{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:13:45Z","timestamp":1790108025082,"version":"4.0.1"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.ejmech.2019.111698","type":"journal-article","created":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T02:01:37Z","timestamp":1568253697000},"page":"111698","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"special_numbering":"C","title":["Continued exploration and tail approach synthesis of benzenesulfonamides containing triazole and dual triazole moieties as carbonic anhydrase I, II, IV and IX inhibitors"],"prefix":"10.1016","volume":"183","author":[{"given":"Lalit","family":"Vats","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0107-2682","authenticated-orcid":false,"given":"Silvia","family":"Bua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3342-702X","authenticated-orcid":false,"given":"Alessio","family":"Nocentini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Gratteri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4262-0323","authenticated-orcid":false,"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawan K.","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2019.111698_bib1","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrd2467","article-title":"Carbonic anhydrases: novel therapeutic applications for inhibitors and activators","volume":"7","author":"Supuran","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejmech.2019.111698_bib2","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1080\/14756366.2018.1428572","article-title":"Carbon-versus sulphur-based zinc binding groups for carbonic anhydrase inhibitors?","volume":"33","author":"Supuran","year":"2018","journal-title":"J.\u00a0Enzym. Inhib. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111698_bib3","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1016\/j.ejmech.2017.11.005","volume":"143","author":"\u017bo\u0142nowska","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111698_bib4","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1080\/1475636040001704461","article-title":"Effects of low molecular weight plasma inhibitors of rainbow trout (Oncorhynchus mykiss) on human erythrocyte carbonic anhydrase-II isozyme activity in\u00a0vitro and rat erythrocytes in\u00a0vivo","volume":"20","author":"H\u0130sar","year":"2005","journal-title":"J.\u00a0Enzym. Inhib. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111698_bib5","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1016\/j.bmc.2009.01.067","article-title":"Carbonic anhydrase inhibitors. Inhibition of human erythrocyte isozymes I and II with a series of antioxidant phenols","volume":"17","author":"Sent\u00fcrk","year":"2009","journal-title":"Biorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111698_bib6","doi-asserted-by":"crossref","first-page":"5791","DOI":"10.1016\/j.bmc.2009.07.019","article-title":"Sildenafil is a strong activator of mammalian carbonic anhydrase isoforms I\u2013XIV","volume":"17","author":"Coban","year":"2009","journal-title":"Biorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111698_bib7","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/j.1747-0285.2010.00965.x","article-title":"Carbonic anhydrase inhibitors: inhibition of human erythrocyte isozymes I and II with a series of phenolic acids","volume":"75","author":"Beyza \u00d6zt\u00fcrk Sar\u0131kaya","year":"2010","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.ejmech.2019.111698_bib8","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1016\/j.bmc.2010.01.076","article-title":"Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I\u2013XIV with a series of natural product polyphenols and phenolic acids","volume":"18","author":"Innocenti","year":"2010","journal-title":"Biorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111698_bib9","doi-asserted-by":"crossref","first-page":"5050","DOI":"10.1016\/j.bmcl.2010.07.038","article-title":"Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I\u2013XV","volume":"20","author":"Innocenti","year":"2010","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2019.111698_bib10","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1111\/j.1747-0285.2011.01104.x","article-title":"In\u00a0vitro inhibition of human carbonic anhydrase I and II isozymes with natural phenolic compounds","volume":"77","author":"\u015eent\u00fcrk","year":"2011","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.ejmech.2019.111698_bib11","doi-asserted-by":"crossref","first-page":"4259","DOI":"10.1016\/j.bmcl.2011.05.071","article-title":"In\u00a0vitro inhibition of \u03b1-carbonic anhydrase isozymes by some phenolic compounds","volume":"21","author":"Sarikaya","year":"2011","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2019.111698_bib12","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.bioorg.2018.09.028","article-title":"Synthesis of different thio-scaffolds bearing sulfonamide with subnanomolar carbonic anhydrase II and IX inhibitory properties and X-ray investigations for their inhibitory mechanism","volume":"81","author":"Angeli","year":"2018","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2019.111698_bib13","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ejmech.2014.05.039","article-title":"Carbonic anhydrase inhibitors. Synthesis of a novel series of 5-substituted 2,4-dichlorobenzenesulfonamides and their inhibition of human cytosolic isozymes I and II and the transmembrane tumor-associated isozymes IX and XII","volume":"82","author":"Slawinski","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111698_bib14","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3109\/14756366.2013.761876","article-title":"Carbonic anhydrases: from biomedical applications of the inhibitors and activators to biotechnological use for CO2 capture","volume":"28","author":"Supuran","year":"2013","journal-title":"J.\u00a0Enzym. Inhib. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111698_bib15","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.ejmech.2017.07.073","article-title":"Novel 4\/3-((4-oxo-5-(2-oxoindolin-3-ylidene) thiazolidin-2-ylidene) amino) benzenesulfonamides: synthesis, carbonic anhydrase inhibitory activity, anticancer activity and molecular modelling studies","volume":"139","author":"Eldehna","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111698_bib16","doi-asserted-by":"crossref","first-page":"825","DOI":"10.2174\/156802607780636690","article-title":"Carbonic anhydrases as drug targets-an overview","volume":"7","author":"Supuran","year":"2007","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111698_bib17","doi-asserted-by":"crossref","first-page":"4336","DOI":"10.1016\/j.bmc.2007.04.020","article-title":"Carbonic anhydrases as targets for medicinal chemistry","volume":"15","author":"Supuran","year":"2007","journal-title":"Biorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111698_bib18","doi-asserted-by":"crossref","first-page":"4421","DOI":"10.1021\/cr200176r","article-title":"Multiple binding modes of inhibitors to carbonic anhydrases: how to design specific drugs targeting 15 different isoforms?","volume":"112","author":"Alterio","year":"2012","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejmech.2019.111698_bib19","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ejmech.2018.12.049","article-title":"Continued exploration of 1,2,4-oxadiazole periphery for carbonic anhydrase-targeting primary arene sulfonamides: discovery of subnanomolar inhibitors of membrane-bound hCA IX isoform that selectively kill cancer cells in hypoxic environment","volume":"164","author":"Krasavin","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111698_bib20","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.bmc.2016.11.027","article-title":"Discovery of 4-sulfamoyl-phenyl-beta-lactams as a new class of potent carbonic anhydrase isoforms I, II, IV and VII inhibitors: the first example of subnanomolar CA IV inhibitors","volume":"25","author":"Angapelly","year":"2017","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111698_bib21","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ejmech.2018.10.068","article-title":"Enhancement of the tail hydrophobic interactions within the carbonic anhydrase IX active site via structural extension: design and synthesis of novel N-substituted isatins-SLC-0111 hybrids as carbonic anhydrase inhibitors and antitumor agents","volume":"162","author":"Eldehna","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111698_bib22","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.bioorg.2019.01.065","article-title":"Click-tailed benzenesulfonamides as potent bacterial carbonic anhydrase inhibitors for targeting Mycobacterium tuberculosis and Vibrio cholerae","volume":"86","author":"Bua","year":"2019","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2019.111698_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejmech.2018.04.016","article-title":"Dual-tail arylsulfone-based benzenesulfonamides differently match the hydrophobic and hydrophilic halves of human carbonic anhydrases active sites: selective inhibitors for the tumor-associated hCA IX isoform","volume":"152","author":"Ibrahim","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111698_bib24","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.ejmech.2005.04.006","article-title":"QSAR study on carbonic anhydrase inhibitors: water-soluble sulfonamides incorporating \u03b2-alanyl moieties, possessing long lasting-intra ocular pressure lowering properties\u2014a molecular connectivity approach","volume":"40","author":"Agrawal","year":"2005","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111698_bib25","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/j.ejmech.2016.11.030","article-title":"Green synthesis and anticancer potential of chalcone linked-1,2,3-triazoles","volume":"126","author":"Yadav","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111698_bib26","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ejmech.2018.06.055","article-title":"Synthesis of pyrazolo [3, 4-d] pyrimidin-4 (5H)-ones tethered to 1, 2, 3-triazoles and their evaluation as potential anticancer agents","volume":"156","author":"Allam","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111698_bib27","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ejmech.2012.12.046","article-title":"Design and synthesis of novel 1, 2, 3-triazole-dithiocarbamate hybrids as potential anticancer agents","volume":"62","author":"Duan","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111698_bib28","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.ejmech.2016.08.031","article-title":"Design, synthesis and biological evaluation of ciprofloxacin tethered bis-1, 2, 3-triazole conjugates as potent antibacterial agents","volume":"124","author":"Kant","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111698_bib29","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.ejmech.2005.01.007","article-title":"Synthesis and antimicrobial activity of 4-phenyl\/cyclohexyl-5-(1-phenoxyethyl)-3-[N-(2-thiazolyl) acetamido] thio-4H-1, 2, 4-triazole derivatives","volume":"40","author":"Turan-Zitouni","year":"2005","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111698_bib30","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.ejmech.2018.08.070","article-title":"Synthesis of 1, 2, 3-triazole linked 4 (3H)-quinazolinones as potent antibacterial agents against multidrug-resistant Staphylococcus aureus","volume":"157","author":"Gatadi","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111698_bib31","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.ejmech.2014.01.014","article-title":"New thiophene-1, 2, 4-triazole-5 (3)-ones: highly bioactive thiosemicarbazides, structures of Schiff bases and triazole\u2013thiols","volume":"84","author":"\u00dcnver","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111698_bib32","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.ejmech.2014.08.009","article-title":"Sequential synthesis of amino-1, 4-naphthoquinone-appended triazoles and triazole-chromene hybrids and their antimycobacterial evaluation","volume":"85","author":"Bala","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111698_bib33","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1016\/j.bmc.2017.03.027","article-title":"Synthesis and carbonic anhydrase inhibition of a series of SLC-0111 analogs","volume":"25","author":"Carta","year":"2017","journal-title":"Biorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111698_bib34","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.ejmech.2018.06.021","article-title":"Design and synthesis of novel benzenesulfonamide containing 1,2,3-triazoles as potent human carbonic anhydrase isoforms I, II, IV and IX inhibitors","volume":"155","author":"Kumar","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111698_bib35","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.ejmech.2018.03.030","article-title":"Synthesis of novel 4-functionalized 1,5-diaryl-1,2,3-triazoles containing benzenesulfonamide moiety as carbonic anhydrase I, II, IV and IX inhibitors","volume":"150","author":"Vats","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111698_bib36","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.bioorg.2019.01.002","article-title":"Synthesis of novel benzenesulfonamide bearing 1,2,3-triazole linked hydroxy-trifluoromethylpyrazolines and hydrazones as selective carbonic anhydrase isoforms IX and XII inhibitors","volume":"85","author":"Sharma","year":"2019","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2019.111698_bib37","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1016\/j.bmc.2014.01.055","article-title":"Benzenesulfonamide bearing 1,2,4-triazole scaffolds as potent inhibitors of tumor associated carbonic anhydrase isoforms hCA IX and hCA XII","volume":"22","author":"Ram","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111698_bib38","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1016\/j.bmc.2016.12.047","article-title":"Benzenesulfonamide bearing imidazothiadiazole and thiazolotriazole scaffolds as potent tumor associated human carbonic anhydrase IX and XII inhibitors","volume":"25","author":"Kumar","year":"2017","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111698_bib39","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1080\/14756366.2017.1367775","article-title":"Synthesis and biological evaluation of benzenesulphonamide-bearing 1,4,5-trisubstituted-1,2,3-triazoles possessing human carbonic anhydrase I, II, IV, and IX inhibitory activity","volume":"32","author":"Kumar","year":"2017","journal-title":"J.\u00a0Enzym. Inhib. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111698_bib40","doi-asserted-by":"crossref","first-page":"2882","DOI":"10.1016\/j.bmc.2016.04.052","article-title":"Novel sulfonamide bearing coumarin scaffolds as selective inhibitors of tumor associated carbonic anhydrase isoforms IX and XII","volume":"24","author":"Chandak","year":"2016","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111698_bib41","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.ejmech.2014.02.023","article-title":"4-Functionalized 1,3-diarylpyrazoles bearing benzenesulfonamide moiety as selective potent inhibitors of the tumor associated carbonic anhydrase isoforms IX and XII","volume":"76","author":"Khloya","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111698_bib42","doi-asserted-by":"crossref","first-page":"3208","DOI":"10.1016\/j.bmcl.2015.05.096","article-title":"Sulfonamide bearing pyrazolylpyrazolines as potent inhibitors of carbonic anhydrase isoforms I, II, IX and XII","volume":"25","author":"Khloya","year":"2015","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2019.111698_bib43","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/j.bmcl.2015.02.004","article-title":"Synthesis and biological evaluation of pyrazolylthiazole carboxylic acids as potent anti-inflammatory-antimicrobial agents","volume":"25","author":"Khloya","year":"2015","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2019.111698_bib44","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.1016\/j.bmc.2016.04.061","article-title":"Pyrazolylbenzo[d]imidazoles as new potent and selective inhibitors of carbonic anhydrase isoforms hCA IX and XII","volume":"24","author":"Kumar","year":"2016","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111698_bib45","doi-asserted-by":"crossref","first-page":"6945","DOI":"10.1016\/j.bmc.2014.10.018","article-title":"4-Functionalized 1,3-diarylpyrazoles bearing 6-aminosulfonylbenzothiazole moiety as potent inhibitors of carbonic anhydrase isoforms hCA I, II, IX and XII","volume":"22","author":"Ram","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111698_bib46","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1039\/C4OB02155J","article-title":"6-Substituted 1, 2-benzoxathiine-2, 2-dioxides are isoform-selective inhibitors of human carbonic anhydrases IX, XII and VA","volume":"13","author":"Tanc","year":"2015","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.ejmech.2019.111698_bib47","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1016\/S0021-9258(18)62326-9","article-title":"The carbon dioxide hydration activity of carbonic anhydrase I. Stop-flow kinetic studies on the native human isoenzymes B and C","volume":"246","author":"Khalifah","year":"1971","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.ejmech.2019.111698_bib48","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/j.bmc.2016.12.040","article-title":"Dithiocarbamates effectively inhibit the \u03b2-carbonic anhydrase from the dandruff-producing fungus Malassezia globosa","volume":"25","author":"Vullo","year":"2017","journal-title":"Biorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111698_bib49","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ejmech.2018.07.054","article-title":"Novel hydrazido benzenesulfonamides-isatin conjugates: synthesis, carbonic anhydrase inhibitory activity and molecular modeling studies","volume":"157","author":"Abo-Ashour","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111698_bib50","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1016\/j.bmc.2017.02.037","article-title":"Synthesis of bulky-tailed sulfonamides incorporating pyrido [2, 3-d][1, 2, 4] triazolo [4, 3-a] pyrimidin-1 (5H)-yl) moieties and evaluation of their carbonic anhydrases I, II, IV and IX inhibitory effects","volume":"25","author":"Fares","year":"2017","journal-title":"Biorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111698_bib51","doi-asserted-by":"crossref","first-page":"10692","DOI":"10.1021\/acs.jmedchem.6b01389","article-title":"Benzenesulfonamides incorporating flexible triazole moieties are highly effective carbonic anhydrase inhibitors: synthesis and kinetic, crystallographic, computational, and intraocular pressure lowering investigations","volume":"59","author":"Nocentini","year":"2016","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111698_bib52","doi-asserted-by":"crossref","first-page":"9004","DOI":"10.1021\/acs.jmedchem.5b01343","article-title":"Efficient expression and crystallization system of cancer-associated carbonic anhydrase isoform IX","volume":"58","author":"Leitans","year":"2015","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111698_bib53","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1002\/chem.201805039","article-title":"Phosphorus versus sulfur: discovery of benzenephosphonamidates as versatile sulfonamide-mimic chemotypes acting as carbonic anhydrase inhibitors","volume":"25","author":"Nocentini","year":"2019","journal-title":"Chem. Eur J."},{"key":"10.1016\/j.ejmech.2019.111698_bib54","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1080\/14756366.2018.1512597","article-title":"Steroids interfere with human carbonic anhydrase activity by using alternative binding mechanisms","volume":"33","author":"Nocentini","year":"2018","journal-title":"J.\u00a0Enzym. Inhib. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111698_bib55","doi-asserted-by":"crossref","first-page":"7840","DOI":"10.1002\/chem.201800941","article-title":"Deciphering the mechanism of human carbonic anhydrases inhibition with sulfocoumarins: computational and experimental studies","volume":"24","author":"Nocentini","year":"2018","journal-title":"Chem. Eur J."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523419308505?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523419308505?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T13:59:47Z","timestamp":1759327187000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523419308505"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":55,"alternative-id":["S0223523419308505"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2019.111698","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Continued exploration and tail approach synthesis of benzenesulfonamides containing triazole and dual triazole moieties as carbonic anhydrase I, II, IV and IX inhibitors","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2019.111698","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111698"}}