{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T02:56:58Z","timestamp":1785207418822,"version":"3.55.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100010221","name":"Higher Education Commision, Pakistan","doi-asserted-by":"publisher","award":["22-1\/HEC\/R&D\/PPCR\/2018"],"award-info":[{"award-number":["22-1\/HEC\/R&D\/PPCR\/2018"]}],"id":[{"id":"10.13039\/501100010221","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010221","name":"Higher Education Commision, Pakistan","doi-asserted-by":"publisher","award":["22-1\/HEC\/R"],"award-info":[{"award-number":["22-1\/HEC\/R"]}],"id":[{"id":"10.13039\/501100010221","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004681","name":"Higher Education Commission, Pakistan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004681","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001459","name":"Ministry of Education - Singapore","doi-asserted-by":"publisher","award":["5291\/Federal\/NRPU\/R&D\/HEC\/2016"],"award-info":[{"award-number":["5291\/Federal\/NRPU\/R&D\/HEC\/2016"]}],"id":[{"id":"10.13039\/501100001459","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.ejmech.2019.111863","type":"journal-article","created":{"date-parts":[[2019,11,10]],"date-time":"2019-11-10T01:22:53Z","timestamp":1573348973000},"page":"111863","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":133,"special_numbering":"C","title":["Design, synthesis, in-vitro, in-vivo and in-silico studies of pyrrolidine-2,5-dione derivatives as multitarget anti-inflammatory\u00a0agents"],"prefix":"10.1016","volume":"186","author":[{"given":"Muhammad Saeed","family":"Jan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sajjad","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fida","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashfaq","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fawad","family":"Mahmood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2419-3172","authenticated-orcid":false,"given":"Umer","family":"Rashid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3553-6089","authenticated-orcid":false,"given":"Obaid-ur-Rahman","family":"Abid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhat","family":"Ullah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4299-2445","authenticated-orcid":false,"given":"Muhammad","family":"Ayaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul","family":"Sadiq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2019.111863_bib1","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s00423-006-0073-1","article-title":"Chronic inflammation and oxidative stress in the genesis and perpetuation of cancer: role of lipid peroxidation, DNA damage, and repair","volume":"391","author":"Bartsch","year":"2006","journal-title":"Langenbeck\u2019s Arch. Surg."},{"key":"10.1016\/j.ejmech.2019.111863_bib2","first-page":"789","article-title":"An experimental evaluation of Albuca setosa aqueous extract on membrane stabilization, protein denaturation and white blood cell migration during acute inflammation","volume":"4","author":"Umapathy","year":"2010","journal-title":"J.\u00a0Med. Plants Res."},{"key":"10.1016\/j.ejmech.2019.111863_bib3","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.cell.2010.03.006","article-title":"Inflammation 2010: new adventures of an old flame","volume":"140","author":"Medzhitov","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.ejmech.2019.111863_bib4","first-page":"189","article-title":"Invitro anti-inflammatory activity of methanol extract of Enicostemma axillare","volume":"3","author":"Leelaprakash","year":"2011","journal-title":"Int. J. Drug Dev. Res."},{"key":"10.1016\/j.ejmech.2019.111863_bib5","first-page":"207","article-title":"In-vitro 5-lipoxygenase inhibition of polyphenolic antioxidants from undomesticated plants of South Africa","volume":"2","author":"Akula","year":"2008","journal-title":"J.\u00a0Med. Plants Res."},{"key":"10.1016\/j.ejmech.2019.111863_bib6","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.mvr.2005.01.007","article-title":"Arachidonic acid cascade in endothelial pathobiology","volume":"69","author":"Bogatcheva","year":"2005","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.ejmech.2019.111863_bib7","first-page":"137","article-title":"Anti-inflammatory effects of the chloroform extract of annona muricata leaves on phospholipase A2 and prostaglandin synthase activities","volume":"8","author":"Oyekachukwu","year":"2017","journal-title":"Transl. Biomed."},{"key":"10.1016\/j.ejmech.2019.111863_bib8","first-page":"525","article-title":"The bioactivity of certain medicinal plants on the stabilization of RBC membrane system","volume":"60","author":"Sadique","year":"1989","journal-title":"Fitoterapia"},{"key":"10.1016\/j.ejmech.2019.111863_bib9","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s00253-006-0553-9","article-title":"Extremolytes: natural compounds from extremophiles for versatile applications","volume":"72","author":"Lentzen","year":"2006","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.ejmech.2019.111863_bib10","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1093\/glycob\/3.2.97","article-title":"Biological roles of oligosaccharides: all of the theories are correct","volume":"3","author":"Varki","year":"1993","journal-title":"Glycobiology"},{"key":"10.1016\/j.ejmech.2019.111863_bib11","doi-asserted-by":"crossref","first-page":"4501","DOI":"10.1021\/cr000033x","article-title":"Serine protease mechanism and specificity","volume":"102","author":"Hedstrom","year":"2002","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejmech.2019.111863_bib12","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/med.10007","article-title":"Bacterial protease inhibitors","volume":"22","author":"Supuran","year":"2002","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.ejmech.2019.111863_bib13","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1128\/MMBR.62.3.597-635.1998","article-title":"Molecular and biotechnological aspects of microbial proteases","volume":"62","author":"Rao","year":"1998","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.ejmech.2019.111863_bib14","doi-asserted-by":"crossref","first-page":"82","DOI":"10.5530\/pj.2011.25.15","article-title":"Phytochemical screening, antimicrobial and in-vitro anti-inflammatory activity of endophytic extracts from Loranthus sp","volume":"3","author":"Govindappa","year":"2011","journal-title":"Pharmacogn. J."},{"key":"10.1016\/j.ejmech.2019.111863_bib15","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.4155\/fmc-2017-0050","article-title":"Multiple target-centric strategy to tame inflammation","volume":"9","author":"Kaur","year":"2017","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111863_bib16","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1002\/ejoc.201201046","article-title":"Enantioselective synthesis of succinimides by Michael addition of 1,3-dicarbonyl compounds to maleimides catalyzed by a chiral bis (2-aminobenzimidazole) organocatalyst","author":"G\u00f3mez-Torres","year":"2013","journal-title":"Eur. J. Org. Chem."},{"key":"10.1016\/j.ejmech.2019.111863_bib17","first-page":"8","article-title":"Succinimides: synthesis, reaction and biological activity","volume":"6","author":"Patil","year":"2014","journal-title":"Int. J. Pharm. Pharm. Sci."},{"key":"10.1016\/j.ejmech.2019.111863_bib18","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1021\/cr960010b","article-title":"The current status of heterocyclic combinatorial libraries","volume":"97","author":"Nefzi","year":"1997","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejmech.2019.111863_bib19","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1021\/jm020067s","article-title":"Indanylidenes. 1. Design and synthesis of (E)-2-(4, 6-difluoro-1-indanylidene) acetamide, a potent, centrally acting muscle relaxant with antiinflammatory and analgesic activity","volume":"46","author":"Musso","year":"2003","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111863_bib20","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1021\/jm00225a023","article-title":"Synthesis and central nervous system depressant activity of some bicyclic amides","volume":"19","author":"Aeberli","year":"1976","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111863_bib21","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1021\/ol060926x","article-title":"A\u00a0dimer of antitubercular alkaloids from the seed fungus Trichoderma species BCC 7579","volume":"8","author":"Isaka","year":"2006","journal-title":"Org. Lett."},{"key":"10.1016\/j.ejmech.2019.111863_bib22","first-page":"67","article-title":"Synthesis of new succinimides and sulphonated derivatives with analgesic action in mice","volume":"3","author":"Corr\u00eaa","year":"1997","journal-title":"J.\u00a0Pharm. Pharmacol. Commun."},{"key":"10.1016\/j.ejmech.2019.111863_bib23","first-page":"224","article-title":"Ethosuximide: from bench to bedside, CNS","volume":"13","author":"G\u00f6ren","year":"2007","journal-title":"Drug Rev."},{"key":"10.1016\/j.ejmech.2019.111863_bib24","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0753-3322(96)82631-X","article-title":"The cytotoxicity of N-pyridinyl and N-quinolinyl substituted derivatives of phthalimide and succinimide","volume":"49","author":"Hall","year":"1995","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejmech.2019.111863_bib25","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.bmcl.2003.11.018","article-title":"Bile acid amides derived from chiral amino alcohols: novel antimicrobials and antifungals","volume":"14","author":"Hazra","year":"2004","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2019.111863_bib26","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1021\/jm00177a024","article-title":"Synthesis and anticancer activity of nitrosourea derivatives of phensuximide","volume":"23","author":"Crider","year":"1980","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111863_bib27","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/ddr.430030603","article-title":"The antihypertensive effect of a selective central muscarinic cholinergic antagonist: N-(4-diethylamino-2-butynyl)-succinimide","volume":"3","author":"Coram","year":"1983","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.ejmech.2019.111863_bib28","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0014-827X(02)01217-X","article-title":"Synthesis and antimicrobial activities of N-substituted imides","volume":"57","author":"Zentz","year":"2002","journal-title":"Il Farmaco"},{"key":"10.1016\/j.ejmech.2019.111863_bib29","doi-asserted-by":"crossref","first-page":"5305","DOI":"10.1016\/S0040-4039(00)87854-5","article-title":"Synthesis of the cytostatic cyclic tetrapeptide, chlamydocin","volume":"24","author":"Rich","year":"1983","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.ejmech.2019.111863_bib30","first-page":"399","article-title":"Inhibition of Guinea pig ileum contraction by phyllanthimide analogues: structure activity relationships","volume":"1","author":"Filho","year":"1995","journal-title":"J.\u00a0Pharm. Pharmacol. Commun."},{"key":"10.1016\/j.ejmech.2019.111863_bib31","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1085\/jgp.200709946","article-title":"Ion channels as drug targets: the next GPCRs","volume":"131","author":"Kaczorowski","year":"2008","journal-title":"J.\u00a0Gen. Physiol."},{"key":"10.1016\/j.ejmech.2019.111863_bib32","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.3390\/molecules15031303","article-title":"Reductive Heck reactions of N-methyl-substituted tricyclic imides","volume":"15","author":"Goksu","year":"2010","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2019.111863_bib33","doi-asserted-by":"crossref","first-page":"3416","DOI":"10.1016\/j.bmc.2011.04.027","article-title":"Design, synthesis, and biological evaluation of substituted hydrazone and pyrazole derivatives as selective COX-2 inhibitors: molecular docking study","volume":"19","author":"Magda","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111863_bib34","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.2174\/1385272820666160530145014","article-title":"Chemistry of cyclic imides: an overview on the past, present and future","volume":"20","author":"Kavitha","year":"2016","journal-title":"Curr. Org. Chem."},{"key":"10.1016\/j.ejmech.2019.111863_bib35","doi-asserted-by":"crossref","first-page":"9287","DOI":"10.1039\/c2ob26382c","article-title":"Chiral picolylamines for Michael and aldol reactions: probing substrate boundaries","volume":"10","author":"Nugent","year":"2012","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.ejmech.2019.111863_bib36","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13065-015-0107-2","article-title":"Synthesis, anticholinesterase and antioxidant potentials of ketoesters derivatives of succinimides: a possible role in the management of Alzheimer\u2019s","volume":"9","author":"Sadiq","year":"2015","journal-title":"Chem. Cent. J."},{"key":"10.1016\/j.ejmech.2019.111863_bib37","doi-asserted-by":"crossref","first-page":"4088","DOI":"10.1002\/chem.201103005","article-title":"Noncovalent bifunctional organocatalysts: powerful tools for contiguous quaternary-tertiary stereogenic carbon formation, scope, and origin of enantioselectivity","volume":"18","author":"Nugent","year":"2012","journal-title":"Chem. Eur J."},{"key":"10.1016\/j.ejmech.2019.111863_bib38","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3389\/fchem.2017.00119","article-title":"Ethyl 3-oxo-2-(2, 5-dioxopyrrolidin-3-yl) butanoate derivatives: anthelmintic and cytotoxic potentials, antimicrobial, and docking studies","volume":"5","author":"Mahmood","year":"2017","journal-title":"Front. Chem."},{"key":"10.1016\/j.ejmech.2019.111863_bib39","doi-asserted-by":"crossref","first-page":"4589","DOI":"10.1039\/c0cc00774a","article-title":"Enantioselective Michael addition of ketones to maleimides catalyzed by bifunctional monosulfonyl DPEN salt","volume":"46","author":"Yu","year":"2010","journal-title":"Chem. Commun."},{"key":"10.1016\/j.ejmech.2019.111863_bib40","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1002\/adsc.201300041","article-title":"Michael addition of ketones and aldehydes to maleimides catalyzed by modularly designed organocatalysts","volume":"355","author":"Muramulla","year":"2013","journal-title":"Adv. Synth. Catal."},{"key":"10.1016\/j.ejmech.2019.111863_bib41","first-page":"473","article-title":"Chiral pyrrolidine sulfonamide catalyzed enantioselective michael addition of cyclohexanones to maleimides","author":"Wang","year":"2011","journal-title":"Synlett"},{"key":"10.1016\/j.ejmech.2019.111863_bib42","first-page":"4345","article-title":"Detrifluoroacetylation reaction of trifluoromethyl-\u03b2-diketones: facile method for the synthesis of succinimide derivatives and 1, 4-diketones","volume":"31","author":"Hua","year":"2018","journal-title":"Eur. J. Org. Chem."},{"key":"10.1016\/j.ejmech.2019.111863_bib43","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.3390\/molecules23071621","article-title":"Application of docking analysis in the prediction and biological evaluation of the lipoxygenase inhibitory action of thiazolyl derivatives of mycophenolic acid","volume":"23","author":"Tsolaki","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2019.111863_bib44","doi-asserted-by":"crossref","first-page":"685","DOI":"10.3390\/molecules23030685","article-title":"Thiazoles and thiazolidinones as COX\/LOX inhibitors","volume":"23","author":"Liaras","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2019.111863_bib45","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.tibs.2007.06.002","article-title":"5-Lipoxygenase: regulation of expression and enzyme activity","volume":"32","author":"R\u00e5dmark","year":"2007","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.ejmech.2019.111863_bib46","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/j.neurobiolaging.2006.06.007","article-title":"The 5-lipoxygenase enzymatic pathway in the mouse brain: young versus old","volume":"28","author":"Chinnici","year":"2007","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.ejmech.2019.111863_bib47","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.neurobiolaging.2005.08.008","article-title":"Inflammation, the complement system and the diseases of aging","volume":"26","author":"McGeer","year":"2005","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.ejmech.2019.111863_bib48","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1586\/ern.09.23","article-title":"Donepezil in the treatment of patients with Alzheimer\u2019s disease","volume":"9","author":"Tsuno","year":"2009","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.ejmech.2019.111863_bib49","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1172\/JCI113000","article-title":"Study of the molecular mechanism of decreased liver synthesis of albumin in inflammation","volume":"79","author":"Moshage","year":"1987","journal-title":"J.\u00a0Clin. Investig."},{"key":"10.1016\/j.ejmech.2019.111863_bib50","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1021\/acschemneuro.8b00102","article-title":"3-Substituted 1, 5-diaryl-1 H-1, 2, 4-triazoles as prospective PET radioligands for imaging brain COX-1 in monkey. Part 1: synthesis and Pharmacology","volume":"9","author":"Singh","year":"2018","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.ejmech.2019.111863_bib51","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1476-9255-4-15","article-title":"Free radical scavenging activity and lipoxygenase inhibition of Mahonia aquifolium extract and isoquinoline alkaloids","volume":"4","author":"Rackova","year":"2007","journal-title":"J.\u00a0Inflamm."},{"key":"10.1016\/j.ejmech.2019.111863_bib52","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/BF02976483","article-title":"Inhibition of heat-induced denaturation of albumin by nonsteroidal antiinflammatory drugs (NSAIDs): pharmacological implications","volume":"24","author":"Saso","year":"2001","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.ejmech.2019.111863_bib53","series-title":"Guideline for the Testing of Chemicals. Acute Oral Toxicity e Acute Toxic Class Method: Test No-423","author":"OECD","year":"2001"},{"key":"10.1016\/j.ejmech.2019.111863_bib54","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.niox.2017.04.006","article-title":"Potential anti-inflammatory effect of LQFM-021 in carrageenan-induced inflammation: the role of nitric oxide","volume":"69","author":"Florentino","year":"2017","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.ejmech.2019.111863_bib55","first-page":"519","article-title":"Anti-inflammatory effects of nortrachelogenin in murine J774 macrophages and in carrageenan-induced paw edema model in the mouse","volume":"234","author":"Laavola","year":"2017","journal-title":"Planta Med."},{"key":"10.1016\/j.ejmech.2019.111863_bib56","series-title":"08; Chemical Computing Group ULC, 1010 Sherbooke St. West, Suite #910","author":"Molecular Operating Environment (MOE)","year":"2016"},{"key":"10.1016\/j.ejmech.2019.111863_bib57","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3390\/molecules21020201","article-title":"Design, synthesis, and biological evaluation of some novel pyrrolizine derivatives as COX inhibitors with anti-inflammatory\/analgesic activities and low ulcerogenic liability","volume":"21","author":"Gouda","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2019.111863_bib58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40659-018-0209-0","article-title":"Isolation of dihydrobenzofuran derivatives from ethnomedicinal species Polygonum barbatum as anticancer compounds","volume":"52","author":"Farooq","year":"2019","journal-title":"Biol. Res."},{"key":"10.1016\/j.ejmech.2019.111863_bib59","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.bioorg.2018.10.035","article-title":"Design, synthesis and bioevaluation of tricyclic fused ring system as dual binding site acetylcholinesterase inhibitors","volume":"83","author":"Tanoli","year":"2019","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2019.111863_bib60","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.bioorg.2018.05.026","article-title":"Design, synthesis, in-vitro thymidine phosphorylase inhibition, in-vivo antiangiogenic and in-silico studies of C-6 substituted dihydropyrimidines","volume":"80","author":"Iftikhar","year":"2018","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.ejmech.2019.111863_bib61","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.steroids.2018.05.008","article-title":"Synthesis, pharmacological evaluation and docking studies of progesterone and testosterone derivatives as anticancer agents","volume":"136","author":"Jabeen","year":"2018","journal-title":"Steroids"},{"key":"10.1016\/j.ejmech.2019.111863_bib62","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3389\/fchem.2018.00055","article-title":"Ursolic acid hydrazide based organometallic complexes: synthesis, characterization, antibacterial, antioxidant, and docking studies","volume":"6","author":"Jabeen","year":"2018","journal-title":"Front. Chem."},{"key":"10.1016\/j.ejmech.2019.111863_bib63","series-title":"Discovery Studio Visualizer","author":"Biovia","year":"2017"}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523419310153?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523419310153?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T12:51:43Z","timestamp":1778676703000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523419310153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":63,"alternative-id":["S0223523419310153"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2019.111863","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design, synthesis, in-vitro, in-vivo and in-silico studies of pyrrolidine-2,5-dione derivatives as multitarget anti-inflammatory\u00a0agents","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2019.111863","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111863"}}