{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T11:34:16Z","timestamp":1774352056620,"version":"3.50.1"},"reference-count":18,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"NSFC","doi-asserted-by":"publisher","award":["81502923"],"award-info":[{"award-number":["81502923"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"NSFC","doi-asserted-by":"publisher","award":["81773631"],"award-info":[{"award-number":["81773631"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"NSFC","doi-asserted-by":"publisher","award":["81302702"],"award-info":[{"award-number":["81302702"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National S&T Major Special Project on Major New Drug Innovations","award":["2018ZX09711001-007-002"],"award-info":[{"award-number":["2018ZX09711001-007-002"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.ejmech.2018.08.057","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T23:07:10Z","timestamp":1534979230000},"page":"994-1004","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Design, synthesis and in\u00a0vitro anti-Zika virus evaluation of novel Sinefungin derivatives"],"prefix":"10.1016","volume":"157","author":[{"given":"Zeyu","family":"Tao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruiyuan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunzheng","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guocheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunhe","family":"Geng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Apeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinghao","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiyong","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Menghao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiyuan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wu","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8491-8115","authenticated-orcid":false,"given":"Mingliang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2018.08.057_bib1","doi-asserted-by":"crossref","DOI":"10.1007\/s13365-018-0614-8","article-title":"Zika virus outbreak: a review of neurological complications, diagnosis, and treatment options","author":"Koppolu","year":"2018","journal-title":"J.\u00a0Neurovirol."},{"key":"10.1016\/j.ejmech.2018.08.057_bib2","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1021\/acsinfecdis.6b00161","article-title":"Zika virus: emergence, phylogenetics, challenges, and opportunities","volume":"2","author":"Rajah","year":"2016","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.ejmech.2018.08.057_bib3","doi-asserted-by":"crossref","DOI":"10.1021\/acsinfecdis.8b00004","article-title":"Potential mechanisms for enhanced Zika epidemic and Disease","author":"Xia","year":"2018","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.ejmech.2018.08.057_bib4","series-title":"All Countries & Territories with Active Zika Virus Transmission","author":"Centers for Disease Control and Prevention","year":"2016"},{"key":"10.1016\/j.ejmech.2018.08.057_bib5","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1126\/science.aam7120","article-title":"A\u00a0single mutation in the prM protein of Zika virus contributes to fetal microcephaly","volume":"358","author":"Yuan","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.ejmech.2018.08.057_bib6","unstructured":"World Health Organization, The History of Zika Virus, http:\/\/www.who.int\/emergencies\/zika-virus\/history\/en\/."},{"key":"10.1016\/j.ejmech.2018.08.057_bib7","doi-asserted-by":"crossref","first-page":"463","DOI":"10.7164\/antibiotics.26.463","article-title":"A9145, a new adenine-containing antifungal antibiotic. I. Discovery and isolation","volume":"26","author":"Hamil","year":"1973","journal-title":"J.\u00a0Antibiot."},{"key":"10.1016\/j.ejmech.2018.08.057_bib8","doi-asserted-by":"crossref","first-page":"466","DOI":"10.7164\/antibiotics.26.466","article-title":"A9145, a new adenine-containing antifungal antibiotic. II. Biological activity","volume":"26","author":"Gordee","year":"1973","journal-title":"J.\u00a0Antibiot."},{"key":"10.1016\/j.ejmech.2018.08.057_bib9","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.1093\/nar\/24.16.3267","article-title":"Methylation inhibitors can increase the rate of cytosine deamination by (cytosine-5)-DNA methyltransferase","volume":"24","author":"Zingg","year":"1996","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ejmech.2018.08.057_bib10","article-title":"S-adenosyl-homocysteine is a weakly bound inhibitor for a flaviviral methyltransferase","volume":"8","author":"Chen","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ejmech.2018.08.057_bib11","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1021\/bi00536a011","article-title":"Effects of S-adenosylhomocysteine analogues on vaccinia viral messenger ribonucleic acid synthesis and methylation","volume":"21","author":"Pugh","year":"1982","journal-title":"Biochemist"},{"key":"10.1016\/j.ejmech.2018.08.057_bib12","doi-asserted-by":"crossref","first-page":"31","DOI":"10.4269\/ajtmh.1983.32.31","article-title":"Antitrypanosomal activity of sinefungin","volume":"32","author":"Dube","year":"1983","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.ejmech.2018.08.057_bib13","doi-asserted-by":"crossref","DOI":"10.1007\/s00018-018-2751-x","article-title":"Structure and function of Zika virus NS5 protein: perspectives for drug design","author":"Wang","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.ejmech.2018.08.057_bib14","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1007\/s00705-017-3345-x","article-title":"Structural basis of Zika virus methyltransferase inhibition by sinefungin","volume":"162","author":"Hercik","year":"2017","journal-title":"Arch. Virol."},{"key":"10.1016\/j.ejmech.2018.08.057_bib15","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1007\/s13311-017-0575-2","article-title":"Therapeutic approaches for Zika virus infection of the nervous system","volume":"14","author":"Abrams","year":"2017","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.ejmech.2018.08.057_bib16","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(00)00129-0","article-title":"Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings","volume":"46","author":"Lipinski","year":"2001","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ejmech.2018.08.057_bib17","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ccr.2011.06.009","article-title":"Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor","volume":"20","author":"Daigle","year":"2011","journal-title":"Canc. Cell"},{"key":"10.1016\/j.ejmech.2018.08.057_bib18","doi-asserted-by":"crossref","first-page":"6233","DOI":"10.1074\/jbc.M110.179184","article-title":"Small molecule inhibitors that selectively block dengue virus methyltransferase","volume":"286","author":"Lim","year":"2011","journal-title":"J.\u00a0Biol. Chem."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S022352341830727X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S022352341830727X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T13:56:22Z","timestamp":1759326982000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S022352341830727X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":18,"alternative-id":["S022352341830727X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2018.08.057","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design, synthesis and in\u00a0vitro anti-Zika virus evaluation of novel Sinefungin derivatives","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2018.08.057","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}