{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T21:15:32Z","timestamp":1793654132010,"version":"4.5.1"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2018A030313539"],"award-info":[{"award-number":["2018A030313539"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"name":"youth innovation project of Guangdong university","award":["E1-KFD015181K35"],"award-info":[{"award-number":["E1-KFD015181K35"]}]},{"name":"Science Foundation of Guangdong Provincial Hospital of Chinese Medicine","award":["2017KT1525"],"award-info":[{"award-number":["2017KT1525"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1016\/j.ejmech.2019.111670","type":"journal-article","created":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T14:15:18Z","timestamp":1567433718000},"page":"111670","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Design, synthesis, and biological evaluation of novel benzodiazepine derivatives as anticancer agents through inhibition of tubulin polymerization in\u00a0vitro and in\u00a0vivo"],"prefix":"10.1016","volume":"182","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9053-3297","authenticated-orcid":false,"given":"Yanqing","family":"Pang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibiao","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiwen","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baijiao","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1880-6200","authenticated-orcid":false,"given":"Xingshu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2019.111670_bib1","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1126\/science.1230582","article-title":"Molecular mechanism of action of microtubule-stabilizing anticancer agents","volume":"339","author":"Prota","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.ejmech.2019.111670_bib2","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/med.20242","article-title":"Drugs that target dynamic microtubules: a new molecular perspective","volume":"31","author":"Stanton","year":"2011","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.ejmech.2019.111670_bib3","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/nature01600","article-title":"Dynamics and mechanics of the microtubule plus end","volume":"422","author":"Howard","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2019.111670_bib4","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nrc1317","article-title":"Microtubules as a target for anticancer drugs","volume":"4","author":"Jordan","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ejmech.2019.111670_bib5","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.2174\/1389557043402946","article-title":"Microtubulin binding sites as target for developing anticancer agents","volume":"4","author":"Islam","year":"2004","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111670_bib6","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/nrd3253","article-title":"Microtubule-binding agents: a dynamic field of cancer therapeutics","volume":"9","author":"Dumontet","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejmech.2019.111670_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/1568011023354290","article-title":"Mechanism of action of antitumor drugs that interact with microtubules and tubulin","volume":"2","author":"Jordan","year":"2002","journal-title":"Curr. Med. Chem. Anti Cancer Agents"},{"key":"10.1016\/j.ejmech.2019.111670_bib8","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/277665a0","article-title":"Promotion of microtubule assembly in\u00a0vitro by taxol","volume":"277","author":"Schiff","year":"1979","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2019.111670_bib9","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/med.20097","article-title":"Anti-mitotic activity of colchicine and the structural basis for its interaction with tubulin","volume":"28","author":"Bhattacharyya","year":"2008","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.ejmech.2019.111670_bib10","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1139\/v82-202","article-title":"Isolation and structure of combretastatin","volume":"60","author":"Pettit","year":"1982","journal-title":"Can. J. Chem."},{"key":"10.1016\/j.ejmech.2019.111670_bib11","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1093\/annonc\/mdq708","article-title":"Phase II trial of combretastatin A4 phosphate, carboplatin, and paclitaxel in patients with platinum-resistant ovarian cancer","volume":"22","author":"Zweifel","year":"2011","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.ejmech.2019.111670_bib12","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1021\/jm9807149","article-title":"Antineoplastic agents. 410. asymmetric hydroxylation of trans-combretastatin A-4","volume":"42","author":"Pettit","year":"1999","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111670_bib13","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.bioorg.2017.04.007","article-title":"Development of combretastatins as potent tubulin polymerization inhibitors","volume":"72","author":"Bukhari","year":"2017","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2019.111670_bib14","doi-asserted-by":"crossref","first-page":"4538","DOI":"10.1021\/jm900321u","article-title":"Isocombretastatins a versus combretastatins a: the forgotten isoCA-4 isomer as a highly promising cytotoxic and antitubulin agent","volume":"52","author":"Messaoudi","year":"2009","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111670_bib15","doi-asserted-by":"crossref","first-page":"7300","DOI":"10.1021\/acs.jmedchem.7b00480","article-title":"Design, synthesis, and biological evaluation of novel selenium-containing isocombretastatins and phenstatins as antitumor agents","volume":"60","author":"Pang","year":"2017","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111670_bib16","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1093\/carcin\/bgt087","article-title":"Millepachine, a novel chalcone, induces G2\/M arrest by inhibiting CDK1 activity and causing apoptosis via ROS-mitochondrial apoptotic pathway in human hepatocarcinoma cells in\u00a0vitro and in\u00a0vivo","volume":"34","author":"Wu","year":"2013","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.ejmech.2019.111670_bib17","doi-asserted-by":"crossref","first-page":"88453","DOI":"10.1039\/C6RA16948A","article-title":"The synthesis and evaluation of new benzophenone derivatives as tubulin polymerization inhibitors","volume":"6","author":"Zhang","year":"2016","journal-title":"RSC Adv."},{"key":"10.1016\/j.ejmech.2019.111670_bib18","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1039\/C6OB02507B","article-title":"Synthesis, in\u00a0vitro and in\u00a0vivo evaluation of new hybrids of millepachine and phenstatin as potent tubulin polymerization inhibitors","volume":"15","author":"An","year":"2017","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.ejmech.2019.111670_bib19","doi-asserted-by":"crossref","first-page":"98527","DOI":"10.1039\/C5RA19270F","article-title":"Synthesis, biological evaluation and mechanism study of a class of cyclic combretastatin A-4 analogues as novel antitumour agents","volume":"5","author":"Yan","year":"2015","journal-title":"RSC Adv."},{"key":"10.1016\/j.ejmech.2019.111670_bib20","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.ejmech.2016.09.056","article-title":"A\u00a0Design, synthesis, and biological evaluation of cyclic-indole derivatives as anti-tumor agents via the inhibition of tubulin polymerization","volume":"125","author":"Yan","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111670_bib21","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.bcp.2015.07.008","article-title":"A\u00a0novel synthetic compound exerts effective anti-tumour activity in\u00a0vivo via the inhibition of tubulin polymerisation in A549 cells","volume":"97","author":"Yan","year":"2015","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejmech.2019.111670_bib22","doi-asserted-by":"crossref","first-page":"7574","DOI":"10.1039\/c3ob41672k","article-title":"Collective synthesis of several 2,7'-cyclolignans and their correlation by chemical transformations","volume":"11","author":"Peng","year":"2013","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.ejmech.2019.111670_bib23","doi-asserted-by":"crossref","first-page":"9279","DOI":"10.1039\/C8OB02196A","article-title":"Synthesis of 2-substituted benzo[b]thiophenes via gold(I)\u2013NHC-catalyzed cyclization of 2-alkynyl thioanisoles","volume":"16","author":"Dillon","year":"2018","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.ejmech.2019.111670_bib24","doi-asserted-by":"crossref","first-page":"6625","DOI":"10.1039\/C5CC01287B","article-title":"Cu-catalyzed oxidative povarov reactions between N-alkyl N-methylanilines and saturated oxa- and thiacycles","volume":"51","author":"Kawade","year":"2015","journal-title":"Chem. Commun."},{"key":"10.1016\/j.ejmech.2019.111670_bib25","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1016\/S0021-9258(18)89437-6","article-title":"4',6-Diamidino-2-phenylindole, a fluorescent probe for tubulin and microtubules","volume":"260","author":"Bonne","year":"1985","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.ejmech.2019.111670_bib26","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1021\/bi00062a003","article-title":"Assembly of purified GDP-tubulin into microtubules induced by taxol and taxotere: reversibility, ligand stoichiometry, and competition","volume":"32","author":"Diaz","year":"1993","journal-title":"Biochemistry"}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523419308141?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523419308141?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,1,17]],"date-time":"2021-01-17T23:38:35Z","timestamp":1610926715000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523419308141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":26,"alternative-id":["S0223523419308141"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2019.111670","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design, synthesis, and biological evaluation of novel benzodiazepine derivatives as anticancer agents through inhibition of tubulin polymerization in\u00a0vitro and in\u00a0vivo","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2019.111670","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111670"}}