{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:19:13Z","timestamp":1792095553349,"version":"4.4.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673369\/H3008"],"award-info":[{"award-number":["81673369\/H3008"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Planning Key Project of Guangdong Province, China","award":["2015B020211005"],"award-info":[{"award-number":["2015B020211005"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.ejmech.2018.03.077","type":"journal-article","created":{"date-parts":[[2018,3,31]],"date-time":"2018-03-31T12:36:16Z","timestamp":1522499776000},"page":"294-303","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"special_numbering":"C","title":["A tumor-targeted Ganetespib-zinc phthalocyanine conjugate for synergistic chemo-photodynamic therapy"],"prefix":"10.1016","volume":"151","author":[{"given":"Liangfeng","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaofei","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeqian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifeng","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunhui","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunshun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2018.03.077_bib1","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/nrc1070","article-title":"Cancer revoked: oncogenes as therapeutic targets","volume":"3","author":"Felsher","year":"2003","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.ejmech.2018.03.077_bib2","first-page":"7495","article-title":"Photosensitization with zinc (II) phthalocyanine as a switch in the decision between apoptosis and necrosis","volume":"61","author":"Fabris","year":"2001","journal-title":"Canc. Res."},{"key":"10.1016\/j.ejmech.2018.03.077_bib3","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.ejmech.2017.12.062","article-title":"Synthesis and biological evaluation of new water-soluble photoactive chlorin conjugate for targeted delivery","volume":"144","author":"Otvagin","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.03.077_bib4","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201605021","article-title":"Self-assembled peptide- and protein-based nanomaterials for antitumor photodynamic and photothermal therapy","volume":"29","author":"Abbas","year":"2017","journal-title":"Adv. Mater."},{"key":"10.1016\/j.ejmech.2018.03.077_bib5","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.ejmech.2017.08.070","article-title":"Recent advances in drug discovery of phototherapeutic non-porphyrinic anticancer agents","volume":"142","author":"Dichiara","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.03.077_bib6","doi-asserted-by":"crossref","first-page":"6693","DOI":"10.1021\/acs.jmedchem.7b00682","article-title":"A\u00a0molecular combination of zinc(II) phthalocyanine and tamoxifen derivative for dual targeting photodynamic therapy and hormone therapy","volume":"60","author":"Zhang","year":"2017","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.03.077_bib7","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S1359-6446(99)01412-9","article-title":"Photodynamic therapeutics: basic principles and clinical applications","volume":"4","author":"Sharman","year":"1999","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.ejmech.2018.03.077_bib8","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.ejmech.2017.09.058","article-title":"Synthesis and biological evaluation of a Platinum(II)-c(RGDyK) conjugate for integrin-targeted photodynamic therapy","volume":"141","author":"Chatzisideri","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.03.077_bib9","doi-asserted-by":"crossref","DOI":"10.1038\/natrevmats.2016.14","article-title":"Analysis of nanoparticle delivery to tumours","volume":"1","author":"Wilhelm","year":"2016","journal-title":"Nat Rev Mater"},{"key":"10.1016\/j.ejmech.2018.03.077_bib10","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/nrclinonc.2010.139","article-title":"Delivering nanomedicine to solid tumors","volume":"7","author":"Jain","year":"2010","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.ejmech.2018.03.077_bib11","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jconrel.2016.11.015","article-title":"To exploit the tumor microenvironment: since the EPR effect fails in the clinic, what is the future of nanomedicine?","volume":"244","author":"Danhier","year":"2016","journal-title":"J.\u00a0Contr. Release"},{"key":"10.1016\/j.ejmech.2018.03.077_bib12","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nrd4519","article-title":"Principles in the design of ligand-targeted cancer therapeutics and imaging agents","volume":"14","author":"Srinivasarao","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejmech.2018.03.077_bib13","doi-asserted-by":"crossref","first-page":"12133","DOI":"10.1021\/acs.chemrev.7b00013","article-title":"Ligand-targeted drug delivery","volume":"117","author":"Srinivasarao","year":"2017","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejmech.2018.03.077_bib14","doi-asserted-by":"crossref","first-page":"5446","DOI":"10.1021\/jm300398q","article-title":"A\u00a0zinc(II) phthalocyanine conjugated with an oxaliplatin derivative for dual chemo- and photodynamic therapy","volume":"55","author":"Lau","year":"2012","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.03.077_bib15","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.ejmech.2016.12.056","article-title":"A\u00a0tumor-targeted activatable phthalocyanine-tetrapeptide-doxorubicin conjugate for synergistic chemo-photodynamic therapy","volume":"127","author":"Ke","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.03.077_bib16","doi-asserted-by":"crossref","first-page":"15883","DOI":"10.1039\/C7NR05402E","article-title":"Phthalocyanine-based coordination polymer nanoparticles for enhanced photodynamic therapy","volume":"9","author":"Huang","year":"2017","journal-title":"Nanoscale"},{"key":"10.1016\/j.ejmech.2018.03.077_bib17","doi-asserted-by":"crossref","first-page":"8667","DOI":"10.1021\/acs.jmedchem.7b01216","article-title":"Photodynamic oncotherapy mediated by gonadotropin-releasing hormone receptors","volume":"60","author":"Xu","year":"2017","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.03.077_bib18","doi-asserted-by":"crossref","first-page":"4973","DOI":"10.1158\/1078-0432.CCR-11-2967","article-title":"Ganetespib (STA-9090), a nongeldanamycin HSP90 inhibitor, has potent antitumor activity in in\u00a0vitro and in\u00a0vivo models of non-small cell lung cancer","volume":"18","author":"Shimamura","year":"2012","journal-title":"Clin. Canc. Res."},{"key":"10.1016\/j.ejmech.2018.03.077_bib19","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nature01913","article-title":"A\u00a0high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors","volume":"425","author":"Kamal","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2018.03.077_bib20","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/nrc1716","article-title":"HSP90 and the chaperoning of cancer","volume":"5","author":"Whitesell","year":"2005","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.ejmech.2018.03.077_bib21","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/ncb0604-479","article-title":"Hsp90 invades the outside","volume":"6","author":"Picard","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ejmech.2018.03.077_bib22","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/ncb1131","article-title":"Functional proteomic screens reveal an essential extracellular role for hsp90 alpha in cancer cell invasiveness","volume":"6","author":"Eustace","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ejmech.2018.03.077_bib23","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.2174\/156802609789895728","article-title":"Update on Hsp90 inhibitors in clinical trial","volume":"9","author":"Kim","year":"2009","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.03.077_bib24","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nrm.2017.20","article-title":"The HSP90 chaperone machinery","volume":"18","author":"Schopf","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ejmech.2018.03.077_bib25","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1158\/1535-7163.MCT-11-0755","article-title":"Ganetespib, a unique triazolone-containing Hsp90 inhibitor, exhibits potent antitumor activity and a superior safety profile for cancer therapy","volume":"11","author":"Ying","year":"2012","journal-title":"Mol. Canc. Therapeut."},{"key":"10.1016\/j.ejmech.2018.03.077_bib26","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1021\/acschembio.7b00006","article-title":"A\u00a0fluorescent Hsp90 probe demonstrates the unique association between extracellular Hsp90 and malignancy in\u00a0vivo","volume":"12","author":"Crowe","year":"2017","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.ejmech.2018.03.077_bib27","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.chembiol.2013.08.004","article-title":"Optical and radioiodinated tethered Hsp90 inhibitors reveal selective internalization of ectopic Hsp90 in malignant breast tumor cells","volume":"20","author":"Barrott","year":"2013","journal-title":"Chem. Biol."},{"key":"10.1016\/j.ejmech.2018.03.077_bib28","doi-asserted-by":"crossref","first-page":"21288","DOI":"10.1073\/pnas.0908151106","article-title":"The regulatory mechanism of Hsp90alpha secretion and its function in tumor malignancy","volume":"106","author":"Wang","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejmech.2018.03.077_bib29","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1124\/mol.115.098269","article-title":"Sequential upregulation of superoxide dismutase 2 and heme oxygenase 1 by tert-butylhydroquinone protects mitochondria during oxidative stress","volume":"88","author":"Sun","year":"2015","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejmech.2018.03.077_bib30","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.canlet.2009.08.015","article-title":"Targeting the 90 kDa heat shock protein improves photodynamic therapy","volume":"289","author":"Ferrario","year":"2010","journal-title":"Canc. Lett."},{"key":"10.1016\/j.ejmech.2018.03.077_bib31","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.7150\/thno.14882","article-title":"HSP90 inhibitor encapsulated photo-theranostic nanoparticles for synergistic combination cancer therapy","volume":"6","author":"Lin","year":"2016","journal-title":"Theranostics"},{"key":"10.1016\/j.ejmech.2018.03.077_bib32","doi-asserted-by":"crossref","first-page":"7163","DOI":"10.1002\/anie.201402189","article-title":"Conjugated-polyelectrolyte-based polyprodrug: targeted and image-guided photodynamic and chemotherapy with on-demand drug release upon irradiation with a single light source","volume":"53","author":"Yuan","year":"2014","journal-title":"Angew Chem. Int. Ed. Engl."},{"key":"10.1016\/j.ejmech.2018.03.077_bib33","series-title":"5-Aryl-4-(5-substituted 2, 4-dihydroxyphenyl)-1, 2, 3-thiadiazoles as Inhibitors of HSP90 Chaperone and the Intermediates for Production Thereof","author":"Matulis","year":"2009"},{"key":"10.1016\/j.ejmech.2018.03.077_bib34","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/nchem.695","article-title":"Lewis acid-catalysed formation of two-dimensional phthalocyanine covalent organic frameworks","volume":"2","author":"Spitler","year":"2010","journal-title":"Nat. Chem."},{"key":"10.1016\/j.ejmech.2018.03.077_bib35","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1039\/b814791d","article-title":"Photophysical properties and intracellular imaging of water-soluble porphyrin dimers for two-photon excited photodynamic therapy","volume":"7","author":"Kuimova","year":"2009","journal-title":"Org. Biomol. Chem."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523418303209?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523418303209?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T22:40:21Z","timestamp":1565304021000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523418303209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":35,"alternative-id":["S0223523418303209"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2018.03.077","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A tumor-targeted Ganetespib-zinc phthalocyanine conjugate for synergistic chemo-photodynamic therapy","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2018.03.077","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}