{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:31:15Z","timestamp":1792783875048,"version":"4.5.0"},"reference-count":134,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Chongqing Technological Innovation and Application Demonstration Project","award":["csct2018jscx-msyb0274"],"award-info":[{"award-number":["csct2018jscx-msyb0274"]}]},{"name":"Chongqing Agriculture Development Project","award":["19532"],"award-info":[{"award-number":["19532"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.ejmech.2019.111711","type":"journal-article","created":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T01:48:37Z","timestamp":1568857717000},"page":"111711","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"special_numbering":"C","title":["Recent progress on anti-Toxoplasma drugs discovery: Design, synthesis and screening"],"prefix":"10.1016","volume":"183","author":[{"given":"Yu","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Qin","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Hong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"14","key":"10.1016\/j.ejmech.2019.111711_bib1","doi-asserted-by":"crossref","first-page":"R770","DOI":"10.1016\/j.cub.2018.05.035","article-title":"Toxoplasma gondii","volume":"28","author":"Kochanowsky","year":"2018","journal-title":"Curr. Biol."},{"issue":"7","key":"10.1016\/j.ejmech.2019.111711_bib2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006351","article-title":"Toxoplasma gondii: entry, association, and physiological influence on the central nervous system","volume":"13","author":"Mendez","year":"2017","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ejmech.2019.111711_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.fawpar.2019.e00053","article-title":"A\u00a0one health approach to vaccines against Toxoplasma gondii","volume":"15","author":"Innes","year":"2019","journal-title":"Food Waterborne Parasitol."},{"issue":"5","key":"10.1016\/j.ejmech.2019.111711_bib4","doi-asserted-by":"crossref","first-page":"794","DOI":"10.4269\/ajtmh.13-0722","article-title":"Neglected parasitic infections in the United States: toxoplasmosis","volume":"90","author":"Jones","year":"2014","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.ejmech.2019.111711_bib5","doi-asserted-by":"crossref","first-page":"273","DOI":"10.2147\/DDDT.S60973","article-title":"Drugs in development for toxoplasmosis: advances, challenges, and current status","volume":"11","author":"Alday","year":"2017","journal-title":"Drug Des. Dev. Ther."},{"issue":"12","key":"10.1016\/j.ejmech.2019.111711_bib6","doi-asserted-by":"crossref","first-page":"7161","DOI":"10.1128\/AAC.02009-15","article-title":"Clinically available medicines demonstrating anti-Toxoplasma activity","volume":"59","author":"Neville","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"issue":"23","key":"10.1016\/j.ejmech.2019.111711_bib7","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1056\/NEJM199212033272306","article-title":"Toxoplasmosis of the central nervous system in the acquired immunodeficiency syndrome","volume":"327","author":"Porter","year":"1992","journal-title":"N.\u00a0Engl. J. Med."},{"issue":"9425","key":"10.1016\/j.ejmech.2019.111711_bib8","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/S0140-6736(04)16412-X","article-title":"Toxoplasmosis","volume":"363","author":"Montoya","year":"2004","journal-title":"The Lancet"},{"issue":"3","key":"10.1016\/j.ejmech.2019.111711_bib9","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.pt.2019.01.005","article-title":"Advances in the development of anti-Toxoplasma gondii vaccines: challenges, opportunities, and perspectives","volume":"35","author":"Wang","year":"2019","journal-title":"Trends Parasitol."},{"issue":"7296","key":"10.1016\/j.ejmech.2019.111711_bib10","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nature09022","article-title":"Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma","volume":"465","author":"Lourido","year":"2010","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.ejmech.2019.111711_bib11","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1038\/nsmb.1818","article-title":"Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors","volume":"17","author":"Ojo","year":"2010","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"7","key":"10.1016\/j.ejmech.2019.111711_bib12","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1021\/ml100096t","article-title":"Discovery of potent and selective inhibitors of calcium-dependent protein kinase 1 (CDPK1) from C. parvum and T. gondii","volume":"1","author":"Murphy","year":"2010","journal-title":"ACS Med. Chem. Lett."},{"issue":"6","key":"10.1016\/j.ejmech.2019.111711_bib13","doi-asserted-by":"crossref","first-page":"3547","DOI":"10.1128\/AAC.01823-13","article-title":"Bumped kinase inhibitor 1294 treats established Toxoplasma gondii infection","volume":"58","author":"Doggett","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"issue":"13","key":"10.1016\/j.ejmech.2019.111711_bib14","doi-asserted-by":"crossref","first-page":"6531","DOI":"10.1021\/acs.jmedchem.6b00760","article-title":"Development of an orally available and central nervous system (CNS) penetrant Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) inhibitor with minimal human ether-a-go-go-related gene (hERG) activity for the treatment of toxoplasmosis","volume":"59","author":"Vidadala","year":"2016","journal-title":"J.\u00a0Med. Chem."},{"issue":"16","key":"10.1016\/j.ejmech.2019.111711_bib15","doi-asserted-by":"crossref","first-page":"5264","DOI":"10.1016\/j.bmcl.2012.06.050","article-title":"Benzoylbenzimidazole-based selective inhibitors targeting Cryptosporidium parvum and Toxoplasma gondii calcium-dependent protein kinase-1","volume":"22","author":"Zhang","year":"2012","journal-title":"Bioorg. Med. Chem. Lett"},{"issue":"1","key":"10.1016\/j.ejmech.2019.111711_bib16","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1021\/ml400315s","article-title":"Potent and selective inhibitors of CDPK1 from T. gondii and C. parvum based on a 5-aminopyrazole-4-carboxamide scaffold","volume":"5","author":"Zhang","year":"2014","journal-title":"ACS Med. Chem. Lett."},{"issue":"12","key":"10.1016\/j.ejmech.2019.111711_bib17","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1021\/acsmedchemlett.5b00319","article-title":"SAR Studies of 5-aminopyrazole-4-carboxamide analogues as potent and selective inhibitors of Toxoplasma gondii CDPK1","volume":"6","author":"Huang","year":"2015","journal-title":"ACS Med. Chem. Lett."},{"issue":"7","key":"10.1016\/j.ejmech.2019.111711_bib18","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.1021\/jm4001314","article-title":"Optimizing small molecule inhibitors of calcium-dependent protein kinase 1 to prevent infection by Toxoplasma gondii","volume":"56","author":"Lourido","year":"2013","journal-title":"J.\u00a0Med. Chem."},{"issue":"24","key":"10.1016\/j.ejmech.2019.111711_bib19","doi-asserted-by":"crossref","first-page":"9976","DOI":"10.1021\/acs.jmedchem.7b01192","article-title":"Inhibition of calcium dependent protein kinase 1 (CDPK1) by pyrazolopyrimidine analogs decreases establishment and reoccurrence of central nervous system disease by Toxoplasma gondii","volume":"60","author":"Rutaganira","year":"2017","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111711_bib20","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.ejmech.2014.10.057","article-title":"A\u00a0small-molecule cell-based screen led to the identification of biphenylimidazoazines with highly potent and broad-spectrum anti-apicomplexan activity","volume":"89","author":"Moine","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111711_bib21","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ejmech.2015.10.004","article-title":"Development of new highly potent imidazo[1,2-b]pyridazines targeting Toxoplasma gondii calcium-dependent protein kinase 1","volume":"105","author":"Moine","year":"2015","journal-title":"Eur. J. Med. Chem."},{"issue":"7","key":"10.1016\/j.ejmech.2019.111711_bib22","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.ijpara.2017.12.006","article-title":"Imidazo[1,2-b]pyridazines targeting Toxoplasma gondii calcium-dependent protein kinase 1 decrease the parasite burden in mice with acute toxoplasmosis","volume":"48","author":"Moine","year":"2018","journal-title":"Int. J. Parasitol."},{"issue":"2","key":"10.1016\/j.ejmech.2019.111711_bib23","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S1359-6446(04)03308-2","article-title":"Targeting DHFR in parasitic protozoa","volume":"10","author":"Anderson","year":"2005","journal-title":"Drug Discov. Today"},{"issue":"12","key":"10.1016\/j.ejmech.2019.111711_bib24","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1021\/acsmedchemlett.6b00328","article-title":"Discovery of potent and selective leads against Toxoplasma gondii dihydrofolate reductase via structure-based design","volume":"7","author":"Welsch","year":"2016","journal-title":"ACS Med. Chem. Lett."},{"issue":"12","key":"10.1016\/j.ejmech.2019.111711_bib25","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1021\/ml400208v","article-title":"Discovery of potent and selective inhibitors of Toxoplasma gondii thymidylate synthase for opportunistic infections","volume":"4","author":"Zaware","year":"2013","journal-title":"ACS Med. Chem. Lett."},{"issue":"20","key":"10.1016\/j.ejmech.2019.111711_bib26","doi-asserted-by":"crossref","first-page":"11409","DOI":"10.1016\/S0021-9258(19)38410-8","article-title":"The protonmotive Q cycle. Energy transduction by coupling of proton translocation to electron transfer by the cytochrome bc1 complex","volume":"265","author":"Trumpower","year":"1990","journal-title":"J.\u00a0Biol. Chem."},{"issue":"7","key":"10.1016\/j.ejmech.2019.111711_bib27","doi-asserted-by":"crossref","first-page":"3961","DOI":"10.1074\/jbc.272.7.3961","article-title":"Atovaquone, a broad spectrum antiparasitic drug, collapses mitochondrial membrane potential in a malarial parasite","volume":"272","author":"Srivastava","year":"1997","journal-title":"J.\u00a0Biol. Chem."},{"issue":"2","key":"10.1016\/j.ejmech.2019.111711_bib28","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01866-16","article-title":"Genetic evidence for cytochrome b Qi site inhibition by 4(1H)-quinolone-3-diarylethers and antimycin in Toxoplasma gondii","volume":"61","author":"Alday","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejmech.2019.111711_bib29","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/cber.19480810103","article-title":"About a new type of compound effective against avian malaria","volume":"81","author":"Salzer","year":"1948","journal-title":"Chem. Ber."},{"issue":"1","key":"10.1016\/j.ejmech.2019.111711_bib30","doi-asserted-by":"crossref","first-page":"12","DOI":"10.4269\/ajtmh.1951.s1-31.12","article-title":"The effect of endochin on experimental toxoplasmosis","volume":"31","author":"Gingrich","year":"1951","journal-title":"Am. J. Trop. Med. Hyg."},{"issue":"39","key":"10.1016\/j.ejmech.2019.111711_bib31","doi-asserted-by":"crossref","first-page":"15936","DOI":"10.1073\/pnas.1208069109","article-title":"Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis","volume":"109","author":"Doggett","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"9","key":"10.1016\/j.ejmech.2019.111711_bib32","doi-asserted-by":"crossref","first-page":"3818","DOI":"10.1021\/jm500147k","article-title":"Discovery, synthesis, and optimization of antimalarial 4(1H)-quinolone-3-diarylethers","volume":"57","author":"Nilsen","year":"2014","journal-title":"J.\u00a0Med. Chem."},{"issue":"11","key":"10.1016\/j.ejmech.2019.111711_bib33","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1021\/acsinfecdis.8b00133","volume":"4","author":"McConnell","year":"2018","journal-title":"ACS Infect. Dis."},{"issue":"35","key":"10.1016\/j.ejmech.2019.111711_bib34","doi-asserted-by":"crossref","first-page":"13192","DOI":"10.1073\/pnas.0603391103","article-title":"Apicoplast fatty acid synthesis is essential for organelle biogenesis and parasite survival in Toxoplasma gondii","volume":"103","author":"Mazumdar","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.ejmech.2019.111711_bib35","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2174\/138945007779315579","article-title":"Fatty acid biosynthesis as a drug target in apicomplexan parasites","volume":"8","author":"Goodman","year":"2007","journal-title":"Curr. Drug Targets"},{"issue":"17","key":"10.1016\/j.ejmech.2019.111711_bib36","doi-asserted-by":"crossref","first-page":"6287","DOI":"10.1021\/jm9017724","article-title":"Identification and development of novel inhibitors of Toxoplasma gondii enoyl reductase","volume":"53","author":"Tipparaju","year":"2010","journal-title":"J.\u00a0Med. Chem."},{"issue":"12","key":"10.1016\/j.ejmech.2019.111711_bib37","doi-asserted-by":"crossref","first-page":"3551","DOI":"10.1016\/j.bmcl.2013.04.035","article-title":"Development of a triclosan scaffold which allows for adaptations on both the A- and B-ring for transport peptides","volume":"23","author":"Muench","year":"2013","journal-title":"Bioorg. Med. Chem. Lett"},{"issue":"7","key":"10.1016\/j.ejmech.2019.111711_bib38","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1002\/cmdc.201300050","article-title":"Modification of triclosan scaffold in search of improved inhibitors for enoyl-acyl carrier protein (ACP) reductase in Toxoplasma gondii","volume":"8","author":"Stec","year":"2013","journal-title":"ChemMedChem"},{"issue":"39","key":"10.1016\/j.ejmech.2019.111711_bib39","doi-asserted-by":"crossref","first-page":"26839","DOI":"10.1074\/jbc.M109.003780","article-title":"Toxoplasma gondii cathepsin L is the primary target of the invasion-inhibitory compound morpholinurea-leucyl-homophenyl-vinyl sulfone phenyl","volume":"284","author":"Larson","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"issue":"10","key":"10.1016\/j.ejmech.2019.111711_bib40","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1016\/j.bmcl.2018.03.020","article-title":"Optimization of dipeptidic inhibitors of cathepsin L for improved Toxoplasma gondii selectivity and CNS permeability","volume":"28","author":"Zwicker","year":"2018","journal-title":"Bioorg. Med. Chem. Lett"},{"issue":"42","key":"10.1016\/j.ejmech.2019.111711_bib41","doi-asserted-by":"crossref","first-page":"30804","DOI":"10.1074\/jbc.M703178200","article-title":"The farnesyl-diphosphate\/geranylgeranyl-diphosphate synthase of Toxoplasma gondii is a bifunctional enzyme and a molecular target of bisphosphonates","volume":"282","author":"Ling","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"issue":"9","key":"10.1016\/j.ejmech.2019.111711_bib42","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.4065\/83.9.1032","article-title":"Bisphosphonates mechanism of action and role in clinical practice","volume":"83","author":"Drake","year":"2008","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.ejmech.2019.111711_bib43","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.ejmech.2012.12.015","article-title":"Design, synthesis and biological evaluation of sulfur-containing 1,1-bisphosphonic acids as antiparasitic agents","volume":"60","author":"Recher","year":"2013","journal-title":"Eur. J. Med. Chem."},{"issue":"2","key":"10.1016\/j.ejmech.2019.111711_bib44","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01590-16","article-title":"In\u00a0vitro and in\u00a0vivo activities of sulfur-containing linear bisphosphonates against apicomplexan parasites","volume":"61","author":"Szajnman","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"issue":"1","key":"10.1016\/j.ejmech.2019.111711_bib45","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.bmc.2013.11.010","article-title":"New insights into molecular recognition of 1,1-bisphosphonic acids by farnesyl diphosphate synthase","volume":"22","author":"Ferrer-Casal","year":"2014","journal-title":"Bioorg. Med. Chem."},{"issue":"5980","key":"10.1016\/j.ejmech.2019.111711_bib46","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1126\/science.1188191","article-title":"A\u00a0plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes","volume":"328","author":"Dvorin","year":"2010","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.ejmech.2019.111711_bib47","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000941","article-title":"Protein kinase a dependent phosphorylation of apical membrane antigen 1 plays an important role in erythrocyte invasion by the malaria parasite","volume":"6","author":"Leykauf","year":"2010","journal-title":"PLoS Pathog."},{"issue":"3","key":"10.1016\/j.ejmech.2019.111711_bib48","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1128\/EC.1.3.317-328.2002","article-title":"Toxoplasma gondii cyclic GMP-dependent kinase: chemotherapeutic targeting of an essential parasite protein kinase","volume":"1","author":"Donald","year":"2002","journal-title":"Eukaryot. Cell"},{"issue":"2","key":"10.1016\/j.ejmech.2019.111711_bib49","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1152\/physrev.00030.2010","article-title":"Mammalian cyclic nucleotide phosphodiesterases: molecular mechanisms and physiological functions","volume":"91","author":"Francis","year":"2011","journal-title":"Physiol. Rev."},{"issue":"4","key":"10.1016\/j.ejmech.2019.111711_bib50","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1021\/cb501004q","article-title":"Identification of potent phosphodiesterase inhibitors that demonstrate cyclic nucleotide-dependent functions in apicomplexan parasites","volume":"10","author":"Howard","year":"2015","journal-title":"ACS Chem. Biol."},{"issue":"10","key":"10.1016\/j.ejmech.2019.111711_bib51","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002280","article-title":"Evolutionarily divergent, unstable filamentous actin is essential for gliding motility in apicomplexan parasites","volume":"7","author":"Skillman","year":"2011","journal-title":"PLoS Pathog."},{"issue":"11","key":"10.1016\/j.ejmech.2019.111711_bib52","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1111\/j.1600-0854.2006.00484.x","article-title":"Regulation of apicomplexan microfilament dynamics by a minimal set of actin-binding proteins","volume":"7","author":"Schuler","year":"2006","journal-title":"Traffic"},{"issue":"6","key":"10.1016\/j.ejmech.2019.111711_bib53","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/S0092-8674(00)81071-5","article-title":"Toxoplasma invasion of mammalian cells is powered by the actin cytoskeleton of the parasite","volume":"84","author":"Dobrowolski","year":"1996","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.ejmech.2019.111711_bib54","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1021\/np400196w","article-title":"Synthetic chondramide A analogues stabilize filamentous actin and block invasion by Toxoplasma gondii","volume":"76","author":"Ma","year":"2013","journal-title":"J.\u00a0Nat. Prod."},{"issue":"7","key":"10.1016\/j.ejmech.2019.111711_bib55","doi-asserted-by":"crossref","first-page":"5163","DOI":"10.1074\/jbc.275.7.5163","article-title":"Effects of jasplakinolide on the kinetics of actin polymerization. An explanation for certain in\u00a0vivo obervations","volume":"275","author":"Bubb","year":"2000","journal-title":"J.\u00a0Biol. Chem."},{"issue":"10","key":"10.1016\/j.ejmech.2019.111711_bib56","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1586\/eri.12.100","article-title":"Toxoplasma histone acetylation remodelers as novel drug targets","volume":"10","author":"Vanagas","year":"2012","journal-title":"Expert Rev. Anti Infect. Ther."},{"issue":"4","key":"10.1016\/j.ejmech.2019.111711_bib57","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1084\/jem.20082826","article-title":"Drug inhibition of HDAC3 and epigenetic control of differentiation in Apicomplexa parasites","volume":"206","author":"Bougdour","year":"2009","journal-title":"J.\u00a0Exp. Med."},{"issue":"11","key":"10.1016\/j.ejmech.2019.111711_bib58","doi-asserted-by":"crossref","first-page":"4843","DOI":"10.1128\/AAC.00462-10","article-title":"Activity of the histone deacetylase inhibitor FR235222 on Toxoplasma gondii: inhibition of stage conversion of the parasite cyst form and study of new derivative compounds","volume":"54","author":"Maubon","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"issue":"4","key":"10.1016\/j.ejmech.2019.111711_bib59","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1128\/AAC.03059-15","article-title":"Garcinol inhibits GCN5-mediated lysine acetyltransferase activity and prevents replication of the parasite Toxoplasma gondii","volume":"60","author":"Jeffers","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"issue":"1","key":"10.1016\/j.ejmech.2019.111711_bib60","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003830","article-title":"Lysine acetyltransferase GCN5b interacts with AP2 factors and is required for Toxoplasma gondii proliferation","volume":"10","author":"Wang","year":"2014","journal-title":"PLoS Pathog."},{"issue":"35","key":"10.1016\/j.ejmech.2019.111711_bib61","doi-asserted-by":"crossref","first-page":"26852","DOI":"10.1074\/jbc.M110.147041","article-title":"Toxoplasma gondii activates hypoxia-inducible factor (HIF) by stabilizing the HIF-1alpha subunit via type I activin-like receptor kinase receptor signaling","volume":"285","author":"Wiley","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"issue":"6","key":"10.1016\/j.ejmech.2019.111711_bib62","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004180","article-title":"Forward genetic screening identifies a small molecule that blocks Toxoplasma gondii growth by inhibiting both host- and parasite-encoded kinases","volume":"10","author":"Brown","year":"2014","journal-title":"PLoS Pathog."},{"issue":"5","key":"10.1016\/j.ejmech.2019.111711_bib63","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1128\/AAC.06450-11","article-title":"Novel N-benzoyl-2-hydroxybenzamide disrupts unique parasite secretory pathway","volume":"56","author":"Fomovska","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"issue":"5185","key":"10.1016\/j.ejmech.2019.111711_bib64","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/2211016a0","article-title":"Mechanism of action of reagents that uncouple oxidative phosphorylation","volume":"221","author":"Weinbach","year":"1969","journal-title":"Nature"},{"issue":"19","key":"10.1016\/j.ejmech.2019.111711_bib65","doi-asserted-by":"crossref","first-page":"8375","DOI":"10.1021\/jm3007596","article-title":"Salicylanilide inhibitors of Toxoplasma gondii","volume":"55","author":"Fomovska","year":"2012","journal-title":"J.\u00a0Med. Chem."},{"issue":"10","key":"10.1016\/j.ejmech.2019.111711_bib66","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1016\/j.bmcl.2005.03.048","article-title":"Synthesis of thiosemicarbazone and 4-thiazolidinone derivatives and their in\u00a0vitro anti-Toxoplasma gondii activity","volume":"15","author":"Tenorio","year":"2005","journal-title":"Bioorg. Med. Chem. Lett"},{"issue":"3","key":"10.1016\/j.ejmech.2019.111711_bib67","doi-asserted-by":"crossref","first-page":"614","DOI":"10.3390\/molecules24030614","article-title":"Systematic identification of thiosemicarbazides for inhibition of Toxoplasma gondii growth in\u00a0vitro","volume":"24","author":"Paneth","year":"2019","journal-title":"Molecules"},{"issue":"8","key":"10.1016\/j.ejmech.2019.111711_bib68","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.3390\/molecules24081618","article-title":"Discovery of potent and selective halogen-substituted imidazole-thiosemicarbazides for inhibition of Toxoplasma gondii growth in\u00a0vitro via structure-based design","volume":"24","author":"Paneth","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2019.111711_bib69","doi-asserted-by":"crossref","first-page":"360","DOI":"10.3389\/fcimb.2018.00360","article-title":"A\u00a0perspective on thiazolidinone scaffold development as a new therapeutic strategy for Toxoplasmosis","volume":"8","author":"Rocha-Roa","year":"2018","journal-title":"Front. Cell Infect. Microbiol."},{"issue":"15","key":"10.1016\/j.ejmech.2019.111711_bib70","doi-asserted-by":"crossref","first-page":"4574","DOI":"10.1021\/jm9005862","article-title":"Synthesis and evaluation of 4-acyl-2-thiazolylhydrazone derivatives for anti-Toxoplasma efficacy in\u00a0vitro","volume":"52","author":"Chimenti","year":"2009","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111711_bib71","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ejmech.2014.08.046","article-title":"Design, synthesis and biological characterization of thiazolidin-4-one derivatives as promising inhibitors of Toxoplasma gondii","volume":"86","author":"D'Ascenzio","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111711_bib72","doi-asserted-by":"crossref","first-page":"103089","DOI":"10.1016\/j.bioorg.2019.103089","article-title":"Discovery of a novel DNA binding agent via design and synthesis of new thiazole hybrids and fused 1,2,4-triazines as potential antitumor agents: computational, spectrometric and in silico studies","volume":"90","author":"El-Wakil","year":"2019","journal-title":"Bioorg. Chem."},{"issue":"4","key":"10.1016\/j.ejmech.2019.111711_bib73","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1007\/s00044-018-2136-6","article-title":"Synthesis, molecular docking, ctDNA interaction, DFT calculation and evaluation of antiproliferative and anti-Toxoplasma gondii activities of 2,4-diaminotriazine-thiazole derivatives","volume":"27","author":"\u0141\u0105czkowski","year":"2018","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.ejmech.2019.111711_bib74","doi-asserted-by":"crossref","first-page":"4786","DOI":"10.2174\/092986711797535326","article-title":"Quinazolinone analogs as potential therapeutic agents","volume":"18","author":"Sharma","year":"2011","journal-title":"Curr. Med. Chem."},{"issue":"9","key":"10.1016\/j.ejmech.2019.111711_bib75","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1016\/j.bmcl.2018.03.036","article-title":"One-pot, multicomponent synthesis of 2,3-disubstituted quinazolin-ones with potent and selective activity against Toxoplasma gondii","volume":"28","author":"Brown","year":"2018","journal-title":"Bioorg. Med. Chem. Lett"},{"issue":"2","key":"10.1016\/j.ejmech.2019.111711_bib76","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.parint.2017.10.010","article-title":"Novel Toxoplasma gondii inhibitor chemotypes","volume":"67","author":"Sanford","year":"2018","journal-title":"Parasitol. Int."},{"issue":"7296","key":"10.1016\/j.ejmech.2019.111711_bib77","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nature09099","article-title":"Chemical genetics of Plasmodium falciparum","volume":"465","author":"Guiguemde","year":"2010","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.ejmech.2019.111711_bib78","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.ijpddr.2018.11.001","article-title":"Derivatives of a benzoquinone acyl hydrazone with activity against Toxoplasma gondii","volume":"8","author":"Sanford","year":"2018","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"issue":"5","key":"10.1016\/j.ejmech.2019.111711_bib79","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.parint.2016.06.013","article-title":"In\u00a0vitro inhibition of Toxoplasma gondii by the anti-malarial candidate, 6-(1,2,6,7-tetraoxaspiro[7.11]nonadec-4-yl)hexan-1-ol","volume":"65","author":"Xin","year":"2016","journal-title":"Parasitol. Int."},{"issue":"3","key":"10.1016\/j.ejmech.2019.111711_bib80","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1128\/AAC.02225-13","article-title":"Spiroindolone that inhibits PfATPase4 is a potent, cidal inhibitor of Toxoplasma gondii tachyzoites in\u00a0vitro and in\u00a0vivo","volume":"58","author":"Zhou","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"issue":"5","key":"10.1016\/j.ejmech.2019.111711_bib81","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1007\/s00436-016-4953-1","article-title":"A\u00a0new type of quinoxalinone derivatives affects viability, invasion, and intracellular growth of Toxoplasma gondii tachyzoites in\u00a0vitro","volume":"115","author":"Rivera Fernandez","year":"2016","journal-title":"Parasitol. Res."},{"issue":"3","key":"10.1016\/j.ejmech.2019.111711_bib82","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1021\/acs.jnatprod.5b01055","article-title":"Natural products as sources of new drugs from 1981 to 2014","volume":"79","author":"Newman","year":"2016","journal-title":"J.\u00a0Nat. Prod."},{"issue":"9","key":"10.1016\/j.ejmech.2019.111711_bib83","doi-asserted-by":"crossref","first-page":"3594","DOI":"10.1021\/jm901857d","article-title":"Thiazole, oxadiazole, and carboxamide derivatives of artemisinin are highly selective and potent inhibitors of Toxoplasma gondii","volume":"53","author":"Hencken","year":"2010","journal-title":"J.\u00a0Med. Chem."},{"issue":"8","key":"10.1016\/j.ejmech.2019.111711_bib84","doi-asserted-by":"crossref","first-page":"2980","DOI":"10.1016\/j.bmcl.2012.02.038","article-title":"Structure-activity studies of some berberine analogs as inhibitors of Toxoplasma gondii","volume":"22","author":"Krivogorsky","year":"2012","journal-title":"Bioorg. Med. Chem. Lett"},{"issue":"12","key":"10.1016\/j.ejmech.2019.111711_bib85","doi-asserted-by":"crossref","first-page":"4466","DOI":"10.1128\/AAC.00903-08","article-title":"Inhibition of Toxoplasma gondii by indirubin and tryptanthrin analogs","volume":"52","author":"Krivogorsky","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"issue":"4","key":"10.1016\/j.ejmech.2019.111711_bib86","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.bmcl.2012.12.024","article-title":"Tryptanthrin derivatives as Toxoplasma gondii inhibitors-structure-activity-relationship of the 6-position","volume":"23","author":"Krivogorsky","year":"2013","journal-title":"Bioorg. Med. Chem. Lett"},{"issue":"14","key":"10.1016\/j.ejmech.2019.111711_bib87","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.2174\/138955709791012247","article-title":"Biological activities of quinoline derivatives","volume":"9","author":"Kumar","year":"2009","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111711_bib88","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.exppara.2014.08.008","article-title":"The potential of quinoline derivatives for the treatment of Toxoplasma gondii infection","volume":"145","author":"Kadri","year":"2014","journal-title":"Exp. Parasitol."},{"issue":"12","key":"10.1016\/j.ejmech.2019.111711_bib89","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/S1359-6446(03)02713-2","article-title":"Drugs from the deep: marine natural products as drug candidates","volume":"8","author":"Haefner","year":"2003","journal-title":"Drug Discov. Today"},{"issue":"39","key":"10.1016\/j.ejmech.2019.111711_bib90","doi-asserted-by":"crossref","first-page":"10015","DOI":"10.1039\/C5OB01506E","article-title":"Synthesis of the cyanobacterial metabolite nostodione A, structural studies and potent antiparasitic activity against Toxoplasma gondii","volume":"13","author":"McNulty","year":"2015","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.ejmech.2019.111711_bib91","doi-asserted-by":"crossref","first-page":"248","DOI":"10.17533\/udea.vitae.17322","article-title":"Naphthoquinones: biological properties and synthesis of lawsone and derivatives-a structured review","volume":"21","author":"L\u00f3pezZ L\u00f3pez","year":"2014","journal-title":"Vitae"},{"issue":"6","key":"10.1016\/j.ejmech.2019.111711_bib92","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.parint.2015.08.010","article-title":"Further evidence that naphthoquinone inhibits Toxoplasma gondii growth in\u00a0vitro","volume":"64","author":"da Silva","year":"2015","journal-title":"Parasitol. Int."},{"issue":"7","key":"10.1016\/j.ejmech.2019.111711_bib93","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/S0031-9422(02)00383-7","article-title":"Usnic acid","volume":"61","author":"Ing\u00f3lfsd\u00f3ttir","year":"2002","journal-title":"Phytochemistry"},{"key":"10.1016\/j.ejmech.2019.111711_bib94","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.exppara.2016.03.021","article-title":"Effects of (+)-usnic acid and (+)-usnic acid-liposome on Toxoplasma gondii","volume":"166","author":"Si","year":"2016","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.ejmech.2019.111711_bib95","doi-asserted-by":"crossref","DOI":"10.1021\/acs.jafc.9b02173","article-title":"Synthesis and biological evaluation of (+)-usnic acid derivatives as potential anti-Toxoplasma gondii agents","author":"Guo","year":"2019","journal-title":"J.\u00a0Agric. Food Chem."},{"key":"10.1016\/j.ejmech.2019.111711_bib96","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.lfs.2016.01.017","article-title":"Ursolic acid (UA): a metabolite with promising therapeutic potential","volume":"146","author":"Kashyap","year":"2016","journal-title":"Life Sci."},{"issue":"2","key":"10.1016\/j.ejmech.2019.111711_bib97","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3390\/ph11020043","article-title":"Evaluation of anti-Toxoplasma gondii effect of ursolic acid as a novel Toxoplasmosis inhibitor","volume":"11","author":"Choi","year":"2018","journal-title":"Pharmaceuticals"},{"issue":"2","key":"10.1016\/j.ejmech.2019.111711_bib98","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3390\/pathogens8020061","article-title":"The mechanism of action of ursolic acid as a potential anti-Toxoplasmosis agent, and its immunomodulatory effects","volume":"8","author":"Choi","year":"2019","journal-title":"Pathogens"},{"issue":"1","key":"10.1016\/j.ejmech.2019.111711_bib99","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1080\/14756366.2019.1584622","article-title":"Synthesis and biological evaluation of ursolic acid derivatives bearing triazole moieties as potential anti-Toxoplasma gondii agents","volume":"34","author":"Luan","year":"2019","journal-title":"J.\u00a0Enzym. Inhib. Med. Chem."},{"issue":"1","key":"10.1016\/j.ejmech.2019.111711_bib100","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s10086-019-1782-8","article-title":"Isolation, structure determination and structure\u2013activity relationship of anti-toxoplasma triterpenoids from Quercus crispula Blume outer bark","volume":"65","author":"Endo","year":"2019","journal-title":"J.\u00a0Wood Sci."},{"issue":"3","key":"10.1016\/j.ejmech.2019.111711_bib101","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0091259","article-title":"A\u00a0novel function for kojic acid, a secondary metabolite from Aspergillus fungi, as antileishmanial agent","volume":"9","author":"Rodrigues","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ejmech.2019.111711_bib102","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.exppara.2019.03.009","article-title":"In\u00a0vitro and in\u00a0vivo evaluation of kojic acid against Toxoplasma gondii in experimental models of acute toxoplasmosis","volume":"200","author":"Montazeri","year":"2019","journal-title":"Exp. Parasitol."},{"issue":"7","key":"10.1016\/j.ejmech.2019.111711_bib103","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1128\/AAC.38.7.1470","article-title":"Licochalcone A, a new antimalarial agent, inhibits in\u00a0vitro growth of the human malaria parasite Plasmodium falciparum and protects mice from P. yoelii infection","volume":"38","author":"Chen","year":"1994","journal-title":"Antimicrob. Agents Chemother."},{"issue":"12","key":"10.1016\/j.ejmech.2019.111711_bib104","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1128\/AAC.37.12.2550","article-title":"Licochalcone A, a novel antiparasitic agent with potent activity against human pathogenic protozoan species of Leishmania","volume":"37","author":"Chen","year":"1993","journal-title":"Antimicrob. Agents Chemother."},{"issue":"2","key":"10.1016\/j.ejmech.2019.111711_bib105","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.ijpddr.2018.02.006","article-title":"Licochalcone A: an effective and low-toxicity compound against Toxoplasma gondii in\u00a0vitro and in\u00a0vivo","volume":"8","author":"Si","year":"2018","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"issue":"3","key":"10.1016\/j.ejmech.2019.111711_bib106","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1128\/AAC.49.3.1169-1176.2005","article-title":"Antimalarial activities and therapeutic properties of febrifugine analogs","volume":"49","author":"Jiang","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"issue":"1","key":"10.1016\/j.ejmech.2019.111711_bib107","doi-asserted-by":"crossref","first-page":"573","DOI":"10.3390\/molecules20010573","article-title":"Halofuginone - the multifaceted molecule","volume":"20","author":"Pines","year":"2015","journal-title":"Molecules"},{"issue":"10","key":"10.1016\/j.ejmech.2019.111711_bib108","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/j.str.2017.07.015","article-title":"Targeting prolyl-tRNA synthetase to accelerate drug discovery against malaria, leishmaniasis, toxoplasmosis, cryptosporidiosis, and coccidiosis","volume":"25","author":"Jain","year":"2017","journal-title":"Structure"},{"issue":"2","key":"10.1016\/j.ejmech.2019.111711_bib109","first-page":"38","article-title":"Transition metal complexes as potential therapeutic agents","volume":"5","author":"Shazia","year":"2010","journal-title":"Biotechnol. Mol. Biol. Rev."},{"issue":"11","key":"10.1016\/j.ejmech.2019.111711_bib110","doi-asserted-by":"crossref","first-page":"3717","DOI":"10.1158\/1078-0432.CCR-03-0746","article-title":"A\u00a0phase I and pharmacological study with imidazolium-trans DMSO-imidazole-tetrachlororuthenate, a novel ruthenium anticancer agent","volume":"10","author":"Rademaker-Lakhai","year":"2004","journal-title":"Clin. Cancer Res."},{"issue":"11","key":"10.1016\/j.ejmech.2019.111711_bib111","doi-asserted-by":"crossref","first-page":"5747","DOI":"10.1128\/AAC.02446-12","article-title":"In\u00a0vitro effects of novel ruthenium complexes in Neospora caninum and Toxoplasma gondii tachyzoites","volume":"57","author":"Barna","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"issue":"12","key":"10.1016\/j.ejmech.2019.111711_bib112","doi-asserted-by":"crossref","first-page":"7374","DOI":"10.1128\/AAC.00057-15","article-title":"Reduction of Toxoplasma gondii development due to inhibition of parasite antioxidant enzymes by a dinuclear iron(III) compound","volume":"59","author":"Portes","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"issue":"122","key":"10.1016\/j.ejmech.2019.111711_bib113","doi-asserted-by":"crossref","first-page":"100606","DOI":"10.1039\/C5RA17690E","article-title":"Antiproliferative activity and conversion of tachyzoite to bradyzoite of Toxoplasma gondii promoted by new zinc complexes containing sulfadiazine","volume":"5","author":"Batista","year":"2015","journal-title":"RSC Adv."},{"issue":"1","key":"10.1016\/j.ejmech.2019.111711_bib114","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s40268-015-0083-y","article-title":"Auranofin: repurposing an old drug for a golden new age","volume":"15","author":"Roder","year":"2015","journal-title":"Drugs R"},{"issue":"6","key":"10.1016\/j.ejmech.2019.111711_bib115","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.febslet.2008.02.028","article-title":"New uses for old drugs. Auranofin, a clinically established antiarthritic metallodrug, exhibits potent antimalarial effects in\u00a0vitro: mechanistic and pharmacological implications","volume":"582","author":"Sannella","year":"2008","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ejmech.2019.111711_bib116","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1038\/nm.2758","article-title":"A\u00a0high-throughput drug screen for Entamoeba histolytica identifies a new lead and target","volume":"18","author":"Debnath","year":"2012","journal-title":"Nat. Med."},{"issue":"7","key":"10.1016\/j.ejmech.2019.111711_bib117","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0002973","article-title":"Auranofin is highly efficacious against Toxoplasma gondii in\u00a0vitro and in an in\u00a0vivo experimental model of acute toxoplasmosis","volume":"8","author":"Andrade","year":"2014","journal-title":"PLoS Neglected Trop. Dis."},{"issue":"8","key":"10.1016\/j.ejmech.2019.111711_bib118","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1086\/428839","article-title":"Nitazoxanide: a new thiazolide antiparasitic agent","volume":"40","author":"Fox","year":"2005","journal-title":"Clin. Infect. Dis."},{"issue":"1","key":"10.1016\/j.ejmech.2019.111711_bib119","doi-asserted-by":"crossref","first-page":"27148","DOI":"10.1038\/srep27148","article-title":"Thiazolides elicit anti-viral innate immunity and reduce HIV replication","volume":"6","author":"Trabattoni","year":"2016","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.ejmech.2019.111711_bib120","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.arcmed.2013.07.002","article-title":"Effect of nitaxozanide and pyrimethamine on astrocytes infected by Toxoplasma gondii invitro","volume":"44","author":"Galv\u00e1n-Ram\u00edrez","year":"2013","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.ejmech.2019.111711_bib121","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.actatropica.2019.04.013","article-title":"Evaluation of nitazoxanide as a novel drug for the treatment of acute and chronic toxoplasmosis","volume":"195","author":"El-Kowrany","year":"2019","journal-title":"Acta Trop."},{"key":"10.1016\/j.ejmech.2019.111711_bib122","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ijpddr.2018.12.004","article-title":"New life for an old drug: in\u00a0vitro and in\u00a0vivo effects of the anthelmintic drug niclosamide against Toxoplasma gondii RH strain","volume":"9","author":"Zhang","year":"2019","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"issue":"11","key":"10.1016\/j.ejmech.2019.111711_bib123","doi-asserted-by":"crossref","first-page":"5581","DOI":"10.1128\/AAC.00868-12","article-title":"A\u00a0focused small-molecule screen identifies 14 compounds with distinct effects on Toxoplasma gondii","volume":"56","author":"Kamau","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"issue":"10","key":"10.1016\/j.ejmech.2019.111711_bib124","doi-asserted-by":"crossref","first-page":"5848","DOI":"10.1128\/AAC.02541-14","article-title":"Repurposing the open access malaria box to discover potent inhibitors of Toxoplasma gondii and Entamoeba histolytica","volume":"58","author":"Boyom","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"issue":"2","key":"10.1016\/j.ejmech.2019.111711_bib125","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01640-17","article-title":"Discovery of new inhibitors of Toxoplasma gondii thanks to the pathogen box","volume":"62","author":"Spalenka","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"issue":"2","key":"10.1016\/j.ejmech.2019.111711_bib126","doi-asserted-by":"crossref","DOI":"10.1128\/mSphere.00042-15","article-title":"Drug repurposing screening identifies novel compounds that effectively inhibit Toxoplasma gondii growth","volume":"1","author":"Dittmar","year":"2016","journal-title":"mSphere"},{"issue":"6","key":"10.1016\/j.ejmech.2019.111711_bib127","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0178203","article-title":"Identification of compounds that suppress Toxoplasma gondii tachyzoites and bradyzoites","volume":"12","author":"Murata","year":"2017","journal-title":"PLoS One"},{"issue":"5806","key":"10.1016\/j.ejmech.2019.111711_bib128","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1126\/science.1133690","article-title":"Polymorphic secreted kinases are key virulence factors in toxoplasmosis","volume":"314","author":"Saeij","year":"2006","journal-title":"Science"},{"issue":"5806","key":"10.1016\/j.ejmech.2019.111711_bib129","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1126\/science.1133643","article-title":"A\u00a0secreted serine-threonine kinase determines virulence in the eukaryotic pathogen Toxoplasma gondii","volume":"314","author":"Taylor","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.ejmech.2019.111711_bib130","first-page":"632424","article-title":"Toxoplasma rhoptries: unique secretory organelles and source of promising vaccine proteins for immunoprevention of toxoplasmosis","volume":"2008","author":"Dlugonska","year":"2008","journal-title":"J.\u00a0Biomed. Biotechnol."},{"issue":"3","key":"10.1016\/j.ejmech.2019.111711_bib131","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1021\/acsinfecdis.5b00102","article-title":"Identification of small molecule inhibitors that block the Toxoplasma gondii rhoptry kinase ROP18","volume":"2","author":"Simpson","year":"2016","journal-title":"ACS Infect. Dis."},{"issue":"12","key":"10.1016\/j.ejmech.2019.111711_bib132","doi-asserted-by":"crossref","first-page":"5438","DOI":"10.1128\/AAC.00455-11","article-title":"A\u00a0novel benzodioxole-containing inhibitor of Toxoplasma gondii growth alters the parasite cell cycle","volume":"55","author":"Kamau","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"issue":"5","key":"10.1016\/j.ejmech.2019.111711_bib133","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nri3210","article-title":"Interferon-inducible effector mechanisms in cell-autonomous immunity","volume":"12","author":"MacMicking","year":"2012","journal-title":"Nat. Rev. Immunol."},{"issue":"10","key":"10.1016\/j.ejmech.2019.111711_bib134","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1021\/acsinfecdis.8b00135","article-title":"High throughput screen identifies interferon gamma-dependent inhibitors of Toxoplasma gondii growth","volume":"4","author":"Radke","year":"2018","journal-title":"ACS Infect. Dis."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523419308633?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523419308633?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T14:07:35Z","timestamp":1759327655000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523419308633"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":134,"alternative-id":["S0223523419308633"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2019.111711","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Recent progress on anti-Toxoplasma drugs discovery: Design, synthesis and screening","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2019.111711","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111711"}}