Sabouraudia"},{"key":"10.1016\/j.ejmech.2017.10.043_bib37","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1091\/mbc.e04-09-0780","article-title":"The G protein-coupled receptor Gpr1 and the Galpha protein Gpa2 act through the cAMP-protein kinase A pathway to induce morphogenesis in Candida albicans","volume":"16","author":"Maidan","year":"2005","journal-title":"Mol. Biol. cell"},{"key":"10.1016\/j.ejmech.2017.10.043_bib38","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/0092-8674(92)90079-R","article-title":"Unipolar cell divisions in the yeast S. cerevisiae lead to filamentous growth: regulation by starvation and RAS","volume":"68","author":"Gimeno","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.ejmech.2017.10.043_bib39","series-title":"Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts-Third Edition","author":"C.a.L.S. Institute","year":"2008"},{"key":"10.1016\/j.ejmech.2017.10.043_bib40","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1016\/j.tiv.2013.08.005","article-title":"Cytotoxic effect of amphotericin B in a myofibroblast cell line","volume":"27","author":"Uribe","year":"2013","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.ejmech.2017.10.043_bib41","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1574-6968.2006.00291.x","article-title":"Microbial adhesion to hydrocarbons: twenty-five years of doing MATH","volume":"262","author":"Rosenberg","year":"2006","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.ejmech.2017.10.043_bib42","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1186\/1471-2334-6-158","article-title":"In\u00a0vivo activity of terpinen-4-ol, the main bioactive component of Melaleuca alternifolia Cheel (tea tree) oil against azole-susceptible and -resistant human pathogenic Candida species","volume":"6","author":"Mondello","year":"2006","journal-title":"BMC Infect. Dis."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523417308437?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523417308437?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T00:30:37Z","timestamp":1603153837000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523417308437"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":42,"alternative-id":["S0223523417308437"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2017.10.043","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery of simplified sampangine derivatives as novel fungal biofilm inhibitors","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2017.10.043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}