{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T13:40:13Z","timestamp":1776865213864,"version":"3.51.2"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Natural science Fund of Science\u00a0and Technology Department in Jilin","award":["20180101010JC"],"award-info":[{"award-number":["20180101010JC"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.ejmech.2019.03.033","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T01:54:42Z","timestamp":1553046882000},"page":"62-70","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Thiophenol-formaldehyde triazole causes apoptosis induction in ovary cancer cells and prevents tumor growth formation in mice model"],"prefix":"10.1016","volume":"172","author":[{"given":"Yan","family":"Jia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihui","family":"Si","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruixin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongjuan","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenwen","family":"Jian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuli","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2019.03.033_bib1","first-page":"71","article-title":"Cancer statistics","volume":"58","author":"Jemal","year":"2008","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.ejmech.2019.03.033_bib2","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.ymthe.2006.02.019","article-title":"Gene transfer approaches for gynecological diseases","volume":"14","author":"Raki","year":"2006","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ejmech.2019.03.033_bib3","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0140-6736(05)17716-2","article-title":"Epidemiology of ovarian cancer: a status report","volume":"365","author":"Bertone-Johnson","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.ejmech.2019.03.033_bib4","first-page":"225","article-title":"Cancer statistics, 2009","volume":"59","author":"Jemal","year":"2009","journal-title":"Ca - Cancer J. Clin."},{"key":"10.1016\/j.ejmech.2019.03.033_bib5","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.ygyno.2017.12.005","article-title":"Genomic landscape of ovarian clear cell carcinoma via whole exome sequencing","volume":"148","author":"Kim","year":"2018","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ejmech.2019.03.033_bib6","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1016\/j.ajpath.2017.06.012","article-title":"Exome sequencing landscape analysis in ovarian clear cell carcinoma shed light on key chromosomal regions and mutation gene networks","volume":"187","author":"Murakami","year":"2017","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ejmech.2019.03.033_bib7","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/modpathol.2013.107","article-title":"Ovarian and endometrial endometrioid carcinomas have distinct CTNNB1 and PTEN mutation profiles","volume":"27","author":"McConechy","year":"2014","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.ejmech.2019.03.033_bib8","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1186\/1746-1596-7-164","article-title":"Estrogen-producing endometrioid adenocarcinoma resembling sex cord-stromal tumor of the ovary: a review of four postmenopausal cases","volume":"7","author":"Katoh","year":"2012","journal-title":"Diagn. Pathol."},{"key":"10.1016\/j.ejmech.2019.03.033_bib9","first-page":"456","article-title":"Triazoles: a valuable insight into recent developments and biological activities","volume":"11","author":"Sahu","year":"2013","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.ejmech.2019.03.033_bib10","first-page":"760","article-title":"WOMBAT and WOMBAT-PK: bioactivity databases for lead and drug discovery","volume":"vols. 1\u20133","author":"Olah","year":"2008"},{"key":"10.1016\/j.ejmech.2019.03.033_bib11","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/2191-2858-2-26","article-title":"Synthesis and evaluation of antitumor activities of novel chiral 1,2,4-triazole Schiff bases bearing \u03b3-butenolide moiety","volume":"2","author":"Li","year":"2012","journal-title":"Org. Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2019.03.033_bib12","first-page":"6","article-title":"Synthesis, characterization and anti-cancer activity of some fluorinated 3,6-diaryl-[1,2,4] triazolo[3,4-b][1,3,4]thiadiazoles","author":"Chowrasia","year":"2013","journal-title":"Arab. J. Chem"},{"key":"10.1016\/j.ejmech.2019.03.033_bib13","unstructured":"P. Chand, J.A. Chesney, B.F. Clem, G.H. Tapolsky, S. Telang, J.O. Trent, Small-Molecule Choline Kinase Inhibitors as Anti-cancer Therapeutics. Patent: US 2011\/0257211 A1."},{"key":"10.1016\/j.ejmech.2019.03.033_bib14","doi-asserted-by":"crossref","first-page":"5948","DOI":"10.1016\/j.bmc.2011.08.063","article-title":"Synthesis and antitumor activity of 1,2,4-triazoles having 1,4-benzodioxan fragment as a novel class of potent methionine aminopeptidase type II inhibitors","volume":"19","author":"Hou","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.03.033_bib15","first-page":"46","article-title":"Docking studies and biological evaluation of anti-cancer activity of new 1,2,4-triazole (4h) derivatives","volume":"1","author":"Georgiyants","year":"2014","journal-title":"Scr. Sci. Pharm."},{"key":"10.1016\/j.ejmech.2019.03.033_bib16","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0014-827X(01)01094-1","article-title":"Synthesis of some halogen-containing 1,2,4-triazolo-1,3,4-thiadiazines and their antibacterial and anticancer screening studies - part I","volume":"56","author":"Holla","year":"2001","journal-title":"Farmaco"},{"key":"10.1016\/j.ejmech.2019.03.033_bib17","doi-asserted-by":"crossref","first-page":"141","DOI":"10.4103\/2231-4040.161515","article-title":"Synthesis, antifungal and antibacterial activity of novel 1,2,4-triazole derivatives","volume":"6","author":"Gupta","year":"2015","journal-title":"J.\u00a0Adv. Pharm. Technol. Res."},{"key":"10.1016\/j.ejmech.2019.03.033_bib18","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.bioorg.2017.01.010","article-title":"Medicinal attributes of 1,2,3-triazoles: current developments","volume":"71","author":"Dheer","year":"2017","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2019.03.033_bib19","doi-asserted-by":"crossref","first-page":"4829","DOI":"10.1016\/j.bmc.2008.03.049","article-title":"1,5-Disubstituted 1,2,3-triazoles as cis-restricted analogues of combretastatin A-4: synthesis, molecular modeling and evaluation as cytotoxic agents and inhibitors of tubulin","volume":"16","author":"Odlo","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.03.033_bib20","doi-asserted-by":"crossref","first-page":"6157","DOI":"10.1016\/j.bmc.2015.07.069","article-title":"Synthesis of 1,2-benzisoxazole tethered 1,2,3-triazoles that exhibit anticancer activity in acute myeloid leukemia cell lines by inhibiting histone deacetylases, and inducing p21 and tubulin acetylation","volume":"23","author":"Ashwini","year":"2015","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.03.033_bib21","first-page":"66","article-title":"Bioactivity of 1,4-disubstituted 1,2,3-triazoles as cytotoxic agents against the various human cell lines","volume":"4","author":"Bathula","year":"2011","journal-title":"Asian J. Pharm. Clin. Res."},{"key":"10.1016\/j.ejmech.2019.03.033_bib22","doi-asserted-by":"crossref","first-page":"663","DOI":"10.3797\/scipharm.1302-04","article-title":"Synthesis of 1,2,3-triazole derivatives and evaluation of their anticancer activity","volume":"81","author":"Pokhodylo","year":"2013","journal-title":"Sci. Pharm."},{"key":"10.1016\/j.ejmech.2019.03.033_bib23","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.ejmech.2013.03.028","article-title":"Synthesis of 3-O-propargylated betulinic acid and its 1,2,3-triazoles as potential apoptotic agents","volume":"63","author":"Majeed","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.03.033_bib24","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.1002\/asia.201100432","article-title":"Click chemistry: 1,2,3-triazoles as pharmacophores","volume":"6","author":"Agalave","year":"2011","journal-title":"Chem. Asian J."},{"key":"10.1016\/j.ejmech.2019.03.033_bib25","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.3892\/ol.2015.3261","article-title":"Tumstatin induces apoptosis mediated by Fas signaling pathway in oral squamous cell carcinoma SCC-VII cells","volume":"10","author":"Hwang-B","year":"2015","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.ejmech.2019.03.033_bib26","first-page":"101","article-title":"Dihydroartiminisin inhibits the growth and metastasis of epithelial ovarian cancer","volume":"27","author":"Wu","year":"2012","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.ejmech.2019.03.033_bib27","doi-asserted-by":"crossref","first-page":"523","DOI":"10.3892\/ijo.2012.1465","article-title":"Orlistat, a novel potent antitumor agent for ovarian cancer: proteomic analysis of ovarian cancer cells treated with Orlistat","volume":"41","author":"Huang","year":"2012","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.ejmech.2019.03.033_bib28","first-page":"101","article-title":"Dihydroartiminisin inhibits the growth and metastasis of epithelial ovarian cancer","volume":"27","author":"Wui","year":"2012","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.ejmech.2019.03.033_bib29","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ygyno.2006.02.037","article-title":"Arsenic trioxide (As(2)O(3)) inhibits peritoneal invasion of ovarian carcinoma cells in\u00a0vitro and in\u00a0vivo","volume":"103","author":"Zhang","year":"2006","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.ejmech.2019.03.033_bib30","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.matbio.2005.06.005","article-title":"Proteoglycan control of cell movement during wound healing and cancer spreading","volume":"24","author":"Cattaruzza","year":"2005","journal-title":"Matrix Biol."},{"key":"10.1016\/j.ejmech.2019.03.033_bib31","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1634\/theoncologist.6-5-415","article-title":"Matrix metalloproteinase inhibitors: current developments and future perspectives","volume":"6","author":"Hoekstra","year":"2001","journal-title":"Oncol."},{"key":"10.1016\/j.ejmech.2019.03.033_bib32","doi-asserted-by":"crossref","first-page":"5606","DOI":"10.1038\/sj.onc.1203877","article-title":"Focal adhesion kinase: a regulator of focal adhesion dynamics and cell movement","volume":"19","author":"Parsons","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/j.ejmech.2019.03.033_bib33","doi-asserted-by":"crossref","first-page":"347","DOI":"10.4161\/cam.3.4.9458","article-title":"The role of focal adhesion kinase in tumor initiation and progression","volume":"3","author":"Provenzano","year":"2009","journal-title":"Cell Adhes. Migrat."},{"key":"10.1016\/j.ejmech.2019.03.033_bib34","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/sj.tpj.6500371","article-title":"Microarray expression profiles of angiogenesis-related genes predict tumor cell response to artemisinins","volume":"6","author":"Anfosso","year":"2006","journal-title":"Pharmacogenomics J."},{"key":"10.1016\/j.ejmech.2019.03.033_bib35","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1093\/jnci\/84.24.1875","article-title":"Tumor angiogenesis: a new significant and independent prognostic indicator in early-stage breast carcinoma","volume":"84","author":"Weidner","year":"1992","journal-title":"J.\u00a0Natl. Cancer Inst."},{"key":"10.1016\/j.ejmech.2019.03.033_bib36","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature01322","article-title":"Inflammation and cancer","volume":"420","author":"Coussens","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2019.03.033_bib37","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1158\/0008-5472.CAN-05-4005","article-title":"Distinct role of macrophages in different tumor microenvironments","volume":"66","author":"Lewis","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejmech.2019.03.033_bib38","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1084\/jem.176.4.1165","article-title":"Expression of adhesion molecules and chemotactic cytokines in cultured human mesothelial cells","volume":"176","author":"Jonjic","year":"1992","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.ejmech.2019.03.033_bib39","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1158\/1078-0432.113.11.1","article-title":"Peritoneal and subperitoneal stroma may facilitate regional spread of ovarian cancer","volume":"11","author":"Wang","year":"2005","journal-title":"Clin. Cancer Res."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S022352341930251X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S022352341930251X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T13:51:51Z","timestamp":1759326711000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S022352341930251X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":39,"alternative-id":["S022352341930251X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2019.03.033","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thiophenol-formaldehyde triazole causes apoptosis induction in ovary cancer cells and prevents tumor growth formation in mice model","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2019.03.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}