{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T14:50:38Z","timestamp":1770907838654,"version":"3.50.1"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100006538","name":"CAN","doi-asserted-by":"publisher","award":["111526934273"],"award-info":[{"award-number":["111526934273"]}],"id":[{"id":"10.13039\/501100006538","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006538","name":"CAN","doi-asserted-by":"publisher","award":["RC-597-2013"],"award-info":[{"award-number":["RC-597-2013"]}],"id":[{"id":"10.13039\/501100006538","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"MINECO","doi-asserted-by":"publisher","award":["BIO2014-52872-R"],"award-info":[{"award-number":["BIO2014-52872-R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002924","name":"FEDER","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["2014-SGR-938"],"award-info":[{"award-number":["2014-SGR-938"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004435","name":"Universidad de Navarra","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004435","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Programa Nacional de Innovaci\u00f3n para la competitividad y productividad","award":["065-FINCYT-BDE-2014"],"award-info":[{"award-number":["065-FINCYT-BDE-2014"]}]},{"name":"Colciencias Grants","award":["528\u20132011"],"award-info":[{"award-number":["528\u20132011"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.ejmech.2018.04.038","type":"journal-article","created":{"date-parts":[[2018,4,24]],"date-time":"2018-04-24T22:32:13Z","timestamp":1524609133000},"page":"489-514","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Structure-activity relationship of new antimalarial 1-aryl-3-susbtituted propanol derivatives: Synthesis, preliminary toxicity profiling, parasite life cycle stage studies, target exploration, and targeted delivery"],"prefix":"10.1016","volume":"152","author":[{"given":"Miguel","family":"Quiliano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Pab\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernest","family":"Moles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Bonilla-Ramirez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Fabing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim Y.","family":"Fong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego A.","family":"Nieto-Aco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David W.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan C.","family":"Pizarro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariane","family":"Vettorazzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adela","family":"L\u00f3pez de Cerain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Deharo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Fern\u00e1ndez-Busquets","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanny","family":"Garavito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Aldana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Galiano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2018.04.038_bib1","series-title":"World Malaria Report 2017, Geneva","author":"WHO","year":"2017"},{"key":"10.1016\/j.ejmech.2018.04.038_bib2","doi-asserted-by":"crossref","first-page":"17050","DOI":"10.1038\/nrdp.2017.50","article-title":"T.N.C. Wells, malaria","volume":"3","author":"Phillips","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.ejmech.2018.04.038_bib3","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/nrmicro.2017.161","article-title":"Drug resistance in Plasmodium","volume":"16","author":"Haldar","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.ejmech.2018.04.038_bib4","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S1473-3099(15)70032-0","article-title":"Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: a cross-sectional survey of the K13 molecular marker","volume":"15","author":"Tun","year":"2015","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.ejmech.2018.04.038_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejmech.2018.01.039","article-title":"Antiplasmodial and antimalarial activities of quinolone derivatives: an overview","volume":"146","author":"Fan","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.04.038_bib6","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ejmech.2017.07.061","article-title":"Quinoline hybrids and their antiplasmodial and antimalarial activities","volume":"139","author":"Hu","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.04.038_bib7","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ijpddr.2014.02.002","article-title":"Drug repurposing and human parasitic protozoan diseases","volume":"4","author":"Andrews","year":"2014","journal-title":"Int. J. Parasitol. Drugs Drug Resist"},{"key":"10.1016\/j.ejmech.2018.04.038_bib8","doi-asserted-by":"crossref","first-page":"123","DOI":"10.4155\/fmc.13.205","article-title":"Realistically, how far are we from a universal malaria drug?","volume":"6","author":"Biamonte","year":"2014","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.ejmech.2018.04.038_bib9","doi-asserted-by":"crossref","first-page":"4622","DOI":"10.1021\/jm960358z","article-title":"Molecular electronic properties of a series of 4-Quinolinecarbinolamines define antimalarial activity profile","volume":"39","author":"Bhattacharjee","year":"1996","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.04.038_bib10","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.ijpddr.2016.09.004","article-title":"Exploring the scope of new arylamino alcohol derivatives: synthesis, antimalarial evaluation, toxicological studies, and target exploration","volume":"6","author":"Quiliano","year":"2016","journal-title":"Int. J. Parasitol. Drugs Drug Resist"},{"key":"10.1016\/j.ejmech.2018.04.038_bib11","doi-asserted-by":"crossref","first-page":"6344","DOI":"10.1021\/acs.jmedchem.6b00591","article-title":"Inhibition of Plasmodium falciparum Hsp90 contributes to the antimalarial activities of Aminoalcohol-carbazoles","volume":"59","author":"Wang","year":"2016","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.04.038_bib12","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.ijpddr.2017.03.007","article-title":"Novel carbazole aminoalcohols as inhibitors of \u03b2-hematin formation: antiplasmodial and antischistosomal activities","volume":"7","author":"Wang","year":"2017","journal-title":"Int. J. Parasitol. Drugs Drug Resist"},{"key":"10.1016\/j.ejmech.2018.04.038_bib13","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.exppara.2011.02.025","article-title":"Aryl piperazine and pyrrolidine as antimalarial agents. Synthesis and investigation of structure-activity relationships","volume":"128","author":"Mendoza","year":"2011","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.ejmech.2018.04.038_bib14","doi-asserted-by":"crossref","first-page":"4120","DOI":"10.3390\/molecules14104120","article-title":"New 1-aryl-3-substituted propanol derivatives as antimalarial agents","volume":"14","author":"Perez-Silanes","year":"2009","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2018.04.038_bib15","doi-asserted-by":"crossref","DOI":"10.5935\/1984-6835.20130081","article-title":"Quinoxaline and Arylaminoalcohol derivatives as antiplasmodial and leishmanicidal agents: a review of our first ten years in the field","volume":"5","author":"Quiliano","year":"2013","journal-title":"Rev. Virtual Quim"},{"key":"10.1016\/j.ejmech.2018.04.038_bib16","doi-asserted-by":"crossref","first-page":"6477","DOI":"10.1021\/jm1006484","article-title":"Synthesis, Structure\u2212Activity relationship, and mode-of-action studies of antimalarial reversed chloroquine compounds","volume":"53","author":"Burgess","year":"2010","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.04.038_bib17","doi-asserted-by":"crossref","first-page":"e01913","DOI":"10.1128\/AAC.01913-16","article-title":"Simplified reversed chloroquines to overcome malaria resistance to Quinoline-based drugs","volume":"61","author":"Gunsaru","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2018.04.038_bib18","doi-asserted-by":"crossref","first-page":"7477","DOI":"10.1021\/jm2005546","article-title":"Optimization of propafenone analogues as antimalarial leads","volume":"54","author":"Lowes","year":"2011","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.04.038_bib19","doi-asserted-by":"crossref","first-page":"4128","DOI":"10.1021\/jm0111200","article-title":"Synthesis and molecular modeling of new 1-Aryl-3-[4-arylpiperazin-1-yl]-1-propane derivatives with high affinity at the serotonin transporter and at 5-HT1A receptors","volume":"45","author":"Or\u00fas","year":"2002","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.04.038_bib20","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1021\/tx000002x","article-title":"Mutagenicity of nitroaromatic compounds","volume":"13","author":"Purohit","year":"2000","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.ejmech.2018.04.038_bib21","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1021\/ci050357s","article-title":"Molecular field extrema as descriptors of biological Activity:\u2009 definition and validation","volume":"46","author":"Cheeseright","year":"2006","journal-title":"J.\u00a0Chem. Inf. Model."},{"key":"10.1016\/j.ejmech.2018.04.038_bib22","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1021\/ci3001277","article-title":"ZINC: a free tool to discover chemistry for biology","volume":"52","author":"Irwin","year":"2012","journal-title":"J.\u00a0Chem. Inf. Model."},{"key":"10.1016\/j.ejmech.2018.04.038_bib23","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J.\u00a0Immunol. Meth."},{"key":"10.1016\/j.ejmech.2018.04.038_bib24","doi-asserted-by":"crossref","first-page":"3714","DOI":"10.1021\/jm000942e","article-title":"Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties","volume":"43","author":"Ertl","year":"2000","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.04.038_bib25","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1023\/A:1020444330011","article-title":"Rate-limited steps of human oral absorption and QSAR studies","volume":"19","author":"Zhao","year":"2002","journal-title":"Pharm. Res. (N. Y.)"},{"key":"10.1016\/j.ejmech.2018.04.038_bib26","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(96)00423-1","article-title":"Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings","volume":"23","author":"Lipinski","year":"1997","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ejmech.2018.04.038_bib27","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1021\/jm020017n","article-title":"Molecular properties that influence the oral bioavailability of drug candidates","volume":"45","author":"Veber","year":"2002","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.04.038_bib28","series-title":"OECD Guideline for Testing of Chemicals\/ Section 4:Health Effects Test No. 471: Bacterial Reverse Mutation Test","year":"1997"},{"key":"10.1016\/j.ejmech.2018.04.038_bib29","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0165-1218(96)90021-X","article-title":"Validation of the SOS\/umu test using test results of 486 chemicals and comparison with the Ames test and carcinogenicity data","volume":"369","author":"Reifferscheid","year":"1996","journal-title":"Mutat. Res. Genet. Toxicol."},{"key":"10.1016\/j.ejmech.2018.04.038_bib30","doi-asserted-by":"crossref","first-page":"e1001169","DOI":"10.1371\/journal.pmed.1001169","article-title":"The activities of current antimalarial drugs on the life cycle stages of Plasmodium: a comparative study with human and rodent parasites","volume":"9","author":"Delves","year":"2012","journal-title":"PLoS Med."},{"key":"10.1016\/j.ejmech.2018.04.038_bib31","doi-asserted-by":"crossref","first-page":"18336","DOI":"10.1074\/jbc.M211309200","article-title":"Heat shock protein 90 function is essential for Plasmodium falciparum growth in human erythrocytes","volume":"278","author":"Banumathy","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.ejmech.2018.04.038_bib32","doi-asserted-by":"crossref","first-page":"e168","DOI":"10.1371\/journal.pcbi.0030168","article-title":"Systems analysis of chaperone networks in the malarial parasite Plasmodium falciparum","volume":"3","author":"Pavithra","year":"2007","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.ejmech.2018.04.038_bib33","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1017\/S0031182014000754","article-title":"Mouse studies on inhibitors of Plasmodium falciparum Hsp90: progress and challenges","volume":"141","author":"Bayih","year":"2014","journal-title":"Parasitology"},{"key":"10.1016\/j.ejmech.2018.04.038_bib34","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1186\/s12936-017-1940-7","article-title":"Identification and characterization of the antiplasmodial activity of Hsp90 inhibitors","volume":"16","author":"Murillo-Solano","year":"2017","journal-title":"Malar. J."},{"key":"10.1016\/j.ejmech.2018.04.038_bib35","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.bbamcr.2011.12.003","article-title":"Heat shock protein 90 from neglected protozoan parasites","volume":"1823","author":"Roy","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejmech.2018.04.038_bib36","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1021\/jm401801t","article-title":"Differences in conformational dynamics between Plasmodium falciparum and human Hsp90 orthologues enable the structure-based discovery of pathogen-selective inhibitors","volume":"57","author":"Wang","year":"2014","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.04.038_bib37","first-page":"411","article-title":"Spread of artemisinin resistance in Plasmodium falciparum malaria, N. Engl","volume":"371","author":"Ashley","year":"2014","journal-title":"J.\u00a0Med."},{"key":"10.1016\/j.ejmech.2018.04.038_bib38","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.biomaterials.2017.08.020","article-title":"ImmunoPEGliposomes for the targeted delivery of novel lipophilic drugs to red blood cells in a falciparum malaria murine model","volume":"145","author":"Moles","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejmech.2018.04.038_bib39","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jconrel.2015.05.284","article-title":"Immunoliposome-mediated drug delivery to Plasmodium-infected and non-infected red blood cells as a dual therapeutic\/prophylactic antimalarial strategy","volume":"210","author":"Moles","year":"2015","journal-title":"J.\u00a0Contr. Release"},{"key":"10.1016\/j.ejmech.2018.04.038_bib40","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1006\/expr.1993.1042","article-title":"Plasmodium falciparum: role of absolute stereochemistry in the antimalarial activity of synthetic amino alcohol antimalarial agents","volume":"76","author":"Karle","year":"1993","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.ejmech.2018.04.038_bib41","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1023\/B:MODI.0000006809.48284.ed","article-title":"Efficient large scale microwave assisted Mannich reactions using substituted acetophenones","volume":"7","author":"Lehmann","year":"2003","journal-title":"Mol. Divers."},{"key":"10.1016\/j.ejmech.2018.04.038_bib42","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1128\/AAC.16.6.710","article-title":"Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique","volume":"16","author":"Desjardins","year":"1979","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2018.04.038_bib43","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1016\/j.bmcl.2017.02.049","article-title":"New hydrazine and hydrazide quinoxaline 1,4-di-N-oxide derivatives: in silico ADMET, antiplasmodial and antileishmanial activity","volume":"27","author":"Quiliano","year":"2017","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2018.04.038_bib44","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1128\/AAC.01607-06","article-title":"Assessment and continued validation of the malaria SYBR Green I-Based fluorescence assay for use in malaria drug screening","volume":"51","author":"Johnson","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2018.04.038_bib45","doi-asserted-by":"crossref","first-page":"42717","DOI":"10.1038\/srep42717","article-title":"SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules","volume":"7","author":"Daina","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2018.04.038_bib46","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s10822-005-8694-y","article-title":"Virtual computational chemistry laboratory - design and description","volume":"19","author":"Tetko","year":"2005","journal-title":"J.\u00a0Comput. Aided Mol. Des."},{"key":"10.1016\/j.ejmech.2018.04.038_bib47","first-page":"219","article-title":"Evaluation of the new system (umu-test) for the detection of environmental mutagens and carcinogens","volume":"147","author":"Oda","year":"1985","journal-title":"Mutat. Res.-Environ. Mutag. Related Subj"},{"key":"10.1016\/j.ejmech.2018.04.038_bib48","first-page":"215","article-title":"A\u00a0microplate version of the SOS\/umu-test for rapid detection of genotoxins and genotoxic potentials of environmental samples","volume":"253","author":"Reifferscheid","year":"1991","journal-title":"Mutat. Res. Environ. Mutagen Relat. Subj."},{"key":"10.1016\/j.ejmech.2018.04.038_bib49","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1080\/00034983.1975.11686997","article-title":"The chemotherapy of rodent malaria, XXII. The value of drug-resistant strains of P. berghei in screening for blood schizontocidal activity","volume":"69","author":"Peters","year":"1975","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"10.1016\/j.ejmech.2018.04.038_bib50","series-title":"Handbook of Animal Models of Infection","first-page":"757","article-title":"Chapter 92-malaria A2-Zak, Oto","author":"Peters","year":"1999"},{"key":"10.1016\/j.ejmech.2018.04.038_bib51","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1007\/s00436-017-5477-z","article-title":"Adaptation and optimization of a fluorescence-based assay for in vivo antimalarial drug screening","volume":"116","author":"Arias","year":"2017","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.ejmech.2018.04.038_bib52","doi-asserted-by":"crossref","first-page":"4760","DOI":"10.1038\/srep04760","article-title":"A\u00a0rapid and robust selection procedure for generating drug-selectable marker-free recombinant malaria parasites","volume":"4","author":"Manzoni","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2018.04.038_bib53","doi-asserted-by":"crossref","first-page":"9490","DOI":"10.1074\/jbc.M311331200","article-title":"A\u00a0role for Apical membrane Antigen 1 during invasion of hepatocytes by Plasmodium falciparum sporozoites","volume":"279","author":"Silvie","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.ejmech.2018.04.038_bib54","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1093\/bioinformatics\/btr664","article-title":"DMAN: a Java tool for analysis of multi-well differential scanning fluorimetry experiments","volume":"28","author":"Wang","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ejmech.2018.04.038_bib55","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0005-2736(91)90295-J","article-title":"Small-volume extrusion apparatus for preparation of large, unilamellar vesicles","volume":"1061","author":"MacDonald","year":"1991","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejmech.2018.04.038_bib56","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jconrel.2016.09.006","article-title":"Development of drug-loaded immunoliposomes for the selective targeting and elimination of rosetting Plasmodium falciparum-infected red blood cells","volume":"241","author":"Moles","year":"2016","journal-title":"J.\u00a0Contr. Release"},{"key":"10.1016\/j.ejmech.2018.04.038_bib57","doi-asserted-by":"crossref","first-page":"418","DOI":"10.2307\/3280287","article-title":"Synchronization of Plasmodium falciparum erythrocytic stages in culture","volume":"65","author":"Lambros","year":"1979","journal-title":"J.\u00a0Parasitol."},{"key":"10.1016\/j.ejmech.2018.04.038_bib58","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1038\/nprot.2009.198","article-title":"Synchronous culture of Plasmodium falciparum at high parasitemia levels","volume":"4","author":"Radfar","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ejmech.2018.04.038_bib59","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jpba.2012.01.021","article-title":"Supercritical fluid chromatography for the enantioseparation of pharmaceuticals","volume":"69","author":"De Klerck","year":"2012","journal-title":"J.\u00a0Pharmaceut. Biomed. Anal."},{"key":"10.1016\/j.ejmech.2018.04.038_bib60","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.supflu.2008.09.012","article-title":"Supercritical fluid chromatography for the 21st century","volume":"47","author":"Taylor","year":"2009","journal-title":"J.\u00a0Supercrit. Fluids"}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523418303726?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523418303726?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,22]],"date-time":"2019-09-22T03:37:46Z","timestamp":1569123466000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523418303726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":60,"alternative-id":["S0223523418303726"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2018.04.038","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structure-activity relationship of new antimalarial 1-aryl-3-susbtituted propanol derivatives: Synthesis, preliminary toxicity profiling, parasite life cycle stage studies, target exploration, and targeted delivery","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2018.04.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}