{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:52:15Z","timestamp":1790232735869,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573269"],"award-info":[{"award-number":["81573269"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21572015"],"award-info":[{"award-number":["21572015"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21877007"],"award-info":[{"award-number":["21877007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91753202"],"award-info":[{"award-number":["91753202"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21702007"],"award-info":[{"award-number":["21702007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011238","name":"State Key Laboratory of Phytochemistry and Plant Resources in West China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011238","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.ejmech.2019.01.074","type":"journal-article","created":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T02:14:00Z","timestamp":1548814440000},"page":"328-338","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"special_numbering":"C","title":["Synthesis and structure-activity relationship studies of water-soluble \u03b2-cyclodextrin-glycyrrhetinic acid conjugates as potential anti-influenza virus agents"],"prefix":"10.1016","volume":"166","author":[{"given":"Shuobin","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8493-5812","authenticated-orcid":false,"given":"Yongmin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihe","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6852-9504","authenticated-orcid":false,"given":"Sulong","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2019.01.074_bib1","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1055\/s-0035-1557893","article-title":"The pharmacological activities of Licorice","volume":"81","author":"Yang","year":"2015","journal-title":"Planta Med."},{"key":"10.1016\/j.ejmech.2019.01.074_bib2","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jconrel.2005.04.007","article-title":"Ethosomes for skin delivery of ammonium glycyrrhizinate: In\u00a0vitro percutaneous permeation through human skin and in\u00a0vivo anti-inflammatory activity on human volunteers","volume":"106","author":"Paolino","year":"2005","journal-title":"J.\u00a0Contr. Release"},{"key":"10.1016\/j.ejmech.2019.01.074_bib3","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1111\/j.2042-7158.1996.tb05998.x","article-title":"Bioavailability study of glycyrrhetic acid after oral administration of glycyrrhizin in rats; Relevance to the intestinal bacterial hydrolysis","volume":"48","author":"Takeda","year":"1996","journal-title":"J.\u00a0Pharm. Pharmacol."},{"key":"10.1016\/j.ejmech.2019.01.074_bib4","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.chroma.2005.03.044","article-title":"Separation and analysis of glycyrrhizin, 18\u03b2-glycyrrhetic acid and 18\u03b1-glycyrrhetic acid in liquorice roots by means of capillary zone electrophoresis","volume":"1081","author":"Sabbioni","year":"2005","journal-title":"J.\u00a0Chromatogr. A"},{"key":"10.1016\/j.ejmech.2019.01.074_bib5","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1080\/13543776.2018.1455828","article-title":"Therapeutic potential of glycyrrhetinic acids: a patent review (2010-2017)","volume":"28","author":"Hussain","year":"2018","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/j.ejmech.2019.01.074_bib6","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1016\/S0149-2918(00)87239-2","article-title":"Pharmacokinetics of intravenous glycyrrhizin after single and multiple doses in patients with chronic hepatitis C infection","volume":"21","author":"van Rossum","year":"1999","journal-title":"Clin. Therapeut."},{"key":"10.1016\/j.ejmech.2019.01.074_bib7","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/281689a0","article-title":"Glycyrrhizic acid inhibits virus growth and inactivates virus-particles","volume":"281","author":"Pompei","year":"1979","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2019.01.074_bib8","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1016\/S0140-6736(03)13615-X","article-title":"Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus","volume":"361","author":"Cinatl","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.ejmech.2019.01.074_bib9","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1016\/j.bmcl.2015.02.074","article-title":"Glycyrrhizic acid derivatives as influenza A\/H1N1 virus inhibitors","volume":"25","author":"Baltina","year":"2015","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2019.01.074_bib10","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.3109\/03639045.2014.980425","article-title":"Preparation and characterization of mucoadhesive nanoparticles of poly (methyl vinyl ether-co-maleic anhydride) containing glycyrrhizic acid intended for vaginal administration","volume":"41","author":"Aguilar-Rosas","year":"2015","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.ejmech.2019.01.074_bib11","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.antiviral.2008.01.160","article-title":"Inhibitory effects of some derivatives of glycyrrhizic acid against Epstein-Barr virus infection: structure-activity relationships","volume":"79","author":"Lin","year":"2008","journal-title":"Antivir. Res."},{"key":"10.1016\/j.ejmech.2019.01.074_bib12","doi-asserted-by":"crossref","DOI":"10.1186\/1743-422X-9-96","article-title":"18\u03b2-glycyrrhetinic acid inhibits rotavirus replication in culture","volume":"9","author":"Hardy","year":"2012","journal-title":"Virol. J."},{"key":"10.1016\/j.ejmech.2019.01.074_bib13","doi-asserted-by":"crossref","first-page":"3473","DOI":"10.1016\/j.bmcl.2012.03.081","article-title":"Synthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents","volume":"22","author":"Wang","year":"2012","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2019.01.074_bib14","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.bioorg.2018.03.018","article-title":"Chemoenzymatic synthesis of new derivatives of glycyrrhetinic acid with antiviral activity. Molecular docking study","volume":"78","author":"Zigolo","year":"2018","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2019.01.074_bib15","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.ijpharm.2010.08.009","article-title":"Effect and mechanism of penetration enhancement of organic base and alcohol on Glycyrrhetinic acid in\u00a0vitro","volume":"399","author":"Hao","year":"2010","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejmech.2019.01.074_bib16","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1248\/cpb.22.1618","article-title":"Studies of oligosaccharides .12. Hydrophilization of glycyrrhetinic acid by coupling to gentio oligosaccharides","volume":"22","author":"Takiura","year":"1974","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.ejmech.2019.01.074_bib17","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/j.biopha.2017.01.157","article-title":"Complexation of phytochemicals with cyclodextrin derivatives - an insight","volume":"88","author":"Suvarna","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejmech.2019.01.074_bib18","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.drudis.2015.11.016","article-title":"Cyclodextrins in pharmaceutical formulations II: solubilization, binding constant, and complexation efficiency","volume":"21","author":"Jambhekar","year":"2016","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.ejmech.2019.01.074_bib19","first-page":"289","article-title":"A\u00a0comparison investigation on the solubilization of betulin and betulinic acid in cyclodextrin derivatives","volume":"7","author":"Wang","year":"2012","journal-title":"Nat Prod Commun"},{"key":"10.1016\/j.ejmech.2019.01.074_bib20","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.foodchem.2017.07.092","article-title":"Complexation between oleanolic and maslinic acids with native and modified cyclodextrins","volume":"240","author":"Loopez-Miranda","year":"2018","journal-title":"Food Chem."},{"key":"10.1016\/j.ejmech.2019.01.074_bib21","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.2174\/0929866521666140807115109","article-title":"New improved drug delivery technologies for pentacyclic triterpenes: a review","volume":"21","author":"Soica","year":"2014","journal-title":"Protein Pept. Lett."},{"key":"10.1016\/j.ejmech.2019.01.074_bib22","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ejphar.2013.06.007","article-title":"Effect of 18 \u03b2-glycyrrhetinic acid and hydroxypropyl gamma cyclodextrin complex on indomethacin-induced small intestinal injury in mice","volume":"714","author":"Ishida","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejmech.2019.01.074_bib23","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1021\/jm970130r","article-title":"6A-O-[(4-biphenylyl)acetyl]-\u03b1-, -\u03b2-, and -\u03b3-cyclodextrins and 6A-deoxy-6A-[[(4-biphenylyl)acetyl]amino]-\u03b1-, -\u03b2-, and -\u03b3-cyclodextrins: potential prodrugs for colon-specific delivery","volume":"40","author":"Uekama","year":"1997","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2019.01.074_bib24","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ijpharm.2009.12.039","article-title":"5-Fluorouracil acetic acid\/\u03b2-cyclodextrin conjugates: drug release behavior in enzymatic and rat cecal media","volume":"388","author":"Udo","year":"2010","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejmech.2019.01.074_bib25","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1038\/srep01104","article-title":"Potential use of folate-appended methyl-\u03b2-cyclodextrin as an anticancer agent","volume":"3","author":"Onodera","year":"2013","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2019.01.074_bib26","doi-asserted-by":"crossref","first-page":"5616","DOI":"10.1016\/j.bmc.2012.07.029","article-title":"Conjugation of cyclodextrin with fullerene as a new class of HCV entry inhibitors","volume":"20","author":"Xiao","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.01.074_bib27","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.carres.2014.08.018","article-title":"Synthesis, characterization, and in\u00a0vitro evaluation of artesunate-\u03b2-cyclodextrin conjugates as novel anti-cancer prodrugs","volume":"400","author":"Jiang","year":"2014","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.ejmech.2019.01.074_bib28","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1002\/cmdc.201300545","article-title":"Synthesis and anti-HCV entry activity studies of \u03b2-cyclodextrin-pentacyclic triterpene conjugates","volume":"9","author":"Xiao","year":"2014","journal-title":"ChemMedChem"},{"key":"10.1016\/j.ejmech.2019.01.074_bib29","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.biomaterials.2015.11.034","article-title":"Pentacyclic triterpenes grafted on CD cores to interfere with influenza virus entry: a dramatic multivalent effect","volume":"78","author":"Xiao","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejmech.2019.01.074_bib30","doi-asserted-by":"crossref","first-page":"4300","DOI":"10.1021\/jm301910a","article-title":"Development of oleanane-type triterpenes as a new class of HCV entry inhibitors","volume":"56","author":"Yu","year":"2013","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2019.01.074_bib31","doi-asserted-by":"crossref","first-page":"10058","DOI":"10.1021\/jm5014067","article-title":"Discovery of pentacyclic triterpenoids as potential entry inhibitors of influenza viruses","volume":"57","author":"Yu","year":"2014","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2019.01.074_bib32","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1002\/med.21484","article-title":"Recent progress in the antiviral activity and mechanism study of pentacyclic triterpenoids and their derivatives","volume":"38","author":"Xiao","year":"2018","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.ejmech.2019.01.074_bib33","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.ejmech.2015.08.034","article-title":"Synthesis and biological evaluation of ring A and\/or C expansion and opening echinocystic acid derivatives for anti-HCV entry inhibitors","volume":"102","author":"Wang","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.01.074_bib34","doi-asserted-by":"crossref","first-page":"8760","DOI":"10.1021\/jo9711549","article-title":"Synthesis of monofacially functionalized cyclodextrins bearing amino pendent groups","volume":"62","author":"Vizitiu","year":"1997","journal-title":"J.\u00a0Org. Chem."},{"key":"10.1016\/j.ejmech.2019.01.074_bib35","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1002\/cber.19290620640","article-title":"The saponification acetyl sugar and relative substances","volume":"62","author":"Zempl\u00e9n","year":"1929","journal-title":"Ber. Dtsch. Chem. Ges."},{"key":"10.1016\/j.ejmech.2019.01.074_bib36","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1021\/ci010368v","article-title":"Prediction of n-octanol\/water partition coefficients from PHYSPROP database using artificial neural networks and E-state indices","volume":"41","author":"Tetko","year":"2001","journal-title":"J.\u00a0Chem. Inf. Comput. Sci."},{"key":"10.1016\/j.ejmech.2019.01.074_bib37","doi-asserted-by":"crossref","first-page":"6752","DOI":"10.1021\/jm901241e","article-title":"Escape from Flatland: increasing saturation as an approach to improving clinical success","volume":"52","author":"Lovering","year":"2009","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2019.01.074_bib38","doi-asserted-by":"crossref","first-page":"3370","DOI":"10.1016\/j.bmc.2014.04.046","article-title":"Amino derivatives of glycyrrhetinic acid as potential inhibitors of cholinesterases","volume":"22","author":"Schwarz","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.01.074_bib39","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.bmc.2009.10.036","article-title":"Synthesis of glycyrrhetinic acid derivatives for the treatment of metabolic diseases","volume":"18","author":"Beseda","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.01.074_bib40","doi-asserted-by":"crossref","first-page":"5356","DOI":"10.1016\/j.ejmech.2011.08.038","article-title":"Synthesis and antitumor activity of ring A modified glycyrrhetinic acid derivatives","volume":"46","author":"Csuk","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.01.074_bib41","first-page":"493","article-title":"A\u00a0simple method of estimating fifty percent endpoint","volume":"27","author":"Ree","year":"1938","journal-title":"Am. J. Hyg."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523419300947?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523419300947?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T18:41:29Z","timestamp":1565203289000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523419300947"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":41,"alternative-id":["S0223523419300947"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2019.01.074","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and structure-activity relationship studies of water-soluble \u03b2-cyclodextrin-glycyrrhetinic acid conjugates as potential anti-influenza virus agents","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2019.01.074","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}