{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T10:50:47Z","timestamp":1781607047503,"version":"3.54.5"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.ejmech.2019.07.057","type":"journal-article","created":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T11:13:35Z","timestamp":1563794015000},"page":"648-655","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Synthesis and biological evaluation of moxifloxacin-acetyl-1,2,3-1H-triazole-methylene-isatin hybrids as potential anti-tubercular agents against both drug-susceptible and drug-resistant Mycobacterium tuberculosis strains"],"prefix":"10.1016","volume":"180","author":[{"given":"Feng","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6369-460X","authenticated-orcid":false,"given":"Yilei","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linjun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangming","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2019.07.057_bib1","series-title":"WHO End TB Strategy-Global Strategy and Targets for Tuberculosis Prevention, Care and Control after 2015","author":"World Health Organization","year":"2015"},{"key":"10.1016\/j.ejmech.2019.07.057_bib2","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1016\/S0140-6736(15)60570-0","article-title":"WHO's new End TB strategy","volume":"385","author":"Uplekar","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.ejmech.2019.07.057_bib3","author":"World Health Organization"},{"key":"10.1016\/j.ejmech.2019.07.057_bib4","article-title":"Tuberculosis series 2019","volume":"45","author":"Silva","year":"2019","journal-title":"J.\u00a0Bras. Pneumol."},{"key":"10.1016\/j.ejmech.2019.07.057_bib5","series-title":"Global Tuberculosis Report 2018","author":"World Health Organization","year":"2018"},{"key":"10.1016\/j.ejmech.2019.07.057_bib6","author":"World Health Organization"},{"key":"10.1016\/j.ejmech.2019.07.057_bib7","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.cclet.2016.07.032","article-title":"Isatin hybrids and their anti-tuberculosis activity","volume":"28","author":"Xu","year":"2017","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.ejmech.2019.07.057_bib8","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.ejmech.2017.07.059","article-title":"Recent advances of pyrazole-containing derivatives as anti-tubercular agents","volume":"139","author":"Gao","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.07.057_bib9","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/j.ejmech.2018.08.095","article-title":"Recent developments of quinolone-based derivatives and their activities against Escherichia coli","volume":"157","author":"Gao","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.07.057_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2019.102965","article-title":"Design, synthesis and molecular modeling studies on novel moxifloxacin derivatives as potential antibacterial and antituberculosis agents","volume":"88","author":"Ture","year":"2019","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2019.07.057_bib11","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.ijantimicag.2017.01.024","article-title":"Population pharmacokinetics of moxifloxacin, cycloserine, p-aminosalicyclic acid and kanamycin for the treatment of multi-drug-resistant tuberculosis","volume":"49","author":"Chang","year":"2017","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.ejmech.2019.07.057_bib12","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S1473-3099(11)70351-6","article-title":"Moxifloxacin for tuberculosis","volume":"12","author":"Mendel","year":"2012","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.ejmech.2019.07.057_bib13","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1002\/jcph.968","article-title":"A\u00a0review of moxifloxacin for the treatment of drug-susceptible tuberculosis","volume":"57","author":"Naidoo","year":"2017","journal-title":"J.\u00a0Clin. Pharmacol."},{"key":"10.1016\/j.ejmech.2019.07.057_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0154778","article-title":"A\u00a0phase 2 randomized trial of a rifapentine plus moxifloxacin-based regimen for treatment of pulmonary tuberculosis","volume":"11","author":"Conde","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.ejmech.2019.07.057_bib15","doi-asserted-by":"crossref","first-page":"e12","DOI":"10.1038\/emi.2016.12","article-title":"Moxifloxacin and gatifloxacin for initial therapy of tuberculosis: a meta-analysis of randomized clinical trials","volume":"5","author":"Ruan","year":"2016","journal-title":"Emerg. Microb. Infect."},{"key":"10.1016\/j.ejmech.2019.07.057_bib16","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.annepidem.2013.12.009","article-title":"Peripheral neuropathy and Guillain-Barr\u00e9 syndrome risks associated with exposure to systemic fluoroquinolones: a pharmacovigilance analysis","volume":"24","author":"Ali","year":"2014","journal-title":"Ann. Epidemiol."},{"key":"10.1016\/j.ejmech.2019.07.057_bib17","first-page":"s211","article-title":"Acute fulminant hepatic failure and toxic epidermal necrolysis associated with the use of moxifloxacin","volume":"98","author":"Deenadayalu","year":"2003","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.ejmech.2019.07.057_bib18","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jphotobiol.2004.11.014","article-title":"Evaluation of phototoxic and photoallergic potentials of 13 compounds by different in\u00a0vitro and in\u00a0vivo methods","volume":"79","author":"Neumann","year":"2005","journal-title":"J.\u00a0Photochem. Photobiol., B"},{"key":"10.1016\/j.ejmech.2019.07.057_bib19","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.ejmech.2019.02.055","article-title":"Comprehensive review on the anti-bacterial activity of 1,2,3-triazole hybrids","volume":"168","author":"Zhang","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.07.057_bib20","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.ejmech.2018.12.017","article-title":"Isatin derivatives and their anti-bacterial activities","volume":"164","author":"Guo","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.07.057_bib21","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1016\/j.drudis.2017.05.014","article-title":"The 1,2,3-triazole ring as a bioisostere in medicinal chemistry","volume":"22","author":"Bonandi","year":"2017","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.ejmech.2019.07.057_bib22","doi-asserted-by":"crossref","first-page":"4857","DOI":"10.1016\/j.bmcl.2009.06.030","article-title":"Respiratory syncytial virus fusion inhibitors. Part 7: structure-activity relationships associated with a series of isatin oximes that demonstrate antiviral activity in\u00a0vivo","volume":"19","author":"Sin","year":"2009","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2019.07.057_bib23","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.ejmech.2017.06.051","article-title":"Triazole derivatives and their anti-tubercular activity","volume":"138","author":"Zhang","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.07.057_bib24","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.ejmech.2018.11.032","article-title":"Fluoroquinolone-isatin hybrids and their biological activities","volume":"162","author":"Xu","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.07.057_bib25","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.ejmech.2017.11.090","article-title":"Synthesis and in\u00a0vitro evaluation of novel substituted isatin-propylene-1H-1,2,3-triazole-4-methylene-moxifloxacin hybrids for their anti-mycobacterial activities","volume":"143","author":"Yan","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.07.057_bib26","doi-asserted-by":"crossref","DOI":"10.1002\/ardp.201900040","article-title":"1H-1,2,3-Triazole tethered isatin-moxifloxacin: design, synthesis and in\u00a0vitro anti-mycobacterial evaluation","volume":"352","author":"Jiang","year":"2019","journal-title":"Arch. der Pharm."},{"key":"10.1016\/j.ejmech.2019.07.057_bib27","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ejmech.2017.05.057","article-title":"Azide-alkyne cycloaddition towards 1H-1,2,3-triazole-tethered gatifloxacin and isatin conjugates: design, synthesis and in\u00a0vitro anti-mycobacterial evaluation","volume":"138","author":"Xu","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.07.057_bib28","doi-asserted-by":"crossref","first-page":"3643","DOI":"10.1016\/j.bmcl.2017.07.023","article-title":"Design, synthesis and in\u00a0vitro anti-mycobacterial evaluation of gatifloxacin-1H-1,2,3-triazole-isatin hybrids","volume":"27","author":"Xu","year":"2017","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2019.07.057_bib29","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/jhet.3004","article-title":"Design, synthesis and in\u00a0vitro anti-mycobacterial activities of 8-OMe ciprofloxacin-1H-1,2,3-triazole-isatin-(thio) semicarbazide\/oxime hybrids","volume":"55","author":"Xu","year":"2018","journal-title":"J.\u00a0Heterocycl. Chem."},{"key":"10.1016\/j.ejmech.2019.07.057_bib30","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/jhet.3382","article-title":"Ciprofloxacin-isatin hybrids and their antimycobacterial activities","volume":"56","author":"Xu","year":"2019","journal-title":"J.\u00a0Heterocycl. Chem."},{"key":"10.1016\/j.ejmech.2019.07.057_bib31","doi-asserted-by":"crossref","first-page":"5207","DOI":"10.1016\/j.bmcl.2005.08.068","article-title":"In silico fragment-based discovery of indolin-2-one analogues as potent DNA gyrase inhibitors","volume":"15","author":"Oblak","year":"2005","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2019.07.057_bib32","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.molstruc.2016.03.036","article-title":"Design, synthesis and antibacterial activity of isatin derivatives as FtsZ inhibitors","volume":"1117","author":"Lian","year":"2016","journal-title":"J.\u00a0Mol. Struct."},{"key":"10.1016\/j.ejmech.2019.07.057_bib33","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.ejmech.2018.09.049","article-title":"Design, synthesis and anti-mycobacterial activity evaluation of benzofuran-isatin hybrids","volume":"159","author":"Gao","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.07.057_bib34","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.ejmech.2019.01.042","article-title":"Benzofuran-isatin-imine hybrids tethered via different length alkyl linkers: design, synthesis and in\u00a0vitro evaluation of anti-tubercular and anti-bacterial activities as well as cytotoxicity","volume":"165","author":"Gao","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.07.057_bib35","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1016\/j.bmc.2019.04.017","article-title":"Benzofuran-isatin hybrids tethered via different length alkyl linkers and their in\u00a0vitro anti-mycobacterial activities","volume":"27","author":"Gao","year":"2019","journal-title":"Bioorg. Med. Chem."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523419306786?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523419306786?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T14:00:48Z","timestamp":1759327248000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523419306786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":35,"alternative-id":["S0223523419306786"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2019.07.057","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and biological evaluation of moxifloxacin-acetyl-1,2,3-1H-triazole-methylene-isatin hybrids as potential anti-tubercular agents against both drug-susceptible and drug-resistant Mycobacterium tuberculosis strains","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2019.07.057","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}