{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T19:50:42Z","timestamp":1779911442752,"version":"3.53.1"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["NRF-2017R1D1A1B03027888"],"award-info":[{"award-number":["NRF-2017R1D1A1B03027888"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.ejmech.2018.10.025","type":"journal-article","created":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T12:37:25Z","timestamp":1539607045000},"page":"78-92","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":73,"special_numbering":"C","title":["Synthesis of cinnamic amide derivatives and their anti-melanogenic effect in \u03b1-MSH-stimulated B16F10 melanoma cells"],"prefix":"10.1016","volume":"161","author":[{"given":"Sultan","family":"Ullah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongwan","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanggwon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Ikram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaeun","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujin","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sik","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pusoon","family":"Chun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung Ryong","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2018.10.025_bib1","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1021\/jf020826f","article-title":"Mushroom tyrosinase: recent prospects","volume":"51","author":"Seo","year":"2003","journal-title":"J.\u00a0Agric. Food Chem."},{"key":"10.1016\/j.ejmech.2018.10.025_bib2","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1046\/j.1467-2494.2000.00021.x","article-title":"Skin colour assessment in safety testing of cosmetics. An overview","volume":"22","author":"Hermanns","year":"2000","journal-title":"Int. J. Cosmet. Sci."},{"key":"10.1016\/j.ejmech.2018.10.025_bib3","doi-asserted-by":"crossref","first-page":"S156","DOI":"10.1038\/jid.1993.69","article-title":"Regulatory mechanisms of melanogenesis: beyond the tyrosinase concept","volume":"100","author":"Prota","year":"1993","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.ejmech.2018.10.025_bib4","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1517\/13543776.2016.1146253","article-title":"Tyrosinase inhibitors: a patent review (2011-2015)","volume":"26","author":"Ullah","year":"2016","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.ejmech.2018.10.025_bib5","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.3390\/ma5091661","article-title":"Natural melanogenesis inhibitors acting through the down-regulation of tyrosinase activity","volume":"5","author":"Chang","year":"2012","journal-title":"Materials"},{"key":"10.1016\/j.ejmech.2018.10.025_bib6","doi-asserted-by":"crossref","first-page":"7995","DOI":"10.1038\/srep07995","article-title":"Discovery of highly potent tyrosinase inhibitor, T1, with significant anti-melanogenesis ability by zebrafish in\u00a0vivo assay and computational molecular modeling","volume":"5","author":"Chen","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2018.10.025_bib7","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1126\/science.6810464","article-title":"Mammalian tyrosinase catalyzes three reactions in the biosynthesis of melanin","volume":"217","author":"Korner","year":"1982","journal-title":"Science"},{"key":"10.1016\/j.ejmech.2018.10.025_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/14756366.2015.1004058","article-title":"Natural, semisynthetic and synthetic tyrosinase inhibitors","volume":"31","author":"Lee","year":"2016","journal-title":"J.\u00a0Enzym. Inhib. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.10.025_bib9","doi-asserted-by":"crossref","first-page":"2902","DOI":"10.1096\/fasebj.5.14.1752358","article-title":"Enzymatic control of pigmentation in mammals","volume":"5","author":"Hearing","year":"1991","journal-title":"Faseb. J."},{"key":"10.1016\/j.ejmech.2018.10.025_bib10","series-title":"The Pigmentary System: Physiology and Pathophysiology","author":"King","year":"1998"},{"key":"10.1016\/j.ejmech.2018.10.025_bib11","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1034\/j.1600-0749.2003.00004.x","article-title":"Effects of melanogenesis-inducing nitric oxide and histamine on the production of eumelanin and pheomelanin in cultured human melanocytes","volume":"16","author":"Lassalle","year":"2003","journal-title":"Pigm. Cell Res."},{"key":"10.1016\/j.ejmech.2018.10.025_bib12","first-page":"287","article-title":"The melanocortin receptors: agonists, antagonists, and the hormonal control of pigmentation","volume":"51","author":"Cone","year":"1996","journal-title":"Recent Prog. Horm. Res."},{"key":"10.1016\/j.ejmech.2018.10.025_bib13","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1034\/j.1600-0749.2002.02055.x","article-title":"Keratinocytes control the pheo\/eumelanin ratio in cultured normal human melanocytes","volume":"15","author":"Duval","year":"2002","journal-title":"Pigm. Cell Res."},{"key":"10.1016\/j.ejmech.2018.10.025_bib14","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1677\/joe.0.1090015","article-title":"Melanocyte-stimulating hormone, tyrosinase activity and the regulation of eumelanogenesis and phaeomelanogenesis in the hair follicular melanocytes of the mouse","volume":"109","author":"Burchill","year":"1986","journal-title":"J.\u00a0Endocrinol."},{"key":"10.1016\/j.ejmech.2018.10.025_bib15","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1006\/excr.2001.5251","article-title":"Melanosomal pH controls rate of melanogenesis, eumelanin\/phaeomelanin ratio and melanosome maturation in melanocytes and melanoma cells","volume":"268","author":"Ancans","year":"2001","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.ejmech.2018.10.025_bib16","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1034\/j.1600-0749.2003.00072.x","article-title":"Quantitative analysis of eumelanin and pheomelanin in humans, mice, and other animals: a comparative review","volume":"16","author":"Ito","year":"2003","journal-title":"Pigm. Cell Res."},{"key":"10.1016\/j.ejmech.2018.10.025_bib17","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1034\/j.1600-0749.2002.1o071.x","article-title":"Ethnic variation in melanin content and composition in photoexposed and photoprotected human skin","volume":"15","author":"Alaluf","year":"2002","journal-title":"Pigm. Cell Res."},{"key":"10.1016\/j.ejmech.2018.10.025_bib18","doi-asserted-by":"crossref","first-page":"R9","DOI":"10.1093\/hmg\/ddp003","article-title":"Molecular genetics of human pigmentation diversity","volume":"18","author":"Sturm","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ejmech.2018.10.025_bib19","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.aquaculture.2004.11.020","article-title":"White background reduces the occurrence of staining, activates melanin-concentrating hormone and promotes somatic growth in barfin flounder","volume":"244","author":"Yamanome","year":"2005","journal-title":"Aquaculture"},{"key":"10.1016\/j.ejmech.2018.10.025_bib20","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1134\/S0026261710030082","article-title":"Phenol oxidase activity in bacteria of the genus Azospirillum","volume":"79","author":"Nikitina","year":"2010","journal-title":"Microbiology"},{"key":"10.1016\/j.ejmech.2018.10.025_bib21","first-page":"35","article-title":"Tyrosinase from Rhizobium etli is involved in nodulation efficiency and symbiosis-associated stress resistance","volume":"13","author":"Pi\u00f1ero","year":"2007","journal-title":"J.\u00a0Mol. Microbiol. Biotechnol."},{"key":"10.1016\/j.ejmech.2018.10.025_bib22","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.24.7.688","article-title":"Occurrence of Parkinson's disease in black patients at charity hospital in New Orleans","volume":"24","author":"Paddison","year":"1974","journal-title":"Neurology"},{"key":"10.1016\/j.ejmech.2018.10.025_bib23","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1097\/00005072-196507000-00003","article-title":"Phase and electron microscopic observations of Lewy bodies and melanin granules in the substantia nigra and locus caeruleus in Parkinson's disease","volume":"24","author":"Duffy","year":"1965","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.ejmech.2018.10.025_bib24","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0047-6374(83)90074-X","article-title":"Possible role of neuromelanin in the pathogenesis of Parkinson's disease","volume":"21","author":"Mann","year":"1983","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.ejmech.2018.10.025_bib25","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/ng1769","article-title":"High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease","volume":"38","author":"Bender","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ejmech.2018.10.025_bib26","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/BF03033137","article-title":"Dopamine-or L-DOPA-induced neurotoxicity: the role of dopamine quinone formation and tyrosinase in a model of Parkinson's disease","volume":"5","author":"Asanuma","year":"2003","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.ejmech.2018.10.025_bib27","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0014-827X(03)00048-X","article-title":"In\u00a0vitro cytotoxicity to human cells in culture of some phenolics from olive oil","volume":"58","author":"Babich","year":"2003","journal-title":"Il Farmaco"},{"key":"10.1016\/j.ejmech.2018.10.025_bib28","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1111\/j.1600-0749.2006.00334.x","article-title":"Hypopigmenting agents: an updated review on biological, chemical and clinical aspects","volume":"19","author":"Solano","year":"2006","journal-title":"Pigm. Cell Res."},{"key":"10.1016\/j.ejmech.2018.10.025_bib29","series-title":"Comprehensive Clinical Plasma Medicine","first-page":"363","article-title":"Perspective in pigmentation disorders","author":"Adhikari","year":"2018"},{"key":"10.1016\/j.ejmech.2018.10.025_bib30","series-title":"Basics in Dermatological Laser Applications","first-page":"81","article-title":"Benign pigmented lesions","author":"Allemann","year":"2011"},{"key":"10.1016\/j.ejmech.2018.10.025_bib31","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1080\/10408399209527599","article-title":"Inhibition of enzymatic browning in foods and beverages","volume":"32","author":"McEvily","year":"1992","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.ejmech.2018.10.025_bib32","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S0022-3565(25)12357-4","article-title":"Arbutin: mechanism of its depigmenting action in human melanocyte culture","volume":"276","author":"Maeda","year":"1996","journal-title":"J.\u00a0Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.ejmech.2018.10.025_bib33","doi-asserted-by":"crossref","first-page":"7408","DOI":"10.1021\/jf051258h","article-title":"Isolation and identification of flavonoids in licorice and a study of their inhibitory effects on tyrosinase","volume":"53","author":"Fu","year":"2005","journal-title":"J.\u00a0Agric. Food Chem."},{"key":"10.1016\/j.ejmech.2018.10.025_bib34","first-page":"361","article-title":"In\u00a0vitro effectiveness of several whitening cosmetic components in human melanocytes","volume":"42","author":"Maeda","year":"1991","journal-title":"J.\u00a0Soc. Cosmet. Chem."},{"key":"10.1016\/j.ejmech.2018.10.025_bib35","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.mrgentox.2015.01.004","article-title":"Evaluation of the repeated-dose liver, bone marrow and peripheral blood micronucleus and comet assays using kojic acid","volume":"780","author":"Ogiwara","year":"2015","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen"},{"key":"10.1016\/j.ejmech.2018.10.025_bib36","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1473-2165.2005.40202.x","article-title":"Hydroquinone and its analogues in dermatology\u2013a potential health risk","volume":"4","author":"Westerhof","year":"2005","journal-title":"J.\u00a0Cosmet. Dermatol."},{"key":"10.1016\/j.ejmech.2018.10.025_bib37","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.cbi.2005.03.034","article-title":"Genotoxicity of the benzene metabolites para-benzoquinone and hydroquinone","volume":"153","author":"Gaskell","year":"2005","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.ejmech.2018.10.025_bib38","doi-asserted-by":"crossref","first-page":"7395","DOI":"10.1021\/acs.jmedchem.7b00967","article-title":"Inhibitors of melanogenesis: an updated review","volume":"17","author":"Pillaiyar","year":"2018","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.10.025_bib39","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1111\/j.1365-2621.1977.tb12677.x","article-title":"Inhibition of growth and aflatoxin production by cinnamon and clove oils. Cinnamic aldehyde and eugenol","volume":"42","author":"Bullerman","year":"1977","journal-title":"J.\u00a0Food Sci."},{"key":"10.1016\/j.ejmech.2018.10.025_bib40","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1271\/bbb.120547","article-title":"A\u00a0novel synthesized tyrosinase inhibitor:(E)-2-((2, 4-dihydroxyphenyl) diazenyl) phenyl 4-methylbenzenesulfonate as an azo-resveratrol analog","volume":"77","author":"Bae","year":"2013","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.ejmech.2018.10.025_bib41","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1080\/09168451.2018.1445518","article-title":"A\u00a0novel synthetic compound, (Z)-5-(3-hydroxy-4-methoxybenzylidene)-2-iminothiazolidin-4-one (MHY773) inhibits mushroom tyrosinase","volume":"82","author":"Jung","year":"2018","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.ejmech.2018.10.025_bib42","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1039\/C4MD00171K","article-title":"Benzylidene-linked thiohydantoin derivatives as inhibitors of tyrosinase and melanogenesis: importance of the \u03b2-phenyl-\u03b1, \u03b2-unsaturated carbonyl functionality","volume":"5","author":"Kim","year":"2014","journal-title":"MedChemComm"},{"key":"10.1016\/j.ejmech.2018.10.025_bib43","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1007\/s12272-013-0184-5","article-title":"Anti-melanogenic effect of (Z)-5-(2, 4-dihydroxybenzylidene) thiazolidine-2, 4-dione, a novel tyrosinase inhibitor","volume":"36","author":"Kim","year":"2013","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.ejmech.2018.10.025_bib44","doi-asserted-by":"crossref","first-page":"3882","DOI":"10.1016\/j.bmc.2018.05.047","article-title":"The tyrosinase inhibitory effects of isoxazolone derivatives with a (Z)-\u03b2-phenyl-\u03b1, \u03b2-unsaturated carbonyl scaffold","volume":"26","author":"Kim","year":"2018","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.10.025_bib45","first-page":"139","article-title":"Tyrosinase inhibitory effect of (E)-2-(substituted benzylidene)-2, 3-dihydro-1H-cyclopenta [a] naphthalen-1-one derivatives","volume":"27","author":"Lee","year":"2017","journal-title":"J.\u00a0Life Sci."},{"key":"10.1016\/j.ejmech.2018.10.025_bib46","first-page":"4259","article-title":"Design, synthesis, and anti-melanogenic effects of (E)-2-benzoyl-3-(substituted phenyl) acrylonitriles","volume":"9","author":"Yun","year":"2015","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.ejmech.2018.10.025_bib47","doi-asserted-by":"crossref","first-page":"7728","DOI":"10.1016\/j.bmc.2015.11.015","article-title":"(E)-2-Cyano-3-(substituted phenyl) acrylamide analogs as potent inhibitors of tyrosinase: a linear \u03b2-phenyl-\u03b1, \u03b2-unsaturated carbonyl scaffold","volume":"23","author":"Son","year":"2018","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2018.10.025_bib48","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.bbagen.2011.03.001","article-title":"Analogs of 5-(substituted benzylidene) hydantoin as inhibitors of tyrosinase and melanin formation","volume":"1810","author":"Ha","year":"2011","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.ejmech.2018.10.025_bib49","doi-asserted-by":"crossref","first-page":"827","DOI":"10.2147\/DDDT.S131538","article-title":"Design, synthesis, and antimelanogenic effects of (2-substituted phenyl-1, 3-dithiolan-4-yl) methanol derivatives","volume":"11","author":"Do Hyun Kim","year":"2017","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.ejmech.2018.10.025_bib50","doi-asserted-by":"crossref","DOI":"10.1002\/poc.3605","article-title":"Proton transfer rate-equilibria in apolar aprotic solvents: a historical perspective","volume":"30","author":"Sen Gupta","year":"2017","journal-title":"J.\u00a0Phys. Org. Chem."},{"key":"10.1016\/j.ejmech.2018.10.025_bib51","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1021\/jo0477650","article-title":"Trifluoroacetic acid-mediated hydroarylation: synthesis of dihydrocoumarins and dihydroquinolones","volume":"70","author":"Li","year":"2005","journal-title":"J.\u00a0Org. Chem."},{"key":"10.1016\/j.ejmech.2018.10.025_bib52","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1021\/cc020027+","article-title":"Combinatorial synthetic design. Solution and polymer-supported synthesis of heterocycles via intramolecular aza Diels\u2212 alder and imino alcohol cyclizations","volume":"4","author":"Spaller","year":"2002","journal-title":"J.\u00a0Comb. Chem."},{"key":"10.1016\/j.ejmech.2018.10.025_bib53","doi-asserted-by":"crossref","first-page":"9698","DOI":"10.1021\/jo801785r","article-title":"Catalytic asymmetric intramolecular hydroamination of alkynes in the presence of a catalyst system consisting of Pd (0)-methyl Norphos (or tolyl Renorphos)-benzoic acid","volume":"73","author":"Narsireddy","year":"2008","journal-title":"J.\u00a0Org. Chem."},{"key":"10.1016\/j.ejmech.2018.10.025_bib54","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1248\/bpb.b15-00300","article-title":"(Z)-2-(Benzo [d] thiazol-2-ylamino)-5-(substituted benzylidene) thiazol-4 (5H)-one Derivatives as Novel Tyrosinase Inhibitors","volume":"38","author":"Kang","year":"2015","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.ejmech.2018.10.025_bib55","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.bbagen.2012.03.018","article-title":"Evaluation of in\u00a0vitro and in\u00a0vivo anti-melanogenic activity of a newly synthesized strong tyrosinase inhibitor (E)-3-(2, 4 dihydroxybenzylidene) pyrrolidine-2, 5-dione (3-DBP)","volume":"1820","author":"Chung","year":"2012","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.ejmech.2018.10.025_bib56","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.bbagen.2012.01.001","article-title":"Characterization of a novel tyrosinase inhibitor, (2RS, 4R)-2-(2, 4-dihydroxyphenyl) thiazolidine-4-carboxylic acid (MHY384)","volume":"1820","author":"Han","year":"2012","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.ejmech.2018.10.025_bib57","doi-asserted-by":"crossref","first-page":"7243","DOI":"10.1016\/j.tetlet.2014.11.053","article-title":"Choline chloride based deep eutectic solvent as an efficient solvent for the benzylation of phenols","volume":"55","author":"Singh","year":"2014","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.ejmech.2018.10.025_bib58","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1021\/jm015568c","article-title":"Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates","volume":"45","author":"Remiszewski","year":"2002","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2018.10.025_bib59","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1248\/bpb.31.154","article-title":"Inhibitory effects of kurarinol, kuraridinol, and trifolirhizin from Sophora flavescens on tyrosinase and melanin synthesis","volume":"31","author":"Hyun","year":"2008","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.ejmech.2018.10.025_bib60","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1002\/(SICI)1096-987X(19981115)19:14<1639::AID-JCC10>3.0.CO;2-B","article-title":"Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function","volume":"19","author":"Morris","year":"1998","journal-title":"J.\u00a0Comput. Chem."},{"key":"10.1016\/j.ejmech.2018.10.025_bib61","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s10822-006-9060-4","article-title":"Development and validation of a modular, extensible docking program: DOCK 5","volume":"20","author":"Moustakas","year":"2006","journal-title":"J.\u00a0Comput. Aided Mol. Des."},{"key":"10.1016\/j.ejmech.2018.10.025_bib62","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1248\/bpb.19.1518","article-title":"A\u00a0combined assay of cell viability and in\u00a0vitro cytotoxicity with a highly water-soluble tetrazolium salt, neutral red and crystal violet","volume":"19","author":"Ishiyama","year":"1996","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.ejmech.2018.10.025_bib63","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1248\/bpb.32.1447","article-title":"Melanogenesis inhibition by gallotannins from Chinese galls in B16 mouse melanoma cells","volume":"32","author":"Chen","year":"2009","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.ejmech.2018.10.025_bib64","doi-asserted-by":"crossref","first-page":"94227","DOI":"10.1039\/C5RA14465E","article-title":"Design and discovery of tyrosinase inhibitors based on a coumarin scaffold","volume":"5","author":"Matos","year":"2015","journal-title":"RSC Adv."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523418308870?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523418308870?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T13:47:13Z","timestamp":1759326433000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523418308870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":64,"alternative-id":["S0223523418308870"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2018.10.025","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis of cinnamic amide derivatives and their anti-melanogenic effect in \u03b1-MSH-stimulated B16F10 melanoma cells","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2018.10.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}