{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:08:25Z","timestamp":1790780905721,"version":"4.1.0"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T00:00:00Z","timestamp":1528761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21401031"],"award-info":[{"award-number":["21401031"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21431001"],"award-info":[{"award-number":["21431001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473102"],"award-info":[{"award-number":["81473102"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21761005"],"award-info":[{"award-number":["21761005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["2015GXNSFAA139043"],"award-info":[{"award-number":["2015GXNSFAA139043"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["2016GXNSFGA380005"],"award-info":[{"award-number":["2016GXNSFGA380005"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009007","name":"Guangxi Normal University","doi-asserted-by":"publisher","award":["2014ZD005"],"award-info":[{"award-number":["2014ZD005"]}],"id":[{"id":"10.13039\/501100009007","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.ejmech.2018.06.018","type":"journal-article","created":{"date-parts":[[2018,6,9]],"date-time":"2018-06-09T10:45:05Z","timestamp":1528541105000},"page":"639-650","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":80,"special_numbering":"C","title":["Mitochondria-targeted platinum(II) complexes induce apoptosis-dependent autophagic cell death mediated by ER-stress in A549 cancer cells"],"prefix":"10.1016","volume":"155","author":[{"given":"Feng-Yang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Ming","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4773-4442","authenticated-orcid":false,"given":"Ke-Bin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Wen","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Feng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You-Nian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2018.06.018_bib1","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nrc2167","article-title":"The resurgence of platinum-based cancer chemotherapy","volume":"7","author":"Kelland","year":"2007","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.ejmech.2018.06.018_bib2","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1021\/cr068207j","article-title":"Direct cellular responses to platinum-induced DNA damage","volume":"107","author":"Jung","year":"2007","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejmech.2018.06.018_bib3","doi-asserted-by":"crossref","first-page":"3436","DOI":"10.1021\/acs.chemrev.5b00597","article-title":"The next generation of platinum drugs: targeted Pt (II) agents, nanoparticle delivery, and Pt (IV) prodrugs","volume":"116","author":"Johnstone","year":"2016","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejmech.2018.06.018_bib4","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1039\/C4DT02627F","article-title":"Oxidative halogenation of cisplatin and carboplatin: synthesis, spectroscopy, and crystal and molecular structures of Pt(IV) prodrugs","volume":"44","author":"Johnstone","year":"2015","journal-title":"Dalton T"},{"key":"10.1016\/j.ejmech.2018.06.018_bib5","doi-asserted-by":"crossref","first-page":"5736","DOI":"10.1021\/acs.jmedchem.7b00433","article-title":"Glycosylated platinum (IV) complexes as substrates for glucose transporters (GLUTs) and organic cation transporters (OCTs) exhibited cancer targeting and human serum albumin binding properties for drug delivery","volume":"60","author":"Ma","year":"2017","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.06.018_bib6","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1021\/acs.bioconjchem.7b00117","article-title":"Anticancer platinum (IV) prodrugs containing monoaminophosphonate ester as a targeting group inhibit matrix metalloproteinases and reverse multidrug resistance","volume":"28","author":"Huang","year":"2017","journal-title":"Bioconjugate Chem."},{"key":"10.1016\/j.ejmech.2018.06.018_bib7","doi-asserted-by":"crossref","first-page":"15564","DOI":"10.1002\/anie.201608936","article-title":"A\u00a0platinum (IV) anticancer prodrug targeting nucleotide excision repair to overcome cisplatin resistance","volume":"55","author":"Wang","year":"2016","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.ejmech.2018.06.018_bib8","doi-asserted-by":"crossref","first-page":"3850","DOI":"10.1021\/om400322s","article-title":"Of bis (2-(diphenylphosphino) ethyl) phenylphosphine in stabilizing binuclear platinum (II) complexes","volume":"32","author":"Raoof","year":"2013","journal-title":"Organometallics"},{"key":"10.1016\/j.ejmech.2018.06.018_bib9","doi-asserted-by":"crossref","first-page":"11052","DOI":"10.1021\/jm301645g","article-title":"Unsymmetric mono-and dinuclear platinum (IV) complexes featuring an ethylene glycol moiety: synthesis, characterization, and biological activity","volume":"55","author":"Pichler","year":"2012","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.06.018_bib10","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1021\/jm501420k","article-title":"Novel antitumor cisplatin and transplatin derivatives containing 1-Methyl-7-Azaindole: synthesis, characterization, and cellular responses","volume":"58","author":"Pracharova","year":"2014","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.06.018_bib11","doi-asserted-by":"crossref","first-page":"8168","DOI":"10.1021\/ic200637t","article-title":"Effect of thioethers on DNA platination by trans-platinum complexes","volume":"50","author":"Li","year":"2011","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.ejmech.2018.06.018_bib12","doi-asserted-by":"crossref","first-page":"3754","DOI":"10.1021\/acs.inorgchem.6b02148","article-title":"A\u00a0new approach to sensitize antitumor monofunctional platinum (II) complexes via short time photo-irradiation","volume":"56","author":"Xue","year":"2016","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.ejmech.2018.06.018_bib13","doi-asserted-by":"crossref","first-page":"996","DOI":"10.4161\/auto.24407","article-title":"Novel monofunctional platinum (II) complex Mono-Pt induces apoptosis-independent autophagic cell death in human ovarian carcinoma cells, distinct from cisplatin","volume":"9","author":"Guo","year":"2013","journal-title":"Autophagy"},{"key":"10.1016\/j.ejmech.2018.06.018_bib14","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1021\/ja4125115","article-title":"The chiral potential of phenanthriplatin and its influence on guanine binding","volume":"136","author":"Johnstone","year":"2014","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2018.06.018_bib15","doi-asserted-by":"crossref","first-page":"7574","DOI":"10.1002\/chem.201600236","article-title":"Nucleotide binding preference of the monofunctional platinum anticancer-agent phenanthriplatin","volume":"22","author":"Riddell","year":"2016","journal-title":"Chem. Eur J."},{"key":"10.1016\/j.ejmech.2018.06.018_bib16","doi-asserted-by":"crossref","first-page":"10651","DOI":"10.1039\/b913896j","article-title":"Non-traditional platinum compounds for improved accumulation, oral bioavailability, and tumor targeting","author":"Lovejoy","year":"2009","journal-title":"Dalton Trans."},{"key":"10.1016\/j.ejmech.2018.06.018_bib17","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1039\/B715903J","article-title":"Towards the rational design of platinum (II) and gold (III) complexes as antitumour agents","author":"Wang","year":"2008","journal-title":"Dalton Trans."},{"key":"10.1016\/j.ejmech.2018.06.018_bib18","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1016\/j.jinorgbio.2006.07.010","article-title":"Sterically hindered complexes of platinum (II) with planar heterocyclic nitrogen donors. A novel complex with 1-methyl-cytosine has a spectrum of activity different from cisplatin and is able of overcoming acquired cisplatin resistance","volume":"100","author":"Margiotta","year":"2006","journal-title":"J.\u00a0Inorg. Biochem."},{"key":"10.1016\/j.ejmech.2018.06.018_bib19","doi-asserted-by":"crossref","first-page":"7574","DOI":"10.1021\/jm800900g","article-title":"A\u00a0non-cross-linking platinum\u2212 acridine agent with potent activity in non-small-cell lung cancer","volume":"51","author":"Ma","year":"2008","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.06.018_bib20","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1007\/s11095-010-0312-6","article-title":"Role of organic cation transporter 1, OCT1 in the pharmacokinetics and toxicity of cis-diammine (pyridine) chloroplatinum (II) and oxaliplatin in mice","volume":"28","author":"Li","year":"2011","journal-title":"Pharm. Res. (N. Y.)"},{"key":"10.1016\/j.ejmech.2018.06.018_bib21","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1002\/chem.200902741","article-title":"Stable anticancer gold (III)\u2013porphyrin complexes: effects of porphyrin structure","volume":"16","author":"Sun","year":"2010","journal-title":"Chem. Eur J."},{"key":"10.1016\/j.ejmech.2018.06.018_bib22","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1039\/B707077M","article-title":"Bioorganometallic chemistry\u2014from teaching paradigms to medicinal applications","volume":"38","author":"Hartinger","year":"2009","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.ejmech.2018.06.018_bib23","doi-asserted-by":"crossref","first-page":"8378","DOI":"10.1002\/chem.201301348","article-title":"Transporting and shielding photosensitisers by using water-soluble organometallic cages: a new strategy in drug delivery and photodynamic therapy","volume":"19","author":"Therrien","year":"2013","journal-title":"Chem. Eur J."},{"key":"10.1016\/j.ejmech.2018.06.018_bib24","doi-asserted-by":"crossref","first-page":"9679","DOI":"10.1039\/c3dt50513h","article-title":"Improving the bioactivity of Zn (II)-curcumin based complexes","volume":"42","author":"Pucci","year":"2013","journal-title":"Dalton Trans."},{"key":"10.1016\/j.ejmech.2018.06.018_bib25","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1021\/ic200443p","article-title":"TCM active ingredient oxoglaucine metal complexes: crystal structure, cytotoxicity, and interaction with DNA","volume":"51","author":"Chen","year":"2012","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.ejmech.2018.06.018_bib26","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.ejmech.2013.04.024","article-title":"Platinum (II) complexes containing aminophosphonate esters: synthesis, characterization, cytotoxicity and action mechanism","volume":"64","author":"Huang","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.06.018_bib27","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ejmech.2013.01.055","article-title":"Platinum (II) complexes with mono-aminophosphonate ester targeting group that induce apoptosis through G1 cell-cycle arrest: synthesis, crystal structure and antitumour activity","volume":"63","author":"Huang","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.06.018_bib28","doi-asserted-by":"crossref","first-page":"4771","DOI":"10.1021\/acs.jmedchem.5b00444","volume":"58","author":"Chen","year":"2015","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.06.018_bib29","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.ejmech.2013.08.033","article-title":"The antitumor activity of zinc (II) and copper (II) complexes with 5, 7-dihalo-substituted-8-quinolinoline","volume":"69","author":"Liu","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.06.018_bib30","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.ejmech.2013.08.007","article-title":"High antitumor activity of 5, 7-dihalo-8-quinolinolato cerium complexes","volume":"68","author":"Chen","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.06.018_bib31","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.ejmech.2012.10.037","article-title":"Synthesis, crystal structure, cytotoxicity and DNA interaction of 5, 7-dichloro-8-quinolinolato-lanthanides","volume":"59","author":"Chen","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.06.018_bib32","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1021\/acs.organomet.7b00678","article-title":"Silver, gold, palladium, and platinum N-heterocyclic carbene complexes containing a selenoether-functionalized imidazol-2-ylidene moiety","volume":"37","author":"Klauke","year":"2018","journal-title":"Organometallics"},{"key":"10.1016\/j.ejmech.2018.06.018_bib33","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1248\/bpb.17.1421","article-title":"Relationship between lipophilicity and skin permeability of various drugs from an ethanol\/water\/lauric acid system","volume":"17","author":"LEE","year":"1994","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.ejmech.2018.06.018_bib34","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.cbpa.2008.03.016","article-title":"The impact of natural products upon modern drug discovery","volume":"12","author":"Ganesan","year":"2008","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.ejmech.2018.06.018_bib35","doi-asserted-by":"crossref","first-page":"8971","DOI":"10.1021\/jm501095r","article-title":"Targeting nucleus DNA with a cyclometalated dipyridophenazineruthenium (II) complex","volume":"57","author":"Huang","year":"2014","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.06.018_bib36","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1021\/mp200298g","article-title":"Unique DNA binding mode of antitumor trinuclear tridentate platinum (II) compound","volume":"8","author":"Olivova","year":"2011","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejmech.2018.06.018_bib37","doi-asserted-by":"crossref","first-page":"6368","DOI":"10.1021\/jm501952r","article-title":"Study on antitumor platinum (II) complexes of chiral diamines with dicyclic species as steric hindrance","volume":"58","author":"Liu","year":"2015","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.06.018_bib38","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1039\/c3mt20270d","article-title":"The induction of mitochondria-mediated apoptosis in cancer cells by ruthenium (II) asymmetric complexes","volume":"5","author":"Qian","year":"2013","journal-title":"Metall"},{"key":"10.1016\/j.ejmech.2018.06.018_bib39","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.biomaterials.2014.10.070","article-title":"Phosphorescent iridium (III)-bis-N-heterocyclic carbene complexes as mitochondria-targeted theranostic and photodynamic anticancer agents","volume":"39","author":"Li","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejmech.2018.06.018_bib40","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.ejmech.2013.10.031","article-title":"Copper (II\/I) complexes of 5-pyridin-2-yl-[1, 3] dioxolo [4, 5-g] isoquinoline: synthesis, crystal structure, antitumor activity and DNA interaction","volume":"70","author":"Huang","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.06.018_bib41","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1126\/science.286.5445.1700","article-title":"Molecular architecture of the rotary motor in ATP synthase","volume":"286","author":"Stock","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.ejmech.2018.06.018_bib42","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nchembio.1712","article-title":"Targeting mitochondria metabolism for cancer therapy","volume":"11","author":"Weinberg","year":"2015","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.ejmech.2018.06.018_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20081386","article-title":"How mitochondria produce reactive oxygen species","volume":"417","author":"Murphy","year":"2009","journal-title":"Biochem. J."},{"key":"10.1016\/j.ejmech.2018.06.018_bib44","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1023\/A:1009616228304","article-title":"Role of reactive oxygen species (ROS) in apoptosis induction","volume":"5","author":"Simon","year":"2000","journal-title":"Apoptosis"},{"key":"10.1016\/j.ejmech.2018.06.018_bib45","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0003-2697(83)90270-1","article-title":"Detection of picomole levels of hydroperoxides using a fluorescent dichlorofluorescein assay","volume":"134","author":"Cathcart","year":"1983","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ejmech.2018.06.018_bib46","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/ijc.22132","article-title":"Acute apoptosis by cisplatin requires induction of reactive oxygen species but is not associated with damage to nuclear DNA","volume":"120","author":"Berndtsson","year":"2006","journal-title":"Int. J. Canc."},{"key":"10.1016\/j.ejmech.2018.06.018_bib47","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s10495-012-0781-7","article-title":"Naringenin prevents high glucose-induced mitochondria-mediated apoptosis involving AIF, Endo-G and caspases","volume":"18","author":"Kapoor","year":"2013","journal-title":"Apoptosis"},{"key":"10.1016\/j.ejmech.2018.06.018_bib48","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0092-8674(04)00046-7","article-title":"Cell death: critical control points","volume":"116","author":"Danial","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.ejmech.2018.06.018_bib49","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1056\/NEJMra0901217","article-title":"Cell death","volume":"361","author":"Hotchkiss","year":"2009","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.ejmech.2018.06.018_bib50","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1002\/jps.20874","article-title":"Oxidative stress and apoptosis: impact on cancer therapy","volume":"96","author":"Ozben","year":"2007","journal-title":"J.\u00a0Pharmacol. Sci."},{"key":"10.1016\/j.ejmech.2018.06.018_bib51","doi-asserted-by":"crossref","first-page":"181","DOI":"10.4161\/auto.3678","article-title":"Methods for monitoring autophagy from yeast to human","volume":"3","author":"Klionsky","year":"2007","journal-title":"Autophagy"},{"key":"10.1016\/j.ejmech.2018.06.018_bib52","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.cell.2009.05.023","article-title":"p62 at the crossroads of autophagy, apoptosis, and cancer","volume":"137","author":"Moscat","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.ejmech.2018.06.018_bib53","doi-asserted-by":"crossref","first-page":"10850","DOI":"10.1074\/jbc.M109.080796","article-title":"Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase","volume":"285","author":"Wu","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.ejmech.2018.06.018_bib54","doi-asserted-by":"crossref","first-page":"3644","DOI":"10.1111\/j.1582-4934.2009.00663.x","article-title":"AMPK-mediated autophagy inhibits apoptosis in cisplatin-treated tumour cells","volume":"13","author":"Harhaji-Trajkovic","year":"2009","journal-title":"J.\u00a0Cell Mol. Med."},{"key":"10.1016\/j.ejmech.2018.06.018_bib55","first-page":"467","article-title":"Phase annealing in SHELX-90: direct methods for larger structures, Acta Crystallogr., Sect. A: Found","volume":"46","author":"Sheldrick","year":"1990","journal-title":"Crystallography"},{"key":"10.1016\/j.ejmech.2018.06.018_bib56","series-title":"SHELXS-97, Program for X-ray Crystal Structure Solution","article-title":"SHELXL-97, program for x-ray crystal structure refinement; g\u00f6ttingen university: g\u00f6ttingen, Germany, 1997","author":"Sheldrick","year":"1997"},{"key":"10.1016\/j.ejmech.2018.06.018_bib57","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jinorgbio.2017.01.001","article-title":"Crystal structure, cytotoxicity and action mechanism of Zn (II)\/Mn (II) complexes with isoquinoline ligands","volume":"169","author":"Wang","year":"2017","journal-title":"J.\u00a0Inorg. Biochem."},{"key":"10.1016\/j.ejmech.2018.06.018_bib58","doi-asserted-by":"crossref","first-page":"11408","DOI":"10.1039\/C5DT00926J","article-title":"Water-soluble oxoglaucine-Y (III), Dy (III) complexes: in\u00a0vitro and in\u00a0vivo anticancer activities by triggering DNA damage, leading to S phase arrest and apoptosis","volume":"44","author":"Wei","year":"2015","journal-title":"Dalton Trans."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523418305099?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523418305099?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,21]],"date-time":"2019-09-21T20:46:26Z","timestamp":1569098786000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523418305099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":58,"alternative-id":["S0223523418305099"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2018.06.018","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitochondria-targeted platinum(II) complexes induce apoptosis-dependent autophagic cell death mediated by ER-stress in A549 cancer cells","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2018.06.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}