{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T09:59:57Z","timestamp":1784023197829,"version":"3.55.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Novartis Hellas S.A.C.I","award":["81939"],"award-info":[{"award-number":["81939"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.ejmech.2017.10.067","type":"journal-article","created":{"date-parts":[[2017,11,11]],"date-time":"2017-11-11T04:16:53Z","timestamp":1510373813000},"page":"1687-1701","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"special_numbering":"C","title":["New metalo-therapeutics of NSAIDs against human breast cancer cells"],"prefix":"10.1016","volume":"143","author":[{"given":"Christina N.","family":"Banti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantina","family":"Papatriantafyllopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasios J.","family":"Tasiopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sotiris K.","family":"Hadjikakou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2017.10.067_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0010-8545(02)00100-5","article-title":"Biomedical uses and applications of inorganic chemistry. An overview","volume":"232","author":"Farrell","year":"2002","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.ejmech.2017.10.067_bib2","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1021\/mp500038g","article-title":"Mitochondrial delivery of doxorubicin via triphenylphosphine modification for overcoming drug resistance in MDA-MB-435\/DOX cells","volume":"11","author":"Han","year":"2014","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejmech.2017.10.067_bib3","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.cbi.2012.05.006","article-title":"Inhibition of mitochondrial complex I by various non-steroidal anti-inflammatory drugs and its protection by quercetin via a coenzyme Q-like action","volume":"199","author":"Sandoval-Acu\u03c1a","year":"2012","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.ejmech.2017.10.067_bib4","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1007\/s00018-008-7511-x","article-title":"NSAIDs and apoptosis","volume":"65","author":"Jana","year":"2008","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.ejmech.2017.10.067_bib5a","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.ica.2011.04.032","article-title":"Synthesis, structural characterization and biological studies of novel mixed ligand Ag(I) complexes with triphenylphosphine and aspirin or salicylic acid","volume":"375","author":"Poyraz","year":"2011","journal-title":"Inorg. Chim. Acta."},{"key":"10.1016\/j.ejmech.2017.10.067_bib5b","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1039\/c2mt20039b","article-title":"Mixed ligand\u2013silver(I) complexes with anti-inflammatory agents which can bind to lipoxygenase and calf-thymus DNA, modulating their function and inducing apoptosis","volume":"4","author":"Banti","year":"2012","journal-title":"Metallomics"},{"key":"10.1016\/j.ejmech.2017.10.067_bib5c","doi-asserted-by":"crossref","first-page":"6848","DOI":"10.1039\/c3dt53175a","article-title":"Novel metallo-therapeutics of the NSAID naproxen. Interaction with intracellular components that leads the cells to apoptosis","volume":"43","author":"Banti","year":"2014","journal-title":"Dalton Trans."},{"key":"10.1016\/j.ejmech.2017.10.067_bib5d","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jinorgbio.2014.10.005","article-title":"Silver(I) metallo-drugs of anti-inflammatory agents salicylic acid and its derivative which modulate cells function","volume":"142","author":"Banti","year":"2015","journal-title":"J.\u00a0Inorg. Biochem."},{"key":"10.1016\/j.ejmech.2017.10.067_bib5e","unstructured":"E.I. Gkaniatsou, C.N. Banti, N. Kourkoumelis, S. Skoulika, M. Manoli, A.J. Tasiopoulos, S.K. Hadjikakou, Novel mixed metal Ag(I)-Sb(III)-metallotherapeutics of the NSAIDs, aspirin and salicylic acid: enhancement of their solubility and bioactivity by using the surfactant CTAB, J. Inorg. Biochem.. 150(2015) 108\u2013119."},{"key":"10.1016\/j.ejmech.2017.10.067_bib6","doi-asserted-by":"crossref","first-page":"8681","DOI":"10.1021\/acs.inorgchem.6b01241","article-title":"Nimesulide silver metallodrugs, containing the mitochondriotropic, triaryl derivatives of pnictogen; Anticancer activity against human breast cancer cells","volume":"55","author":"Banti","year":"2016","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.ejmech.2017.10.067_bib7","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1039\/c3mt00046j","article-title":"Anti-proliferative and anti-tumor activity of silver(I) compounds","volume":"5","author":"Banti","year":"2013","journal-title":"Metallomics"},{"key":"10.1016\/j.ejmech.2017.10.067_bib8","doi-asserted-by":"crossref","first-page":"3048","DOI":"10.1002\/ejic.201501480","article-title":"Non-steroidal anti-inflammatory drugs (NSAIDs) in metal complexes and their effect at the cellular level","author":"Banti","year":"2016","journal-title":"Eur. J. Inorg. Chem."},{"key":"10.1016\/j.ejmech.2017.10.067_bib9","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1146\/annurev.pharmtox.47.120505.105110","article-title":"Targeting antioxidants to mitochondria by conjugation to lipophilic cations","volume":"47","author":"Murphy","year":"2007","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.ejmech.2017.10.067_sref9","doi-asserted-by":"crossref","first-page":"10446","DOI":"10.1039\/b909587j","article-title":"Synthesis, structural characterization and in\u00a0vitro cytotoxicity of new Au(III) and Au(I) complexes with thioamides","author":"Kouroulis","year":"2009","journal-title":"Dalton Trans."},{"key":"10.1016\/j.ejmech.2017.10.067_bib10b","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jinorgbio.2012.01.014","article-title":"Synthesis, characterization and biological studies of new antimony(III) halide complexes with \u03c9-thiocaprolactam","volume":"109","author":"Ozturk","year":"2012","journal-title":"J.\u00a0Inorg. Biochem."},{"key":"10.1016\/j.ejmech.2017.10.067_bib10c","doi-asserted-by":"crossref","first-page":"14568","DOI":"10.1039\/c2dt31527k","article-title":"Synthesis, structural characterization and in\u00a0vitro inhibitory studies against human breast cancer of the bis-(2,6-di-tert-butylphenol)tin(IV) dichloride and its complexes","volume":"41","author":"Shpakovsky","year":"2012","journal-title":"Dalton Trans."},{"key":"10.1016\/j.ejmech.2017.10.067_bib10d","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1071\/CH12448","article-title":"Structural and in\u00a0vitro biological studies of organotin(IV) precursors; selective inhibitory activity against human breast cancer cells, positive to estrogen receptors","volume":"65","author":"Balas","year":"2012","journal-title":"Aust. J. Chem."},{"key":"10.1016\/j.ejmech.2017.10.067_bib10e","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.ica.2014.02.006","article-title":"Assessment of organotins against the linoleic acid, glutathione and CT-DNA","volume":"423","author":"Banti","year":"2014","journal-title":"Inorg. Chim. Acta"},{"key":"10.1016\/j.ejmech.2017.10.067_bib10f","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.ejmech.2014.03.028","article-title":"A\u00a0novel silver iodide metalo-drug: experimental and computational modelling assessment of its interaction with intracellular DNA, lipoxygenase and glutathione","volume":"77","author":"Banti","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2017.10.067_bib10g","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.poly.2014.11.027","article-title":"Mono-nuclear cis-Pd(II) chloride complex of the thio-nucleotide analogue 5-methyl-thiouracil and its biological activity","volume":"87","author":"Banti","year":"2015","journal-title":"Polyhedron"},{"key":"10.1016\/j.ejmech.2017.10.067_bib10h","first-page":"29026","article-title":"Novel bismuth(III) bromide or iodide compounds; Synthesis, characterization and biological activity against human adenocarcinoma cell lines","volume":"6","author":"Arda","year":"2016","journal-title":"RCS Adv."},{"key":"10.1016\/j.ejmech.2017.10.067_bib11","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1039\/DT9850000321","article-title":"Chemical and structural aspects of silver-triphenylarsine complexes and silver-tin complex salts","author":"Nardelli","year":"1985","journal-title":"J.\u00a0Chem. Soc. Dalton Trans."},{"key":"10.1016\/j.ejmech.2017.10.067_bib12","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/S0010-8545(99)00039-9","article-title":"Structural and solution chemistry of gold(I) and silver(I) complexes of bidentate pyridyl phosphines: selective antitumour agents","volume":"185\u2212186","author":"Berners-Price","year":"1999","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.ejmech.2017.10.067_bib13a","doi-asserted-by":"crossref","DOI":"10.1155\/2009\/542979","article-title":"Synthesis, characterization, and biological studies of organotin(IV) derivatives with o- or p-hydroxybenzoic acids","author":"Abdellah","year":"2009","journal-title":"Bioinorg. Chem. Appl."},{"key":"10.1016\/j.ejmech.2017.10.067_bib13b","first-page":"189","article-title":"The infrared spectra and structure of acetylsalicylic acid (aspirin) and its oxyanion: an ab initio force field treatment","volume":"378","author":"Binev","year":"1996","journal-title":"J.\u00a0Mol. Struct."},{"key":"10.1016\/j.ejmech.2017.10.067_bib14","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1210\/mend.14.9.0526","article-title":"Plasma membrane estrogen receptors signal to antiapoptosis in breast cancer","volume":"14","author":"Razandi","year":"2000","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.ejmech.2017.10.067_bib15a","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.1073\/pnas.83.8.2496","article-title":"Phenol red in tissue culture media is a weak estrogen: implications concerning the study of estrogen-responsive cells in culture","volume":"83","author":"Berthois","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejmech.2017.10.067_bib15b","doi-asserted-by":"crossref","first-page":"5627","DOI":"10.1039\/c3an00807j","article-title":"Detection of an estrogen derivative in two breast cancer cell lines using a single core multimodal probe for imaging (SCoMPI) imaged by a panel of luminescent and vibrational techniques","volume":"138","author":"Clede","year":"2013","journal-title":"Analyst"},{"key":"10.1016\/j.ejmech.2017.10.067_bib15c","doi-asserted-by":"crossref","first-page":"7444","DOI":"10.1039\/c0dt00169d","article-title":"Organometallic cyclic polyphenols derived from 1,2-(\u03b1-keto tri or tetra methylene) ferrocene show strong antiproliferative activity on hormone-independent breast cancer cells","volume":"39","author":"Plazuk","year":"2010","journal-title":"Dalton Trans."},{"key":"10.1016\/j.ejmech.2017.10.067_bib16a","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1093\/mutage\/gei055","article-title":"The evaluation of micronucleus frequency by acridine orange fluorescent staining in peripheral blood of rats treated with lead acetate","volume":"20","author":"Celik","year":"2005","journal-title":"Mutagenesis"},{"key":"10.1016\/j.ejmech.2017.10.067_bib16b","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/956835","article-title":"Potential uses, limitations, and basic procedures of micronuclei and nuclear abnormalities in buccal cells","author":"Torres-Bugar\u00edn","year":"2014","journal-title":"Dis. Markers"},{"key":"10.1016\/j.ejmech.2017.10.067_bib16c","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1002\/jat.3028","article-title":"Comparative genotoxicity of nanosilver in human liver HepG2 and colon Caco2 cells evaluated by fluorescent microscopy of cytochalasin B-blocked micronucleus formation","volume":"34","author":"Sahu","year":"2014","journal-title":"J.\u00a0Appl. Toxicol."},{"key":"10.1016\/j.ejmech.2017.10.067_bib17","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1046\/j.1365-2133.2000.03882.x","article-title":"C2-ceramide induces apoptosis in a human squamous cell carcinoma cell line","volume":"143","author":"Sugiki","year":"2000","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.ejmech.2017.10.067_bib18a","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/cyto.a.20357","article-title":"Discontinuous fragmentation of nuclear DNA during apoptosis revealed by discrete \u201csub-G1\u201d peaks on DNA content histograms","volume":"71A","author":"Kajstura","year":"2007","journal-title":"Cytom. Part A"},{"key":"10.1016\/j.ejmech.2017.10.067_bib18b","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.ejmech.2014.04.026","article-title":"Synthesis, characterization and anti-proliferative activity of heterocyclic hypervalent organoantimony compounds","volume":"79","author":"Chen","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2017.10.067_bib19a","doi-asserted-by":"crossref","first-page":"881","DOI":"10.3892\/ol.2013.1772","article-title":"\u03b2-diketone-cobalt complexes inhibit DNA synthesis and induce S-phase arrest in rat C6 glioma cells","volume":"7","author":"Zhang","year":"2014","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.ejmech.2017.10.067_bib19b","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1039\/c4mt00034j","article-title":"Potent organometallic osmium compounds induce mitochondria-mediated apoptosis and S-phase cell cycle arrest in A549 non-small cell lung cancer cells","volume":"6","author":"van Rijt","year":"2014","journal-title":"Metallomics"},{"key":"10.1016\/j.ejmech.2017.10.067_bib20","doi-asserted-by":"crossref","first-page":"26553","DOI":"10.1074\/jbc.M202040200","article-title":"Abrogation of the S Phase DNA damage checkpoint Results in S Phase progression or premature mitosis depending on the concentration of 7-hydroxystaurosporine and the kinetics of Cdc25C activation","volume":"277","author":"Kohn","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.ejmech.2017.10.067_bib21","doi-asserted-by":"crossref","first-page":"4459","DOI":"10.1002\/cncr.24514","article-title":"Gold (III) porphyrin complexes induce apoptosis and cell cycle arrest and inhibit tumor growth in colon cancer","author":"Tu","year":"2009","journal-title":"Cancer"},{"key":"10.1016\/j.ejmech.2017.10.067_bib22a","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/17135","article-title":"Molecular characterization of mitochondrial apoptosis-inducing factor","volume":"397","author":"Susin","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2017.10.067_bib22b","doi-asserted-by":"crossref","first-page":"19449","DOI":"10.1038\/srep19449","article-title":"Ruthenium(II) complexes with 2-Phenylimidazo[4,5-f][1,10] phenanthroline derivatives that strongly combat cisplatin-resistant tumor cells","volume":"6","author":"Zeng","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2017.10.067_bib23","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1152\/physrev.00013.2006","article-title":"Mitochondrial membrane permeabilization in cell death","volume":"87","author":"Kroemer","year":"2007","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejmech.2017.10.067_bib24","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/sj.bjp.0707576","article-title":"[Pt(O,O\u2032-acac)(\u03b3-acac)(DMS)], a new Pt compound exerting fast cytotoxicity in MCF-7 breast cancer cells via the mitochondrial apoptotic pathway","volume":"153","author":"Muscella","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejmech.2017.10.067_bib25a","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/1476-511X-11-142","article-title":"Conjugated linoleic acid or omega 3 fatty acids increase mitochondrial biosynthesis and metabolism in skeletal muscle cells","volume":"11","author":"Vaughan","year":"2012","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.ejmech.2017.10.067_bib25b","first-page":"327","article-title":"Biological studies of new organotin(IV) complexes of thioamide ligandsm Eur","volume":"43","author":"Xanthopoulou","year":"2008","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2017.10.067_bib26","doi-asserted-by":"crossref","first-page":"4389","DOI":"10.1039\/c2dt11759b","article-title":"DNA binding and antiproliferative activity toward human carcinoma cells of copper(II) and zinc(II) complexes of a 2,5-diphenyl[1,3,4]oxadiazole derivative","volume":"41","author":"Terenzi","year":"2012","journal-title":"Dalton Trans."},{"key":"10.1016\/j.ejmech.2017.10.067_bib27a","series-title":"Oxford Diffraction Ltd., 2006 (Release 28-08-2006 CrysAlis171.NET)","author":"CrysAlis RED","year":"2006"},{"key":"10.1016\/j.ejmech.2017.10.067_bib27b","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1107\/S0108767390000277","article-title":"Phase annealing in SHELX-90: direct methods for larger structures","volume":"46","author":"Sheldrick","year":"1990","journal-title":"Acta Crystallogr. A"},{"key":"10.1016\/j.ejmech.2017.10.067_bib27c","series-title":"SHELXL-97, Program for the Refinement of Crystal Structures","author":"Sheldrick","year":"1997"}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523417308693?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523417308693?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T21:32:34Z","timestamp":1540416754000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523417308693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":49,"alternative-id":["S0223523417308693"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2017.10.067","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"New metalo-therapeutics of NSAIDs against human breast cancer cells","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2017.10.067","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}