{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T23:02:04Z","timestamp":1788822124958,"version":"build-2803163510"},"reference-count":76,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Rhodes University Sandisa Imbewu"},{"name":"National Research Foundation of South Africa"},{"name":"South African Research Chairs Initiative of the Department of Science and Technology and National Research Foundation of South Africa","award":["98566"],"award-info":[{"award-number":["98566"]}]},{"name":"National Research Foundation CPRR","award":["105829"],"award-info":[{"award-number":["105829"]}]},{"DOI":"10.13039\/501100001322","name":"South African Medical Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001322","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.ejmech.2019.111924","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T11:38:19Z","timestamp":1575286699000},"page":"111924","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Repurposing a polymer precursor: Synthesis and in\u00a0vitro medicinal potential of ferrocenyl 1,3-benzoxazine derivatives"],"prefix":"10.1016","volume":"187","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1608-6801","authenticated-orcid":false,"given":"Mziyanda","family":"Mbaba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura M.K.","family":"Dingle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devon","family":"Cash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo-Anne de la","family":"Mare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dustin","family":"Laming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2734-0999","authenticated-orcid":false,"given":"Heinrich C.","family":"Hoppe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrienne L.","family":"Edkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Setshaba D.","family":"Khanye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2019.111924_bib1","series-title":"Handbook of Benzoxazine Resins","first-page":"3","article-title":"Chapter 1 - overview and historical background of polybenzoxazine research","author":"Ishida","year":"2011"},{"key":"10.1016\/j.ejmech.2019.111924_bib2","first-page":"1","article-title":"3, 4\u2013dihydro\u20132H\u20131, 3\u2013benzoxazines and their oxo\u2013derivatives chemistry and bioactivities","volume":"83","author":"Eldin","year":"2019","journal-title":"J.\u00a0Serb. Chem. Soc."},{"key":"10.1016\/j.ejmech.2019.111924_bib3","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1038\/1781351a0","article-title":"Biological activity of benzoxazine-1, 3 derivatives, particularly against experimental sarcoma","volume":"178","author":"Urba\u0144ski","year":"1956","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2019.111924_bib4","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1021\/jm00341a004","article-title":"Dihydro-1,3-oxazine derivatives and their antitumor activity","volume":"6","author":"Chyli\u0144ska","year":"1963","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111924_bib5","first-page":"107","article-title":"Isolation and characterization of a cyclic hydroxamate from Zea mays","volume":"39","author":"Hamilton","year":"1962","journal-title":"Cereal Chem."},{"key":"10.1016\/j.ejmech.2019.111924_bib6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/(SICI)1521-4184(199801)331:1<3::AID-ARDP3>3.0.CO;2-2","article-title":"Relationships between the chemical structure of antimycobacterial substances and their activity against atypical strains. Part 14: 3-Aryl-6, 8-dihalogeno-2H-1, 3-benzoxazine-2, 4 (3H)-diones","volume":"331","author":"Waisser","year":"1998","journal-title":"Arch. Pharm."},{"key":"10.1016\/j.ejmech.2019.111924_bib7","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/sj.bjp.0706873","article-title":"Small molecules with antimicrobial activity against E. coli and P. aeruginosa identified by high-throughput screening","volume":"149","author":"De La Fuente","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejmech.2019.111924_bib8","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/jhet.533","article-title":"Synthesis of 2, 3-diaryl-3, 4-dihydro-2H-1, 3-benzoxazines and their fungicidal activities","volume":"48","author":"Tang","year":"2011","journal-title":"J.\u00a0Heterocycl. Chem."},{"key":"10.1016\/j.ejmech.2019.111924_bib9","doi-asserted-by":"crossref","first-page":"8174","DOI":"10.3390\/molecules17078174","article-title":"Synthesis and fungicidal activity of novel 2, 3-disubstituted-1, 3-benzoxazines","volume":"17","author":"Tang","year":"2012","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2019.111924_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0102759","article-title":"Novel benzoxazine-based aglycones block glucose uptake in\u00a0vivo by inhibiting glycosidases","volume":"9","author":"Bharathkumar","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ejmech.2019.111924_bib11","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.1248\/cpb.39.2896","article-title":"Synthesis and biological activities of new 2-substituted 1, 4-benzoxazine derivatives","volume":"39","author":"Kajino","year":"1991","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.ejmech.2019.111924_bib12","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1016\/j.bmcl.2005.11.054","article-title":"Studies toward the discovery of the next generation of antidepressants. Part 5: 3, 4-Dihydro-2H-benzo [1, 4] oxazine derivatives with dual 5-HT 1A receptor and serotonin transporter affinity","volume":"16","author":"Zhou","year":"2006","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2019.111924_bib13","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1002\/(SICI)1099-0488(19960430)34:6<1019::AID-POLB1>3.0.CO;2-T","article-title":"Physical and mechanical characterization of near-zero shrinkage polybenzoxazines","volume":"34","author":"Ishida","year":"1996","journal-title":"J.\u00a0Polym. Sci., Part B: Polym. Phys."},{"key":"10.1016\/j.ejmech.2019.111924_bib14","doi-asserted-by":"crossref","first-page":"5117","DOI":"10.1021\/ma401014h","article-title":"Examining the initiation of the polymerization mechanism and network development in aromatic polybenzoxazines","volume":"46","author":"Hamerton","year":"2013","journal-title":"Macromolecules"},{"key":"10.1016\/j.ejmech.2019.111924_bib15","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.reactfunctpolym.2017.06.009","article-title":"Adapting benzoxazine chemistry for unconventional applications","volume":"129","author":"Kiskan","year":"2018","journal-title":"React. Funct. Polym."},{"key":"10.1016\/j.ejmech.2019.111924_bib16","first-page":"594","article-title":"Cardanol benzoxazine-sulfur copolymers for Li-S batteries: symbiosis of sustainability and performance","volume":"1","author":"Shukla","year":"2016","journal-title":"Chemistry"},{"key":"10.1016\/j.ejmech.2019.111924_bib17","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1021\/acsenergylett.6b00245","article-title":"Rational sulfur cathode design for lithium\u2013sulfur batteries: sulfur-embedded benzoxazine polymers","volume":"1","author":"Je","year":"2016","journal-title":"ACS Energy Lett"},{"key":"10.1016\/j.ejmech.2019.111924_bib18","series-title":"Thermosets: Structure, Properties, and Applications","first-page":"543","article-title":"Benzoxazine resins as smart materials and future perspectives","author":"Kiskan","year":"2018"},{"key":"10.1016\/j.ejmech.2019.111924_bib19","series-title":"Bioorganometallics: Biomolecules, Labeling, Medicine","first-page":"1","article-title":"A\u00a0novel field of research: bioorganometallic chemistry, origins, and founding principles","author":"Jaouen","year":"2006"},{"key":"10.1016\/j.ejmech.2019.111924_bib20","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.cbpa.2012.01.013","article-title":"The potential of organometallic complexes in medicinal chemistry","volume":"16","author":"Gasser","year":"2012","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.ejmech.2019.111924_bib21","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1021\/om100964h","article-title":"Bioorganometallics: future trends in drug discovery, analytical chemistry, and catalysis","volume":"30","author":"Hillard","year":"2011","journal-title":"Organometallics"},{"key":"10.1016\/j.ejmech.2019.111924_bib22","series-title":"Medicinal Organometallic Chemistry","first-page":"155","article-title":"Bioorganometallic chemistry and malaria","author":"Biot","year":"2010"},{"key":"10.1016\/j.ejmech.2019.111924_bib23","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1039\/B707077M","article-title":"Bioorganometallic chemistry\u2014from teaching paradigms to medicinal applications","volume":"38","author":"Hartinger","year":"2009","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.ejmech.2019.111924_bib24","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1002\/anie.200504604","article-title":"New principles in medicinal organometallic chemistry","volume":"45","author":"Schatzschneider","year":"2006","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.ejmech.2019.111924_bib25","doi-asserted-by":"crossref","DOI":"10.1038\/s41570-017-0066","article-title":"The medicinal chemistry of ferrocene and its derivatives","volume":"1","author":"Patra","year":"2017","journal-title":"Nat. Rev. Chem"},{"key":"10.1016\/j.ejmech.2019.111924_bib26","doi-asserted-by":"crossref","first-page":"6350","DOI":"10.1039\/c2dt12460b","article-title":"Small organometallic compounds as antibacterial agents","volume":"41","author":"Patra","year":"2012","journal-title":"Dalton Trans."},{"key":"10.1016\/j.ejmech.2019.111924_bib27","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.jorganchem.2017.03.038","article-title":"Advances in the design of organometallic anticancer complexes","volume":"839","author":"Zhang","year":"2017","journal-title":"J.\u00a0Organomet. Chem."},{"key":"10.1016\/j.ejmech.2019.111924_bib28","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ccr.2018.01.009","article-title":"The mechanism of tumour cell death by metal-based anticancer drugs is not only a matter of DNA interactions","volume":"360","author":"Bergamo","year":"2018","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.ejmech.2019.111924_bib30","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.2174\/1568026614666140808122329","article-title":"Ferroquine as an oxidative shock antimalarial","volume":"14","author":"Dive","year":"2014","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111924_bib31","doi-asserted-by":"crossref","first-page":"15896","DOI":"10.1038\/s41598-017-16154-2","article-title":"Ferroquine, the next generation antimalarial drug, has antitumor activity","volume":"7","author":"Kondratskyi","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejmech.2019.111924_bib32","doi-asserted-by":"crossref","first-page":"8802","DOI":"10.1039\/C5CS00486A","article-title":"Ferrocifen type anti cancer drugs","volume":"44","author":"Jaouen","year":"2015","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.ejmech.2019.111924_bib33","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1039\/CC9960000955","article-title":"Ferrocenyl hydroxytamoxifen: a prototype for a new range of oestradiol receptor site-directed cytotoxics","author":"Top","year":"1996","journal-title":"Chem. Commun."},{"key":"10.1016\/j.ejmech.2019.111924_bib34","first-page":"309","article-title":"Pharmacological profile of benzoxazines: a short review","volume":"2","author":"Siddiqui","year":"2010","journal-title":"J.\u00a0Chem. Pharm. Res."},{"key":"10.1016\/j.ejmech.2019.111924_bib35","doi-asserted-by":"crossref","first-page":"10387","DOI":"10.1021\/jm300831b","article-title":"Mimicking the intramolecular hydrogen bond: synthesis, biological evaluation, and molecular modeling of benzoxazines and quinazolines as potential antimalarial agents","volume":"55","author":"Gemma","year":"2012","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111924_bib36","doi-asserted-by":"crossref","first-page":"5256","DOI":"10.1007\/s00044-013-0534-3","article-title":"Synthesis, biological evaluation and molecular docking studies of 1, 3-benzoxazine derivatives as potential anticancer agents","volume":"22","author":"Garg","year":"2013","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.ejmech.2019.111924_bib37","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3390\/50200099","article-title":"Novel coumarin derivatives with expected biological activity","volume":"5","author":"Nofal","year":"2000","journal-title":"Molecules"},{"key":"10.1016\/j.ejmech.2019.111924_bib38","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/s11030-016-9662-2","article-title":"Microwave-assisted Synthesis and antifungal activity of coumarin [8, 7-e][1, 3] oxazine derivatives","volume":"20","author":"Zhang","year":"2016","journal-title":"Mol. Divers."},{"key":"10.1016\/j.ejmech.2019.111924_bib39","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/j.bmcl.2013.12.117","article-title":"Synthesis of 2H-1, 3-benzoxazin-4 (3H)-one derivatives containing indole moiety: their in\u00a0vitro evaluation against PDE4B","volume":"24","author":"Rao","year":"2014","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.ejmech.2019.111924_bib40","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/j.polymer.2012.01.052","article-title":"Preparation of novel benzoxazine monomers containing ferrocene moiety and properties of polybenzoxazines","volume":"53","author":"Li","year":"2012","journal-title":"Polymer"},{"key":"10.1016\/j.ejmech.2019.111924_bib41","doi-asserted-by":"crossref","first-page":"4909","DOI":"10.1016\/j.polymer.2013.06.056","article-title":"A\u00a0novel thermal-resistant copolymer from polysiloxane-based polybenzoxazine precursor and ferrocene-based benzoxazine monomer","volume":"54","author":"Li","year":"2013","journal-title":"Polymer"},{"key":"10.1016\/j.ejmech.2019.111924_bib42","doi-asserted-by":"crossref","first-page":"3715","DOI":"10.1021\/jm970401y","article-title":"Synthesis and antimalarial activity in\u00a0vitro and in\u00a0vivo of a new ferrocene\u2212 chloroquine analogue","volume":"40","author":"Biot","year":"1997","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111924_bib43","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1021\/ja01170a063","article-title":"3, 4-Dihydro-1, 3, 2H-Benzoxazines. Reaction of p-substituted phenols with N, N-dimethylolamines","volume":"71","author":"Burke","year":"1949","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.ejmech.2019.111924_bib44","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0022-328X(98)00866-3","article-title":"The dichloromethane induced fragmentation of ferrocenylmethyldimethylamine. Mechanistic aspects and crystallographic and electrochemical investigation of the (FcCH2) 2NMe2+ and FcCH2NMe2H+ ions","volume":"570","author":"Winter","year":"1998","journal-title":"J.\u00a0Organomet. Chem."},{"key":"10.1016\/j.ejmech.2019.111924_bib45","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/187426a0","article-title":"Anti-neoplastic activity of tetrahydro-1, 3-oxazine derivatives","volume":"187","author":"Urba\u0144ski","year":"1960","journal-title":"Nature"},{"key":"10.1016\/j.ejmech.2019.111924_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-2725(08)60840-5","article-title":"1,3-Oxazine derivatives","volume":"23","author":"Eckstein","year":"1979","journal-title":"Adv. Heterocycl. Chem."},{"key":"10.1016\/j.ejmech.2019.111924_bib47","doi-asserted-by":"crossref","first-page":"5227","DOI":"10.1016\/S0040-4039(01)00991-1","article-title":"Preparation of carbamates from amines and alcohols under mild conditions","volume":"42","author":"D\u2019Addona","year":"2001","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.ejmech.2019.111924_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jorganchem.2015.04.009","article-title":"Synthesis, characterization and pharmacological evaluation of ferrocenyl azines and their rhodium (I) complexes","volume":"788","author":"Stringer","year":"2015","journal-title":"J.\u00a0Organomet. Chem."},{"key":"10.1016\/j.ejmech.2019.111924_bib49","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.ejmech.2014.10.024","article-title":"1H-1,2,3-triazole tethered isatin-ferrocene conjugates: synthesis and in\u00a0vitro antimalarial evaluation","volume":"87","author":"Kumar","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111924_bib50","doi-asserted-by":"crossref","first-page":"5662","DOI":"10.1016\/j.bmc.2017.08.049","article-title":"A\u00a0novel class of plasmodial ClpP protease inhibitors as potential antimalarial agents","volume":"25","author":"Mundra","year":"2017","journal-title":"Biorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111924_bib51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/0929867304666220309194437","article-title":"Anticancer and cytotoxic properties of Mannich bases","volume":"4","author":"Dimmock","year":"1997","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111924_bib52","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.ejmech.2014.10.076","article-title":"Mannich bases in medicinal chemistry and drug design","volume":"89","author":"Roman","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111924_bib53","doi-asserted-by":"crossref","first-page":"3214","DOI":"10.1021\/jm9018383","article-title":"Antimalarial versus cytotoxic properties of dual drugs derived from 4-aminoquinolines and Mannich bases: interaction with DNA","volume":"53","author":"Wenzel","year":"2010","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111924_bib54","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1007\/s12272-011-1006-2","article-title":"DNA binding, antiviral activities and cytotoxicity of new furochromone and benzofuran derivatives","volume":"34","author":"Abdelhafez","year":"2011","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.ejmech.2019.111924_bib55","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.ejmech.2013.08.038","article-title":"Synthesis, cytotoxicity and DNA binding of oxoazabenzo [de] anthracenes derivatives in colon cancer Caco-2 cells","volume":"69","author":"Di Salvo","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2019.111924_bib56","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jphotobiol.2012.03.012","article-title":"Study of DNA\u2013emodin interaction by FTIR and UV\u2013vis spectroscopy","volume":"111","author":"Saito","year":"2012","journal-title":"J.\u00a0Photochem. Photobiol., B"},{"key":"10.1016\/j.ejmech.2019.111924_bib57","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.saa.2012.05.045","article-title":"Spectroscopic studies on the interaction of calf thymus DNA with the drug levetiracetam","volume":"96","author":"Shahabadi","year":"2012","journal-title":"Spectrochim. Acta"},{"key":"10.1016\/j.ejmech.2019.111924_bib58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jphotobiol.2013.03.013","article-title":"Drug\u2013DNA interactions and their study by UV\u2013Visible, fluorescence spectroscopies and cyclic voltametry","volume":"124","author":"Sirajuddin","year":"2013","journal-title":"J.\u00a0Photochem. Photobiol., B"},{"key":"10.1016\/j.ejmech.2019.111924_bib59","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1007\/s10812-013-9811-7","article-title":"Mechanisms for binding between methylene blue and DNA","volume":"80","author":"Vardevanyan","year":"2013","journal-title":"J.\u00a0Appl. Spectrosc."},{"key":"10.1016\/j.ejmech.2019.111924_bib60","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3390\/chemosensors6020018","article-title":"The use of Hoechst dyes for DNA staining and beyond","volume":"6","author":"Bucevi\u010dius","year":"2018","journal-title":"Chemosensors"},{"key":"10.1016\/j.ejmech.2019.111924_bib61","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1039\/C5AN02140E","article-title":"A\u00a0new insight into the interaction of cisplatin with DNA: ROA spectroscopic studies on the therapeutic effect of the drug","volume":"141","author":"G\u0105sior-G\u0142ogowska","year":"2016","journal-title":"Analyst"},{"key":"10.1016\/j.ejmech.2019.111924_bib62","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.jinorgbio.2010.04.005","article-title":"Structure of duplex DNA containing the cisplatin 1, 2-{Pt (NH3) 2} 2+-d (GpG) cross-link at 1.77 \u00c5 resolution","volume":"104","author":"Todd","year":"2010","journal-title":"J.\u00a0Inorg. Biochem."},{"key":"10.1016\/j.ejmech.2019.111924_bib63","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/cyto.990060304","article-title":"Fluorescence studies of Hoechst 33342 with supercoiled and relaxed plasmid pBR322 DNA","volume":"6","author":"Sandhu","year":"1985","journal-title":"Cytometry"},{"key":"10.1016\/j.ejmech.2019.111924_bib64","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.redox.2013.12.020","article-title":"OpenComet: an automated tool for comet assay image analysis","volume":"2","author":"Gyori","year":"2014","journal-title":"Redox Biol"},{"key":"10.1016\/j.ejmech.2019.111924_bib65","doi-asserted-by":"crossref","first-page":"13262","DOI":"10.1039\/C4CP01280A","article-title":"Are all polar molecules hydrophilic? Hydration numbers of nitro compounds and nitriles in aqueous solution","volume":"16","author":"Sagawa","year":"2014","journal-title":"Phys. Chem. Chem. Phys."},{"key":"10.1016\/j.ejmech.2019.111924_bib66","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading Trott, Oleg; Olson","volume":"31","author":"Vina","year":"2010","journal-title":"Arthur. J. Comput. Chem."},{"key":"10.1016\/j.ejmech.2019.111924_bib67","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera\u2014a visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J.\u00a0Comput. Chem."},{"key":"10.1016\/j.ejmech.2019.111924_bib68","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1080\/1062936X.2010.502299","article-title":"Theory of docking scores and its application to a customizable scoring function","volume":"21","author":"Takahashi","year":"2010","journal-title":"SAR QSAR Environ. Res."},{"key":"10.1016\/j.ejmech.2019.111924_bib69","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jinorgbio.2017.04.014","article-title":"Ferrocenyl and organic novobiocin derivatives: synthesis and their in\u00a0vitro biological activity","volume":"172","author":"Mbaba","year":"2017","journal-title":"J.\u00a0Inorg. Biochem."},{"key":"10.1016\/j.ejmech.2019.111924_bib70","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1126\/science.781840","article-title":"Human malaria parasites in continuous culture","volume":"193","author":"Trager","year":"1976","journal-title":"Science"},{"key":"10.1016\/j.ejmech.2019.111924_bib71","doi-asserted-by":"crossref","first-page":"e4385","DOI":"10.1002\/aoc.4385","article-title":"New thiazolidine-2,4-dione derivatives combined with organometallic ferrocene: synthesis, structure and antiparasitic activity","volume":"32","author":"Oderinlo","year":"2018","journal-title":"Appl. Organomet. Chem."},{"key":"10.1016\/j.ejmech.2019.111924_bib72","doi-asserted-by":"crossref","first-page":"205","DOI":"10.4269\/ajtmh.1993.48.205","article-title":"Measurement of the lactate dehydrogenase activity of Plasmodium falciparum as an assessment of parasitemia","volume":"48","author":"Makler","year":"1993","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.ejmech.2019.111924_bib73","doi-asserted-by":"crossref","first-page":"985","DOI":"10.2307\/3282883","article-title":"Continuous cultivation of Trypanosoma brucei blood stream forms in a medium containing a low concentration of serum protein without feeder cell layers","author":"Hirumi","year":"1989","journal-title":"J.\u00a0Parasitol."},{"key":"10.1016\/j.ejmech.2019.111924_bib74","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3390\/medicina55050206","article-title":"Anti-trypanosomal and antimalarial properties of tetralone derivatives and structurally related benzocycloalkanones","volume":"55","author":"Beteck","year":"2019","journal-title":"Medicina"},{"key":"10.1016\/j.ejmech.2019.111924_bib75","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00775-018-1634-9","article-title":"Novobiocin\u2013ferrocene conjugates possessing anticancer and antiplasmodial activity independent of HSP90 inhibition","volume":"24","author":"Mbaba","year":"2019","journal-title":"J.\u00a0Biol. Inorg. Chem."},{"key":"10.1016\/j.ejmech.2019.111924_bib76","doi-asserted-by":"crossref","first-page":"3696","DOI":"10.1021\/acs.jctc.5b00255","article-title":"ff14SB: improving the accuracy of protein side chain and backbone parameters from ff99SB","volume":"11","author":"Maier","year":"2015","journal-title":"J.\u00a0Chem. Theory Comput."},{"key":"10.1016\/j.ejmech.2019.111924_bib77","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jmgm.2005.12.005","article-title":"Automatic atom type and bond type perception in molecular mechanical calculations","volume":"25","author":"Wang","year":"2006","journal-title":"J.\u00a0Mol. Graph. Model."}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523419310761?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523419310761?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T14:04:34Z","timestamp":1759327474000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523419310761"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":76,"alternative-id":["S0223523419310761"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2019.111924","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Repurposing a polymer precursor: Synthesis and in\u00a0vitro medicinal potential of ferrocenyl 1,3-benzoxazine derivatives","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2019.111924","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111924"}}