{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T02:28:10Z","timestamp":1771036090781,"version":"3.50.1"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100010002","name":"Ministry of Education","doi-asserted-by":"publisher","award":["106N501CE1"],"award-info":[{"award-number":["106N501CE1"]}],"id":[{"id":"10.13039\/100010002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010002","name":"Ministry of Education","doi-asserted-by":"publisher","award":["107QR001I5"],"award-info":[{"award-number":["107QR001I5"]}],"id":[{"id":"10.13039\/100010002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["103G603-14"],"award-info":[{"award-number":["103G603-14"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["106-2113-M-007-011-MY2"],"award-info":[{"award-number":["106-2113-M-007-011-MY2"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["107-3017-F-007-002"],"award-info":[{"award-number":["107-3017-F-007-002"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.ejmech.2019.01.037","type":"journal-article","created":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T17:42:58Z","timestamp":1548092578000},"page":"136-143","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Chikungunya virus inhibition by synthetic coumarin\u2013guanosine conjugates"],"prefix":"10.1016","volume":"166","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9225-8484","authenticated-orcid":false,"given":"Jih Ru","family":"Hwu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Chieh","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Yu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kui-Thong","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Chen","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fa-Kuen","family":"Shieh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergey O.","family":"Bachurin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1977-4797","authenticated-orcid":false,"given":"Alexey","family":"Ustyugov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shwu-Chen","family":"Tsay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2019.01.037_bib1","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/nrmicro2368","article-title":"Biology and pathogenesis of chikungunya virus","volume":"8","author":"Schwartz","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.ejmech.2019.01.037_bib2","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1093\/trstmh\/trv094","article-title":"Estimating the burden of disease and the economic cost attributable to chikungunya, Colombia","volume":"109","author":"Cardona-Ospina","year":"2015","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.ejmech.2019.01.037_bib3","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/nm.4253","article-title":"A\u00a0chikungunya fever vaccine utilizing an insect-specific virus platform","volume":"23","author":"Erasmus","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejmech.2019.01.037_bib4","series-title":"New Horizons of Process Chemistry: Scalable Reactions and Technologies","first-page":"251","article-title":"Antiviral agents towards chikungunya virus: structures, syntheses, and isolation from natural sources","author":"Hwu","year":"2017"},{"key":"10.1016\/j.ejmech.2019.01.037_bib5","doi-asserted-by":"crossref","first-page":"21899","DOI":"10.1074\/jbc.M802444200","article-title":"Inhibition of chikungunya virus infection in cultured human muscle cells by furin inhibitors: impairment of the maturation of the E2 surface glycoprotein","volume":"283","author":"Ozden","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.ejmech.2019.01.037_bib6a","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.fitote.2012.05.004","article-title":"Chemical constituents of anacolosa pervilleana and their antiviral activities","volume":"83","author":"Bourjot","year":"2012","journal-title":"Fitoterapia"},{"key":"10.1016\/j.ejmech.2019.01.037_bib6b","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/S1995-7645(14)60343-6","article-title":"Anti-chikungunya activity of luteolin and apigenin rich fraction from cynodon dactylon","volume":"8","author":"Murali","year":"2015","journal-title":"Asian Pac. J. Trop. Med."},{"key":"10.1016\/j.ejmech.2019.01.037_bib6c","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0028923","article-title":"Inhibitors of alphavirus entry and replication identified with a stable chikungunya replicon cell line and virus-based assays","volume":"6","author":"Pohjala","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ejmech.2019.01.037_bib6d","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.bjid.2015.10.004","article-title":"Chikungunya: bending over the Americas and the rest of the world","volume":"20","author":"Madariaga","year":"2016","journal-title":"Braz. J. Infect. Dis."},{"key":"10.1016\/j.ejmech.2019.01.037_bib6e","doi-asserted-by":"crossref","first-page":"3617","DOI":"10.3390\/molecules19033617","article-title":"A\u00a0potent inhibitor of chikungunya virus replication","volume":"19","author":"Bourjot","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2019.01.037_bib7","doi-asserted-by":"crossref","first-page":"4219","DOI":"10.1016\/j.bmc.2017.06.049","article-title":"The medicinal chemistry of chikungunya virus","volume":"25","author":"da Silva-J\u00fanior","year":"2017","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.01.037_bib8a","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.antiviral.2017.06.003","article-title":"Antiviral activity of [1,2,3]triazolo[4,5-d]pyrimidin- 7(6H)-ones against chikungunya virus targeting the viral capping nsP1","volume":"144","author":"Gigante","year":"2017","journal-title":"Antivir. Res."},{"key":"10.1016\/j.ejmech.2019.01.037_bib8b","doi-asserted-by":"crossref","first-page":"3165","DOI":"10.1021\/acs.jmedchem.7b00180","article-title":"Structural optimizations of thieno[3,2-b]pyrrole derivatives for the development of metabolically stable inhibitors of chikungunya virus","volume":"60","author":"Ching","year":"2017","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2019.01.037_bib8c","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.antiviral.2017.08.008","article-title":"Bis(benzofuran-thiazolidinone)s and bis(benzofuran\u2013thiazinanone)s as inhibiting agents for chikungunya virus","volume":"146","author":"Hwu","year":"2017","journal-title":"Antivir. Res."},{"key":"10.1016\/j.ejmech.2019.01.037_bib9","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.phytochem.2015.08.012","article-title":"Comparative inhibitory effect of prenylated coumarins, ferulenol and ferprenin, contained in the \u2018poisonous chemotype\u2019 of Ferula communis on mammal liver microsomal VKORC1 activity","volume":"118","author":"Louvet","year":"2015","journal-title":"Phytochemistry"},{"key":"10.1016\/j.ejmech.2019.01.037_bib10a","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ejphar.2009.04.015","article-title":"A\u00a0synthetic coumarin (4-methyl-7 hydroxy coumarin) has anti-cancer potentials against DMBA-induced skin cancer in mice","volume":"614","author":"Bhattacharyya","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejmech.2019.01.037_bib10b","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.bbrc.2006.05.037","article-title":"Study of hyaluronan synthase inhibitor, 4-methylumbelliferone derivatives on human pancreatic cancer cell (KP1-NL)","volume":"45","author":"Morohashi","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejmech.2019.01.037_bib11","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.ejmech.2016.07.056","article-title":"Therapeutic potential of coumarins as antiviral agents","volume":"123","author":"Hassan","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.01.037_bib12","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.antiviral.2015.03.013","article-title":"Benzouracil\u2212coumarin\u2212arene conjugates as inhibiting agents for chikungunya virus","volume":"118","author":"Hwu","year":"2015","journal-title":"Antivir. Res."},{"key":"10.1016\/j.ejmech.2019.01.037_sref10","unstructured":"For anti-HCV, see:"},{"key":"10.1016\/j.ejmech.2019.01.037_bib13a","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.antiviral.2007.09.003","article-title":"Synthesis of new benzimidazole\u2013coumarin conjugates as anti-hepatitis C virus agents","volume":"77","author":"Hwu","year":"2008","journal-title":"Antivir. Res."},{"key":"10.1016\/j.ejmech.2019.01.037_bib13b","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1021\/jm801240d","article-title":"Structure-activity relationship of new anti-hepatitis C virus agents: heterobicycle-coumarin conjugates","volume":"52","author":"Neyts","year":"2009","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2019.01.037_bib13c","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1021\/jm101337v","article-title":"Coumarin\u2013purine ribofuranoside conjugates as new agents against hepatitis C virus","volume":"54","author":"Hwu","year":"2011","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2019.01.037_bib13d","first-page":"1144","article-title":"Development of new sulfur-containing conjugated compounds as anti-HCV agents, Phosphorus Sulfur Silicon Relat","volume":"186","author":"Hwu","year":"2011","journal-title":"Elementa"},{"key":"10.1016\/j.ejmech.2019.01.037_bib13e","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.ejmech.2013.02.008","article-title":"Coumarins hinged directly on benzimidazoles and their ribofuranosides to inhibit hepatitis C virus","volume":"63","author":"Tsay","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.01.037_bib13f","doi-asserted-by":"crossref","first-page":"228","DOI":"10.3390\/molecules21020228","article-title":"Synthesis and structure\u2212activity relationship of imidazole\u2013coumarin conjugates against hepatitis C virus","volume":"21","author":"Tsay","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2019.01.037_bib13g","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.36876\/smjhrt.1009","article-title":"New conjugated compounds coming on stream against hepatitis C virus","volume":"2","author":"Tsay","year":"2016","journal-title":"SM J. Hepat. Res. Treat."},{"key":"10.1016\/j.ejmech.2019.01.037_sref11","unstructured":"For anti-HIV see:"},{"key":"10.1016\/j.ejmech.2019.01.037_bib14a","doi-asserted-by":"crossref","first-page":"3683","DOI":"10.1080\/00397910903531649","article-title":"Synthesis of baylis\u2013hillman-derived phosphonated 3-(benzylaminomethyl)coumarins","volume":"40","author":"Rashamuse","year":"2010","journal-title":"Synth. Commun."},{"key":"10.1016\/j.ejmech.2019.01.037_bib14b","doi-asserted-by":"crossref","first-page":"3200","DOI":"10.1021\/jm00046a002","article-title":"Structure-based design of HIV protease inhibitors: 4-hydroxycoumarins and 4-hydroxy-2-pyrones as nonpeptidic inhibitors","volume":"37","author":"Thaisrivongs","year":"1994","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2019.01.037_bib15","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.1016\/j.bmc.2010.04.009","article-title":"Synthesis, anticoagulant and PIVKA-II induced by new 4-hydroxycoumarin derivatives","volume":"18","author":"Abdelhafez","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.01.037_bib16","doi-asserted-by":"crossref","first-page":"3788","DOI":"10.1016\/j.ejmech.2011.05.044","article-title":"Synthesis and antimicrobial properties of some new thiazolyl coumarin derivatives","volume":"46","author":"Arshad","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.01.037_bib17","first-page":"735","article-title":"Structures of antimutagenic constituents in the peels of citrus limon","volume":"71","author":"Matsumoto","year":"2017","journal-title":"J.\u00a0Nat. Med."},{"key":"10.1016\/j.ejmech.2019.01.037_bib18","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.ejmech.2011.12.025","article-title":"Antitumor agents 292. Design, synthesis and pharmacological study of S- and O-substituted 7-mercapto- or hydroxy-coumarins and chromones as potent cytotoxic agents","volume":"49","author":"Chen","year":"2012","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.01.037_bib19","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.ejmech.2015.06.017","article-title":"Recent progress in the drug development of coumarin derivatives as potent antituberculosis agents","volume":"100","author":"Keri","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.01.037_bib20","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1016\/j.bmc.2013.02.017","article-title":"A\u00a0comprehensive review on synthesis and designing aspects of coumarin derivatives as monoamine oxidase inhibitors for depression and Alzheimer's disease","volume":"21","author":"Patil","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.01.037_bib21","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1055\/s-2003-37716","article-title":"Coumarins and carbazoles from Clausena excavata exhibited antimycobacterial and antifungal activities","volume":"69","author":"Sunthitikawinsakul","year":"2003","journal-title":"Planta Med."},{"key":"10.1016\/j.ejmech.2019.01.037_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0156625","article-title":"Antioxidant activities of 4-methylumbelliferone derivatives","volume":"11","author":"Al-Majedy","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.ejmech.2019.01.037_bib23","doi-asserted-by":"crossref","first-page":"830","DOI":"10.2174\/1568026615666150220112437","article-title":"Cardiovascular effects of coumarins besides their antioxidant activity","volume":"15","author":"Najmanova","year":"2015","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.01.037_bib24","doi-asserted-by":"crossref","first-page":"8713","DOI":"10.1016\/j.bmc.2008.07.081","article-title":"Novel angular furoquinolinones bearing flexible chain as antitumor agent: design, synthesis, cytotoxic evaluation, and DNA-binding studies","volume":"16","author":"Xie","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.01.037_bib25a","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1046\/j.0306-5251.2001.01391.x","article-title":"6-Thioguanine in children with acute lymphoblastic leukaemia: influence of food on parent drug pharmacokinetics and 6-thioguanine nucleotide concentrations","volume":"51","author":"Lancaster","year":"2001","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.ejmech.2019.01.037_bib25b","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1097\/00042737-200504000-00012","article-title":"Promising treatment of autoimmune hepatitis with 6-thioguanine after adverse events on azathioprine","volume":"17","author":"de Boer","year":"2005","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ejmech.2019.01.037_bib25c","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1086\/342049","article-title":"Eradication of human immunodeficiency virus type 1-infected cells by a combination of antimetabolic cytotoxic chemotherapy and antiviral chemotherapy in\u00a0vitro: a pilot study","volume":"186","author":"Yang","year":"2002","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.ejmech.2019.01.037_bib26","doi-asserted-by":"crossref","first-page":"10080","DOI":"10.1021\/jm501434y","article-title":"Imidazopyridine- and purine-thioacetamide derivatives: potent inhibitors of nucleotide pyrophosphatase\/phosphodiesterase 1 (NPP1)","volume":"57","author":"Chang","year":"2014","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2019.01.037_bib27","doi-asserted-by":"crossref","first-page":"6213","DOI":"10.1093\/nar\/8.24.6213","article-title":"Halogenation of tubercidin by N-halosuccinimides. A direct route to 5-bromotubercidin, a reversible inhibitor of RNA synthesis in eukaryotic cells","volume":"8","author":"Bergstrom","year":"1980","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ejmech.2019.01.037_bib28","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1021\/ja01060a057","article-title":"Purine nucleosides. VII. direct bromination of adenosine, deoxyadenosine, guanosine, and related purine nucleosides","volume":"86","author":"Holmes","year":"1964","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2019.01.037_bib29","doi-asserted-by":"crossref","first-page":"14741","DOI":"10.1021\/ja0364827","article-title":"Supramolecular helices via self-assembly of 8-oxoguanosines","volume":"125","author":"Giorgi","year":"2003","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2019.01.037_bib30a","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1021\/jm00047a014","article-title":"Small-molecule immunostimulants. Synthesis and activity of 7,8-disubstituted guanosines and structurally related compounds","volume":"37","author":"Reitz","year":"1994","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2019.01.037_bib30b","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1055\/s-1989-27150","article-title":"Synthesis of the 3',5'-cyclic phosphates from unprotected nucleosides","author":"Genieser","year":"1989","journal-title":"Synthesis"},{"key":"10.1016\/j.ejmech.2019.01.037_bib31","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1002\/cber.19811140404","article-title":"Nucleoside Syntheses, XXII Nucleoside synthesis with trimethylsilyl triflate and perchlorate as catalysts","volume":"114","author":"Vorbr\u00fcggen","year":"1981","journal-title":"Chem. Ber."},{"key":"10.1016\/j.ejmech.2019.01.037_bib32","series-title":"Spectrometric Identification of Organic Compounds","first-page":"98","author":"Silverstein","year":"2005"},{"key":"10.1016\/j.ejmech.2019.01.037_bib33","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.antiviral.2013.01.002","article-title":"Computer-aided identification, design and synthesis of a novel series of compounds with selective antiviral activity against chikungunya virus","volume":"98","author":"Bassetto","year":"2013","journal-title":"Antivir. Res."},{"key":"10.1016\/j.ejmech.2019.01.037_bib34","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nrd3701","article-title":"Finding the sweet spot: the role of nature and nurture in medicinal chemistry","volume":"11","author":"Hann","year":"2012","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejmech.2019.01.037_bib35","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1021\/cc9800071","article-title":"A\u00a0knowledge-based approach in designing combinatorial or medicinal chemistry libraries for drug discovery. 1. A qualitative and quantitative characterization of known drug databases","volume":"1","author":"Ghose","year":"1999","journal-title":"J.\u00a0Comb. Chem."},{"key":"10.1016\/j.ejmech.2019.01.037_bib36","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/481455a","article-title":"Drug discovery: chemical beauty contest","volume":"481","author":"Leeson","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2019.01.037_bib37","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1021\/jm030767c","article-title":"Determination of conformer-specific partition coefficients in octanol\/water systems","volume":"46","author":"Kraszni","year":"2003","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2019.01.037_bib38","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S1056-8719(00)00107-6","article-title":"Drug-like properties and the causes of poor solubility and poor permeability","volume":"44","author":"Lipinski","year":"2000","journal-title":"J.\u00a0Pharmacol. Toxicol. Methods"}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523419300479?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523419300479?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T13:47:38Z","timestamp":1759326458000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523419300479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":57,"alternative-id":["S0223523419300479"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2019.01.037","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chikungunya virus inhibition by synthetic coumarin\u2013guanosine conjugates","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2019.01.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}