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Asp."},{"key":"10.1016\/j.ejmech.2019.07.043_bib76","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1080\/17415993.2018.1441841","article-title":"One-pot three-component synthesis of some novel ethyl 3-alkyl-2-thioxo-2, 3-dihydrothiazole-4-carboxylates under solvent-and catalyst-free conditions at room temperature","volume":"39","author":"Iravani","year":"2018","journal-title":"J.\u00a0Sulfur Chem."},{"key":"10.1016\/j.ejmech.2019.07.043_bib77","first-page":"191","article-title":"Utility of chloroacetonitrile in construction of some hitherto novel pyrazole and thiazole derivatives","volume":"15","author":"Khalil","year":"2018","journal-title":"J.\u00a0Iran. Chem. Soc."},{"key":"10.1016\/j.ejmech.2019.07.043_bib78","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1080\/00397911.2017.1412465","article-title":"Synthesis and evaluation of some new 5-(hetaryl) thiazoles as potential antimicrobial agents","volume":"48","author":"Bondock","year":"2018","journal-title":"Synth. 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Chem."},{"key":"10.1016\/j.ejmech.2019.07.043_bib81","doi-asserted-by":"crossref","first-page":"3287","DOI":"10.1016\/j.bmc.2018.04.056","article-title":"Efficiency of newly prepared thiazole derivatives against some cutaneous fungi","volume":"26","author":"Ouf","year":"2018","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.07.043_bib82","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ejps.2019.04.005","article-title":"Design, computational studies, synthesis and biological evaluation of thiazole-based molecules as anticancer agents","volume":"134","author":"Patel","year":"2019","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejmech.2019.07.043_bib83","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.ejmech.2018.01.015","article-title":"Synthesis and biological evaluation of 4-amino-5-cinnamoylthiazoles as chalcone-like anticancer agents","volume":"145","author":"Ayati","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.07.043_bib84","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.ejmech.2017.12.040","article-title":"Synthesis, anticancer activity and mechanism of action of new thiazole derivatives","volume":"144","author":"de Santana","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.07.043_bib85","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/j.bmcl.2017.01.094","article-title":"Synthesis, molecular docking and \u03b1-glucosidase inhibition of 2-((5, 6-diphenyl-1, 2, 4-triazin-3-yl) thio)-N-arylacetamides","volume":"27","author":"Wang","year":"2017","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2019.07.043_bib86","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1007\/s00044-017-1851-8","article-title":"Synthesis, docking, and evaluation of novel thiazoles for potent antidiabetic activity","volume":"26","author":"Sravanthi","year":"2017","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.ejmech.2019.07.043_bib87","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.bioorg.2018.03.015","article-title":"Synthesis, biological evaluation, and docking studies of novel 5, 6-diaryl-1, 2, 4-triazine thiazole derivatives as a new class of \u03b1-glucosidase inhibitors","volume":"78","author":"Wang","year":"2018","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2019.07.043_bib88","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1007\/s11164-017-3164-4","article-title":"Synthesis and biological evaluation of new 2-aryl-4-((4-aryl-1H-1, 2, 3-triazol-1-yl) methyl) thiazole derivatives","volume":"44","author":"Shinde","year":"2018","journal-title":"Res. Chem. Intermed."},{"key":"10.1016\/j.ejmech.2019.07.043_bib89","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.bmcl.2017.01.018","article-title":"Synthesis and biological evaluation of thiazole derivatives as novel USP7 inhibitors, Bioorg","volume":"27","author":"Chen","year":"2017","journal-title":"Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2019.07.043_bib90","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.biopha.2016.12.112","article-title":"Thiosemicarbazones and Phthalyl-Thiazoles compounds exert antiviral activity against yellow fever virus and Saint Louis encephalitis virus","volume":"87","author":"Pacca","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejmech.2019.07.043_bib91","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.ejmech.2015.08.005","article-title":"Synthesis and antiviral activity of some new bis-1, 3-thiazole derivatives","volume":"102","author":"Dawood","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.07.043_bib92","doi-asserted-by":"crossref","first-page":"7445","DOI":"10.1016\/S0040-4020(03)01070-6","article-title":"The chemistry of isothiazoles","volume":"59","author":"Elgazwy","year":"2003","journal-title":"Tetrahedron"},{"key":"10.1016\/j.ejmech.2019.07.043_bib93","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/S0959-6380(99)80012-9","article-title":"5 Five-membered ring systems: with N & S (Se) Atoms","volume":"11","author":"Bradley","year":"1999","journal-title":"Prog. Heterocycl. Chem."},{"key":"10.1016\/j.ejmech.2019.07.043_bib94","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1070\/RC2002v071n08ABEH000738","article-title":"Isothiazoles (1, 2-thiazoles): synthesis, properties and applications","volume":"71","author":"Kaberdin","year":"2002","journal-title":"Russ. Chem. Rev."},{"key":"10.1016\/j.ejmech.2019.07.043_bib95","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1039\/a703033i","article-title":"Reaction of trithiazyl trichloride with active methylene compounds","volume":"1","author":"Duan","year":"1997","journal-title":"J.\u00a0Chem. Soc. Perkin."},{"key":"10.1016\/j.ejmech.2019.07.043_bib96","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/186221a0","article-title":"Sulphasomizole (5-p-Aminobenzenesulphonamido-3-Methyl\/sothiazole): a new antibacterial sulphonamide","volume":"186","author":"Adams","year":"1960","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2019.07.043_bib97","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0022-3565(25)12023-5","article-title":"Ziprasidone (CP-88,059): a new antipsychotic with combined dopamine and serotonin receptor antagonist activity","volume":"275","author":"Seeger","year":"1995","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejmech.2019.07.043_bib98","doi-asserted-by":"crossref","first-page":"329","DOI":"10.2165\/00023210-200115040-00006","article-title":"Perospirone","volume":"15","author":"Onrust","year":"2001","journal-title":"CNS Drugs"},{"key":"10.1016\/j.ejmech.2019.07.043_bib99","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.ejmech.2006.01.009","article-title":"Isothiazoles. Part XV. A mild and efficient synthesis of new antiproliferative 5-sulfanylsubstituted 3-alkylaminoisothiazole 1, 1-dioxides","volume":"41","author":"Clerici","year":"2006","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.07.043_bib100","doi-asserted-by":"crossref","first-page":"5050","DOI":"10.1021\/acs.orglett.6b02499","article-title":"Synthesis of isothiazole via the rhodium-catalyzed transannulation of 1, 2, 3-thiadiazoles with nitriles","volume":"18","author":"Seo","year":"2016","journal-title":"Org. Lett."},{"key":"10.1016\/j.ejmech.2019.07.043_bib101","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1021\/acs.orglett.6b00997","article-title":"Metal-and catalyst-free, formal [4+ 1] annulation via tandem C=O\/C=S functionalization: one-pot access to 3, 5-disubstituted\/annulated isothiazoles","volume":"18","author":"Shukla","year":"2016","journal-title":"Org. Lett."},{"key":"10.1016\/j.ejmech.2019.07.043_bib102","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1021\/acs.jmedchem.8b00994","volume":"62","author":"Bollinger","year":"2018","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2019.07.043_bib103","doi-asserted-by":"crossref","first-page":"39593","DOI":"10.1039\/C8RA07619G","article-title":"Design, synthesis and fungicidal activity of isothiazole\u2013thiazole derivatives","volume":"8","author":"Wu","year":"2018","journal-title":"RSC Adv."},{"key":"10.1016\/j.ejmech.2019.07.043_bib104","first-page":"731","article-title":"Design, synthesis and biological evaluation of isothiazole based 1, 2, 4-trizaole derivatives, chin","volume":"36","author":"Chen","year":"2018","journal-title":"J.\u00a0Chem."},{"key":"10.1016\/j.ejmech.2019.07.043_bib105","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1021\/acsmedchemlett.7b00233","article-title":"Discovery of an isothiazole-based phenylpropanoic acid GPR120 agonist as a development candidate for Type 2 diabetes","volume":"8","author":"Zhang","year":"2017","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.ejmech.2019.07.043_bib106","first-page":"2336","article-title":"Design and synthesis of selective CDK8\/19 dual inhibitors: discovery of 4, 5-dihydrothieno [3\u2032, 4\u2032: 3, 4] benzo [1, 2-d] isothiazole derivatives, Bioorg","volume":"25","author":"Ono","year":"2017","journal-title":"Med. Chem."},{"key":"10.1016\/j.ejmech.2019.07.043_bib107","doi-asserted-by":"crossref","first-page":"4677","DOI":"10.1016\/j.bmc.2017.07.008","article-title":"Synthesis and diabetic neuropathic pain-alleviating effects of 2N-(pyrazol-3-yl) methylbenzo [d] isothiazole-1, 1-dioxide derivatives","volume":"25","author":"Hong","year":"2017","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.07.043_bib108","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1002\/cber.19851180430","article-title":"Synthese und Reaktionen des 4, 5-Dichlor-1, 2, 3-dithiazolium-chlorids","volume":"118","author":"Appel","year":"1985","journal-title":"Chem. Ber."},{"key":"10.1016\/j.ejmech.2019.07.043_bib109","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1070\/RC2008v077n06ABEH003784","article-title":"Synthesis and properties of 1, 2, 3-dithiazoles","volume":"77","author":"Konstantinova","year":"2008","journal-title":"Russ. Chem. Rev."},{"key":"10.1016\/j.ejmech.2019.07.043_bib110","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.mencom.2015.09.005","article-title":"Novel long-lived \u03c0-heterocyclic radical anion: a hybrid of 1, 2, 5-thiadiazo-and 1, 2, 3-dithiazolidyls","volume":"25","author":"Chulanova","year":"2015","journal-title":"Mendeleev Commun."},{"key":"10.1016\/j.ejmech.2019.07.043_bib111","series-title":"German Patent, Chem. Abstr. 102","first-page":"113064","author":"Mayer","year":"1985"},{"key":"10.1016\/j.ejmech.2019.07.043_bib112","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0968-0896(01)00294-2","article-title":"Antimicrobial and antitumor activity of N-heteroimmine-1, 2, 3-dithiazoles and their transformation in triazolo-, imidazo-, and pyrazolopirimidines","volume":"10","author":"Baraldi","year":"2002","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.07.043_bib113","doi-asserted-by":"crossref","first-page":"10321","DOI":"10.1021\/acs.joc.6b01307","article-title":"formation of 1, 4, 2-dithiazolidines or 1, 3-thiazetidines from 1, 1-Dichloro-2-nitroethene and phenylthiourea derivatives","volume":"81","author":"Feng","year":"2016","journal-title":"J.\u00a0Org. Chem."},{"key":"10.1016\/j.ejmech.2019.07.043_bib114","doi-asserted-by":"crossref","first-page":"4387","DOI":"10.1016\/j.tet.2017.05.098","article-title":"Synthesis of novel five-membered endocyclic sulfoximines\u20141-aryl-3-(arylimino)-3, 5-dihydro-1, 4, 2-dithiazole 1-oxides","volume":"73","author":"Hua","year":"2017","journal-title":"Tetrahedron"},{"key":"10.1016\/j.ejmech.2019.07.043_bib115","doi-asserted-by":"crossref","first-page":"4819","DOI":"10.1021\/acs.orglett.8b01970","article-title":"Photocatalytic construction of S\u2013S and C\u2013S Bonds promoted by acridinium salt: an unexpected pathway to synthesize 1, 2, 4-Dithiazoles","volume":"20","author":"Huang","year":"2018","journal-title":"Org. Lett."},{"key":"10.1016\/j.ejmech.2019.07.043_bib116","doi-asserted-by":"crossref","first-page":"596","DOI":"10.3390\/molecules21050596","article-title":"Fused 1, 2, 3-dithiazoles: convenient synthesis, structural characterization, and electrochemical properties","volume":"21","author":"Konstantinova","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2019.07.043_bib117","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.bcp.2017.07.006","article-title":"Potent inhibitors of human LAT1 (SLC7A5) transporter based on dithiazole and dithiazine compounds for development of anticancer drugs","volume":"143","author":"Napolitano","year":"2017","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejmech.2019.07.043_bib118","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1002\/cmdc.201600260","article-title":"Evaluation of substituted 1, 2, 3-dithiazoles as inhibitors of the feline immunodeficiency virus (FIV) nucleocapsid protein via a proposed zinc ejection mechanism","volume":"11","author":"Asquith","year":"2016","journal-title":"ChemMedChem"},{"key":"10.1016\/j.ejmech.2019.07.043_bib119","doi-asserted-by":"crossref","first-page":"9265","DOI":"10.1007\/s00253-016-7759-2","article-title":"Dithiazole thione derivative as competitive NorA efflux pump inhibitor to curtail multi drug resistant clinical isolate of MRSA in a zebrafish infection model","volume":"100","author":"Lowrence","year":"2016","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.ejmech.2019.07.043_bib120","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1039\/C7NJ03846A","article-title":"Dihydro-2 H-thiopyran-3 (4 H)-one-1, 1-dioxide\u2013a versatile building block for the synthesis of new thiopyran-based heterocyclic systems","volume":"2","author":"Palchykov","year":"2018","journal-title":"New J. Chem."},{"key":"10.1016\/j.ejmech.2019.07.043_bib121","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s11030-008-9098-4","article-title":"Ionic liquid promoted preparation of 4H-thiopyran and pyrimidine nucleoside-thiopyran hybrids through one-pot multi-component reaction of thioamide","volume":"13","author":"Zhang","year":"2009","journal-title":"Mol. Divers."},{"key":"10.1016\/j.ejmech.2019.07.043_bib122","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1080\/17415993.2013.789517","article-title":"Synthesis, metallation and nucleophilic reactivity of 2, 6-bis (trialkylsilyl)-4H-thiopyrans","volume":"34","author":"Nocentini","year":"2013","journal-title":"J.\u00a0Sulfur Chem."},{"key":"10.1016\/j.ejmech.2019.07.043_bib123","doi-asserted-by":"crossref","first-page":"7836","DOI":"10.1039\/C7NJ01211J","article-title":"A\u00a0convenient electro-catalyzed multicomponent synthesis of 4 H-thiopyran derivatives","volume":"41","author":"Dubey","year":"2017","journal-title":"New J. Chem."},{"key":"10.1016\/j.ejmech.2019.07.043_bib124","first-page":"526","article-title":"Mechanistic study on a novel pseudo-five-component synthesis of 4 H-thiopyrans, phosphorus sulfur silicon relat","volume":"192","author":"Asadbegi","year":"2017","journal-title":"Elements"},{"key":"10.1016\/j.ejmech.2019.07.043_bib125","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1515\/znb-2017-0183","article-title":"Fused thia-heterocycles via isothiocyanates. Part II. A convenient synthesis of some new thieno [2, 3-b] thiopyran-4-one derivatives","volume":"73","author":"El-Agha","year":"2018","journal-title":"Z.\u00a0Naturforschung B"},{"key":"10.1016\/j.ejmech.2019.07.043_bib126","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1080\/00397911.2017.1346810","article-title":"Efficient multicomponent synthesis of spiro [indoline-3, 4\u2032-thiopyran]-2-ones","volume":"47","author":"Kurva","year":"2017","journal-title":"Synth. 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Lett."},{"key":"10.1016\/j.ejmech.2019.07.043_bib129","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/cbdd.12356","article-title":"Identification of 1, 4-dihydrothieno [3\u2032, 2\u2032: 5, 6] thiopyrano [4, 3-c] pyrazole derivatives as human 5-Lipo-oxygenase inhibitors","volume":"84","author":"Hu","year":"2014","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.ejmech.2019.07.043_bib130","first-page":"1","article-title":"Synthesis and antimicrobial evaluation of some new bicyclopyrazolone-based thiopyran ring systems","volume":"66","author":"Pasha","year":"2019","journal-title":"J.\u00a0Chin. Chem. Soc."},{"key":"10.1016\/j.ejmech.2019.07.043_bib131","doi-asserted-by":"crossref","first-page":"5268","DOI":"10.1016\/j.bmc.2017.07.049","article-title":"Design, synthesis and biological evaluation of novel antitumor spirotetrahydrothiopyran\u2013oxindole derivatives as potent p53-MDM2 inhibitors","volume":"25","author":"Ji","year":"2017","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.07.043_bib132","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1021\/acs.orglett.6b00155","article-title":"Meeting organocatalysis with drug discovery: asymmetric synthesis of 3, 3\u2032-Spirooxindoles fused with tetrahydrothiopyrans as novel p53-MDM2 inhibitors","volume":"18","author":"Wang","year":"2016","journal-title":"Org. Lett."},{"key":"10.1016\/j.ejmech.2019.07.043_bib133","doi-asserted-by":"crossref","first-page":"7291","DOI":"10.1007\/s11164-017-3075-4","article-title":"Synthesis and characterization of sulfide, sulfoxide and sulfone derivatives of thiopyran: antimicrobial evaluation","volume":"43","author":"Pasha","year":"2017","journal-title":"Res. Chem. Intermed."},{"key":"10.1016\/j.ejmech.2019.07.043_bib134","first-page":"1245","article-title":"Synthesis, anticancer and antiviral activities of novel thiopyrano [2, 3-d] thiazole-6-carbaldehydes, Phosphorus Sulfur Silicon Relat","volume":"191","author":"Lozynskyi","year":"2016","journal-title":"Elements"},{"key":"10.1016\/j.ejmech.2019.07.043_bib135","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ejmech.2015.08.027","article-title":"Investigation of new 2-aryl substituted Benzothiopyrano [4, 3-d] pyrimidines as kinase inhibitors targeting vascular endothelial growth factor receptor 2","volume":"103","author":"Salerno","year":"2015","journal-title":"Eur. J. Med. 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Sci. A Polym. Chem."},{"key":"10.1016\/j.ejmech.2019.07.043_bib139","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1016\/j.tetlet.2015.03.023","article-title":"Facile synthesis of 3-aldehyde-2-substituted thiophenes through Lewis base catalyzed [3+ 2] cycloaddition of 1, 4-dithiane-2, 5-diols with ynals","volume":"56","author":"Shi","year":"2015","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.ejmech.2019.07.043_bib140","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1002\/adsc.201800241","article-title":"Fe-catalyzed dithiane radical induced C\u2212 S bond activation\u2212 addition to \u03b1, \u03b2-unsaturated ketones","volume":"360","author":"Min","year":"2018","journal-title":"Adv. Synth. 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Chem. Lett."},{"key":"10.1016\/j.ejmech.2019.07.043_bib145","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s41061-018-0184-5","article-title":"Analysis of US FDA-approved drugs containing sulfur atoms","volume":"376","author":"Scott","year":"2018","journal-title":"Top. Curr. Chem."},{"key":"10.1016\/j.ejmech.2019.07.043_bib146","doi-asserted-by":"crossref","first-page":"8376","DOI":"10.1021\/acs.joc.8b01029","article-title":"Synthesis of 1, 4-thiazepines","volume":"83","author":"Kelgokmen","year":"2018","journal-title":"J.\u00a0Org. 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Lett"},{"key":"10.1016\/j.ejmech.2019.07.043_bib149","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/jccs.201600778","article-title":"Synthesis and characterization of thiazepine\/benzothiazepine derivatives through intramolecular C-2 ring expansion pathway","volume":"64","author":"Preet","year":"2017","journal-title":"J.\u00a0Chin. Chem. Soc."},{"key":"10.1016\/j.ejmech.2019.07.043_bib150","first-page":"1265","article-title":"Synthesis and characterization of thiazepine derivatives and their biological activity","volume":"56 B","author":"Kumari","year":"2017","journal-title":"Indian J. Chem."},{"key":"10.1016\/j.ejmech.2019.07.043_bib151","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.ejmech.2017.01.021","article-title":"Synthesis and anti-proliferative activity evaluation of novel benzo [d][1, 3] dioxoles-fused 1, 4-thiazepines","volume":"127","author":"Wu","year":"2017","journal-title":"Eur. J. Med. 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