{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T01:28:27Z","timestamp":1793842107404,"version":"4.6.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.ejmech.2020.112039","type":"journal-article","created":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T19:39:26Z","timestamp":1578512366000},"page":"112039","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"special_numbering":"C","title":["Anticancer activity of 4\u2032-phenyl-2,2\u2032:6\u2032,2\u2033-terpyridines \u2013 behind the metal complexation"],"prefix":"10.1016","volume":"189","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4283-3126","authenticated-orcid":false,"given":"Katarzyna","family":"Malarz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7757-7321","authenticated-orcid":false,"given":"Dawid","family":"Zych","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u0142","family":"Kuczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6219-7369","authenticated-orcid":false,"given":"Robert","family":"Musio\u0142","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2228-1475","authenticated-orcid":false,"given":"Anna","family":"Mrozek-Wilczkiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejmech.2020.112039_bib1","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1039\/B400653B","article-title":"Recent developments in the supramolecular chemistry of terpyridine-metal complexes","volume":"33","author":"Hofmeier","year":"2004","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.ejmech.2020.112039_bib2","doi-asserted-by":"crossref","first-page":"E137","DOI":"10.3390\/ma9030137","article-title":"Terpyridine and quaterpyridine complexes as sensitizers for photovoltaic applications","volume":"9","author":"Saccone","year":"2016","journal-title":"Materials"},{"key":"10.1016\/j.ejmech.2020.112039_bib3","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cis.2013.12.010","article-title":"From terpyridine-based assemblies to metallo-supramolecular polyelectrolytes (MEPEs)","volume":"207","author":"Schwarz","year":"2014","journal-title":"Adv. Colloid Interface Sci."},{"key":"10.1016\/j.ejmech.2020.112039_bib4","doi-asserted-by":"crossref","first-page":"5728","DOI":"10.1002\/adma.201103612","article-title":"The marriage of terpyridines and inorganic nanoparticles: synthetic aspects, characterization techniques, and potential applications","volume":"23","author":"Winter","year":"2011","journal-title":"Adv. Mater."},{"key":"10.1016\/j.ejmech.2020.112039_bib5","doi-asserted-by":"crossref","first-page":"803292","DOI":"10.1155\/2011\/803292","article-title":"Synthesis, characterization, crystal structure, and biological studies of a cadmium(II) complex with a tridentate ligand 4\u2019-chloro-2,2\u2019:6\u2019,2\u2019\u2019-terpyridine","volume":"2011","author":"Saghatforoush","year":"2011","journal-title":"Bioinorgan. Chem. Appl."},{"key":"10.1016\/j.ejmech.2020.112039_bib6","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1155\/MBD.1996.185","article-title":"Properties of binuclear rhodium(II) complexes and their antibacterial activity","volume":"3","author":"Pruchnik","year":"1996","journal-title":"Met. Based Drugs"},{"key":"10.1016\/j.ejmech.2020.112039_bib7","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1039\/b716011a","article-title":"Synthesis, characterization and electrochemistry of 4\u2019-functionalized 2,2\u2019:6\u2019,2\u2019\u2019-terpyridine ruthenium(II) complexes and their biological activity","author":"Anthonysamy","year":"2008","journal-title":"Dalton Trans."},{"key":"10.1016\/j.ejmech.2020.112039_bib8","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.saa.2013.09.049","article-title":"Effect of substituent of terpyridines on the in\u00a0vitro antioxidant, antitubercular, biocidal and fluorescence studies of copper(II) complexes with clioquinol","volume":"117","author":"Kharadi","year":"2014","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.ejmech.2020.112039_bib9","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1021\/jm991053y","article-title":"Cytotoxicity of 2,2\u2019:6\u2019,2 - terpyridineplatinum(II) complexes against human ovarian carcinoma","volume":"42","author":"Lowe","year":"1999","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112039_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jinorgbio.2016.10.001","article-title":"New 4\u2019-(4-chlorophenyl)-2,2\u2019:6\u2019,2\u2033-terpyridine ruthenium(II) complexes: synthesis, characterization, interaction with DNA\/BSA and cytotoxicity studies","volume":"169","author":"Milutinovi\u0107","year":"2017","journal-title":"J.\u00a0Inorg. Biochem."},{"key":"10.1016\/j.ejmech.2020.112039_bib11","doi-asserted-by":"crossref","first-page":"4948","DOI":"10.1016\/j.bmc.2014.06.039","article-title":"Apoptosis-inducing effect of a palladium(II) saccharinate complex of terpyridine on human breast cancer cells in\u00a0vitro and in\u00a0vivo","volume":"22","author":"Ari","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112039_bib12","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.2174\/0929867321666140601201803","article-title":"DNA binding mode of transition metal complexes, a relationship to tumor cell toxicity","volume":"21","author":"Ashfaq","year":"2014","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112039_bib13","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jinorgbio.2017.06.002","article-title":"Recent development of transition metal complexes with in\u00a0vivo antitumor activity","volume":"177","author":"Liang","year":"2017","journal-title":"J.\u00a0Inorg. Biochem."},{"key":"10.1016\/j.ejmech.2020.112039_bib14","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.msec.2017.03.085","article-title":"Heteroleptic silver(I) complexes with 2,2\u2032:6\u2032,2\u2033-terpyridines and naproxen: DNA interaction, EGFR\/VEGFR2 kinase, growth inhibition and cell cycle arrest studies","volume":"76","author":"Mahendiran","year":"2017","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.ejmech.2020.112039_bib15","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.ejmech.2014.09.004","article-title":"6,6\"-dimethyl-2,2\u2019:6\u2019,2\"-terpyridine revisited: new fluorescent silver(I) helicates with in\u00a0vitro antiproliferative activity via selective nucleoli targeting","volume":"86","author":"Fik","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112039_bib16","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1039\/C5MT00149H","article-title":"Targeting copper in cancer therapy: \u201cCopper that Cancer\u201d","volume":"7","author":"Denoyer","year":"2015","journal-title":"Metallomics"},{"key":"10.1016\/j.ejmech.2020.112039_bib17","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1089\/ars.2010.3363","article-title":"Mitochondrial ROS generation and its regulation: mechanisms involved in H2O2 signaling","volume":"14","author":"Rigoulet","year":"2011","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.ejmech.2020.112039_bib18","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ceb.2014.09.010","article-title":"ROS-dependent signal transduction","volume":"33","author":"Reczek","year":"2015","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.ejmech.2020.112039_bib19","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nrd2803","article-title":"Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?","volume":"8","author":"Trachootham","year":"2009","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejmech.2020.112039_bib20","doi-asserted-by":"crossref","first-page":"477","DOI":"10.18632\/oncotarget.24844","article-title":"The role of oxidative stress in activity of anticancer thiosemicarbazones","volume":"9","author":"Malarz","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.ejmech.2020.112039_bib21","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.ejmech.2013.07.051","article-title":"DNA binding and cytotoxicity of copper (II) imidazole terpyridine complexes: role of oxyanion, hydrogen bonding and \u03c0-\u03c0 interaction","volume":"68","author":"Manikandamathavan","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112039_bib22","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.ejmech.2012.06.039","article-title":"Effect of coordinated ligands on antiproliferative activity and DNA cleavage property of three mononuclear Cu(II)-terpyridine complexes","volume":"57","author":"Manikandamathavan","year":"2012","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112039_bib23","doi-asserted-by":"crossref","first-page":"16061","DOI":"10.1039\/C5DT02211H","article-title":"The effect of potential supramolecular-bond promoters on the DNA-interacting abilities of copper-terpyridine compounds","volume":"44","author":"Grau","year":"2015","journal-title":"Dalton Trans."},{"key":"10.1016\/j.ejmech.2020.112039_bib24","doi-asserted-by":"crossref","first-page":"7794","DOI":"10.1039\/C5DT03831F","article-title":"Targeting of DNA molecules, BSA\/: C -Met tyrosine kinase receptors and anti-proliferative activity of bis(terpyridine)copper(II) complexes","volume":"45","author":"Mahendiran","year":"2016","journal-title":"Dalton Trans."},{"key":"10.1016\/j.ejmech.2020.112039_bib25","doi-asserted-by":"crossref","first-page":"5271","DOI":"10.1021\/jm900552r","article-title":"Thiosemicarbazones from the old to new: iron chelators that are more than just ribonucleotide reductase inhibitors","volume":"52","author":"Yu","year":"2009","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112039_bib26","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.ejmech.2019.03.027","article-title":"Anticancer activity of the thiosemicarbazones that are based on di-2-pyridine ketone and quinoline moiety","volume":"171","author":"Mrozek-Wilczkiewicz","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejmech.2020.112039_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0188767","article-title":"Piperazinyl fragment improves anticancer activity of triapine","volume":"13","author":"Rejmund","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.ejmech.2020.112039_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0110291","article-title":"Exploring the anti-cancer activity of novel thiosemicarbazones generated through the combination of retro-fragments: dissection of critical structure-activity relationships","volume":"9","author":"Serda","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ejmech.2020.112039_bib29","doi-asserted-by":"crossref","first-page":"7009","DOI":"10.1002\/slct.201801204","article-title":"4\u2032-Phenyl-2,2\u2032:6\u2032,2\u2032\u2032-terpyridine derivatives containing 1-substituted-2,3-triazole ring: synthesis, characterization and anticancer activity","volume":"3","author":"Zych","year":"2018","journal-title":"ChemistrySelect"},{"key":"10.1016\/j.ejmech.2020.112039_bib30","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1055\/s-0028-1088159","article-title":"Azido- and ethynyl-substituted 2,2\u2032:6\u2032,2\u2032\u2032-terpyridines as suitable substrates for click reactions","volume":"2009","author":"Winter","year":"2009","journal-title":"Synthesis"},{"key":"10.1016\/j.ejmech.2020.112039_bib31","doi-asserted-by":"crossref","first-page":"3480","DOI":"10.1002\/ejic.201600325","article-title":"Iridium(III) complexes of terpyridine- and terpyridine-analogous ligands bearing sugar residues and their in\u00a0vitro activity","volume":"2016","author":"Prokop","year":"2016","journal-title":"Eur. J. Inorg. Chem."},{"key":"10.1016\/j.ejmech.2020.112039_bib32","first-page":"133","article-title":"Highly selective detection of Zn2+ and Cd2+ with a simple amino-terpyridine compound in solution and solid state","volume":"128","author":"Chao","year":"2016","journal-title":"J.\u00a0Chem. Sci."},{"key":"10.1016\/j.ejmech.2020.112039_bib33","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1039\/C6DT03660K","article-title":"Novel mitochondria targeted copper(II) complexes of ferrocenyl terpyridine and anticancer active 8-hydroxyquinolines showing remarkable cytotoxicity, DNA and protein binding affinity","volume":"46","author":"Deka","year":"2017","journal-title":"Dalton Trans."},{"key":"10.1016\/j.ejmech.2020.112039_bib34","doi-asserted-by":"crossref","first-page":"12656","DOI":"10.1039\/C9DT01922G","article-title":"Copper(II) complexes with 2,2\u2032:6\u2032,2\u2032\u2032-terpyridine, 2,6-di(thiazol-2-yl)pyridine and 2,6-di(pyrazin-2-yl)pyridine substituted with quinolines. Synthesis, structure, antiproliferative activity, and catalytic activity in the oxidation of alkanes","volume":"48","author":"Choroba","year":"2019","journal-title":"Dalton Trans."},{"key":"10.1016\/j.ejmech.2020.112039_bib35","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1016\/j.bbamcr.2016.09.012","article-title":"Activation of apoptosis signalling pathways by reactive oxygen species","volume":"1863","author":"Redza-Dutordoir","year":"2016","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.ejmech.2020.112039_bib36","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1182\/blood-2007-03-076737","article-title":"Iron chelation and regulation of the cell cycle: 2 Mechanisms of posttranscriptional regulation of the universal cyclin-dependent kinase inhibitor p21CIP1\/WAF1 by iron depletion","volume":"110","author":"Fu","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.ejmech.2020.112039_bib37","doi-asserted-by":"crossref","first-page":"3505","DOI":"10.1039\/C4DT02700K","article-title":"Metal complex interactions with DNA","volume":"44","author":"Pages","year":"2015","journal-title":"Dalton Trans."},{"key":"10.1016\/j.ejmech.2020.112039_bib38","doi-asserted-by":"crossref","first-page":"9081","DOI":"10.1039\/C6NJ01880G","article-title":"A\u00a0water-soluble Pd(II) complex with a terpyridine ligand: experimental and molecular modeling studies of the interaction with DNA and BSA; and in\u00a0vitro cytotoxicity investigations against five human cancer cell lines","volume":"40","author":"Darabi","year":"2016","journal-title":"New J. Chem."},{"key":"10.1016\/j.ejmech.2020.112039_bib39","doi-asserted-by":"crossref","first-page":"4936","DOI":"10.1039\/C5RA24919H","article-title":"Interaction of Cd(II) and Ni(II) terpyridine complexes with model polynucleotides: a multidisciplinary approach","volume":"6","author":"Barone","year":"2016","journal-title":"RSC Adv."},{"key":"10.1016\/j.ejmech.2020.112039_bib40","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jinorgbio.2014.08.006","article-title":"Synthesis, DNA interaction and anticancer activity of copper(II) complexes with 4\u2032-phenyl-2,2\u2032:6\u2032,2\u2033-terpyridine derivatives","volume":"141","author":"Liang","year":"2014","journal-title":"J.\u00a0Inorg. Biochem."},{"key":"10.1016\/j.ejmech.2020.112039_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0142678","article-title":"Design, synthesis and in\u00a0vitro activity of anticancer styrylquinolines. The p53 independent mechanism of action","volume":"10","author":"Mrozek-Wilczkiewicz","year":"2015","journal-title":"PLoS One"}],"container-title":["European Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523420300064?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0223523420300064?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T14:04:45Z","timestamp":1759327485000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0223523420300064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":41,"alternative-id":["S0223523420300064"],"URL":"https:\/\/doi.org\/10.1016\/j.ejmech.2020.112039","relation":{},"ISSN":["0223-5234"],"issn-type":[{"value":"0223-5234","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anticancer activity of 4\u2032-phenyl-2,2\u2032:6\u2032,2\u2033-terpyridines \u2013 behind the metal complexation","name":"articletitle","label":"Article Title"},{"value":"European Journal of Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejmech.2020.112039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112039"}}