{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T02:09:08Z","timestamp":1781489348585,"version":"3.54.1"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573292"],"award-info":[{"award-number":["81573292"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573292"],"award-info":[{"award-number":["81573292"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.ejmech.2018.04.005","type":"journal-article","created":{"date-parts":[[2018,4,3]],"date-time":"2018-04-03T14:03:26Z","timestamp":1522764206000},"page":"434-449","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":78,"special_numbering":"C","title":["Design, synthesis, cytotoxicity and mechanism of novel dihydroartemisinin-coumarin hybrids as potential anti-cancer agents"],"prefix":"10.1016","volume":"151","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0242-8532","authenticated-orcid":false,"given":"Haonan","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuang","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhua","family":"Mou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2018.04.005_bib1","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1039\/B816679J","article-title":"Artemisinin and its derivatives: a novel class of anti-malarial and anti-cancer agents","volume":"39","author":"Chaturvedi","year":"2010","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.ejmech.2018.04.005_bib2","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/hed.20524","article-title":"Effects of artemisinin and its derivatives on growth inhibition and apoptosis of oral cancer cells","volume":"29","author":"MSD","year":"2007","journal-title":"Head Neck"},{"key":"10.1016\/j.ejmech.2018.04.005_bib3","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1111\/j.1582-4934.2008.00360.x","article-title":"Dihydroartemisinin induces apoptosis and sensitizes human ovarian cancer cells to carboplatin therapy","volume":"13","author":"Tao","year":"2009","journal-title":"J.\u00a0Cell Mol. Med."},{"key":"10.1016\/j.ejmech.2018.04.005_bib4","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.bmcl.2013.11.032","article-title":"Synthesis of a novel series of artemisinin dimers with potent anticancer activity involving Sonogashira cross-coupling reaction","volume":"24","author":"Buragohain","year":"2014","journal-title":"Bioorg. Med. Chem. Lett"},{"issue":"1","key":"10.1016\/j.ejmech.2018.04.005_bib5","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.canlet.2010.01.001","article-title":"Sun BDihydroartemisinin inactivates NF-kappaB and potentiates the anti-tumor effect of gemcitabine on pancreatic cancer both in\u00a0vitro and in\u00a0vivo","volume":"293","author":"Wang","year":"2010","journal-title":"Canc. Lett."},{"key":"10.1016\/j.ejmech.2018.04.005_bib6","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.ejmech.2015.10.040","article-title":"Combating P-glycoprotein-mediated multidrug resistance with 10-O-phenyl dihydroartemisinin ethers in MCF-7 cells","volume":"108","author":"Zhong","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.04.005_bib7","first-page":"145","article-title":"Gastric tumor, in: atlas of gastrointestinal endomicroscopy","year":"2012","journal-title":"Sci. World"},{"key":"10.1016\/j.ejmech.2018.04.005_bib8","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1364\/JOSAA.28.000118","article-title":"Analysis of electromagnetic scattering by uniaxial anisotropic bispheres","volume":"28","author":"Li","year":"2011","journal-title":"J.\u00a0Opt. Soc. Am. A"},{"key":"10.1016\/j.ejmech.2018.04.005_bib9","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.bmcl.2010.12.059","article-title":"Synthesis and evaluation of a class of new coumarin triazole derivatives as potential antimicrobial agents","volume":"21","author":"Shi","year":"2011","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2018.04.005_bib10","doi-asserted-by":"crossref","first-page":"12931","DOI":"10.1021\/bi048999g","article-title":"Inhibition of protein kinase CK2 by condensed polyphenolic derivatives. An in\u00a0vitro and in\u00a0vivo study","volume":"43","author":"Meggio","year":"2004","journal-title":"Biochemistry"},{"key":"10.1016\/j.ejmech.2018.04.005_bib11","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1021\/jm070909t","article-title":"Coumarin as attractive casein kinase 2 (CK2) inhibitor scaffold: an integrate approach to elucidate the putative binding motif and explain structure\u2013activity relationships","volume":"51","author":"Chilin","year":"2008","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.04.005_bib12","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1021\/jm901287j","article-title":"Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins","volume":"53","author":"Maresca","year":"2010","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.04.005_bib13","doi-asserted-by":"crossref","first-page":"7255","DOI":"10.1016\/j.bmcl.2010.10.094","article-title":"7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar\/subnanomolar range","volume":"20","author":"Maresca","year":"2010","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2018.04.005_bib14","doi-asserted-by":"crossref","first-page":"4511","DOI":"10.1016\/j.bmcl.2010.06.040","article-title":"Coumarins incorporating hydroxy- and chloro-moieties selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II","volume":"20","author":"Maresca","year":"2010","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2018.04.005_bib15","doi-asserted-by":"crossref","first-page":"5308","DOI":"10.1016\/j.bmc.2014.07.052","article-title":"Attachment of carbohydrates to methoxyaryl moieties leads to highly selective inhibitors of the cancer associated carbonic anhydrase isoforms IX and XII","volume":"22","author":"Riafrecha","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.04.005_bib16","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1111\/j.1582-4934.2009.00994.x","article-title":"Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer","volume":"14","author":"Chiche","year":"2010","journal-title":"J.\u00a0Cell Mol. Med."},{"key":"10.1016\/j.ejmech.2018.04.005_bib17","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1042\/bse0430165","article-title":"Hypoxia in cancer cell metabolism and pH regulation","volume":"43","author":"Brahimi-Horn","year":"2007","journal-title":"Essays Biochem."},{"key":"10.1016\/j.ejmech.2018.04.005_bib18","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s10555-007-9064-0","article-title":"Regulation of tumor pH and the role of carbonic anhydrase 9","volume":"26","author":"Swietach","year":"2007","journal-title":"Canc. Metastasis Rev."},{"key":"10.1016\/j.ejmech.2018.04.005_bib19","doi-asserted-by":"crossref","first-page":"758","DOI":"10.3390\/molecules21060758","article-title":"Design, synthesis and cytotoxicity of novel dihydroartemisinin-coumarin hybrids via click chemistry","volume":"21","author":"Tian","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2018.04.005_bib20","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1021\/ja809683v","article-title":"Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors","volume":"131","author":"Maresca","year":"2009","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2018.04.005_bib21","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s40139-017-0139-5","article-title":"Autophagy and ferroptosis\u2014what is the connection?","volume":"5","author":"Kang","year":"2017","journal-title":"Current Pathobiology Reports"},{"key":"10.1016\/j.ejmech.2018.04.005_bib22","doi-asserted-by":"crossref","first-page":"517","DOI":"10.18632\/oncoscience.160","article-title":"Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells","volume":"2","author":"Eling","year":"2015","journal-title":"Oncoscience"}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523418303325?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523418303325?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T22:38:02Z","timestamp":1565303882000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523418303325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":22,"alternative-id":["S0223523418303325"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2018.04.005","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design, synthesis, cytotoxicity and mechanism of novel dihydroartemisinin-coumarin hybrids as potential anti-cancer agents","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2018.04.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}