{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T03:44:27Z","timestamp":1793245467027,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Research Grants Council of the Hong Kong Special Administrative Region","award":["14303214"],"award-info":[{"award-number":["14303214"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.ejmech.2019.06.082","type":"journal-article","created":{"date-parts":[[2019,6,29]],"date-time":"2019-06-29T02:03:38Z","timestamp":1561773818000},"page":"828-836","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Construction of cathepsin B-responsive fluorescent probe and photosensitizer using a ferrocenyl boron dipyrromethene dark quencher"],"prefix":"10.1016","volume":"179","author":[{"given":"Qiong","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ligang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy C.H.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0315-8538","authenticated-orcid":false,"given":"Pui-Chi","family":"Lo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2019.06.082_bib1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.cbpa.2009.09.029","article-title":"Near-infrared fluorescence: application to in\u00a0vivo molecular imaging","volume":"14","author":"Hilderbrand","year":"2010","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.ejmech.2019.06.082_bib2","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1021\/acs.accounts.6b00239","article-title":"Tissue-specific near-infrared fluorescence imaging","volume":"49","author":"Owens","year":"2016","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.ejmech.2019.06.082_bib3","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1021\/ar300273v","article-title":"FRET-based small-molecule fluorescent probes: rational design and bioimaging applications","volume":"46","author":"Yuan","year":"2013","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.ejmech.2019.06.082_bib4","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/j.drudis.2017.04.006","article-title":"Recent advances in activatable fluorescence imaging probes for tumor imaging","volume":"22","author":"Zhao","year":"2017","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.ejmech.2019.06.082_bib5","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1177\/002215549904700910","article-title":"Alexa dyes, a series of new fluorescent dyes that yield exceptionally bright, photostable conjugates","volume":"47","author":"Panchuk-Voloshina","year":"1999","journal-title":"J.\u00a0Histochem. Cytochem."},{"key":"10.1016\/j.ejmech.2019.06.082_bib6","article-title":"Fluorescent J-aggregates of cyanine dyes: basic research and applications review","volume":"6","author":"Bricks","year":"2018","journal-title":"Methods Appl. Fluoresc."},{"key":"10.1016\/j.ejmech.2019.06.082_bib7","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/nmeth.1248","article-title":"Quantum dots versus organic dyes as fluorescent labels","volume":"5","author":"Resch-Genger","year":"2008","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ejmech.2019.06.082_bib8","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1002\/chem.201203427","article-title":"Bioconjugatable azo-based dark-quencher dyes: synthesis and application to protease-activatable far-red fluorescent probes","volume":"19","author":"Chevalier","year":"2013","journal-title":"Chem. Eur J."},{"key":"10.1016\/j.ejmech.2019.06.082_bib9","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1021\/bc100457s","article-title":"Synthesis, in\u00a0vitro evaluation, and in\u00a0vivo metabolism of fluor\/quencher compounds containing IRDye 800CW and black hole quencher-3 (BHQ-3)","volume":"22","author":"Linder","year":"2011","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.ejmech.2019.06.082_bib10","doi-asserted-by":"crossref","first-page":"5443","DOI":"10.1002\/adfm.201400419","article-title":"Protease-activatable hybrid nanoprobe for tumor imaging","volume":"24","author":"Wang","year":"2014","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.ejmech.2019.06.082_bib11","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1021\/acs.bioconjchem.5b00170","article-title":"Human transport protein carrier for controlled photoactivation of antitumor prodrug and real-time intracellular tumor imaging","volume":"26","author":"Li","year":"2015","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.ejmech.2019.06.082_bib12","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.ab.2009.02.024","article-title":"A\u00a0nonfluorescent, broad-range quencher dye for F\u00f6rster resonance energy transfer assays","volume":"388","author":"Peng","year":"2009","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ejmech.2019.06.082_bib13","doi-asserted-by":"crossref","first-page":"17225","DOI":"10.1021\/jacs.7b07913","article-title":"DNA aptamer-based activatable probes for photoacoustic imaging in living mice","volume":"139","author":"Zhang","year":"2017","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2019.06.082_bib14","doi-asserted-by":"crossref","first-page":"7069","DOI":"10.1021\/am302704a","article-title":"Graphene oxide as a quencher for fluorescent assay of amino acids, peptides, and proteins","volume":"4","author":"Li","year":"2012","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.ejmech.2019.06.082_bib15","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.1021\/acs.analchem.7b04171","article-title":"Two-photon DNAzyme-gold nanoparticle probe for imaging intracellular metal ions","volume":"90","author":"Yang","year":"2018","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ejmech.2019.06.082_bib16","doi-asserted-by":"crossref","first-page":"4001","DOI":"10.1039\/C5AN00320B","article-title":"A\u00a0turn-on near-infrared fluorescent chemosensor for selective detection of lead ions based on a fluorophore\u2013gold nanoparticle assembly","volume":"140","author":"Wang","year":"2015","journal-title":"Analyst"},{"key":"10.1016\/j.ejmech.2019.06.082_bib17","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1021\/bc200424r","article-title":"Multi-path quenchers: efficient quenching of common fluorophores","volume":"22","author":"Crisalli","year":"2011","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.ejmech.2019.06.082_bib18","doi-asserted-by":"crossref","first-page":"4759","DOI":"10.1021\/jacs.5b00246","article-title":"Development of a series of near-infrared dark quenchers based on Si-rhodamines and their application to fluorescent probes","volume":"137","author":"Myochin","year":"2015","journal-title":"J.\u00a0Am. Soc. Chem."},{"key":"10.1016\/j.ejmech.2019.06.082_bib19","doi-asserted-by":"crossref","first-page":"17798","DOI":"10.1039\/C6DT03141B","article-title":"A\u00a0biotin-conjugated glutathione-responsive FRET-based fluorescent probe with a ferrocenyl BODIPY as the dark quencher","volume":"45","author":"Shi","year":"2016","journal-title":"Dalton Trans."},{"key":"10.1016\/j.ejmech.2019.06.082_bib20","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1039\/C5TC01222H","article-title":"Preparation of Bodipy-ferrocene dyads and modulation of the singlet\/triplet excited state of bodipy via electron transfer and triplet energy transfer","volume":"4","author":"Wu","year":"2016","journal-title":"J.\u00a0Mater. Chem. C"},{"key":"10.1016\/j.ejmech.2019.06.082_bib21","doi-asserted-by":"crossref","first-page":"3044","DOI":"10.1021\/acs.inorgchem.6b03158","article-title":"Synthesis and characterization of ferrocenyl chlorins, 1,1\u2019-ferrocene-linked chlorin dimers, and their BODIPY analogues","volume":"56","author":"Arkhypchuk","year":"2017","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.ejmech.2019.06.082_bib22","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.jorganchem.2010.01.009","article-title":"Synthesis of boron-dipyrromethene-ferrocene conjugates","volume":"695","author":"Rajeswara Rao","year":"2010","journal-title":"J.\u00a0Organomet. Chem."},{"key":"10.1016\/j.ejmech.2019.06.082_bib23","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1517\/14728222.2013.740461","article-title":"Cathepsin B as a cancer target","volume":"17","author":"Gondi","year":"2013","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.ejmech.2019.06.082_bib24","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.biomaterials.2017.01.020","article-title":"In\u00a0vivo near-infrared imaging and phototherapy of tumors using a cathepsin B-activated fluorescent probe","volume":"122","author":"Chen","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejmech.2019.06.082_bib25","doi-asserted-by":"crossref","first-page":"3486","DOI":"10.1021\/acs.chemmater.8b01149","article-title":"Cascade-promoted photo-chemotherapy against resistant cancers by enzyme-responsive polyprodrug nanoplatforms","volume":"30","author":"Wang","year":"2018","journal-title":"Chem. Mater."},{"key":"10.1016\/j.ejmech.2019.06.082_bib26","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1021\/acsami.6b14446","article-title":"Multifunctional metal-organic framework nanoprobe for cathepsin B-activated cancer cell imaging and chemo-photodynamic therapy","volume":"9","author":"Liu","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.ejmech.2019.06.082_bib27","doi-asserted-by":"crossref","first-page":"4225","DOI":"10.1002\/chem.201103516","article-title":"A\u00a0phthalocyanine-peptide conjugate with high in\u00a0vitro photodynamic activity and enhanced in\u00a0vivo tumor-retention property","volume":"18","author":"Ke","year":"2012","journal-title":"Chem. Eur J."},{"key":"10.1016\/j.ejmech.2019.06.082_bib28","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.dyepig.2018.11.055","article-title":"Synthesis and biological evaluation of phthalocyanine-peptide conjugate for EGFR-targeted photodynamic therapy and bioimaging","volume":"163","author":"Yu","year":"2019","journal-title":"Dyes Pigm."},{"key":"10.1016\/j.ejmech.2019.06.082_bib29","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1021\/bc500258b","article-title":"Cell uptake and localization studies of squaramide based fluorescent probes","volume":"25","author":"Sampedro","year":"2014","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.ejmech.2019.06.082_bib30","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3892\/ijo.2012.1754","article-title":"Cathepsin B-cleavable doxorubicin prodrugs for targeted cancer therapy","volume":"42","author":"Zhong","year":"2013","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.ejmech.2019.06.082_bib31","series-title":"Solid Phase Peptide Synthesis: a Practical Approach","author":"Atherton","year":"1989"}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523419306099?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523419306099?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T14:04:31Z","timestamp":1759327471000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523419306099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":31,"alternative-id":["S0223523419306099"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2019.06.082","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Construction of cathepsin B-responsive fluorescent probe and photosensitizer using a ferrocenyl boron dipyrromethene dark quencher","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2019.06.082","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}