{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:11:50Z","timestamp":1792102310753,"version":"4.4.0"},"reference-count":90,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81603318"],"award-info":[{"award-number":["81603318"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Characteristic Innovation Projects of Guangdong Province","award":["2016KTSCX013"],"award-info":[{"award-number":["2016KTSCX013"]}]},{"name":"High-Level University","award":["A1-AFD018171Z11027"],"award-info":[{"award-number":["A1-AFD018171Z11027"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K99HL138272"],"award-info":[{"award-number":["K99HL138272"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R00HL138272"],"award-info":[{"award-number":["R00HL138272"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.ejmech.2018.10.020","type":"journal-article","created":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T12:37:32Z","timestamp":1539607052000},"page":"192-204","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Quantitative and systems pharmacology 4. Network-based analysis of drug pleiotropy on coronary artery disease"],"prefix":"10.1016","volume":"161","author":[{"given":"Jiansong","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuipu","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanting","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feixiong","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2018.10.020_bib1","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.cpcardiol.2009.10.002","article-title":"Growing epidemic of coronary heart disease in low- and middle-income countries","volume":"35","author":"Gaziano","year":"2010","journal-title":"Curr. Probl. Cardiol."},{"key":"10.1016\/j.ejmech.2018.10.020_bib2","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.amjmed.2014.04.015","article-title":"The epidemic of the 20(th) century: coronary heart disease","volume":"127","author":"Dalen","year":"2014","journal-title":"Am. J. Med."},{"key":"10.1016\/j.ejmech.2018.10.020_bib3","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/nrcardio.2016.101","article-title":"Precision medicine in cardiology","volume":"13","author":"Antman","year":"2016","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.ejmech.2018.10.020_bib4","doi-asserted-by":"crossref","first-page":"e146","DOI":"10.1161\/CIR.0000000000000485","article-title":"Heart disease and stroke statistics-2017 update: a report from the American heart association","volume":"135","author":"Benjamin","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.ejmech.2018.10.020_bib5","article-title":"Challenges of ascertaining national trends in the incidence of coronary heart disease in the United States","volume":"3","author":"Ford","year":"2014","journal-title":"J.\u00a0Am. Heart Assoc."},{"key":"10.1016\/j.ejmech.2018.10.020_bib6","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1093\/bib\/bbv020","article-title":"A\u00a0Survey of current trends in computational drug repositioning","volume":"17","author":"Li","year":"2016","journal-title":"Briefings Bioinf."},{"key":"10.1016\/j.ejmech.2018.10.020_bib7","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.tips.2013.03.004","article-title":"Challenges and opportunities of drug repositioning","volume":"34","author":"Novac","year":"2013","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ejmech.2018.10.020_bib8","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.2174\/1568026616666160216152138","article-title":"Repositioning of drugs in cardiometabolic disorders: importance and current scenario","volume":"16","author":"Katare","year":"2016","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.10.020_bib9","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1021\/acs.jcim.7b00216","article-title":"Quantitative and systems pharmacology. 1. In silico prediction of drug-target interactions of natural products enables new targeted cancer therapy","volume":"57","author":"Fang","year":"2017","journal-title":"J.\u00a0Chem. Inf. Model."},{"key":"10.1016\/j.ejmech.2018.10.020_bib10","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbx045","article-title":"In silico polypharmacology of natural products","author":"Fang","year":"2017","journal-title":"Briefings Bioinf."},{"key":"10.1016\/j.ejmech.2018.10.020_bib11","doi-asserted-by":"crossref","first-page":"e4","DOI":"10.1017\/erm.2018.3","article-title":"What has traditional Chinese medicine delivered for modern medicine?","volume":"20","author":"Wang","year":"2018","journal-title":"Expet Rev. Mol. Med."},{"key":"10.1016\/j.ejmech.2018.10.020_bib12","doi-asserted-by":"crossref","first-page":"2952","DOI":"10.1016\/j.jacc.2017.04.041","article-title":"Traditional Chinese medicine for cardiovascular disease: evidence and potential mechanisms","volume":"69","author":"Hao","year":"2017","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.ejmech.2018.10.020_bib13","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.jep.2011.08.071","article-title":"Analysis on outcome of 5284 patients with coronary artery disease: the role of integrative medicine","volume":"141","author":"Gao","year":"2012","journal-title":"J.\u00a0Ethnopharmacol."},{"key":"10.1016\/j.ejmech.2018.10.020_bib14","first-page":"5086","article-title":"The therapeutical effect of Chinese medicine for the treatment of atherosclerotic coronary heart disease","volume":"23","author":"Zhang","year":"2017","journal-title":"Curr. Pharmaceut. Des."},{"key":"10.1016\/j.ejmech.2018.10.020_bib15","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/clpt.2013.40","article-title":"Systems pharmacology for drug discovery and development: paradigm shift or flash in the Pan?","volume":"93","author":"Vicini","year":"2013","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.ejmech.2018.10.020_bib16","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/psp4.12172","article-title":"Systems pharmacology-based discovery of natural products for precision oncology through targeting cancer mutated genes","volume":"6","author":"Fang","year":"2017","journal-title":"CPT Pharmacometrics Syst. Pharmacol."},{"key":"10.1016\/j.ejmech.2018.10.020_bib17","doi-asserted-by":"crossref","first-page":"747","DOI":"10.3389\/fphar.2017.00747","article-title":"Quantitative and systems pharmacology 3. Network-based identification of new targets for natural products enables potential uses in aging-associated disorders","volume":"8","author":"Fang","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejmech.2018.10.020_bib18","doi-asserted-by":"crossref","first-page":"3104","DOI":"10.1038\/s41598-018-21468-w","article-title":"The mechanisms of Bushen-Yizhi formula as a therapeutic agent against alzheimer's disease","volume":"8","author":"Cai","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2018.10.020_bib19","doi-asserted-by":"crossref","first-page":"D932","DOI":"10.1093\/nar\/gkw993","article-title":"DrugCentral: online drug compendium","volume":"45","author":"Ursu","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ejmech.2018.10.020_bib20","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1038\/ng.3314","article-title":"The support of human genetic evidence for approved drug indications","volume":"47","author":"Nelson","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ejmech.2018.10.020_bib21","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1017\/S0007114509359127","article-title":"Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: a double-blinded, placebo-controlled cross-over study","volume":"102","author":"Egert","year":"2009","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.ejmech.2018.10.020_bib22","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1002\/mnfr.201500144","article-title":"Quercetin is a potent anti-atherosclerotic compound by activation of SIRT1 signaling under OxLDL stimulation","volume":"59","author":"Hung","year":"2015","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.ejmech.2018.10.020_bib23","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.fitote.2008.05.003","article-title":"Early induction of LDL receptor gene expression by genistein in DLD-1 colon cancer cell line","volume":"79","author":"Caruso","year":"2008","journal-title":"Fitoterapia"},{"key":"10.1016\/j.ejmech.2018.10.020_bib24","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.1111\/bph.13108","article-title":"Kaempferol enhances endothelium-dependent relaxation in the porcine coronary artery through activation of large-conductance Ca(2+) -activated K(+) channels","volume":"172","author":"Xu","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejmech.2018.10.020_bib25","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1111\/j.1476-5381.2009.00556.x","article-title":"Quercetin and its major metabolites selectively modulate cyclic GMP-dependent relaxations and associated tolerance in pig isolated coronary artery","volume":"159","author":"Suri","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejmech.2018.10.020_bib26","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.thromres.2014.12.016","article-title":"Dietary flavonoids intake and the risk of coronary heart disease: a dose-response meta-analysis of 15 prospective studies","volume":"135","author":"Jiang","year":"2015","journal-title":"Thromb. Res."},{"key":"10.1016\/j.ejmech.2018.10.020_bib27","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.pharep.2017.08.014","article-title":"Therapeutic drug monitoring of digoxin-20 Years of experience","volume":"70","author":"Grzesk","year":"2018","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.ejmech.2018.10.020_bib28","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1161\/CIRCULATIONAHA.116.026945","article-title":"Cardiovascular toxicity of illicit anabolic-androgenic steroid use","volume":"135","author":"Baggish","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.ejmech.2018.10.020_bib29","doi-asserted-by":"crossref","first-page":"D1091","DOI":"10.1093\/nar\/gkt1068","article-title":"DrugBank 4.0: shedding new light on drug metabolism","volume":"42","author":"Law","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ejmech.2018.10.020_bib30","doi-asserted-by":"crossref","first-page":"5116","DOI":"10.1038\/s41467-018-05116-5","article-title":"Network-based approach to prediction and population-based validation of in silico drug repurposing","volume":"9","author":"Cheng","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejmech.2018.10.020_bib31","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1021\/ci600426e","article-title":"Evaluating virtual screening methods: good and bad metrics for the \u201cearly recognition\u201d problem","volume":"47","author":"Truchon","year":"2007","journal-title":"J.\u00a0Chem. Inf. Model."},{"key":"10.1016\/j.ejmech.2018.10.020_bib32","doi-asserted-by":"crossref","first-page":"6560","DOI":"10.1021\/jm301916b","article-title":"Hit identification and optimization in virtual screening: practical recommendations based on a critical literature analysis","volume":"56","author":"Zhu","year":"2013","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.10.020_bib33","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1161\/CIRCRESAHA.115.306532","article-title":"RhoA\/rho-kinase in the cardiovascular system","volume":"118","author":"Shimokawa","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejmech.2018.10.020_bib34","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1161\/01.RES.0000251668.39526.c7","article-title":"Rho kinase inhibition improves endothelial function in human subjects with coronary artery disease","volume":"99","author":"Nohria","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejmech.2018.10.020_bib35","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1039\/c2md00320a","article-title":"Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2)","volume":"3","author":"Pireddu","year":"2012","journal-title":"Med Chem Comm"},{"key":"10.1016\/j.ejmech.2018.10.020_bib36","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0735-1097(02)02632-3","article-title":"Rho-kinase inhibition with intracoronary fasudil prevents myocardial ischemia in patients with coronary microvascular spasm","volume":"41","author":"Mohri","year":"2003","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.ejmech.2018.10.020_bib37","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1021\/acs.jcim.7b00641","article-title":"In silico pharmacoepidemiologic evaluation of drug-induced cardiovascular complications using combined classifiers","volume":"58","author":"Cai","year":"2018","journal-title":"J.\u00a0Chem. Inf. Model."},{"key":"10.1016\/j.ejmech.2018.10.020_bib38","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1002\/phar.1584","article-title":"Safety of nonsteroidal antiinflammatory drugs in patients with cardiovascular disease","volume":"35","author":"Danelich","year":"2015","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.ejmech.2018.10.020_bib39","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD004771.pub4","article-title":"Intravenous or intramuscular parecoxib for acute postoperative pain in adults","author":"Lloyd","year":"2009","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.ejmech.2018.10.020_bib40","first-page":"U1755","article-title":"Increased risk of cardiovascular events with parecoxib\/valdecoxib: a systematic review and meta-analysis","volume":"118","author":"Aldington","year":"2005","journal-title":"N.\u00a0Z. Med. J."},{"key":"10.1016\/j.ejmech.2018.10.020_bib41","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1021\/jm000069h","article-title":"N-[[(5-methyl-3-phenylisoxazol-4-yl)-phenyl]sulfonyl]propanamide, sodium salt, parecoxib sodium: a potent and selective inhibitor of COX-2 for parenteral administration","volume":"43","author":"Talley","year":"2000","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.10.020_bib42","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1111\/bcp.13048","article-title":"Cardiovascular effects of cyclooxygenase-2 inhibitors: a mechanistic and clinical perspective","volume":"82","author":"Patrono","year":"2016","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.ejmech.2018.10.020_bib43","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1530\/EJE-07-0455","article-title":"Glucocorticoids and cardiovascular disease","volume":"157","author":"Walker","year":"2007","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.ejmech.2018.10.020_bib44","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1007\/s40265-014-0282-9","article-title":"Systemic glucocorticoid therapy: a review of its metabolic and cardiovascular adverse events","volume":"74","author":"Fardet","year":"2014","journal-title":"Drugs"},{"key":"10.1016\/j.ejmech.2018.10.020_bib45","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ijcard.2014.03.019","article-title":"Dexamethasone for the prevention of acute mountain sickness: systematic review and meta-analysis","volume":"173","author":"Tang","year":"2014","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ejmech.2018.10.020_bib46","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1177\/00912700122012670","article-title":"Cardiac adverse effects of early dexamethasone treatment in preterm infants: a randomized clinical trial","volume":"41","author":"Zecca","year":"2001","journal-title":"J.\u00a0Clin. Pharmacol."},{"key":"10.1016\/j.ejmech.2018.10.020_bib47","doi-asserted-by":"crossref","first-page":"19244","DOI":"10.1073\/pnas.0705517104","article-title":"Antiinflammatory glucocorticoid receptor ligand with reduced side effects exhibits an altered protein-protein interaction profile","volume":"104","author":"Miner","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejmech.2018.10.020_bib48","doi-asserted-by":"crossref","first-page":"417387","DOI":"10.1155\/2012\/417387","article-title":"Traditional Chinese herbal products for coronary heart disease: an overview of cochrane reviews","volume":"2012","author":"Qiu","year":"2012","journal-title":"Evid. Based complement. Altern. Med."},{"key":"10.1016\/j.ejmech.2018.10.020_bib49","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1111\/bph.13492","article-title":"Antioxidant effects of resveratrol in the cardiovascular system","volume":"174","author":"Xia","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejmech.2018.10.020_bib50","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.bbadis.2014.10.016","article-title":"Preclinical and clinical evidence for the role of resveratrol in the treatment of cardiovascular diseases","volume":"1852","author":"Zordoky","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejmech.2018.10.020_bib51","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1139\/Y09-013","article-title":"Resveratrol: a promising agent in promoting cardioprotection against coronary heart disease","volume":"87","author":"Penumathsa","year":"2009","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.ejmech.2018.10.020_bib52","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.redox.2017.05.027","article-title":"SIRT1 inhibition causes oxidative stress and inflammation in patients with coronary artery disease","volume":"13","author":"Chan","year":"2017","journal-title":"Redox Biol"},{"key":"10.1016\/j.ejmech.2018.10.020_bib53","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1021\/jm301032j","article-title":"Discovery and mechanism study of SIRT1 activators that promote the deacetylation of fluorophore-labeled substrate","volume":"56","author":"Wu","year":"2013","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.10.020_bib54","doi-asserted-by":"crossref","first-page":"41017","DOI":"10.1038\/srep41017","article-title":"Luteolin improves cardiac dysfunction in heart failure rats by regulating sarcoplasmic reticulum Ca(2+)-ATPase 2A","volume":"7","author":"Hu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2018.10.020_bib55","doi-asserted-by":"crossref","first-page":"692","DOI":"10.3389\/fphar.2017.00692","article-title":"Luteolin: a flavonoid that has multiple cardio-protective effects and its molecular mechanisms","volume":"8","author":"Luo","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejmech.2018.10.020_bib56","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.pharmthera.2007.06.013","article-title":"Potential of p38-MAPK inhibitors in the treatment of ischaemic heart disease","volume":"116","author":"Clark","year":"2007","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejmech.2018.10.020_bib57","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1093\/cvr\/cvn037","article-title":"Lipopolysaccharide-induced myocardial protection against ischaemia\/reperfusion injury is mediated through a PI3K\/Akt-dependent mechanism","volume":"78","author":"Ha","year":"2008","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejmech.2018.10.020_bib58","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1159\/000330068","article-title":"Luteolin inhibits apoptosis and improves cardiomyocyte contractile function through the PI3K\/akt pathway in simulated ischemia\/reperfusion","volume":"88","author":"Fang","year":"2011","journal-title":"Pharmacology"},{"key":"10.1016\/j.ejmech.2018.10.020_bib59","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.lfs.2014.11.014","article-title":"Luteolin inhibits ROS-activated MAPK pathway in myocardial ischemia\/reperfusion injury","volume":"122","author":"Yu","year":"2015","journal-title":"Life Sci."},{"key":"10.1016\/j.ejmech.2018.10.020_bib60","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","article-title":"Antiinflammatory therapy with canakinumab for atherosclerotic disease","volume":"377","author":"Ridker","year":"2017","journal-title":"N.\u00a0Z. Med. J."},{"key":"10.1016\/j.ejmech.2018.10.020_bib61","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.lfs.2008.12.005","article-title":"Daidzein administration in\u00a0vivo reduces myocardial injury in a rat ischemia\/reperfusion model by inhibiting NF-kappaB activation","volume":"84","author":"Kim","year":"2009","journal-title":"Life Sci."},{"key":"10.1016\/j.ejmech.2018.10.020_bib62","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1002\/mnfr.201300482","article-title":"Daidzein regulates proinflammatory adipokines thereby improving obesity-related inflammation through PPARgamma","volume":"58","author":"Sakamoto","year":"2014","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.ejmech.2018.10.020_bib63","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1007\/s12192-010-0187-9","article-title":"Caffeic acid protects rat heart mitochondria against isoproterenol-induced oxidative damage","volume":"15","author":"Kumaran","year":"2010","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.ejmech.2018.10.020_bib64","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1248\/bpb.32.1371","article-title":"Effect of caffeic acid on tumor necrosis factor-alpha-induced vascular inflammation in human umbilical vein endothelial cells","volume":"32","author":"Moon","year":"2009","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.ejmech.2018.10.020_bib65","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature12873","article-title":"Genetics of rheumatoid arthritis contributes to biology and drug discovery","volume":"506","author":"Okada","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2018.10.020_bib66","first-page":"333","article-title":"SDTNBI: an integrated network and chemoinformatics tool for systematic prediction of drug-target interactions and drug repositioning","volume":"18","author":"Wu","year":"2017","journal-title":"Briefings Bioinf."},{"key":"10.1016\/j.ejmech.2018.10.020_bib67","doi-asserted-by":"crossref","first-page":"3372","DOI":"10.1111\/bph.13629","article-title":"In silico prediction of chemical mechanism of action via an improved network-based inference method","volume":"173","author":"Wu","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejmech.2018.10.020_bib68","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/j.cell.2017.10.049","article-title":"A\u00a0next generation connectivity Map: L1000 platform and the first 1,000,000 profiles","volume":"171","author":"Subramanian","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.ejmech.2018.10.020_bib69","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.cels.2018.03.012","article-title":"A\u00a0library of phosphoproteomic and chromatin signatures for characterizing cellular responses to drug perturbations","volume":"6","author":"Litichevskiy","year":"2018","journal-title":"Cell Syst."},{"key":"10.1016\/j.ejmech.2018.10.020_bib70","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1007\/s00210-016-1252-4","article-title":"Pleiotropic effects of statins: new therapeutic targets in drug design","volume":"389","author":"Bedi","year":"2016","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."},{"key":"10.1016\/j.ejmech.2018.10.020_bib71","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1093\/jamia\/ocw007","article-title":"A\u00a0network-based drug repositioning infrastructure for precision cancer medicine through targeting significantly mutated genes in the human cancer genomes","volume":"23","author":"Cheng","year":"2016","journal-title":"J.\u00a0Am. Med. Inf. Assoc."},{"key":"10.1016\/j.ejmech.2018.10.020_bib72","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s11655-008-0281-3","article-title":"Effect of shengmai injection on vascular endothelial and heart functions in patients with coronary heart disease complicated with diabetes mellitus","volume":"14","author":"Zhang","year":"2008","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.ejmech.2018.10.020_bib73","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jep.2010.04.017","article-title":"Buyang Huanwu decoction ameliorates coronary heart disease with Qi deficiency and blood stasis syndrome by reducing CRP and CD40 in rats","volume":"130","author":"Zhang","year":"2010","journal-title":"J.\u00a0Ethnopharmacol."},{"key":"10.1016\/j.ejmech.2018.10.020_bib74","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1021\/ci0003101","article-title":"Traditional Chinese medicine database and application on the web","volume":"41","author":"He","year":"2001","journal-title":"J.\u00a0Chem. Inf. Comput. Sci."},{"key":"10.1016\/j.ejmech.2018.10.020_bib75","doi-asserted-by":"crossref","first-page":"D1089","DOI":"10.1093\/nar\/gks1100","article-title":"TCMID: traditional Chinese medicine integrative database for herb molecular mechanism analysis","volume":"41","author":"Xue","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ejmech.2018.10.020_bib76","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1758-2946-6-13","article-title":"TCMSP: a database of systems pharmacology for drug discovery from herbal medicines","volume":"6","author":"Ru","year":"2014","journal-title":"J.\u00a0Cheminf."},{"key":"10.1016\/j.ejmech.2018.10.020_bib77","article-title":"TCM Database@Taiwan: the World's Largest Traditional Chinese Medicine Database for Drug Screening in Silico","volume":"6","author":"Chen","year":"2011","journal-title":"PloS One"},{"key":"10.1016\/j.ejmech.2018.10.020_bib78","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1038\/s41598-017-03039-7","article-title":"TCM-mesh: the database and analytical system for network pharmacology analysis for TCM preparations","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2018.10.020_bib79","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1186\/s12906-015-0758-5","article-title":"TM-MC: a database of medicinal materials and chemical compounds in northeast Asian traditional medicine","volume":"15","author":"Kim","year":"2015","journal-title":"BMC Complement Altern. Med."},{"key":"10.1016\/j.ejmech.2018.10.020_bib80","doi-asserted-by":"crossref","first-page":"D945","DOI":"10.1093\/nar\/gkw1074","article-title":"The ChEMBL database in 2017","volume":"45","author":"Gaulton","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ejmech.2018.10.020_bib81","doi-asserted-by":"crossref","first-page":"D1045","DOI":"10.1093\/nar\/gkv1072","article-title":"BindingDB in 2015: a public database for medicinal chemistry, computational chemistry and systems pharmacology","volume":"44","author":"Gilson","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ejmech.2018.10.020_bib82","doi-asserted-by":"crossref","first-page":"D380","DOI":"10.1093\/nar\/gkv1277","article-title":"STITCH 5: augmenting protein-chemical interaction networks with tissue and affinity data","volume":"44","author":"Szklarczyk","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ejmech.2018.10.020_bib83","doi-asserted-by":"crossref","first-page":"D1055","DOI":"10.1093\/nar\/gkq1165","article-title":"HIT: linking herbal active ingredients to targets","volume":"39","author":"Ye","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ejmech.2018.10.020_bib84","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1758-2946-3-33","article-title":"Open Babel: an open chemical toolbox","volume":"3","author":"O'Boyle","year":"2011","journal-title":"J.\u00a0Cheminf."},{"key":"10.1016\/j.ejmech.2018.10.020_bib85","doi-asserted-by":"crossref","first-page":"D789","DOI":"10.1093\/nar\/gku1205","article-title":"OMIM.org: online mendelian inheritance in man (OMIM(R)), an online catalog of human genes and genetic disorders","volume":"43","author":"Amberger","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ejmech.2018.10.020_bib86","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s00439-017-1779-6","article-title":"The human gene mutation database: towards a comprehensive repository of inherited mutation data for medical Research, genetic diagnosis and next-generation sequencing studies","volume":"136","author":"Stenson","year":"2017","journal-title":"Hum. Genet."},{"key":"10.1016\/j.ejmech.2018.10.020_bib87","doi-asserted-by":"crossref","first-page":"D1001","DOI":"10.1093\/nar\/gkt1229","article-title":"The NHGRI GWAS catalog, a curated resource of SNP-trait associations","volume":"42","author":"Welter","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ejmech.2018.10.020_bib88","doi-asserted-by":"crossref","first-page":"D972","DOI":"10.1093\/nar\/gkw838","article-title":"The comparative Toxicogenomics database: update 2017","volume":"45","author":"Davis","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ejmech.2018.10.020_bib89","doi-asserted-by":"crossref","first-page":"D833","DOI":"10.1093\/nar\/gkw943","article-title":"DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variants","volume":"45","author":"Pinero","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ejmech.2018.10.020_bib90","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","author":"Benjamini","year":"1995","journal-title":"J.\u00a0Roy. Stat. Soc. B"}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523418308821?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523418308821?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T13:48:15Z","timestamp":1759326495000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523418308821"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":90,"alternative-id":["S0223523418308821"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2018.10.020","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quantitative and systems pharmacology 4. Network-based analysis of drug pleiotropy on coronary artery disease","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2018.10.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}