{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:11:40Z","timestamp":1789168300633,"version":"build-2803163510"},"reference-count":101,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003443","name":"Ministry of Education and Science of the Russian Federation","doi-asserted-by":"publisher","award":["4.6764.2017\/BP"],"award-info":[{"award-number":["4.6764.2017\/BP"]}],"id":[{"id":"10.13039\/501100003443","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["18-13-00447"],"award-info":[{"award-number":["18-13-00447"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["16-43-630823"],"award-info":[{"award-number":["16-43-630823"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["17-03-01292"],"award-info":[{"award-number":["17-03-01292"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.ejmech.2018.08.009","type":"journal-article","created":{"date-parts":[[2018,8,6]],"date-time":"2018-08-06T05:25:29Z","timestamp":1533533129000},"page":"214-235","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"special_numbering":"C","title":["Molecular design, synthesis and biological evaluation of cage compound-based inhibitors of hepatitis C virus p7 ion channels"],"prefix":"10.1016","volume":"158","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6710-0722","authenticated-orcid":false,"given":"Vadim A.","family":"Shiryaev","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2091-7022","authenticated-orcid":false,"given":"Eugene V.","family":"Radchenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir A.","family":"Palyulin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolay S.","family":"Zefirov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolay I.","family":"Bormotov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga A.","family":"Serova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larisa N.","family":"Shishkina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marat R.","family":"Baimuratov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kseniya M.","family":"Bormasheva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulia A.","family":"Gruzd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena A.","family":"Ivleva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina V.","family":"Leonova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton V.","family":"Lukashenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9217-0792","authenticated-orcid":false,"given":"Dmitry V.","family":"Osipov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitaliy A.","family":"Osyanin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander N.","family":"Reznikov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera A.","family":"Shadrikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia E.","family":"Sibiryakova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilya M.","family":"Tkachenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri N.","family":"Klimochkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.ejmech.2018.08.009_bib1","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.bbamem.2013.09.004","article-title":"The minimalist architectures of viroporins and their therapeutic implications","volume":"1838","author":"OuYang","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"issue":"6","key":"10.1016\/j.ejmech.2018.08.009_bib2","doi-asserted-by":"crossref","first-page":"3261","DOI":"10.3390\/v7062771","article-title":"Viral membrane channels: role and function in the virus life cycle","volume":"7","author":"Sze","year":"2015","journal-title":"Viruses"},{"issue":"8","key":"10.1016\/j.ejmech.2018.08.009_bib3","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1099\/vir.0.000201","article-title":"Viroporins: structure, function and potential as antiviral targets","volume":"96","author":"Scott","year":"2015","journal-title":"J.\u00a0Gen. Virol."},{"issue":"2","key":"10.1016\/j.ejmech.2018.08.009_bib4","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.bbamem.2010.05.006","article-title":"Viral proteins function as ion channels","volume":"1808","author":"Wang","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"issue":"1","key":"10.1016\/j.ejmech.2018.08.009_bib5","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.sbi.2010.12.002","article-title":"Structural and dynamic mechanisms for the function and inhibition of the M2 proton channel from influenza A virus","volume":"21","author":"Wang","year":"2011","journal-title":"Curr. Opin. Struct. Biol."},{"issue":"4","key":"10.1016\/j.ejmech.2018.08.009_bib6","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/bip.22623","article-title":"Recent progress in designing inhibitors that target the drug-resistant M2 proton channels from the influenza A viruses","volume":"104","author":"Wang","year":"2015","journal-title":"Biopolymers"},{"key":"10.1016\/j.ejmech.2018.08.009_bib7","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.virol.2014.04.018","article-title":"The elusive function of the hepatitis C virus p7 protein","volume":"462\u2013463","author":"Atoom","year":"2014","journal-title":"Virology"},{"issue":"8","key":"10.1016\/j.ejmech.2018.08.009_bib8","doi-asserted-by":"crossref","first-page":"4461","DOI":"10.3390\/v7082826","article-title":"Structural and functional properties of the hepatitis C virus p7 viroporin","volume":"7","author":"Madan","year":"2015","journal-title":"Viruses"},{"key":"10.1016\/j.ejmech.2018.08.009_bib9","series-title":"Hepatitis C, WHO Fact Sheet No. 164, October 2017","author":"WHO","year":"2017"},{"key":"10.1016\/j.ejmech.2018.08.009_bib10","doi-asserted-by":"crossref","first-page":"17006","DOI":"10.1038\/nrdp.2017.6","article-title":"Hepatitis C virus infection","volume":"3","author":"Manns","year":"2017","journal-title":"Nat. Rev. Dis. Prim."},{"issue":"2","key":"10.1016\/j.ejmech.2018.08.009_bib11","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/nrgastro.2016.176","article-title":"Global epidemiology and burden of HCV infection and HCV-related disease","volume":"14","author":"Thrift","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"3","key":"10.1016\/j.ejmech.2018.08.009_bib12","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.cld.2017.03.012","article-title":"Economic burden of hepatitis C infection","volume":"21","author":"Stepanova","year":"2017","journal-title":"Clin. Liver Dis."},{"issue":"2","key":"10.1016\/j.ejmech.2018.08.009_bib13","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.jhep.2018.03.026","article-title":"EASL recommendations on treatment of hepatitis C 2018","volume":"69","author":"European Association for the Study of the Liver","year":"2018","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.ejmech.2018.08.009_bib14","first-page":"118","article-title":"Direct antiviral agents (DAAs) \u2013 a new age in the treatment of hepatitis C virus infection","volume":"183","author":"Spengler","year":"2018","journal-title":"Pharmac. Pharm. Theurap."},{"key":"10.1016\/j.ejmech.2018.08.009_bib15","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.antiviral.2017.02.014","article-title":"Current therapy for chronic hepatitis C: the role of direct-acting antivirals","volume":"142","author":"Li","year":"2017","journal-title":"Antivir. Res."},{"issue":"21","key":"10.1016\/j.ejmech.2018.08.009_bib16","doi-asserted-by":"crossref","first-page":"921","DOI":"10.4254\/wjh.v9.i21.921","article-title":"Is the 25-year hepatitis C marathon coming to an end to declare victory?","volume":"9","author":"Ahmed","year":"2017","journal-title":"World J. Hepatol."},{"issue":"33","key":"10.1016\/j.ejmech.2018.08.009_bib17","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.4254\/wjh.v9.i33.1239","article-title":"Global elimination of hepatitis C virus infection: progresses and the remaining challenges","volume":"9","author":"Taherkhani","year":"2017","journal-title":"World J. Hepatol."},{"issue":"5","key":"10.1016\/j.ejmech.2018.08.009_bib18","doi-asserted-by":"crossref","first-page":"3516","DOI":"10.1021\/cr100264t","article-title":"The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivatives","volume":"113","author":"Wanka","year":"2013","journal-title":"Chem. Rev."},{"issue":"7","key":"10.1016\/j.ejmech.2018.08.009_bib19","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1007\/s11172-015-1035-y","article-title":"Antiviral properties of cage compounds. New prospects","volume":"64","author":"Klimochkin","year":"2015","journal-title":"Russ. Chem. Bull."},{"issue":"6","key":"10.1016\/j.ejmech.2018.08.009_bib20","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1111\/j.1525-1497.2004.30057.x","article-title":"Amantadine therapy for chronic hepatitis C","volume":"19","author":"Smith","year":"2004","journal-title":"J.\u00a0Gen. Intern. Med."},{"issue":"1\u20133","key":"10.1016\/j.ejmech.2018.08.009_bib21","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S0014-5793(02)03851-6","article-title":"The p7 protein of hepatitis C virus forms an ion channel that is blocked by the antiviral drug, Amantadine","volume":"535","author":"Griffin","year":"2003","journal-title":"FEBS Lett."},{"issue":"9","key":"10.1016\/j.ejmech.2018.08.009_bib22","doi-asserted-by":"crossref","first-page":"e1001087","DOI":"10.1371\/journal.ppat.1001087","article-title":"Intracellular proton conductance of the hepatitis C virus p7 protein and its contribution to infectious virus production","volume":"6","author":"Wozniak","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ejmech.2018.08.009_bib23","first-page":"CD010125","article-title":"Aminoadamantanes for chronic hepatitis C","volume":"5","author":"Lamers","year":"2014","journal-title":"Cochrane Database Syst. Rev."},{"issue":"7","key":"10.1016\/j.ejmech.2018.08.009_bib24","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.dld.2010.04.009","article-title":"Amantadine for treatment of hepatitis C: time to say \u201cenough is enough\u201d?","volume":"42","author":"Piccolo","year":"2010","journal-title":"Dig. Liver Dis."},{"issue":"6","key":"10.1016\/j.ejmech.2018.08.009_bib25","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1002\/hep.22555","article-title":"Genotype-dependent sensitivity of hepatitis C virus to inhibitors of the p7 ion channel","volume":"48","author":"Griffin","year":"2008","journal-title":"Hepatology"},{"issue":"11","key":"10.1016\/j.ejmech.2018.08.009_bib26","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1016\/j.bpj.2016.04.018","article-title":"Patch-clamp study of hepatitis C p7 channels reveals genotype-specific sensitivity to inhibitors","volume":"110","author":"Breitinger","year":"2016","journal-title":"Biophys. J."},{"issue":"4","key":"10.1016\/j.ejmech.2018.08.009_bib27","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1177\/135965350601100408","article-title":"Amino acid variations in hepatitis C virus p7 and sensitivity to antiviral combination therapy with amantadine in chronic hepatitis C","volume":"11","author":"Mihm","year":"2006","journal-title":"Antivir. Ther."},{"issue":"6","key":"10.1016\/j.ejmech.2018.08.009_bib28","doi-asserted-by":"crossref","first-page":"803","DOI":"10.3851\/IMP2663","article-title":"Investigation of viral escape mutations within HCV p7 during treatment with amantadine in patients with chronic hepatitis C","volume":"18","author":"Vermehren","year":"2013","journal-title":"Antivir. Ther."},{"issue":"16","key":"10.1016\/j.ejmech.2018.08.009_bib29","doi-asserted-by":"crossref","first-page":"7970","DOI":"10.1128\/JVI.00521-09","article-title":"Determinants of hepatitis C virus p7 ion channel function and drug sensitivity identified in\u00a0vitro","volume":"83","author":"StGelais","year":"2009","journal-title":"J.\u00a0Virol."},{"issue":"1","key":"10.1016\/j.ejmech.2018.08.009_bib30","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/hep.24371","article-title":"Resistance mutations define specific antiviral effects for inhibitors of the hepatitis C virus p7 ion channel","volume":"54","author":"Foster","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.ejmech.2018.08.009_bib31","first-page":"307","article-title":"Targeting the channel activity of viroporins","volume":"vol. 2016","author":"To","year":"2016"},{"issue":"17","key":"10.1016\/j.ejmech.2018.08.009_bib32","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.4155\/fmc.14.121","article-title":"\u201cToo little, too late?\u201d Will inhibitors of the hepatitis C virus p7 ion channel ever be used in the clinic?","volume":"6","author":"Griffin","year":"2014","journal-title":"Future Med. Chem."},{"issue":"3","key":"10.1016\/j.ejmech.2018.08.009_bib33","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1124\/mol.116.105346","article-title":"Pharmacological characterization of the spectrum of antiviral activity and genetic barrier to drug resistance of M2-S31N channel blockers","volume":"90","author":"Ma","year":"2016","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejmech.2018.08.009_bib34","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.antiviral.2017.01.006","article-title":"An M2-V27A channel blocker demonstrates potent in\u00a0vitro and in\u00a0vivo antiviral activities against amantadine-sensitive and -resistant influenza A viruses","volume":"140","author":"Hu","year":"2017","journal-title":"Antivir. Res."},{"issue":"2","key":"10.1016\/j.ejmech.2018.08.009_bib35","doi-asserted-by":"crossref","first-page":"154","DOI":"10.2174\/1573409912666160505113408","article-title":"Design of broad-spectrum inhibitors of influenza A virus M2 proton channels: a molecular modeling approach","volume":"12","author":"Klimochkin","year":"2016","journal-title":"Curr. Comput. Aided Drug Des."},{"issue":"7455","key":"10.1016\/j.ejmech.2018.08.009_bib36","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/nature12283","article-title":"Unusual architecture of the p7 channel from hepatitis C virus","volume":"498","author":"OuYang","year":"2013","journal-title":"Nature"},{"issue":"31","key":"10.1016\/j.ejmech.2018.08.009_bib37","doi-asserted-by":"crossref","first-page":"12712","DOI":"10.1073\/pnas.0905966106","article-title":"The 3-dimensional structure of a hepatitis C virus p7 ion channel by electron microscopy","volume":"106","author":"Luik","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"41","key":"10.1016\/j.ejmech.2018.08.009_bib38","doi-asserted-by":"crossref","first-page":"31446","DOI":"10.1074\/jbc.M110.122895","article-title":"NMR structure and ion channel activity of the p7 protein from hepatitis C virus","volume":"285","author":"Montserret","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"issue":"20","key":"10.1016\/j.ejmech.2018.08.009_bib39","doi-asserted-by":"crossref","first-page":"4920","DOI":"10.1016\/j.bmc.2016.07.063","article-title":"Assessing the physiological relevance of alternate architectures of the p7 protein of hepatitis C virus in different environments","volume":"24","author":"Holzmann","year":"2016","journal-title":"Bioorg. Med. Chem."},{"issue":"3\u20134","key":"10.1016\/j.ejmech.2018.08.009_bib40","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s10858-015-9912-0","article-title":"Transverse relaxation dispersion of the p7 membrane channel from hepatitis C virus reveals conformational breathing","volume":"61","author":"Dev","year":"2015","journal-title":"J.\u00a0Biomol. NMR"},{"issue":"6","key":"10.1016\/j.ejmech.2018.08.009_bib41","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/j.bbamem.2015.03.006","article-title":"Genotype-specific differences in structural features of hepatitis C virus (HCV) p7 membrane protein","volume":"1848","author":"Kalita","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"issue":"7A","key":"10.1016\/j.ejmech.2018.08.009_bib42","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1016\/j.bbamem.2016.04.004","article-title":"Asymmetric dynamics of ion channel forming proteins \u2013 hepatitis C virus (HCV) p7 bundles","volume":"1858","author":"Kalita","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"issue":"9","key":"10.1016\/j.ejmech.2018.08.009_bib43","doi-asserted-by":"crossref","first-page":"e1002702","DOI":"10.1371\/journal.pcbi.1002702","article-title":"The p7 protein of hepatitis C virus forms structurally plastic, minimalist ion channels","volume":"8","author":"Chandler","year":"2012","journal-title":"PLoS Comput. Biol."},{"issue":"12","key":"10.1016\/j.ejmech.2018.08.009_bib44","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1080\/07391102.2016.1230519","article-title":"Molecular dynamics investigation on structural and transport properties of p7 ion channel","volume":"35","author":"Behmard","year":"2017","journal-title":"J.\u00a0Biomol. Struct. Dyn."},{"issue":"4","key":"10.1016\/j.ejmech.2018.08.009_bib45","doi-asserted-by":"crossref","first-page":"e93613","DOI":"10.1371\/journal.pone.0093613","article-title":"In depth analysis on the binding sites of adamantane derivatives in HCV (hepatitis C virus) p7 channel based on the NMR structure","volume":"9","author":"Du","year":"2014","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.ejmech.2018.08.009_bib46","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1007\/s13238-016-0256-7","article-title":"Structural basis of interaction between the hepatitis C virus p7 channel and its blocker hexamethylene amiloride","volume":"7","author":"Zhao","year":"2016","journal-title":"Protein Cell"},{"key":"10.1016\/j.ejmech.2018.08.009_bib47","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.bpc.2017.11.002","article-title":"Understanding the inhibitory mechanism of BIT225 drug against p7 viroporin using computational study","volume":"233","author":"Behmard","year":"2018","journal-title":"Biophys. Chem."},{"issue":"2","key":"10.1016\/j.ejmech.2018.08.009_bib48","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1002\/hep.26685","article-title":"Structure-guided design affirms inhibitors of hepatitis C virus p7 as a viable class of antivirals targeting virion release","volume":"59","author":"Foster","year":"2014","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.ejmech.2018.08.009_bib49","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1111\/cbdd.13162","article-title":"Interaction of antivirals with a heptameric bundle model of the p7 protein of hepatitis C virus","volume":"91","author":"Dahl","year":"2018","journal-title":"Chem. Biol. Drug Des."},{"issue":"6","key":"10.1016\/j.ejmech.2018.08.009_bib50","doi-asserted-by":"crossref","first-page":"e0126510","DOI":"10.1371\/journal.pone.0126510","article-title":"Computational docking study of p7 ion channel from HCV genotype 3 and genotype 4 and its interaction with natural compounds","volume":"10","author":"Mathew","year":"2015","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.ejmech.2018.08.009_bib51","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1007\/s11094-012-0686-3","article-title":"Synthesis and antiviral activity of new adamantane derivatives","volume":"45","author":"Moiseev","year":"2012","journal-title":"Pharm. Chem. J."},{"issue":"1","key":"10.1016\/j.ejmech.2018.08.009_bib52","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s11094-017-1548-9","article-title":"Synthesis and antiviral properties of ethyl(3-ethyladamant-1-yl)carbamate","volume":"51","author":"Klimochkin","year":"2017","journal-title":"Pharm. Chem. J."},{"issue":"11","key":"10.1016\/j.ejmech.2018.08.009_bib53","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1007\/s10593-014-1628-7","article-title":"Adamantylation of pyridine derivatives","volume":"50","author":"Shadrikova","year":"2015","journal-title":"Chem. Heterocycl. Comp."},{"issue":"6","key":"10.1016\/j.ejmech.2018.08.009_bib54","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s10822-011-9440-2","article-title":"Online chemical modeling environment (OCHEM): web platform for data storage, model development and publishing of chemical information","volume":"25","author":"Sushko","year":"2011","journal-title":"J.\u00a0Comput. Aided Mol. Des."},{"issue":"2","key":"10.1016\/j.ejmech.2018.08.009_bib55","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1007\/s11172-016-1340-0","article-title":"Prediction of human intestinal absorption of drug compounds","volume":"65","author":"Radchenko","year":"2016","journal-title":"Russ. Chem. Bull."},{"issue":"1","key":"10.1016\/j.ejmech.2018.08.009_bib56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0166-3542(03)00174-8","article-title":"Bovine viral diarrhea virus as a surrogate model of hepatitis C virus for the evaluation of antiviral agents","volume":"60","author":"Buckwold","year":"2003","journal-title":"Antivir. Res."},{"issue":"2","key":"10.1016\/j.ejmech.2018.08.009_bib57","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.antiviral.2010.02.312","article-title":"A\u00a0novel Hepatitis C virus p7 ion channel inhibitor, BIT225, inhibits bovine viral diarrhea virus in\u00a0vitro and shows synergism with recombinant interferon-alpha-2b and nucleoside analogues","volume":"86","author":"Luscombe","year":"2010","journal-title":"Antivir. Res."},{"key":"10.1016\/j.ejmech.2018.08.009_bib58","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.antiviral.2013.10.015","article-title":"Pore-forming activity of pestivirus p7 in a minimal model system supports genus-specific viroporin function","volume":"101","author":"Largo","year":"2014","journal-title":"Antivir. Res."},{"issue":"3","key":"10.1016\/j.ejmech.2018.08.009_bib59","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1006\/jmbi.1993.1626","article-title":"Comparative protein modelling by satisfaction of spatial restraints","volume":"234","author":"\u0160ali","year":"1993","journal-title":"J.\u00a0Mol. Biol."},{"issue":"9","key":"10.1016\/j.ejmech.2018.08.009_bib60","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1093\/bioinformatics\/btp033","article-title":"Jalview Version 2 \u2013 a multiple sequence alignment editor and analysis workbench","volume":"25","author":"Waterhouse","year":"2009","journal-title":"Bioinformatics"},{"issue":"11","key":"10.1016\/j.ejmech.2018.08.009_bib61","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1002\/jcc.20945","article-title":"CHARMM-GUI: a Web-based graphical user interface for CHARMM","volume":"29","author":"Jo","year":"2008","journal-title":"J.\u00a0Comput. Chem."},{"issue":"27","key":"10.1016\/j.ejmech.2018.08.009_bib62","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1002\/jcc.23702","article-title":"CHARMM-GUI Membrane Builder toward realistic biological membrane simulations","volume":"35","author":"Wu","year":"2014","journal-title":"J.\u00a0Comput. Chem."},{"issue":"1","key":"10.1016\/j.ejmech.2018.08.009_bib63","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1021\/acs.jctc.5b00935","article-title":"CHARMM-GUI input generator for NAMD, GROMACS, AMBER, OpenMM, and CHARMM\/OpenMM simulations using the CHARMM36 additive force field","volume":"12","author":"Lee","year":"2016","journal-title":"J.\u00a0Chem. Theor. Comput."},{"key":"10.1016\/j.ejmech.2018.08.009_bib64","series-title":"AMBER 2015","author":"Case","year":"2015"},{"issue":"2","key":"10.1016\/j.ejmech.2018.08.009_bib65","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/wcms.1121","article-title":"An overview of the Amber biomolecular simulation package","volume":"3","author":"Salomon-Ferrer","year":"2013","journal-title":"WIREs. Comput. Mol. Sci."},{"issue":"9","key":"10.1016\/j.ejmech.2018.08.009_bib66","doi-asserted-by":"crossref","first-page":"3878","DOI":"10.1021\/ct400314y","article-title":"Routine microsecond molecular dynamics simulations with AMBER on GPUs. 2. Explicit solvent Particle Mesh Ewald","volume":"9","author":"Salomon-Ferrer","year":"2013","journal-title":"J.\u00a0Chem. Theor. Comput."},{"issue":"25","key":"10.1016\/j.ejmech.2018.08.009_bib67","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1002\/jcc.23354","article-title":"CHARMM36 all-atom additive protein force field: validation based on comparison to NMR data","volume":"34","author":"Huang","year":"2013","journal-title":"J.\u00a0Comput. Chem."},{"issue":"23","key":"10.1016\/j.ejmech.2018.08.009_bib68","doi-asserted-by":"crossref","first-page":"7830","DOI":"10.1021\/jp101759q","article-title":"Update of the CHARMM all-atom additive force field for lipids: validation on six lipid types","volume":"114","author":"Klauda","year":"2010","journal-title":"J.\u00a0Phys. Chem. B"},{"issue":"4","key":"10.1016\/j.ejmech.2018.08.009_bib69","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1002\/jcc.21367","article-title":"CHARMM general force field: a force field for drug-like molecules compatible with the CHARMM all-atom additive biological force fields","volume":"31","author":"Vanommeslaeghe","year":"2010","journal-title":"J.\u00a0Comput. Chem."},{"issue":"13","key":"10.1016\/j.ejmech.2018.08.009_bib70","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera \u2013 a visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J.\u00a0Comput. Chem."},{"key":"10.1016\/j.ejmech.2018.08.009_bib71","unstructured":"Sybyl-X 2.1, Certara L.P., St Louis, Mo., 2013. www.certara.com."},{"key":"10.1016\/j.ejmech.2018.08.009_bib72","unstructured":"ACD ChemSketch 2015, Advanced Chemistry Development, Inc., Toronto, Canada, 2015. www.acdlabs.com."},{"key":"10.1016\/j.ejmech.2018.08.009_bib73","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1758-2946-3-33","article-title":"Open Babel: an open chemical toolbox","volume":"3","author":"O'Boyle","year":"2011","journal-title":"J.\u00a0Cheminf."},{"issue":"1","key":"10.1016\/j.ejmech.2018.08.009_bib74","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1758-2946-4-17","article-title":"Avogadro: an advanced semantic chemical editor, visualization, and analysis platform","volume":"4","author":"Hanwell","year":"2012","journal-title":"J.\u00a0Cheminf."},{"issue":"5","key":"10.1016\/j.ejmech.2018.08.009_bib75","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1038\/nprot.2016.051","article-title":"Computational protein-ligand docking and virtual drug screening with the AutoDock suite","volume":"11","author":"Forli","year":"2016","journal-title":"Nat. Protoc."},{"issue":"16","key":"10.1016\/j.ejmech.2018.08.009_bib76","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"Autodock 4 and AutoDockTools4: automated docking with selective receptor flexibility","volume":"30","author":"Morris","year":"2009","journal-title":"J.\u00a0Comput. Chem."},{"issue":"2","key":"10.1016\/j.ejmech.2018.08.009_bib77","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J.\u00a0Comput. Chem."},{"issue":"7","key":"10.1016\/j.ejmech.2018.08.009_bib78","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1134\/S1070427206070111","article-title":"Anticorrosive properties of N-acetylmethylpyridinium bromides","volume":"79","author":"Yurchenko","year":"2006","journal-title":"Russ. J. Appl. Chem."},{"issue":"10","key":"10.1016\/j.ejmech.2018.08.009_bib79","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1134\/S1070428016100146","article-title":"Synthesis of substituted 1-[2-(adamantan-1-yl)ethyl]piperidines","volume":"52","author":"Shadrikova","year":"2016","journal-title":"Russ. J. Org. Chem."},{"issue":"11","key":"10.1016\/j.ejmech.2018.08.009_bib80","doi-asserted-by":"crossref","first-page":"5505","DOI":"10.1021\/jo400621r","article-title":"Reactions of o-Quinone methides with pyridinium methylides: a diastereoselective synthesis of 1,2-dihydronaphtho[2,1-b]furans and 2,3-dihydrobenzofurans","volume":"78","author":"Osyanin","year":"2013","journal-title":"J.\u00a0Org. Chem."},{"issue":"2","key":"10.1016\/j.ejmech.2018.08.009_bib81","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/jlcr.2590060210","article-title":"Preparation of ring-labelled adamantane derivatives. I. 2-adamantanecarboxylic acid-2-14C and 2-methyladamantane-2-14C","volume":"6","author":"Majerski","year":"1970","journal-title":"J.\u00a0Labelled Comp."},{"issue":"3","key":"10.1016\/j.ejmech.2018.08.009_bib82","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S0040-4020(01)97892-5","article-title":"Synthesis of some 4-mono and 4,5-disubstituted homoadamantanes (tricyclo[4.3.1.13,8]undecanes)","volume":"26","author":"Schlatmann","year":"1970","journal-title":"Tetrahedron"},{"issue":"10","key":"10.1016\/j.ejmech.2018.08.009_bib83","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1134\/S1070428015100048","article-title":"Synthesis of nitroxy- and hydroxy-substituted polycarboxylic acids of the adamantane series","volume":"51","author":"Gavrilova","year":"2015","journal-title":"Russ. J. Org. Chem."},{"issue":"11","key":"10.1016\/j.ejmech.2018.08.009_bib84","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1134\/S1070428016110026","article-title":"Synthesis of adamantane functional derivatives basing on N-[(adamantan-1-yl)alkyl]acetamides","volume":"52","author":"Ivleva","year":"2016","journal-title":"Russ. J. Org. Chem."},{"issue":"10","key":"10.1016\/j.ejmech.2018.08.009_bib85","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1134\/S1070428016100043","article-title":"Synthesis of amino polycarboxylic acids of the adamantane series","volume":"52","author":"Ivleva","year":"2016","journal-title":"Russ. J. Org. Chem."},{"issue":"43","key":"10.1016\/j.ejmech.2018.08.009_bib86","doi-asserted-by":"crossref","first-page":"6101","DOI":"10.1016\/j.tet.2017.08.025","article-title":"Reactions of tetracyclic \u03b3-sultones with N-nucleophiles. Novel synthesis of 3,4-disubstituted homoadamantanes","volume":"73","author":"Baimuratov","year":"2017","journal-title":"Tetrahedron"},{"issue":"3","key":"10.1016\/j.ejmech.2018.08.009_bib87","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1134\/S1070428017030034","article-title":"Reactions of \u03b3-sultones containing a polycyclic fragment","volume":"53","author":"Leonova","year":"2017","journal-title":"Russ. J. Org. Chem."},{"key":"10.1016\/j.ejmech.2018.08.009_bib88","series-title":"Methods and Compounds Producing Dipeptidyl Peptidase IV Inhibitors and Intermediates Thereof","author":"Bristol-Myers Squibb Company","year":"2004"},{"issue":"1","key":"10.1016\/j.ejmech.2018.08.009_bib89","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1134\/S1070428015010054","article-title":"Transformations of allyl bromides of the adamantane series in the Ritter reaction","volume":"51","author":"Leonova","year":"2015","journal-title":"Russ. J. Org. Chem."},{"key":"10.1016\/j.ejmech.2018.08.009_bib90","doi-asserted-by":"crossref","DOI":"10.1134\/S1070428018110040","article-title":"Synthesis and transformations of adamantyl-containing aziridines","author":"Leonova","year":"2018","journal-title":"Russ. J. Org. Chem."},{"issue":"10","key":"10.1016\/j.ejmech.2018.08.009_bib91","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1055\/s-0036-1588411","article-title":"Reactions of o-quinone methides with halogenated 1H-azoles: access to benzo[e]azolo[1,3]oxazines","volume":"49","author":"Osipov","year":"2017","journal-title":"Synthesis"},{"issue":"26","key":"10.1016\/j.ejmech.2018.08.009_bib92","doi-asserted-by":"crossref","first-page":"5267","DOI":"10.1021\/jo00200a056","article-title":"Reaction of lithium o-lithiophenoxide with carbonyl compounds","volume":"49","author":"Talley","year":"1984","journal-title":"J.\u00a0Org. Chem."},{"issue":"13","key":"10.1016\/j.ejmech.2018.08.009_bib93","doi-asserted-by":"crossref","first-page":"4554","DOI":"10.1021\/jo1007898","article-title":"Copper-catalyzed coupling reaction of C\u2212OMe bonds adjacent to a nitrogen atom with terminal alkynes","volume":"75","author":"Yao","year":"2010","journal-title":"J.\u00a0Org. Chem."},{"issue":"11","key":"10.1016\/j.ejmech.2018.08.009_bib94","first-page":"2280","article-title":"The first example of Ni(II)-catalyzed asymmetric addition of \u03b2-oxophosphonate to nitroalkene","volume":"84","author":"ReznikovAN","year":"2014","journal-title":"Russ. J. Org. Chem."},{"issue":"15","key":"10.1016\/j.ejmech.2018.08.009_bib95","doi-asserted-by":"crossref","first-page":"4852","DOI":"10.1021\/ja00483a035","article-title":"Synthesis of acetylenes from carboxylic acid derivatives via \u03b2-keto sulfones","volume":"100","author":"Bartlett","year":"1978","journal-title":"J.\u00a0Am. Chem. Soc."},{"issue":"2","key":"10.1016\/j.ejmech.2018.08.009_bib96","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/jhet.5570410208","article-title":"Syntheses and NMR, MS and X-ray investigations of homoadamantane-fused pyridopyrimidinones","volume":"41","author":"Gyarmati","year":"2004","journal-title":"J.\u00a0Heterocycl. Chem."},{"issue":"3","key":"10.1016\/j.ejmech.2018.08.009_bib97","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1021\/jm00249a004","article-title":"6-Phenyl-4,5-dihydro-3(2H)-pyridazinones. Series of hypotensive agents","volume":"17","author":"Curran","year":"1974","journal-title":"J.\u00a0Med. Chem."},{"issue":"5","key":"10.1016\/j.ejmech.2018.08.009_bib98","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1021\/ol7031043","article-title":"Tin-free Giese reaction and the related radical carbonylation using alkyl iodides and cyanoborohydrides","volume":"10","author":"Ryu","year":"2008","journal-title":"Org. Lett."},{"issue":"2","key":"10.1016\/j.ejmech.2018.08.009_bib99","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1134\/S1070428014020079","article-title":"Reaction of adamantane series olefins with N-bromosuccinimide","volume":"50","author":"Leonova","year":"2014","journal-title":"Russ. J. Org. Chem."},{"issue":"10","key":"10.1016\/j.ejmech.2018.08.009_bib100","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.1016\/j.bmc.2005.12.056","article-title":"Heterocyclic rimantadine analogues with antiviral activity","volume":"14","author":"Zoidis","year":"2006","journal-title":"Bioorg. Med. Chem."},{"issue":"1\u20132","key":"10.1016\/j.ejmech.2018.08.009_bib101","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0166-3542(02)00196-1","article-title":"Potential antiviral therapeutics for smallpox, monkeypox and other orthopoxvirus infections","volume":"57","author":"Baker","year":"2003","journal-title":"Antivir. Res."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523418306676?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523418306676?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T13:46:11Z","timestamp":1759326371000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523418306676"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":101,"alternative-id":["S0223523418306676"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2018.08.009","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular design, synthesis and biological evaluation of cage compound-based inhibitors of hepatitis C virus p7 ion channels","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2018.08.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}