{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T22:04:25Z","timestamp":1786745065018,"version":"build-2736575974"},"reference-count":314,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20170626"],"award-info":[{"award-number":["BK20170626"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2016M603061"],"award-info":[{"award-number":["2016M603061"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.ejmech.2018.08.095","type":"journal-article","created":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T12:25:05Z","timestamp":1535804705000},"page":"1223-1248","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":107,"special_numbering":"C","title":["Recent developments of quinolone-based derivatives and their activities against Escherichia coli"],"prefix":"10.1016","volume":"157","author":[{"given":"Feng","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangming","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2018.08.095_bib1","doi-asserted-by":"crossref","first-page":"e1000344","DOI":"10.1371\/journal.pgen.1000344","article-title":"Organised genome dynamics in the Escherichia coli species results in highly diverse adaptive paths","volume":"5","author":"Touchon","year":"2009","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ejmech.2018.08.095_bib2","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1128\/mr.46.3.241-280.1982","article-title":"Biosynthesis of vitamin K (menaquinone) in bacteria","volume":"46","author":"Bentley","year":"1982","journal-title":"Microbiol. Rev."},{"key":"10.1016\/j.ejmech.2018.08.095_bib3","first-page":"651","article-title":"Global burden of Shigella infections: implications for vaccine development and implementation of control strategies","volume":"77","author":"Kotloff","year":"1999","journal-title":"Bull. World Health Organ."},{"key":"10.1016\/j.ejmech.2018.08.095_bib4","first-page":"197","article-title":"The global burden of diarrhoeal disease, as estimated from studies published between 1992 and 2000","volume":"81","author":"Kosek","year":"2003","journal-title":"Bull. World Health Organ."},{"key":"10.1016\/j.ejmech.2018.08.095_bib5","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S1286-4579(03)00049-2","article-title":"Medical and economic impact of extraintestinal infections due to Escherichia coli: focus on an increasingly important endemic problem","volume":"5","author":"Russo","year":"2003","journal-title":"Microb. Infect."},{"key":"10.1016\/j.ejmech.2018.08.095_bib6","doi-asserted-by":"crossref","first-page":"e1003475","DOI":"10.1371\/journal.pcbi.1003475","article-title":"Escherichia coli peptidoglycan structure and mechanics as predicted by atomic-scale simulations","volume":"10","author":"Gumbart","year":"2014","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.ejmech.2018.08.095_bib7","doi-asserted-by":"crossref","first-page":"6205","DOI":"10.1021\/acs.jmedchem.7b00453","article-title":"Identification and structure-activity relationships of novel compounds that potentiate the activities of antibiotics in Escherichia coli","volume":"60","author":"Haynes","year":"2017","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib8","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.ejmech.2018.01.078","article-title":"Ciprofloxacin derivatives and their antibacterial activities","volume":"146","author":"Zhang","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib9","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.ejmech.2017.09.050","article-title":"4-Quinolone hybrids and their antibacterial activities","volume":"141","author":"Hu","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib10","doi-asserted-by":"crossref","first-page":"4874","DOI":"10.1021\/jm501881c","article-title":"Origins of the quinolone class of antibacterials: an expended \u201cdiscovery story\u201d","volume":"58","author":"Bisacchi","year":"2015","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib11","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.ejmech.2017.11.082","article-title":"4-Quinolone derivatives and their activities against Gram positive pathogens","volume":"144","author":"Zhang","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib12","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.ejmech.2017.04.002","article-title":"Isoniazid derivatives and their anti-tubercular activity","volume":"133","author":"Hu","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib13","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.ejmech.2018.01.080","article-title":"Fluoroquinolone derivatives and their anti-tubercular activities","volume":"146","author":"Fan","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib14","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.2174\/1389557511009011046","article-title":"Development of integrase inhibitors of quinolone acid derivatives for treatment of AIDS: an overview","volume":"10","author":"Luo","year":"2010","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib15","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1021\/np400847t","article-title":"4-Quinolone alkaloids from Melochia odorata","volume":"77","author":"Jadulco","year":"2014","journal-title":"J.\u00a0Nat. Prod."},{"key":"10.1016\/j.ejmech.2018.08.095_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejmech.2018.01.039","article-title":"Antiplasmodial and antimalarial activities of quinolone derivatives: a overview","volume":"146","author":"Fan","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib17","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ejmech.2017.07.061","article-title":"Quinoline hybrids and their antiplasmodial and antimalarial activities","volume":"139","author":"Hu","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib18","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1021\/acsmedchemlett.7b00545","article-title":"Synthesis and biological screening of pyrano[3,2-c]quinoline analogues as anti-inflammatory and anticancer agents","volume":"9","author":"Upadhyay","year":"2018","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2018.08.095_bib19","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.2174\/15680266113139990133","article-title":"Insight view on possible role of fluoroquinolones in cancer therapy","volume":"13","author":"Sharma","year":"2013","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib20","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.cclet.2016.07.024","article-title":"Synthesis and in\u00a0vitro antitumor activity of novel naphthyridinone derivatives","volume":"28","author":"Jia","year":"2017","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.ejmech.2018.08.095_bib21","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1021\/ar7000843","article-title":"Hybrid Molecules with a dual mode of action: dream or reality","volume":"41","author":"Meunier","year":"2008","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.ejmech.2018.08.095_bib22","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.ejmech.2016.08.039","article-title":"Hybrid molecules: the privileged scaffolds for various pharmaceuticals","volume":"124","author":"Shaveta","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib23","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.cclet.2016.07.032","article-title":"Isatin hybrids and their anti-tuberculosis activity","volume":"2","author":"Xu","year":"2017","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.ejmech.2018.08.095_bib24","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.ejmech.2017.05.004","article-title":"Recent developments of coumarin-containing derivatives and their anti-tubercular activity","volume":"136","author":"Hu","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib25","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.ejmech.2017.06.051","article-title":"Triazole derivatives and their anti-tubercular activity","volume":"138","author":"Zhang","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib26","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.ejmech.2017.07.059","article-title":"Recent advances of pyrazole-containing derivatives as anti-tubercular agents","volume":"139","author":"Xu","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib27","doi-asserted-by":"crossref","first-page":"4","DOI":"10.2174\/2211352516666180215151216","article-title":"Recent advances of 2-Quinolone-based derivatives as anti-tubercular agents","volume":"16","author":"Liu","year":"2018","journal-title":"Anti-Infect. Agents"},{"key":"10.1016\/j.ejmech.2018.08.095_bib28","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.bmcl.2015.12.028","article-title":"Oxidative burst inhibition, cytotoxicity and antibacterial acriquinoline alkaloids from citrus reticulate (blanco)","volume":"26","author":"Marie","year":"2016","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2018.08.095_bib29","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.bioorg.2017.09.015","article-title":"Application of the morita-baylis-hillman reaction in the synthesis of 3-[(N-Cycloalkylbenzamido)methyl]-2-Quinolones as potential HIV-1 integrase inhibitors","volume":"75","author":"Sekgota","year":"2017","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib30","doi-asserted-by":"crossref","first-page":"3353","DOI":"10.1016\/j.bmcl.2017.06.009","article-title":"Novel 3-Fluoro-6-methoxyquinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV","volume":"27","author":"Mitton-Fry","year":"2017","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2018.08.095_bib31","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.ejmech.2011.11.041","article-title":"Synthesis and biological evaluation of some thiazolidinones as antimicrobial agents","volume":"48","author":"Patel","year":"2012","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib32","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1515\/hc.2011.006","article-title":"Microwave assisted synthesis and in\u00a0vitro antimicrobial assessment of quinolone based s-triazines","volume":"17","author":"Patel","year":"2011","journal-title":"Heterocycl. Commun."},{"key":"10.1016\/j.ejmech.2018.08.095_bib33","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.jfluchem.2011.06.021","article-title":"Synthesis, characterization and pharmacological activities of 2-[4-cyano-(3-trifluoromethyl)phenyl amino)]-4-(4-quinoline\/coumarin-4-yloxy)-6-(fluoropiperazinyl)-s-triazines","volume":"132","author":"Patel","year":"2011","journal-title":"J.\u00a0Fluorine Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib34","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1002\/jhet.1769","article-title":"Different heterocycles functionalized s-triazine analogues: design, synthesis and in\u00a0vitro antimicrobial, antituberculosis, and anti-HIV assessment","volume":"51","author":"Patel","year":"2014","journal-title":"J.\u00a0Heterocycl. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib35","doi-asserted-by":"crossref","first-page":"478","DOI":"10.2174\/157017812802139681","article-title":"Synthesis of novel quinolone and coumarin based 1,3,4-thiadiazolyl and 1,3,4-oxadiazolyl N-mannich bases as potential antimicrobials","volume":"9","author":"Patel","year":"2012","journal-title":"Lett. Org. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib36","first-page":"179","article-title":"Synthesis and evaluation of antimicrobial activity of 1-benzoyl-1H-pyrazolo[4,3-c]quinolin-4(5H)-ones","volume":"2","author":"Murugesh","year":"2011","journal-title":"Int. Res. J. Pharm."},{"key":"10.1016\/j.ejmech.2018.08.095_bib37","first-page":"2485","article-title":"Antimicrobial activity and synthesis of quinoline-based chalcones","volume":"7","author":"Azad","year":"2007","journal-title":"J.\u00a0Appl. Sci."},{"key":"10.1016\/j.ejmech.2018.08.095_bib38","doi-asserted-by":"crossref","first-page":"61","DOI":"10.7897\/2230-8407.041014","article-title":"Synthesis and biological evaluation of some novel pyrazoline derivatives derived from N-substituted quinolinyl chalcones","volume":"4","author":"Fernandes","year":"2013","journal-title":"Int. Res. J. Pharm."},{"key":"10.1016\/j.ejmech.2018.08.095_bib39","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s00044-013-0608-2","article-title":"Solvent-free, one-pot synthesis and biological evaluation of some new dipyrazolo[3,4-b:40,30-e]pyranylquinolones and their precursors","volume":"23","author":"Parmar","year":"2014","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.ejmech.2018.08.095_bib40","doi-asserted-by":"crossref","first-page":"6916","DOI":"10.1021\/jm300690s","article-title":"Novel N-linked aminopiperidine inhibitors of bacterial topoisomerase type II with reduced pKa: antibacterial agents with an improved safety profile","volume":"55","author":"Reck","year":"2012","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib41","doi-asserted-by":"crossref","first-page":"7834","DOI":"10.1021\/jm2008826","article-title":"Novel N-linked aminopiperidine inhibitors of bacterial topoisomerase type II: broad-spectrum antibacterial agents with reduced hERG activity","volume":"54","author":"Reck","year":"2011","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib42","first-page":"518","article-title":"Synthesis and biological evaluation of some novel Schiff bases of 2-quinolones","volume":"6","author":"Kumar","year":"2014","journal-title":"Int. J. Pharm. Pharmaceut. Sci."},{"key":"10.1016\/j.ejmech.2018.08.095_bib43","first-page":"165","article-title":"Synthesis, antimicrobial and anti-inflammatory studies of some novel schiff base derivatives","volume":"6","author":"Kumar","year":"2014","journal-title":"Int. J. Drug Dev. Res."},{"key":"10.1016\/j.ejmech.2018.08.095_bib44","doi-asserted-by":"crossref","first-page":"5227","DOI":"10.1007\/s00044-013-0518-3","article-title":"In-silico design, synthesis and evaluation of novel DNA-gyrase B inhibitors","volume":"22","author":"Shiroya","year":"2013","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.ejmech.2018.08.095_bib45","first-page":"381","article-title":"Synthesis and antimicrobial activity of 4-hydroxy-1-methyl\/phenyl-3-substituted quinolin-2(1H)-ones","volume":"17","author":"Mamledesai","year":"2018","journal-title":"Indian J. Heterocycl. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib46","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1002\/jhet.2081","article-title":"Synthesis and antimicrobial evaluation of novel polyfused heterocycles-based quinolone","volume":"52","author":"Hamama","year":"2015","journal-title":"J.\u00a0Heterocycl. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib47","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1002\/jhet.2821","article-title":"Ionic liquid mediated green synthesis of spirooxindoles from N-methyl quinolones and their anti bacterial activity","volume":"54","author":"Bhupathi","year":"2017","journal-title":"J.\u00a0Heterocycl. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib48","first-page":"643","article-title":"Synthesis, characterization and biological evaluation of novel C-2 substituted benzimidazole heterocycles","volume":"9","author":"Goudgaon","year":"2015","journal-title":"J.\u00a0Pharm. Res."},{"key":"10.1016\/j.ejmech.2018.08.095_bib49","first-page":"1724","article-title":"Synthesis, characterization, antibacterial Pharmanest an Int. J. Adv. Pharmaceut. Sci.evaluation of novel Schiff's bases of 2-quinolone","volume":"5","author":"Kaur","year":"2014","journal-title":"PHARMANEST - An International Journal of Advances in Pharmaceutical Sciences"},{"key":"10.1016\/j.ejmech.2018.08.095_bib50","first-page":"4162","article-title":"Synthesis of 7-substituted-4-hydroxyquinolin-2(1H)-one for anti-bacterial and anti-fungal activity","volume":"4","author":"Subba","year":"2012","journal-title":"Int. J. Pharm. Technol."},{"key":"10.1016\/j.ejmech.2018.08.095_bib51","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.phytol.2012.03.007","article-title":"Glycopentaphyllone: the first isolation of hydroperoxyquinolone from the fruits of Glycosmis pentaphylla","volume":"5","author":"Sripisut","year":"2012","journal-title":"Phytochem. Lett."},{"key":"10.1016\/j.ejmech.2018.08.095_bib52","doi-asserted-by":"crossref","first-page":"5558","DOI":"10.1021\/bi500682e","article-title":"Role of the water-metal ion bridge in mediating interactions between quinolones and Escherichia coli topoisomerase IV","volume":"53","author":"Aldred","year":"2014","journal-title":"Biochemist"},{"key":"10.1016\/j.ejmech.2018.08.095_bib53","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/S0960-894X(03)00208-7","article-title":"Piperazinyl-linked fluoroquinolone dimers possessing potent antibacterial activity against drug-resistant strains of Staphylococcus aureus","volume":"13","author":"Kerns","year":"2003","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2018.08.095_bib54","doi-asserted-by":"crossref","first-page":"3238","DOI":"10.1021\/jm701428b","article-title":"Synthesis and Antibacterial Activity of Novel Pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic Acid Derivatives Carrying the 3-Cyclopropylaminomethyl-4-substituted-1-pyrrolidinyl group as a C-10 substituent","volume":"51","author":"Asahina","year":"2008","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib55","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ejmech.2015.09.030","article-title":"Synthesis, antimycobacterial and antibacterial activity of fluoroquinolone derivatives containing an 3-alkoxyimino-4-(cyclopropylanimo)methylpyrrolidine moiety","volume":"104","author":"Zhang","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib56","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.ejmech.2016.09.053","article-title":"Synthesis, evaluation, and CoMFA study of fluoroquinophenoxazine derivatives as bacterial topoisomerase IA inhibitors","volume":"125","author":"Liu","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib57","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.1021\/jm00074a028","article-title":"Quinolinecarboxylic Acids. 3. Synthesis and Antibacterial Evaluation of 2-Substituted-7-oxo-2,3-dihydro-7-pyrido[l,2,3-de][l,4]benzothiazine-6-carboxylic acids related to rufloxacin","volume":"36","author":"Cecchetti","year":"1993","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib58","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/jhet.5570370213","article-title":"New 1,8-peri-annelated tricyclic quinolone antibacterials","volume":"37","author":"Miao","year":"2000","journal-title":"J.\u00a0Heterocycl. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib59","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1023\/A:1015189626030","article-title":"Synthesis and antibacterial activity of 1,3,4-thia(oxa)diazino[6,5,4-I,j]quinoline derivatives","volume":"35","author":"Nosova","year":"2001","journal-title":"Pharm. Chem. J."},{"key":"10.1016\/j.ejmech.2018.08.095_bib60","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1021\/jm00079a011","article-title":"Synthesis and antibacterial activity of new tetracyclic quinolone antibacterials","volume":"35","author":"Taguchi","year":"1992","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib61","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1021\/jm00070a005","article-title":"Synthesis and antibacterial activity of a new series of tetracyclic pyridonecarboxylic acids","volume":"36","author":"Jinbo","year":"1993","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib62","doi-asserted-by":"crossref","first-page":"3148","DOI":"10.1021\/jm00073a014","article-title":"Synthesis and antibacterial activity of a new series of tetracyclic pyridonecarboxylic acids. 21a","volume":"36","author":"Jinbo","year":"1993","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib63","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1021\/jm00043a018","article-title":"Synthesis and antibacterial activity of thiazolopyrazine-incorporated tetracyclic quinolone antibacterial agents. 2l","volume":"37","author":"Jinbo","year":"1994","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib64","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1021\/jm00031a007","article-title":"Synthesis and antibacterial activity of thiazolopyrazine-incorporated tetracyclic quinolone antibacterials","volume":"37","author":"Inoue","year":"1994","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib65","doi-asserted-by":"crossref","first-page":"4727","DOI":"10.1021\/jm00103a011","article-title":"Studies on pyridonecarboxylic acids. 1. Synthesis and antibacterial evaluation of 7-Substituted-6-halo-4-oxo-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acids 1","volume":"35","author":"Segawa","year":"1992","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib66","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.3987\/COM-99-8712","article-title":"Synthesis and antibacterial activity of novel 7-substituted 6-fluoro-1-methylene-4-oxo-4H-[1,3]thiazeto[3.2-a]quinoline-3-carboxylic acid derivatives","volume":"51","author":"Matsuoka","year":"1999","journal-title":"Heterocycles"},{"key":"10.1016\/j.ejmech.2018.08.095_bib67","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1248\/cpb.47.1765","article-title":"Synthesis and antibacterial activity of novel 7-substituted-6-fluoro-1-fluoromethyl-4-oxo-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid derivatives","volume":"47","author":"Matsuoka","year":"1999","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.ejmech.2018.08.095_bib68","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1021\/jm00158a037","article-title":"Synthesis and biological activity of benzothiazolo[3,2-a]quinolone antibecterial agents","volume":"29","author":"Chu","year":"1986","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib69","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1021\/jm00169a033","article-title":"Synthesis and antibacterial activity of thiazolo-, oxazolo-, and imidazolo-[3,2-a][1,8]naphthylidenecarboxylic acid","volume":"33","author":"Hondo","year":"1990","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib70","first-page":"185","article-title":"QSARs on bactericidal activity of 3-carboxy-4-quinolones","volume":"59","author":"Tarko","year":"2008","journal-title":"Rev. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib71","doi-asserted-by":"crossref","first-page":"777","DOI":"10.3109\/14756366.2013.855925","article-title":"Design synthesis and antibacterial activity studies of new thiadiazoloquinolone compounds","volume":"29","author":"Al-Qawasmeh","year":"2014","journal-title":"J.\u00a0Enzym. Inhib. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib72","doi-asserted-by":"crossref","first-page":"3469","DOI":"10.1021\/jm00097a004","article-title":"Synthesis and Antibacterial Activity of 1-(Substituted pyrrolyl)-7-(substituted amino)-6-fluoro-l,4-dihydro-4-oxo-3-quinolinecarboxylic acids","volume":"35","author":"Liu","year":"1992","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib73","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1021\/jm00149a003","article-title":"Synthesis and structure-activity relationships of novel arylfluoroquinolone antibacterial agents","volume":"28","author":"Chu","year":"1985","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib74","doi-asserted-by":"crossref","first-page":"4693","DOI":"10.1021\/jm0497895","article-title":"A\u00a0prodrug approach toward the development of water soluble fluoroquinolones and structure-activity relationships of quinoline-3-carboxylic acids","volume":"47","author":"Baker","year":"2004","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib75","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.ejmech.2014.08.063","article-title":"Novel hybrids of metronidazole and quinolones: synthesis, bioactive evaluation, cytotoxicity, preliminary antimicrobial mechanism and effect of metal ions on their transportation by human serum albumin","volume":"86","author":"Cui","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib76","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/jhet.2034","article-title":"Synthesis of novel N-triazolo methyl substituted fluoroquinolones and their antimicrobial activity","volume":"52","author":"Kumar","year":"2015","journal-title":"J.\u00a0Heterocycl. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib77","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.1016\/j.bmcl.2013.03.118","article-title":"Synthesis and biological evaluation of a class of quinolone triazoles as potential antimicrobial agents and their interactions with calf thymus DNA","volume":"23","author":"Cui","year":"2013","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2018.08.095_bib78","first-page":"126","article-title":"Design, practical synthesis and biological evaluation of novel 1,3,4-oxadiazole derivatives incorporated with quinolone moiety as microbial agents","volume":"5","author":"Ramana","year":"2013","journal-title":"Der Pharma Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib79","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1248\/cpb.56.346","article-title":"Synthesis of new quinolone antibiotics utilizing azetidine derivatives obtained from 1-azabicyclo[1.1.0]butane","volume":"56","author":"Ikee","year":"2008","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.ejmech.2018.08.095_bib80","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1021\/jm00105a020","article-title":"Three-dimension structure-activity relationships and receptor mapping of N1-substituents of quinolone antibacterials","volume":"34","author":"Ohta","year":"1991","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib81","doi-asserted-by":"crossref","first-page":"3443","DOI":"10.1021\/jm040204g","article-title":"Synthesis and antibacterial activity of the 4-Quinolone-3-carboxylic acid derivatives having a trifluoromethyl group as a novel N-1 substituent","volume":"48","author":"Asahina","year":"2005","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib82","doi-asserted-by":"crossref","first-page":"3444","DOI":"10.1021\/jm00074a027","article-title":"Fluorocyclopropyl quinolones. 1. Synthesis and structure-activity relationships of 1-(2-fluorocyclopropyl)-3-pyridonecarboxylic acid antibacterial agents","volume":"36","author":"Atarashi","year":"1993","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib83","doi-asserted-by":"crossref","first-page":"3344","DOI":"10.1021\/jm00046a019","article-title":"(Fluorocyclopropyl)quinolones. 2. Synthesis and stereochemical structure-activity relationships of chiral 7-(7-amino-5-azaspiro[2,4]heptan-5 -yl)-1-(2-fluorocyclopropyl)quinolone antibacterial agents","volume":"37","author":"Kimura","year":"1994","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib84","doi-asserted-by":"crossref","first-page":"731","DOI":"10.2165\/11207380-000000000-00000","article-title":"Sitafloxacin in bacterial infections","volume":"71","author":"Keating","year":"2011","journal-title":"Drugs"},{"key":"10.1016\/j.ejmech.2018.08.095_bib85","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1021\/jm00093a024","volume":"35","author":"Remuzon","year":"1992","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib86","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1021\/jm00105a006","volume":"34","author":"Remuzon","year":"1991","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib87","doi-asserted-by":"crossref","first-page":"3194","DOI":"10.1021\/jm0402061","article-title":"Synthesis and antibacterial activity of 1-(2-Fluorovinyl)-7-substituted-4-quinolone-3-carboxylic acid derivatives, conformationally restricted analogues of fleroxacin","volume":"48","author":"Asahina","year":"2005","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib88","first-page":"114","article-title":"Synthesis of 6-Fluoro-7-cyclic amino-substituted dicarboxylic acid quinolones and their antibacterial activity","volume":"51","author":"Kumar","year":"2014","journal-title":"J.\u00a0Heterocycl. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib89","doi-asserted-by":"crossref","first-page":"637","DOI":"10.2174\/157017811799304322","article-title":"Quinolone dimers as potential antibacterial agents","volume":"8","author":"Chepyala","year":"2011","journal-title":"Lett. Org. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib90","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/(SICI)1098-1128(199609)16:5<433::AID-MED3>3.0.CO;2-W","article-title":"Fluoroquinolone antibacterials: SAR, mechanism of action, resistance, and clinical aspects","volume":"16","author":"Gootz","year":"1996","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.ejmech.2018.08.095_bib91","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1021\/op700014t","article-title":"Practical synthesis and molecular structure of a potent broad-spectrum antibacterial isothiazoloquinolone","volume":"11","author":"Hashimoto","year":"2007","journal-title":"Org. Process Res. Dev."},{"key":"10.1016\/j.ejmech.2018.08.095_bib92","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/j.bmcl.2005.11.065","volume":"16","author":"Wiles","year":"2006","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2018.08.095_bib93","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/j.bmcl.2005.11.064","volume":"16","author":"Wiles","year":"2006","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2018.08.095_bib94","first-page":"379","article-title":"Structure-activity relationships in quinolone antibacterials: design, synthesis and biological activities of novel isothiazoloquinolones","volume":"14","author":"Chu","year":"1988","journal-title":"Drugs Exp. Clin. Res."},{"key":"10.1016\/j.ejmech.2018.08.095_bib95","doi-asserted-by":"crossref","first-page":"3268","DOI":"10.1021\/jm101604v","article-title":"Exploration of the activity of 7-Pyrrolidino-8-methoxyisothiazoloquinolones against methicillin-resistant Staphylococcus aureus (MRSA)","volume":"54","author":"Kim","year":"2011","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib96","doi-asserted-by":"crossref","first-page":"4585","DOI":"10.1016\/j.bmcl.2011.05.112","article-title":"Synthesis and evaluation of 1-cyclopropyl-2-thioalkyl-8-methoxy fluoroquinolones","volume":"21","author":"Marks","year":"2011","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2018.08.095_bib97","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.tet.2017.12.010","article-title":"Synthesis of 2-alkenyl-3-hydroxyquinolin-4(1H)-ones as promising antimicrobial and fluorescent agents","volume":"74","author":"Horak","year":"2018","journal-title":"Tetrahedron"},{"key":"10.1016\/j.ejmech.2018.08.095_bib98","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1002\/jhet.1040","article-title":"Synthesis and antibacterial activity of new diaryldiamines","volume":"49","author":"Samrin","year":"2012","journal-title":"J.\u00a0Heterocycl. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib99","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S0014-827X(01)01112-0","article-title":"Synthesis and antibacterial activity of 2-substituted 6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids","volume":"56","author":"Jung","year":"2001","journal-title":"Il Farmaco"},{"key":"10.1016\/j.ejmech.2018.08.095_bib100","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.4067\/S0717-97072012000300008","article-title":"Synthesis of 2-methyl-4-quinolone-3-acetic acids with potential antibacterial activity","volume":"57","author":"Chattha","year":"2012","journal-title":"J.\u00a0Chil. Chem. Soc."},{"key":"10.1016\/j.ejmech.2018.08.095_bib101","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.bmcl.2012.12.045","article-title":"Synthesis and antibacterial evaluation of a novel tricyclic oxaborole-fused fluoroquinolone","volume":"23","author":"Li","year":"2013","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2018.08.095_bib102","first-page":"2604","article-title":"Synthesis, antibacterial activity and molecular docking of substituted naphthyridines as potential DNA gyrase inhibitors","volume":"3","author":"Omar","year":"2018","journal-title":"Chemistry"},{"key":"10.1016\/j.ejmech.2018.08.095_bib103","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1002\/jccs.201600199","article-title":"Oxidative cyclization of isoniazid with fluoroquinolones: synthesis, antibacterial and antitubercular activity of new 2,5-disubstituted-1,3,4-Oxadiazoles","volume":"64","author":"Khan","year":"2017","journal-title":"J.\u00a0Chin. Chem. Soc."},{"key":"10.1016\/j.ejmech.2018.08.095_bib104","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1128\/AAC.33.2.131","article-title":"Structure-activity relationships of the fluoroquinolones","volume":"33","author":"Chu","year":"1989","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2018.08.095_bib105","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.cclet.2012.01.029","article-title":"Synthesis and antitumor and antibacterial evaluation of fluoroquinolone derivatives (III): mono- and bis-Schiff-bases","volume":"23","author":"Hu","year":"2012","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.ejmech.2018.08.095_bib106","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1248\/cpb.c13-00797","article-title":"New hydroxamic acid derivatives of fluoroquinolones: synthesis and evaluation of antibacterial and anticancer properties","volume":"62","author":"Rajulu","year":"2014","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.ejmech.2018.08.095_bib107","doi-asserted-by":"crossref","first-page":"103","DOI":"10.2174\/1570180814666170710160751","article-title":"Nalidixic acid Schiff bases: synthesis and biological evaluation","volume":"15","author":"Husain","year":"2018","journal-title":"Lett. Drug Des. Discov."},{"key":"10.1016\/j.ejmech.2018.08.095_bib108","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1007\/s00044-011-9728-8","article-title":"Pyridoquinolones containing azetidinones: synthesis and their biological evaluation","volume":"21","author":"Patel","year":"2012","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.ejmech.2018.08.095_bib109","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s11094-009-0300-5","article-title":"Synthesis and antimicrobial activity of 2-phenyl-3-{1-cyclopropyl-6-fluoro-7-[4-methylpiperazin-1-yl]-4-quinolone}carboxamido-3-thiazolidin-4-ones","volume":"43","author":"Patel","year":"2009","journal-title":"Pharm. Chem. J."},{"key":"10.1016\/j.ejmech.2018.08.095_bib110","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.ejmech.2013.06.056","article-title":"Synthesis and study of 1-ethyl-3-carbohydrazide and 3-[1-oxo-2-hydrazino-3-{p-toluenesulfon}]quinolone derivatives against bacterial infections","volume":"67","author":"Srivastava","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib111","first-page":"515","article-title":"Microwave-assisted synthesis and biological activity of ester, carbothioate and carbohydrazide derivative compounds of the drug ciprofloxacin","volume":"10","author":"Jafar","year":"2017","journal-title":"J.\u00a0Chem. Pharmaceut. Sci."},{"key":"10.1016\/j.ejmech.2018.08.095_bib112","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.ejmech.2017.07.004","article-title":"Design, synthesis and 2D QSAR study of novel pyridine and quinolone hydrazone derivatives as potential antimicrobial and antitubercular agents","volume":"138","author":"Abdelrahman","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib113","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.3762\/bjoc.9.176","article-title":"Synthesis and biological activities of the respiratory chain inhibitor aurachin D and new ring versus chain analogues","volume":"9","author":"Li","year":"2013","journal-title":"Beilstein J. Org. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib114","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.4067\/S0717-97072012000300008","article-title":"Synthesis of 2-methyl-4-quinolone-3-acetic acids with potential antibacterial activity","volume":"57","author":"Chattha","year":"2012","journal-title":"J.\u00a0Chil. Chem. Soc."},{"key":"10.1016\/j.ejmech.2018.08.095_bib115","doi-asserted-by":"crossref","first-page":"5961","DOI":"10.1016\/j.bmcl.2011.07.060","article-title":"Preparation and antibacterial evaluation of decarboxylated fluoroquinolones","volume":"21","author":"Nguyen","year":"2011","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2018.08.095_bib116","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.ejmech.2016.10.011","article-title":"Multi-targeting exploration of new 2-aminothiazolyl quinolones: synthesis, antimicrobial evaluation, interaction with DNA, combination with topoisomerase IV and penetrability into cells","volume":"124","author":"Cheng","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib117","doi-asserted-by":"crossref","first-page":"4488","DOI":"10.1021\/acs.jmedchem.5b01678","article-title":"Novel 3-aminothiazolquinolones: design, synthesis, bioactive evaluation, SARs, and preliminary antibacterial mechanism","volume":"59","author":"Cui","year":"2016","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib118","first-page":"880","article-title":"Synthesis, characterization and microbial assay of new pyridoquinolone-3-carboxamides","volume":"51B","author":"Patel","year":"2012","journal-title":"Indian J. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib119","first-page":"969","article-title":"Synthesis of novel \u03b1-amino acid functionalized 6-fluoroquinolones, their antibacterial activity and molecular docking studies","volume":"51B","author":"Lingaiah","year":"2012","journal-title":"Indian J. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib120","first-page":"254","article-title":"Synthesis, characterization & biological studies of newer class of quinolone derivatives","volume":"8","author":"Gangrade","year":"2017","journal-title":"Int. J. Pharma Sci. Res."},{"key":"10.1016\/j.ejmech.2018.08.095_bib121","first-page":"530","article-title":"Prodrugs of nalidixic acid and norfloxacin","volume":"40B","author":"Khan","year":"2001","journal-title":"Indian J. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib122","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1007\/s00044-010-9443-x","article-title":"Synthesis and in\u00a0vitro microbial activities of amides of pyridoquinolone","volume":"20","author":"Patel","year":"2011","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.ejmech.2018.08.095_bib123","first-page":"126","article-title":"Synthesis of amide derivatives of quinolone and their antimicrobial studies","volume":"46B","author":"Patel","year":"2007","journal-title":"Indian J. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib124","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1021\/jm00092a014","article-title":"Synthesis and structure-activity relationships of cephalosporins with C-3\u2019 catechol-containing residues","volume":"35","author":"Arnould","year":"1992","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib125","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/jac\/31.1.81","article-title":"RO 23-9424, a new cephalosporin 3'-quinolone: in-vitro antimicrobial activity and tentative disc diffusion interpretive criteria","volume":"31","author":"Pfaller","year":"1993","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.ejmech.2018.08.095_bib126","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nrd2202","article-title":"Multi-targeting by monotherapeutic antibacterials","volume":"6","author":"Silver","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejmech.2018.08.095_bib127","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1021\/cb500313f","article-title":"Orthogonal control of antibacterial activity with light","volume":"9","author":"Velema","year":"2014","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.ejmech.2018.08.095_bib128","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jphotobiol.2008.05.001","article-title":"Synthesis, primary photophysical and antibacterial properties of naphthyl ester cinoxacin and nalidixic acid derivatives","volume":"92","author":"Vargas","year":"2008","journal-title":"J.\u00a0Photochem. Photobiol. B Biol."},{"key":"10.1016\/j.ejmech.2018.08.095_bib129","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1021\/jm00088a019","article-title":"Dual-action penems and carbapenems","volume":"35","author":"Corraz","year":"1992","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib130","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1021\/jm00163a013","article-title":"Cephalosporin 3\u2019-quinolone esters with a dual mode of action","volume":"33","author":"Albrecht","year":"1990","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib131","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1128\/AAC.33.7.1067","article-title":"Mode of action of dual-action cephalosporin RO 23-9424","volume":"33","author":"Georgopapadakou","year":"1989","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2018.08.095_bib132","first-page":"123","article-title":"Quinolones: recent structural and clinical developments","volume":"3","author":"Emami","year":"2005","journal-title":"Iran. J. Pharm. Res. (IJPR)"},{"key":"10.1016\/j.ejmech.2018.08.095_bib133","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1021\/jm00079a028","article-title":"Potent non-6-fluoro-substituted quinolone antibacterials: synthesis and biological activity","volume":"35","author":"Ledoussal","year":"1992","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib134","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1021\/jm00107a039","article-title":"Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote nl-substituent in determining the structure-activity relationship","volume":"34","author":"Domagala","year":"1991","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib135","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1021\/jm00107a040","article-title":"Synthesis and biological activity of 5-alkyl-1,7,8-trisubstituted-6-fluoroquinolone-3-carboxylic acids","volume":"34","author":"Hagen","year":"1991","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib136","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1248\/cpb.43.2123","article-title":"Imidazo- and triazoloquinolones as antibacterial agents. Synthesis and structure-activity relationships","volume":"43","author":"Fujita","year":"1995","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.ejmech.2018.08.095_bib137","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1248\/cpb.44.987","article-title":"5-Alkoxyimidazoquinolones as antibacterial agents. Synthesis and structure-activity relationships","volume":"44","author":"Fujita","year":"1996","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.ejmech.2018.08.095_bib138","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1248\/cpb.c17-00717","article-title":"Discovery of a novel fluoroquinolone antibiotic candidate WFQ-228 with potent antimicrobial activity and the potential to overcome major drug resistance","volume":"66","author":"Hirano","year":"2018","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.ejmech.2018.08.095_bib139","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1016\/S0968-0896(99)00207-2","article-title":"Studies on 6-aminoquinolones: synthesis and antibacterial evaluation of 6-Amino-8-ethyl- and 6-Amino-8-methoxyquinolones","volume":"7","author":"Cecchetti","year":"1999","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib140","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1021\/jm950558v","article-title":"Studies on 6-aminoquinolones: synthesis and antibacterial evaluation of 6-Amino-8-methylquinolones","volume":"39","author":"Cecchetti","year":"1996","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib141","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1021\/jm960385p","article-title":"Chemometric methodologies in a quantitative structure-activity relationship study: the antibacterial activity of 6-aminoquinolones","volume":"40","author":"Cecchetti","year":"1997","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib142","doi-asserted-by":"crossref","first-page":"120","DOI":"10.2174\/1570178613666151124200117","article-title":"Synthesis and biological activity of some new N1-(4-oxoquinolin-6-yl)amidrazones","volume":"13","author":"Musameh","year":"2013","journal-title":"Lett. Org. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib143","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s11030-016-9695-6","article-title":"Synthesis of first ever 4-quinolone-3-carboxylic acid-appended spirooxindole-pyrrolidine derivatives and their biological applications","volume":"21","author":"Arasakumar","year":"2017","journal-title":"Mol. Divers."},{"key":"10.1016\/j.ejmech.2018.08.095_bib144","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jac\/dkg212","article-title":"Development of the quinolones","volume":"51","author":"Andersson","year":"2003","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.ejmech.2018.08.095_bib145","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1021\/jm0510023","article-title":"Hybrid antibacterials. DNA polymerase-topoisomerase inhibitors","volume":"49","author":"Zhi","year":"2006","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib146","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.1128\/AAC.44.12.3351-3356.2000","article-title":"Antibacterial spectrum of a novel des-fluoro(6) quinolone, BMS-284756","volume":"44","author":"Fung-Tomc","year":"2000","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2018.08.095_bib147","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1128\/AAC.43.5.1077","article-title":"In\u00a0vitro and in\u00a0vivo antimicrobial activities of T-3811ME, a novel des-F(6)-quinolone","volume":"43","author":"Takahata","year":"1999","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2018.08.095_bib148","first-page":"1324","article-title":"1-Cyclopropyl-8-(difluoromethoxy)-7-[1(R)-methyl-2,3-dihydro-1H-isoindol-5-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid monomethanesulfonate monohydrate","volume":"24","author":"Graul","year":"1999","journal-title":"Drugs Future"},{"key":"10.1016\/j.ejmech.2018.08.095_bib149","doi-asserted-by":"crossref","first-page":"4952","DOI":"10.1021\/jm960414w","article-title":"Potent 6-Desfluoro-8-methylquinolones as new lead compounds in antibacterial Chemotherapy1","volume":"39","author":"Cecchetti","year":"1996","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib150","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1016\/S0960-894X(03)00399-8","article-title":"Synthesis and biological testing of non-fluorinated analogues of levofloxacin","volume":"13","author":"Gray","year":"2003","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2018.08.095_bib151","doi-asserted-by":"crossref","DOI":"10.1002\/jhet.3244","article-title":"4-Quinolone derivatives and their activities against Gram-negative pathogens","author":"Jiang","year":"2018","journal-title":"J.\u00a0Heterocycl. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib152","doi-asserted-by":"crossref","first-page":"5214","DOI":"10.1128\/AAC.01054-10","article-title":"Effect of N-1\/C-8 ring fusion and C-7 ring structure on fluoroquinolone lethality","volume":"54","author":"Malik","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2018.08.095_bib153","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.14233\/ajchem.2014.15949","article-title":"Synthesis and antibacterial activity of novel levofloxacin analogues","volume":"26","author":"Zhang","year":"2014","journal-title":"Asian J. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib154","doi-asserted-by":"crossref","first-page":"375","DOI":"10.2174\/138955706776361493","article-title":"Structural features of new quinolones and relationship to antibacterial activity against gram-positive bacteria","volume":"6","author":"Emami","year":"2006","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib155","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1128\/AAC.01311-05","article-title":"Antibacterial activity and mechanism of action of a novel anilinouracil-fluoroquinolone hybrid compound","volume":"51","author":"Butler","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2018.08.095_bib156","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1002\/jhet.3234","article-title":"Quinolone-triazole hybrids and their biological activities","volume":"55","author":"Xu","year":"2018","journal-title":"J.\u00a0Heterocycl. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib157","doi-asserted-by":"crossref","first-page":"3699","DOI":"10.1016\/j.bmcl.2015.06.041","article-title":"Design and biological evaluation of novel quinolone-based metronidazole derivatives as potent Cu2+ mediated DNA-targeting antibacterial agents","volume":"25","author":"Zhang","year":"2015","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2018.08.095_bib158","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/cbdd.12395","article-title":"Design, synthesis, antibacterial evaluation and docking study of novel 2-Hydroxy-3-(nitroimidazolyl)-propyl-derived quinolone","volume":"85","author":"Li","year":"2015","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.ejmech.2018.08.095_bib159","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ejmech.2016.01.052","article-title":"Discovery of membrane active benzimidazole quinolones-based topoisomerase inhibitors as potential DNA-binding antimicrobial agents","volume":"111","author":"Zhang","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib160","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1515\/hc-2012-0082","article-title":"Synthesis and antimicrobial evaluation of substituted benzimidazolyl fluoroquinolones under conventional and microwave irradiation conditions","volume":"18","author":"Guruswamy","year":"2012","journal-title":"Heterocycl. Commun."},{"key":"10.1016\/j.ejmech.2018.08.095_bib161","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1515\/znb-2015-0126","article-title":"Heterocycles [h]-fused to 4-oxoquinoline-3-carboxylic acid. Part XI: synthesis and antibacterial activity of 4-fluoro-6-oxoimidazo[4,5-h]quinoline-7-carboxylic acids","volume":"71","author":"Zahra","year":"2016","journal-title":"Z.\u00a0Naturforsch."},{"key":"10.1016\/j.ejmech.2018.08.095_bib162","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.cclet.2010.06.011","article-title":"Synthesis and in\u00a0vitro antibacterial activities of 7-(3-aminopyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)quinolone derivatives","volume":"21","author":"Guo","year":"2010","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.ejmech.2018.08.095_bib163","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/cbdd.12299","article-title":"Discovery of the highly potent fluoroquinolone-based benzothiazolyl-4-thiazolidinone hybrids as antibacterials","volume":"84","author":"Patel","year":"2014","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.ejmech.2018.08.095_bib164","first-page":"715","article-title":"Synthesis and screening of quinolone antibiotic isosters","volume":"12","author":"Shaban","year":"2008","journal-title":"J.\u00a0Chem. Res."},{"key":"10.1016\/j.ejmech.2018.08.095_bib165","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1021\/jm00166a025","article-title":"The synthesis and antibacterial activities of quinolones containing five- and six-membered heterocyclic substituents at the 7-position","volume":"33","author":"Cooper","year":"1990","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib166","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1002\/jhet.5570280323","article-title":"Quinolone antibacterials. 1. 7-(2-Substituted-4-thiazolyl and thiazolidinyl)quinolones","volume":"28","author":"Zhang","year":"1991","journal-title":"J.\u00a0Heterocycl. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib167","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1002\/jhet.5570280324","article-title":"Quinolone antibacterials. 2. 6-Substituted-7-(2-thiazolyl and thiazolidinyl)quinolones","volume":"28","author":"Zhang","year":"1991","journal-title":"J.\u00a0Heterocycl. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib168","doi-asserted-by":"crossref","first-page":"353","DOI":"10.2174\/157018008784912072","article-title":"Synthesis and biological evaluation of a new series of benzothiazole-quinolone hybrids as antibacterial agents","volume":"5","author":"Kamal","year":"2008","journal-title":"Lett. Drug Des. Discov."},{"key":"10.1016\/j.ejmech.2018.08.095_bib169","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/14756366.2011.611943","article-title":"Synthesis and biological evaluation of novel benzothiazole clubbed fluoroquinolone derivatives","volume":"28","author":"Sharma","year":"2013","journal-title":"J.\u00a0Enzym. Inhib. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib170","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S0014-827X(03)00191-5","article-title":"Synthesis and in\u00a0vitro antibacterial activity of some N-(5-aryl-1,3,4-thiadiazole-2-yl)piperazinyl quinolone derivatives","volume":"58","author":"Foroumadi","year":"2003","journal-title":"Il Farmaco"},{"key":"10.1016\/j.ejmech.2018.08.095_bib171","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1007\/s00044-012-0074-2","article-title":"Synthesis and antibacterial, antimycobacterial and docking studies of novel N-piperazinyl fluoroquinolones","volume":"22","author":"Agrawal","year":"2013","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.ejmech.2018.08.095_bib172","doi-asserted-by":"crossref","first-page":"3543","DOI":"10.1016\/j.ejmech.2011.04.035","article-title":"Synthesis, antibacterial evaluation and QSAR studies of 7-[4-(5-aryl-1,3,4-oxadiazole-2-yl)piperazinyl] quinolone derivatives","volume":"46","author":"Kumar","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib173","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.2174\/1570180813666160712222922","article-title":"Microwave assisted synthesis and antimicrobial activity evaluation of new heterofunctionalized norfloxacine derivatives","volume":"13","author":"Mentese","year":"2016","journal-title":"Lett. Drug Des. Discov."},{"key":"10.1016\/j.ejmech.2018.08.095_bib174","doi-asserted-by":"crossref","first-page":"5363","DOI":"10.1016\/j.bmcl.2012.07.064","article-title":"Design, synthesis and evaluation of clinafloxacin triazole hybrids as a new type of antibacterial and antifungal agents","volume":"22","author":"Wang","year":"2012","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2018.08.095_bib175","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ejmech.2012.11.040","article-title":"Synthesis and in\u00a0vitro activity of 1,2,4-triazole-ciprofloxacin hybrids against drug-susceptible and drug-resistant bacteria","volume":"60","author":"Plech","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib176","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.ejmech.2015.04.058","article-title":"Search for factors affecting antibacterial activity and toxicity of 1,2,4-triazole-ciprofloxacin hybrids","volume":"97","author":"Plech","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib177","doi-asserted-by":"crossref","first-page":"444","DOI":"10.2174\/1570180813666161024165613","article-title":"Structure-based hybridization, conventional and microwave irradiated synthesis, biological evaluation and molecular docking studies of new compounds derived from thiomorpholin","volume":"14","author":"Demirci","year":"2017","journal-title":"Lett. Drug Des. Discov."},{"key":"10.1016\/j.ejmech.2018.08.095_bib178","first-page":"636","article-title":"Novel microwave assisted synthesis and antimicrobial activity of new quinolone-hybrids","volume":"13","author":"Ceylan","year":"2016","journal-title":"Lett. Drug Des. Discov."},{"key":"10.1016\/j.ejmech.2018.08.095_bib179","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1002\/jhet.2760","article-title":"Conventional and microwave-assisted total synthesis, antioxidant capacity, biological activity, and molecular docking studies of new hybrid compounds","volume":"54","author":"Demirci","year":"2017","journal-title":"J.\u00a0Heterocycl. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib180","doi-asserted-by":"crossref","first-page":"e1800261","DOI":"10.1002\/cbdv.201800261","article-title":"Design, synthesis and antibacterial evaluation of 1-[(1R, 2S)-2-Fluorocyclopropyl]ciprofloxacin-1,2,4-triazole-5(4H)-thione hybrids","volume":"15","author":"Gao","year":"2018","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.ejmech.2018.08.095_bib181","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1016\/j.ejmech.2017.10.042","article-title":"Synthesis, antibacterial properties and 2D-QSAR studies of quinolonetriazole conjugates","volume":"143","author":"Faidallah","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib182","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.ejmech.2011.10.049","article-title":"Synthesis of osteotropic hydroxybisphosphonate derivatives of fluoroquinolone antibacterials","volume":"47","author":"McPherson","year":"2012","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib183","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.bmcl.2006.11.048","article-title":"Synthesis and antibacterial activities of new quinolone derivatives utilizing 1-azabicyclo[1.1.0]butane","volume":"17","author":"Ikee","year":"2007","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2018.08.095_bib184","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s11030-017-9795-y","article-title":"Synthesis of novel tetrazole containing hybrid ciprofloxacin and pipemidic acid analogues and preliminary biological evaluation of their antibacterial and antiproliferative activity","volume":"22","author":"Dileep","year":"2018","journal-title":"Mol. Divers."},{"key":"10.1016\/j.ejmech.2018.08.095_bib185","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1016\/S0968-0896(03)00083-X","article-title":"Design, synthesis and biological evaluation of oxazolidinone-quinolone hybrids","volume":"11","author":"Hubschwerlen","year":"2003","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib186","doi-asserted-by":"crossref","first-page":"4213","DOI":"10.1016\/j.bmcl.2003.07.021","article-title":"Novel oxazolidinone\u2013quinolone hybrid antimicrobials","volume":"13","author":"Gordeev","year":"2003","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2018.08.095_bib187","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ijantimicag.2014.03.016","article-title":"Ecological impact of MCB3837 on the normal human microbiota","volume":"44","author":"Rashid","year":"2014","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.ejmech.2018.08.095_bib188","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1517\/17460441.2010.508069","article-title":"Dual-acting hybrid antibiotics: a promising strategy to combat bacterial resistance","volume":"5","author":"Pokrovskaya","year":"2010","journal-title":"Expet Opin. Drug Discov."},{"key":"10.1016\/j.ejmech.2018.08.095_bib189","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/ardp.200600169","article-title":"Synthesis and antibacterial activity of new 7-piperazinylquinolones containing a functionalized 2-(Furan-3-yl)ethyl moiety","volume":"340","author":"Foroumadi","year":"2007","journal-title":"Arch. Pharm. Chemi Life Sci."},{"key":"10.1016\/j.ejmech.2018.08.095_bib190","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1211\/146080899128734181","article-title":"Synthesis and in-vitro antibacterial activity of new N-substituted piperazinyl quinolones","volume":"5","author":"Foroumadi","year":"1999","journal-title":"Pharm. Pharmacol. Commun."},{"key":"10.1016\/j.ejmech.2018.08.095_bib191","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1211\/146080800128736196","article-title":"Synthesis and in\u00a0vitro antibacterial activity of N-piperazinyl quinolone derivatives with derivatives with a 2-thienyl group","volume":"6","author":"Mirzaei","year":"2000","journal-title":"Pharm. Pharmacol. Commun."},{"key":"10.1016\/j.ejmech.2018.08.095_bib192","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.1016\/j.bmc.2005.12.058","article-title":"Synthesis and antibacterial activity of N-[2-[5-(methylthio)thiophen-2-yl]-2-oxoethyl] and N-[2-[5-(methylthio)thiophen-2-yl]-2-(oxyimino)ethyl]piperazinylquinolone derivatives","volume":"14","author":"Formoumadi","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib193","doi-asserted-by":"crossref","first-page":"4536","DOI":"10.1016\/j.bmcl.2005.07.005","article-title":"Synthesis and antibacterial activity of N-[2-(5-bromothiophen-2-yl)-2-oxoethyl] and N-[(2-5-bromothiophen-2-yl)-2-oximinoethyl] derivatives of piperazinyl quinolones","volume":"15","author":"Foroumadi","year":"2005","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2018.08.095_bib194","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1248\/cpb.55.894","article-title":"Synthesis and antibacterial activity of new N-[2-(Thiophen-3-yl)ethyl] piperazinyl quinolones","volume":"55","author":"Letafat","year":"2007","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.ejmech.2018.08.095_bib195","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/ardp.200700090","article-title":"Synthesis and antibacterial activity of quinolone-based compounds containing a coumarin moiety","volume":"341","author":"Emami","year":"2008","journal-title":"Arch. Pharm. Chemi Life Sci."},{"key":"10.1016\/j.ejmech.2018.08.095_bib196","doi-asserted-by":"crossref","first-page":"3620","DOI":"10.1016\/j.bmc.2014.05.018","article-title":"Novel 3-arylfuran-2(5H)-one-fluoroquinolone hybrid: design, synthesis and evaluation as antibacterial agent","volume":"22","author":"Wang","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib197","doi-asserted-by":"crossref","first-page":"5865","DOI":"10.1016\/j.bmc.2004.08.028","article-title":"Design, synthesis and biological evaluation of novel non-nucleoside HIV-1 reverse transcriptase inhibitors with broad-spectrum chemotherapeutic properties","volume":"12","author":"Sriram","year":"2004","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib198","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0223-5234(00)00125-2","article-title":"Synthesis, antibacterial, antifungal and anti-HIV activities of norfloxacin Mannich bases","volume":"35","author":"Pandeya","year":"2000","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib199","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s00044-005-0135-x","article-title":"Synthesis, antiviral and antibacterial activities of isatin Mannich bases","volume":"14","author":"Sriram","year":"2005","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.ejmech.2018.08.095_bib200","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.farmac.2005.03.005","article-title":"Newer aminopyrimidinimino isatin analogues as non-nucleoside HIV-1 reverse transcriptase inhibitors for HIV and other opportunistic infections of AIDS: design, synthesis and biological evaluation","volume":"60","author":"Sriram","year":"2005","journal-title":"Il Farmaco"},{"key":"10.1016\/j.ejmech.2018.08.095_bib201","first-page":"103","article-title":"Synthesis, antibacterial, antifungal and anti-HIV evaluation of norfloxacin Mannich bases","volume":"67","author":"Pandeya","year":"1999","journal-title":"Sci. Pharm."},{"key":"10.1016\/j.ejmech.2018.08.095_bib202","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.ejmech.2018.07.025","article-title":"Design, synthesis and antimicrobial evaluation of propylene-tethered ciprofloxacin-isatin hybrids","volume":"156","author":"Wang","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib203","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0960-894X(97)10222-0","article-title":"Methyloxime-substituted aminopyrrolidine: a new surrogate for 7-basic group","volume":"8","author":"Hong","year":"1998","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2018.08.095_bib204","doi-asserted-by":"crossref","first-page":"3584","DOI":"10.1021\/jm970202e","volume":"40","author":"Hong","year":"1997","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib205","doi-asserted-by":"crossref","first-page":"3071","DOI":"10.1128\/AAC.46.9.3071-3074.2002","article-title":"In\u00a0vitro and in\u00a0vivo antibacterial activities of DW286, a new fluoronaphthyridone antibiotic","volume":"46","author":"Yun","year":"2002","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2018.08.095_bib206","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1128\/AAC.01407-05","article-title":"In\u00a0vitro and in\u00a0vivo antibacterial activities of DW-224a, a new fluoronaphthyridone","volume":"50","author":"Park","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2018.08.095_bib207","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.14233\/ajchem.2014.15943","article-title":"Antibacterial activity of naphthyridone derivatives containing 8-Alkoxyimino-1,6-dizaspiro[3,4]octane scaffolds","volume":"26","author":"Feng","year":"2014","journal-title":"Asian J. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib208","doi-asserted-by":"crossref","first-page":"8264","DOI":"10.1016\/j.tet.2011.08.089","article-title":"Synthesis of naphthyridone derivatives containing 8-Alkoxyimino-1,6-dizaspiro[3.4]octane scaffolds","volume":"67","author":"Feng","year":"2011","journal-title":"Tetrahedron"},{"key":"10.1016\/j.ejmech.2018.08.095_bib209","doi-asserted-by":"crossref","first-page":"3377","DOI":"10.1016\/j.bmcl.2011.04.002","article-title":"Design, synthesis and in\u00a0vitro antibacterial activity of 7-(4-Alkoxyimino-3-aminomethylpiperidin-1-yl)fluoroquinolone derivatives","volume":"21","author":"Chai","year":"2011","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2018.08.095_bib210","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1016\/j.bmcl.2016.03.050","article-title":"Synthesis, antimycobacterial and antibacterial activity of 1-(6-Amino-3,5-difluoropyridin-2-yl)fluoroquinolone derivatives containing an oxime functional moiety","volume":"26","author":"Huang","year":"2016","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2018.08.095_bib211","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1002\/cmdc.201200210","article-title":"Design, synthesis, and in\u00a0vitro antibacterial activity of fluoroquinolone derivatives containing a chiral 3-(Alkoxyimino)-2-(aminomethyl)azetidine moiety","volume":"7","author":"Lv","year":"2012","journal-title":"ChemMedChem"},{"key":"10.1016\/j.ejmech.2018.08.095_bib212","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.ejmech.2014.09.029","article-title":"Synthesis, antimycobacterial and antibacterial evaluation of l-[(1R,2S)-2-Fluorocyclopropyl]fluoroquinolone derivatives containing an oxime functional moiety","volume":"86","author":"Liu","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib213","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ejmech.2012.07.010","article-title":"Synthesis and in\u00a0vitro antibacterial activity of gemifloxacin derivatives containing a substituted benzyloxime moiety","volume":"55","author":"Feng","year":"2012","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib214","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ejmech.2015.09.030","article-title":"Synthesis, antimycobacterial and antibacterial activity of fluoroquinolone derivatives containing an 3-alkoxyimino-4-(cyclopropylanimo)methylpyrrolidine moiety","volume":"104","author":"Zhang","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib215","doi-asserted-by":"crossref","first-page":"5195","DOI":"10.1016\/j.bmcl.2010.07.006","article-title":"Synthesis and in\u00a0vitro antibacterial activity of quinolone\/naphthyridone derivatives containing 3-Alkoxyimino-4-(methyl)aminopiperidine scaffolds","volume":"20","author":"Chai","year":"2010","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2018.08.095_bib216","doi-asserted-by":"crossref","first-page":"5058","DOI":"10.1016\/j.bmcl.2015.10.027","article-title":"Synthesis, antimycobacterial and antibacterial activity of l-[(1R,2S)-2-Fluorocyclopropyl]naphthyridone derivatives containing an oxime-functionalized pyrrolidine moiety","volume":"25","author":"Huang","year":"2015","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2018.08.095_bib217","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/ardp.200900191","article-title":"Synthesis and in\u00a0vitro antibacterial activity of 7-(3-Alkoxyimino-4-methyl-4-methylaminopiperidin-1-yl)-Fluoroquinolone derivatives","volume":"343","author":"Zhang","year":"2010","journal-title":"Arch. Pharm. Chemi Life Sci."},{"key":"10.1016\/j.ejmech.2018.08.095_bib218","doi-asserted-by":"crossref","first-page":"6822","DOI":"10.3390\/molecules19056822","article-title":"Synthesis and antibacterial activity of amino acid and dipeptide prodrugs of IMB-070593, a fluoroquinolone candidate","volume":"19","author":"Zhang","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2018.08.095_bib219","doi-asserted-by":"crossref","first-page":"3872","DOI":"10.3390\/molecules18043872","article-title":"Synthesis, in\u00a0vitro antimycobacterial and antibacterial evaluation of IMB-070593 derivatives containing a substituted benzyloxime moiety","volume":"18","author":"Wei","year":"2013","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2018.08.095_bib220","first-page":"819","article-title":"Synthesis and antibacterial activity of 7-(3-Amino-4-alkoxyimino-1-piperidyl)quinolones","volume":"43","author":"Wang","year":"2008","journal-title":"Acta Pharm. Sin."},{"key":"10.1016\/j.ejmech.2018.08.095_bib221","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.bmcl.2010.12.073","article-title":"Synthesis and in\u00a0vitro antibacterial activity of 7-(3-Alkoxyimino-5-amino\/methylaminopiperidin-1-yl)fluoroquinolone derivatives","volume":"21","author":"Zhang","year":"2011","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2018.08.095_bib222","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1016\/j.bmcl.2013.01.048","article-title":"Synthesis and in\u00a0vitro antibacterial activity of quinolone\/naphthyridone derivatives containing 3-Alkoxyimino-4-(methyl)aminopiperidine scaffolds","volume":"23","author":"Lv","year":"2013","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2018.08.095_bib223","doi-asserted-by":"crossref","first-page":"4063","DOI":"10.1016\/j.ejmech.2009.04.041","article-title":"Synthesis and in\u00a0vitro antibacterial activity of 7-(4-Alkoxyimino-3-amino-3-methylpiperidin-1-yl)fluoroquinolone derivatives","volume":"44","author":"Chai","year":"2009","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib224","first-page":"819","article-title":"Synthesis and antibacterial activity of 7-(3-Amino-4-alkoxyimino-1-piperidyl)quinolones","volume":"43","author":"Wang","year":"2008","journal-title":"Acta Pharm. Sin."},{"key":"10.1016\/j.ejmech.2018.08.095_bib225","doi-asserted-by":"crossref","first-page":"5498","DOI":"10.1016\/j.ejmech.2010.08.050","article-title":"Synthesis and in\u00a0vitro antibacterial activity of fluoroquinolone derivatives containing 3-(N\u2019-Alkoxycarbamimidoyl)-4-(alkoxyimino) pyrrolidines","volume":"45","author":"Guo","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib226","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1016\/j.ejmech.2011.03.026","article-title":"Synthesis and in\u00a0vitro antibacterial activity of 7-(3-Alkoxyimino-4-amino-4-methylpiperidin-1-yl) fluoroquinolone derivatives","volume":"46","author":"Wang","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib227","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.ejmech.2006.12.034","article-title":"Synthesis and antibacterial activity of levofloxacin derivatives with certain bulky residues on piperazine ring","volume":"42","author":"Foroumadi","year":"2007","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib228","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.1016\/j.bmcl.2006.03.103","article-title":"Synthesis and antibacterial activity of new fluoroquinolones containing a substituted N-(phenethyl)piperazine moiety","volume":"16","author":"Foroumadi","year":"2006","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2018.08.095_bib229","doi-asserted-by":"crossref","first-page":"3809","DOI":"10.1021\/jm000153x","article-title":"Synthesis, antibacterial, and cytotoxic evaluation of certain 7-substituted norfloxacin derivatives","volume":"43","author":"Fang","year":"2000","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib230","doi-asserted-by":"crossref","first-page":"4267","DOI":"10.1016\/j.ejmech.2011.06.032","article-title":"Synthesis and in vitro antibacterial activity of a series of novel gatifloxacin derivatives","volume":"46","author":"Chai","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib231","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1016\/j.bmc.2017.02.068","article-title":"Covalently linked kanamycin-Ciprofloxacin hybrid antibiotics as a tool to fight bacterial resistance","volume":"25","author":"Shavit","year":"2017","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib232","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1021\/jm900028n","article-title":"Design, synthesis, and evaluation of novel fluoroquinolone-aminoglycoside hybrid antibiotics","volume":"52","author":"Pokrovskaya","year":"2009","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib233","doi-asserted-by":"crossref","first-page":"857","DOI":"10.7164\/antibiotics.51.857","article-title":"Preparation and antimicrobial assessment of 2-Thioether-linked quinolonyl-carbapenems","volume":"51","author":"Hershberger","year":"1998","journal-title":"J.\u00a0Antibiot."},{"key":"10.1016\/j.ejmech.2018.08.095_bib234","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1128\/AAC.01649-07","article-title":"In\u00a0vitro evaluation of CBR-2092, a novel rifamycin-quinolone hybrid antibiotic: studies of the mode of action in Staphylococcus aureus","volume":"52","author":"Robertson","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2018.08.095_bib235","doi-asserted-by":"crossref","first-page":"6645","DOI":"10.1021\/acs.jmedchem.6b00485","article-title":"Development of a dual-acting antibacterial agent (TNP-2092) for the treatment of persistent bacterial infections","volume":"59","author":"Ma","year":"2016","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib236","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1128\/AAC.01651-07","article-title":"In\u00a0vitro evaluation of CBR-2092, a novel rifamycin-quinolone hybrid antibiotic: microbiology profiling studies with staphylococci and streptococci","volume":"52","author":"Robertson","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2018.08.095_bib237","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/1098-1128(200007)20:4<231::AID-MED1>3.0.CO;2-N","article-title":"The 2-pyridone antibacterial agents: bacterial topoisomerase inhibitors","volume":"20","author":"Li","year":"2000","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.ejmech.2018.08.095_bib238","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.1016\/j.bmcl.2012.02.019","article-title":"Structure aided design of chimeric antibiotics","volume":"22","author":"Karoli","year":"2012","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2018.08.095_bib239","doi-asserted-by":"crossref","first-page":"3899","DOI":"10.1021\/jm990015b","article-title":"Glycosylation of fluoroquinolones through direct and oxygenated polymethylene linkages as a sugar-mediated active transport system for antimicrobials","volume":"42","author":"Jung","year":"1999","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib240","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/cbdd.12503","article-title":"Novel glycoconjugate of 8-fluoro norfloxacin derivatives as gentamicin-resistant Staphylococcus aureus inhibitors: synthesis and molecular modelling studies","volume":"86","author":"Azad","year":"2015","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.ejmech.2018.08.095_bib241","doi-asserted-by":"crossref","first-page":"3468","DOI":"10.1016\/j.bmcl.2015.07.010","article-title":"Synthesis of ciprofloxacin dimers for evaluation of bacterial permeability in atypical chemical space","volume":"25","author":"Ross","year":"2015","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2018.08.095_bib242","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/BF02464368","article-title":"Synthesis and turbeculostatic activity of podands with fluoroquinolone fragments","volume":"31","author":"Fedorova","year":"1997","journal-title":"Pharm. Chem. J."},{"key":"10.1016\/j.ejmech.2018.08.095_bib243","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.diagmicrobio.2005.11.004","article-title":"Susceptibility studies of piperazinyl cross-linked fluoroquinolone dimers against test strains of Gram-positive and Gram-negative bacteria","volume":"54","author":"Kerns","year":"2006","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"10.1016\/j.ejmech.2018.08.095_bib244","doi-asserted-by":"crossref","first-page":"5487","DOI":"10.1016\/j.ejmech.2011.09.011","article-title":"Design, synthesis and antibacterial activity of fluoroquinolones containing bulky arenesulfonyl fragment: 2D-QSAR and docking study","volume":"46","author":"Abdel-Aziz","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib245","doi-asserted-by":"crossref","first-page":"e1171","DOI":"10.3390\/molecules22071171","article-title":"Synthesis and in\u00a0vitro antimycobacterial and antibacterial activity of 8-OMe ciprofloxacin-hydrozone\/azole hybrids","volume":"22","author":"Xu","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2018.08.095_bib246","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ejmech.2016.03.086","article-title":"Synthesis and biological evaluation of novel structural hybrids of benzofuroxan derivatives and fluoroquinolones","volume":"116","author":"Chugunova","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib247","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1016\/j.bmcl.2009.01.007","article-title":"Synthesis of citrate-ciprofloxacin conjugates","volume":"19","author":"Md-Saleh","year":"2009","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2018.08.095_bib248","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ejmech.2013.07.032","article-title":"Mannich bases of 7-piperazinylquinolones and kojic acid derivatives: synthesis, in\u00a0vitro antibacterial activity and in silico study","volume":"68","author":"Emami","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib249","doi-asserted-by":"crossref","first-page":"3435","DOI":"10.1128\/AAC.47.11.3435-3441.2003","article-title":"Synthesis, degradation, and antimicrobial properties of targeted macromolecular prodrugs of norfloxacin","volume":"47","author":"Roseeuw","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2018.08.095_bib250","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1016\/j.bmcl.2014.01.065","article-title":"Synthesis and antibacterial evaluation of amino acid-antibiotic conjugates","volume":"24","author":"Ibrahim","year":"2014","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2018.08.095_bib251","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.ijantimicag.2009.11.022","article-title":"Phenothiazinium-fluoroquinolone drug conjugates","volume":"35","author":"Wainwright","year":"2010","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.ejmech.2018.08.095_bib252","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1021\/jm990508g","article-title":"Synthesis and activities of pyoverdin-quinolone adducts: a prospective approach to a specific therapy against Pseudomonas aeruginosa","volume":"44","author":"Hennard","year":"2001","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib253","first-page":"551","article-title":"Synthesis and in-vitro antibacterial activity of some novel N-nicotinoyl-1-ethyl-6-fluoro-1,4-dihydro-7-piperazin-1-yl-4-oxoquinoline-3-carboxylates","volume":"65","author":"Sharma","year":"2008","journal-title":"Acta Pol. Pharm."},{"key":"10.1016\/j.ejmech.2018.08.095_bib254","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1021\/bc300610f","article-title":"Trihydroxamate siderophore-fluoroquinolone conjugates are selective sideromycin antibiotics that target Staphylococcus aureus","volume":"24","author":"Wencewicz","year":"2013","journal-title":"Bioconjugate Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib255","doi-asserted-by":"crossref","first-page":"3461","DOI":"10.1039\/c3ob40162f","article-title":"Staphyloferrin A as siderophore-component in fluoroquinolone-based Trojan horse antibiotics","volume":"21","author":"Milner","year":"2013","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib256","doi-asserted-by":"crossref","first-page":"4044","DOI":"10.1021\/jm400265k","article-title":"Biscatecholate-monohydroxamate mixed ligand siderophore-carbacephalosporin conjugates are selective sideromycin antibiotics that target acinetobacter baumannii","volume":"56","author":"Wencewicaz","year":"2013","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib257","first-page":"225","article-title":"Synthesis and in-vitro antibacterial activities of acetylanthracene and acetylphenanthrene derivatives of some fluoroquinolones","volume":"10","author":"Shamsa","year":"2011","journal-title":"Iran. J. Pharm. Res. (IJPR)"},{"key":"10.1016\/j.ejmech.2018.08.095_bib258","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1021\/jm00014a005","article-title":"Synthesis and antibacterial activity of some novel l-substituted 1,4-Dihydro-4-oxo-7-pyridinyl-3-quinolinecarboxyl acids. Potent antistaphylococcal agents","volume":"38","author":"Reuman","year":"1995","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib259","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1021\/jm00163a024","article-title":"Synthesis and structure-activity relations hips of new 74 3-(Fluoromethyl)piperazinyl]- and -(Fluorohomopiperazinyl)quinolone antibacterials","volume":"33","author":"Ziegler","year":"1990","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib260","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1021\/jm00106a029","article-title":"Quinolone antibacterials: preparation and activity of bridged bicyclic analogues of the C7-piperazine","volume":"34","author":"Kiely","year":"1991","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib261","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1021\/jm00082a001","article-title":"Synthesis and structure-activity relationships of 7-diazabicycloalkylquinolones, including danofloxacin, a new quinolone antibacterial agent for veterinary Medicine1","volume":"35","author":"McGuirk","year":"1992","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib262","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1021\/jm00164a060","article-title":"New quinolone antibacterial agents. Synthesis and biological activity of 7-(3,3- or 3,4-Disubstituted-l-pyrrolidinyl)quinoline-3-carboxyl acids","volume":"33","author":"Hagen","year":"1990","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib263","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1021\/jm00059a012","article-title":"Quinolone antibacterials containing the new 7434 1-Aminoethy1)-1-pyrrolidinyl]Side chain: the effects of the 1-aminoethyl moiety and its stereochemical configurations on potency and in\u00a0vivo efficacy","volume":"36","author":"Domagala","year":"1993","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib264","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1021\/jm00032a005","article-title":"Synthesis and antibacterial activity of new quinolones containing a 7-[3-(l-Amino-l-methylethy1)-l-pyrrolidinyl]Moiety. Gram-positive agents with excellent oral activity and low side-effect potential","volume":"37","author":"Hagen","year":"1994","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib265","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1021\/jm00088a011","article-title":"Quinolone antibacterial agents. Synthesis and structure-activity relationships of a series of amino acid prodrugs of racemic and chiral 7-(3-Amino-l-pyrrolidinyl)quinolones. Highly soluble quinolone prodrugs with in\u00a0vivo Pseudomonas activity","volume":"35","author":"Sanchez","year":"1992","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib266","doi-asserted-by":"crossref","first-page":"3238","DOI":"10.1021\/jm701428b","article-title":"Synthesis and Antibacterial Activity of Novel Pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic Acid Derivatives Carrying the 3-Cyclopropylaminomethyl-4-substituted-1-pyrrolidinyl Group as a C-10 substituent","volume":"51","author":"Asahina","year":"2008","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib267","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1021\/jm020328y","article-title":"Synthesis and structure-activity relationships of 5-Amino-6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-8-methylquinolonecarboxylic acid antibacterials having fluorinated 7-[(3R)-3-(1-Aminocyclopropan-1-yl)pyrrolidin-1-yl] Substituents1","volume":"46","author":"Inagaki","year":"2003","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib268","doi-asserted-by":"crossref","first-page":"3694","DOI":"10.1128\/AAC.47.12.3694-3698.2003","article-title":"Effects of DQ-113, a new quinolone, against methicillin- and vancomycin-resistant Staphylococcus aureus-caused hematogenous pulmonary infections in mice","volume":"47","author":"Kaneko","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2018.08.095_bib269","first-page":"3034","article-title":"In\u00a0vitro antibacterial activity of DX-619, a novel des-fluoro(6) quinolone","volume":"49","author":"Fujikawa","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2018.08.095_bib270","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1128\/AAC.01223-06","article-title":"Lack of effect of DX-619, a novel des-fluoro(6) quinolone, on glomerular filtration rate measured by serum clearance of cold iohexol","volume":"51","author":"Sarapa","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2018.08.095_bib271","doi-asserted-by":"crossref","first-page":"4077","DOI":"10.1128\/AAC.00847-06","article-title":"Molecular characteristics and in\u00a0vitro susceptibility to antimicrobial agents, including the des-fluoro(6) quinolone DX-619, of panton-valntine leucocidin-positive multidrug-resistant Staphylococcus aureus isolates from the community and hospital","volume":"50","author":"Yamamato","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2018.08.095_bib272","doi-asserted-by":"crossref","first-page":"3750","DOI":"10.1128\/AAC.47.12.3750-3759.2003","article-title":"In\u00a0vitro and in\u00a0vivo antibacterial activities of DK-507k, a novel fluoroquinolone","volume":"47","author":"Otani","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2018.08.095_bib273","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1128\/AAC.01150-08","article-title":"In\u00a0vitro activity of the quinolone WCK 771 against recent U.S. hospital and community-acquired Staphylococcus aureus pathogens with various resistance types","volume":"53","author":"Bhagwat","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2018.08.095_bib274","doi-asserted-by":"crossref","first-page":"4754","DOI":"10.1128\/AAC.48.12.4754-4761.2004","article-title":"Antistaphylococcal activity of WCK 771, a tricyclic fluoroquinolone, in animal infection models","volume":"48","author":"Patel","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2018.08.095_bib275","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1021\/jm301650g","article-title":"Design, synthesis, and biological evaluations of novel 7-[7-Amino-7-methyl-5-azaspiro[2.4]heptan-5-yl]-8-methoxyquinolines with potential antibacterial activity against respiratory pathogens","volume":"56","author":"Odagiri","year":"2013","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib276","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1128\/AAC.00853-07","article-title":"In\u00a0vitro and in\u00a0vivo antibacterial activities of DC-159a, a new fluoroquinolone","volume":"52","author":"Hoshino","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2018.08.095_bib277","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1021\/jm00170a035","article-title":"Quinolone antibacterial agents substituted at the 7-position with spiroamines. Synthesis and structure-activity relationships","volume":"33","author":"Culbertson","year":"1990","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib278","doi-asserted-by":"crossref","first-page":"7557","DOI":"10.3390\/molecules18077557","article-title":"New 7-[4-(4-(un)Substituted)piperazine-1-Carbonyl-piperazin-1-yl] derivatives of fluoroquinolone: synthesis and antimicrobial evaluation","volume":"18","author":"Chen","year":"2013","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2018.08.095_bib279","doi-asserted-by":"crossref","first-page":"6513","DOI":"10.1016\/j.bmcl.2012.05.026","article-title":"Study on the antibacterial properities of N-acylated ciprofloxacins","volume":"22","author":"Cormier","year":"2012","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2018.08.095_bib280","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1007\/s00044-013-0699-9","article-title":"Novel derivatives of 5-amino-1-cyclopropyl-7-[(3R,5S)3,5-dimethylpiperazine-1-yl]-6,8-difluoro-4-oxo-quinoline-3-carboxylic acid: their synthesis, antimicrobial, antifungal, and urease inhibitory studies","volume":"23","author":"Arayne","year":"2014","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.ejmech.2018.08.095_bib281","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1007\/s11095-013-1250-x","article-title":"Pharmacological characterization of 7-(4-(Piperazin-1-yl)) ciprofloxacin derivatives: antibacterial activity, cellular accumulation, susceptibility to efflux transporters, and intracellular activity","volume":"31","author":"Marquez","year":"2014","journal-title":"Pharm. Res. (N. Y.)"},{"key":"10.1016\/j.ejmech.2018.08.095_bib282","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ijantimicag.2006.02.013","article-title":"Antibacterial evaluation of a collection of norfloxacin and ciprofloxacin derivatives against multiresistant bacteria","volume":"28","author":"Vila","year":"2006","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.ejmech.2018.08.095_bib283","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1002\/jhet.1927","article-title":"Synthesis, characterization, and antimicrobial activities of novel N-substituted \u03b2-hydroxy amines and \u03b2-hydroxy ethers that contained 8-methoxy fluoroquinolones","volume":"53","author":"Guruswamy","year":"2016","journal-title":"J.\u00a0Heterocycl. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib284","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1093\/jac\/dkr203","article-title":"Interaction of N-Methyl-2-alkenyl-4-quinolones with ATP-dependent MurE ligase of Mycobacterium tuberculosis: antibacterial activity, molecular docking and inhibition kinetics","volume":"36","author":"Guzman","year":"2011","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.ejmech.2018.08.095_bib285","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/ptr.4987","article-title":"Quinolone alkaloids from fructus euodiae show activity against methicillin-resistant Staphylococcus aureus","volume":"28","author":"Pan","year":"2014","journal-title":"Phytother Res."},{"key":"10.1016\/j.ejmech.2018.08.095_bib286","doi-asserted-by":"crossref","first-page":"8217","DOI":"10.3390\/molecules17078217","article-title":"Synthesis and antibacterial evaluation of a new series of N-Alkyl-2-alkynyl\/(E)-alkenyl-4-(1H)-quinolones","volume":"17","author":"Wube","year":"2012","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2018.08.095_bib287","doi-asserted-by":"crossref","first-page":"5971","DOI":"10.1016\/j.bmcl.2012.07.040","article-title":"Synthesis, antimycobacterial and antibacterial activity of ciprofloxacin derivatives containing a N-substituted benzyl moiety","volume":"22","author":"Wang","year":"2012","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2018.08.095_bib288","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.1021\/jm00172a039","article-title":"Synthesis of antimicrobial agents. 3. Syntheses and antibacterial activities of 7- (4-hydroxypiperazin-1- yl) quinolones","volume":"33","author":"Uno","year":"1990","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib289","doi-asserted-by":"crossref","first-page":"5545","DOI":"10.1016\/j.bmcl.2016.10.002","article-title":"Allicin-inspired thiolated fluoroquinolones as antibacterials against ESKAPE pathogens","volume":"26","author":"Sheppard","year":"2016","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2018.08.095_bib290","doi-asserted-by":"crossref","first-page":"5232","DOI":"10.1021\/jm050035f","article-title":"A\u00a0chiral benzoquinolizine-2-carboxylic acid arginine salt active against vancomycin-resistant Staphylococcus aureus","volume":"48","author":"de Souza","year":"2005","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib291","doi-asserted-by":"crossref","first-page":"3928","DOI":"10.1016\/j.bmcl.2015.07.044","article-title":"Synthesis and biological evaluation of levofloxacin core-based derivatives with potent antibacterial activity against resistant Gram-positive pathogens","volume":"25","author":"Huang","year":"2015","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2018.08.095_bib292","doi-asserted-by":"crossref","first-page":"5790","DOI":"10.1128\/AAC.05044-11","article-title":"Randomized, double-blind, phase II, multicentre study evaluating the safety\/tolerability and efficacy of JNJ-Q2, a novel fluoroquinolone, compared with linezolid for treatment of acute bacterial skin and skin structure infection","volume":"55","author":"Covington","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2018.08.095_bib293","doi-asserted-by":"crossref","first-page":"5512","DOI":"10.1128\/AAC.00470-11","article-title":"Antistaphylococcal activities of the new fluoroquinolone JNJ-Q2","volume":"55","author":"Morrow","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2018.08.095_bib294","doi-asserted-by":"crossref","first-page":"3631","DOI":"10.1128\/AAC.00162-11","article-title":"JNJ-Q2, a new fluoroquinolone with potent in\u00a0vitro activity against Staphylococcus aureus, including multidrug-resistant and fluoroquinolone-resistant strains","volume":"55","author":"Farrell","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2018.08.095_bib295","doi-asserted-by":"crossref","first-page":"5502","DOI":"10.1016\/j.bmcl.2014.10.014","article-title":"7-(4-Alkylidenylpiperidinyl)-quinolone bacterial topoisomerase inhibitors","volume":"24","author":"Grant","year":"2014","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2018.08.095_bib296","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1021\/jm00059a002","article-title":"7-Azetidinylquinolones as antibacterial agents. Synthesis and structure-activity Relationships1","volume":"36","author":"Frigola","year":"1993","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib297","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1021\/jm00007a017","volume":"38","author":"Frigola","year":"1995","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib298","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1021\/jm00007a017","article-title":"7-Azetidinylquinolones as antibacterial agents. 3.1 synthesis, properties and structure-activity relationships of the stereoisomers containing a 7-(3-Amino-2-methyl- 1-azetidinyl) Moiety2","volume":"38","author":"Frigola","year":"1995","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib299","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1021\/jm0205090","article-title":"Novel antibacterial 8-chloroquinolone with a distorted orientation of the N1-(5-Amino-2,4-difluorophenyl) group","volume":"45","author":"Kuramoto","year":"2003","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib300","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.ijantimicag.2014.07.017","article-title":"In\u00a0vitro activity of WQ-3810, a novel fluoroquinolone, against multidrug-resistant and fluoroquinolone-resistant pathogens","volume":"44","author":"Kazamori","year":"2014","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.ejmech.2018.08.095_bib301","doi-asserted-by":"crossref","first-page":"7688","DOI":"10.1016\/j.bmcl.2012.09.106","article-title":"Synthesis and antibacterial activity of new fluoroquinolones containing a cis- or trans-cyclohexane moiety","volume":"22","author":"Qi","year":"2012","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2018.08.095_bib302","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.bmcl.2015.11.063","article-title":"Synthesis of novel ethyl 1-ethyl-6-fluoro-7-(fatty amido)-1,4-dihydro-4-oxoquinoline-3-carboxylate derivatives and their biological evaluation","volume":"26","author":"Venepally","year":"2016","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2018.08.095_bib303","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1007\/s00044-013-0873-0","article-title":"New azetidine-3-carbonyl-N-methyl-hydrazino derivatives of fluoroquinolones: synthesis and evaluation of antibacterial and anticancer properties","volume":"23","author":"Rajulu","year":"2014","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.ejmech.2018.08.095_bib304","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.ejmech.2014.08.065","article-title":"A\u00a0new efficient route to 7-aryl-6-fluoro-8-nitroquinolones as potent antibacterial agents","volume":"86","author":"Al-Trawneh","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib305","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1007\/s00044-011-9692-3","article-title":"Synthesis and antibacterial activity of novel 7-haloanilino-8-nitrofluoroquinolone derivatives","volume":"21","author":"AL-Hiari","year":"2012","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.ejmech.2018.08.095_bib306","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/j.bmcl.2003.12.044","article-title":"Syntheses and biological evaluation of new fluoroquinolone antibacterials containing chiral oxiimino","volume":"14","author":"Choi","year":"2004","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2018.08.095_bib307","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1016\/S0968-0896(99)00207-2","article-title":"Studies on 6-Aminoquinolones: synthesis and antibacterial evaluation of 6-amino-8-ethyl- and 6-amino","volume":"7","author":"Cecchetti","year":"1999","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib308","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1248\/cpb.48.1667","article-title":"Studies on 8-methoxyquinolones: synthesis and antibacterial activity of 7-(3-Amino-4-substituted)pyrrolidinyl derivatives","volume":"48","author":"Kawakami","year":"2000","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.ejmech.2018.08.095_bib309","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.3987\/COM-11-12274","article-title":"Heterocycles [h]-Fused to 4-Oxoquinoline-3-carboxylic acid. Part IX. Synthesis of 2,6-dioxotetrahydro-1H-pyrrolo[3,2-h]quinoline-7-carboxylic acid","volume":"83","author":"Zahra","year":"2011","journal-title":"Heterocycles"},{"key":"10.1016\/j.ejmech.2018.08.095_bib310","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1086\/314061","article-title":"Clinical pharmacology of gatifloxacin, a new fluoroquinolone","volume":"31","author":"Grasela","year":"2000","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.ejmech.2018.08.095_bib311","doi-asserted-by":"crossref","first-page":"3344","DOI":"10.1021\/jm00046a019","article-title":"(Fluorocyclopropyl)quinolones. 2. Synthesis and stereochemical structure-activity relationships of chiral 7-(7-Amino-5-azaspiro[2.4]heptan-5-yl)-1-(2-fluorocyclopropyl)quinolone antibacterial agents","volume":"37","author":"Kimura","year":"1994","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib312","doi-asserted-by":"crossref","first-page":"4745","DOI":"10.1021\/jm00103a013","article-title":"Fluoroquinolones: relationships between structural variations, mammalian cell cytotoxicity and antimicrobial activity","volume":"35","author":"Suto","year":"1992","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib313","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1021\/jm00186a014","article-title":"Structure-activity relationships of antibacterial 6,7- and 7,8-disubstituted 1-alkyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acids","volume":"23","author":"Koga","year":"1980","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.08.095_bib314","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.3390\/12061240","article-title":"Synthesis and antibacterial properties of new 8-nitrofluoroquinolone derivatives","volume":"12","author":"Al-Hiari","year":"2007","journal-title":"Molecules"}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523418307670?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523418307670?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T13:59:13Z","timestamp":1759327153000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523418307670"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":314,"alternative-id":["S0223523418307670"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2018.08.095","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Recent developments of quinolone-based derivatives and their activities against Escherichia coli","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2018.08.095","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}